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Comparing single and multi-joint methods to detect knee joint proprioception deficits post primary unilateral total knee arthroplasty.

Ouattas A, Wellsandt E, Hunt NH, Boese CK, Knarr BA.

Clin Biomech (Bristol, Avon). 2019 Jun 14;68:197-204. doi: 10.1016/j.clinbiomech.2019.06.006. [Epub ahead of print]


Falcipain Inhibitors Based on the Natural Product Gallinamide A Are Potent in Vitro and in Vivo Antimalarials.

Stoye A, Juillard A, Tang AH, Legac J, Gut J, White KL, Charman SA, Rosenthal PJ, Grau GER, Hunt NH, Payne RJ.

J Med Chem. 2019 Jun 13;62(11):5562-5578. doi: 10.1021/acs.jmedchem.9b00504. Epub 2019 May 22.


Blood‒Brain Barrier Pathology and CNS Outcomes in Streptococcus pneumoniae Meningitis.

Yau B, Hunt NH, Mitchell AJ, Too LK.

Int J Mol Sci. 2018 Nov 11;19(11). pii: E3555. doi: 10.3390/ijms19113555. Review.


Interplay of extracellular vesicles and other players in cerebral malaria pathogenesis.

Debs S, Cohen A, Hosseini-Beheshti E, Chimini G, Hunt NH, Grau GER.

Biochim Biophys Acta Gen Subj. 2019 Feb;1863(2):325-331. doi: 10.1016/j.bbagen.2018.10.012. Epub 2018 Oct 17. Review.


Investigation of the Tissue Distribution and Physiological Roles of Indoleamine 2,3-Dioxygenase-2.

Jusof FF, Bakmiwewa SM, Weiser S, Too LK, Metz R, Prendergast GC, Fraser ST, Hunt NH, Ball HJ.

Int J Tryptophan Res. 2017 Oct 9;10:1178646917735098. doi: 10.1177/1178646917735098. eCollection 2017.


Increased Indoleamine 2,3-Dioxygenase and Quinolinic Acid Expression in Microglia and Müller Cells of Diabetic Human and Rodent Retina.

Hu P, Hunt NH, Arfuso F, Shaw LC, Uddin MN, Zhu M, Devasahayam R, Adamson SJ, Benson VL, Chan-Ling T, Grant MB.

Invest Ophthalmol Vis Sci. 2017 Oct 1;58(12):5043-5055. doi: 10.1167/iovs.17-21654.


Hydrogen peroxide dynamics in subcellular compartments of malaria parasites using genetically encoded redox probes.

Rahbari M, Rahlfs S, Przyborski JM, Schuh AK, Hunt NH, Fidock DA, Grau GE, Becker K.

Sci Rep. 2017 Sep 5;7(1):10449. doi: 10.1038/s41598-017-10093-8.


TIGR4 strain causes more severe disease than WU2 strain in a mouse model of Streptococcus pneumoniae meningitis: a common pathogenic role for interferon-γ.

Yau B, Too LK, Ball HJ, Hunt NH.

Microbes Infect. 2017 Jul - Aug;19(7-8):413-421. doi: 10.1016/j.micinf.2017.04.002. Epub 2017 Apr 22.


Controlled release of artemisone for the treatment of experimental cerebral malaria.

Golenser J, Buchholz V, Bagheri A, Nasereddin A, Dzikowski R, Guo J, Hunt NH, Eyal S, Vakruk N, Greiner A.

Parasit Vectors. 2017 Mar 1;10(1):117. doi: 10.1186/s13071-017-2018-7.


Behavioral and cognitive data in mice with different tryptophan-metabolizing enzymes knocked out.

Too LK, Li KM, Suarna C, Maghzal GJ, Stocker R, McGregor IS, Hunt NH.

Data Brief. 2016 Sep 6;9:275-87. doi: 10.1016/j.dib.2016.08.071. eCollection 2016 Dec.


Deletion of TDO2, IDO-1 and IDO-2 differentially affects mouse behavior and cognitive function.

Too LK, Li KM, Suarna C, Maghzal GJ, Stocker R, McGregor IS, Hunt NH.

Behav Brain Res. 2016 Oct 1;312:102-17. doi: 10.1016/j.bbr.2016.06.018. Epub 2016 Jun 15.


Antibody-induced neutrophil depletion prior to the onset of pneumococcal meningitis influences long-term neurological complications in mice.

Too LK, Mitchell AJ, McGregor IS, Hunt NH.

Brain Behav Immun. 2016 Aug;56:68-83. doi: 10.1016/j.bbi.2016.01.021. Epub 2016 Mar 7.


The kynurenine pathway and parasitic infections that affect CNS function.

Hunt NH, Too LK, Khaw LT, Guo J, Hee L, Mitchell AJ, Grau GE, Ball HJ.

Neuropharmacology. 2017 Jan;112(Pt B):389-398. doi: 10.1016/j.neuropharm.2016.02.029. Epub 2016 Feb 26. Review.


Mechanisms of murine cerebral malaria: Multimodal imaging of altered cerebral metabolism and protein oxidation at hemorrhage sites.

Hackett MJ, Aitken JB, El-Assaad F, McQuillan JA, Carter EA, Ball HJ, Tobin MJ, Paterson D, de Jonge MD, Siegele R, Cohen DD, Vogt S, Grau GE, Hunt NH, Lay PA.

Sci Adv. 2015 Dec 18;1(11):e1500911. doi: 10.1126/sciadv.1500911. eCollection 2015 Dec.


Altered behaviour and cognitive function following combined deletion of Toll-like receptors 2 and 4 in mice.

Too LK, McGregor IS, Baxter AG, Hunt NH.

Behav Brain Res. 2016 Apr 15;303:1-8. doi: 10.1016/j.bbr.2016.01.024. Epub 2016 Jan 13.


Synergistic induction of CXCL10 by interferon-gamma and lymphotoxin-alpha in astrocytes: Possible role in cerebral malaria.

Bakmiwewa SM, Weiser S, Grey M, Heng B, Guillemin GJ, Ball HJ, Hunt NH.

Cytokine. 2016 Feb;78:79-86. doi: 10.1016/j.cyto.2015.11.024. Epub 2015 Dec 11.


Benzo[b]quinolizinium Derivatives Have a Strong Antimalarial Activity and Inhibit Indoleamine Dioxygenase.

Jortzik E, Zocher K, Isernhagen A, Mailu BM, Rahlfs S, Viola G, Wittlin S, Hunt NH, Ihmels H, Becker K.

Antimicrob Agents Chemother. 2015 Oct 12;60(1):115-25. doi: 10.1128/AAC.01066-15. Print 2016 Jan.


An effective, low-cost method for achieving and maintaining hypoxia during cell culture studies.

Bakmiwewa SM, Heng B, Guillemin GJ, Ball HJ, Hunt NH.

Biotechniques. 2015 Oct 1;59(4):223-4, 226, 228-9. doi: 10.2144/000114341. eCollection 2015 Oct.


Interferon-γ-Induced Nitric Oxide Synthase-2 Contributes to Blood/Brain Barrier Dysfunction and Acute Mortality in Experimental Streptococcus pneumoniae Meningitis.

Yau B, Mitchell AJ, Too LK, Ball HJ, Hunt NH.

J Interferon Cytokine Res. 2016 Feb;36(2):86-99. doi: 10.1089/jir.2015.0078. Epub 2015 Sep 29.


Effects of dietary fat profile on gut permeability and microbiota and their relationships with metabolic changes in mice.

Lam YY, Ha CW, Hoffmann JM, Oscarsson J, Dinudom A, Mather TJ, Cook DI, Hunt NH, Caterson ID, Holmes AJ, Storlien LH.

Obesity (Silver Spring). 2015 Jul;23(7):1429-39. doi: 10.1002/oby.21122. Epub 2015 Jun 5.


IRGM3 contributes to immunopathology and is required for differentiation of antigen-specific effector CD8+ T cells in experimental cerebral malaria.

Guo J, McQuillan JA, Yau B, Tullo GS, Long CA, Bertolino P, Roediger B, Weninger W, Taylor GA, Hunt NH, Ball HJ, Mitchell AJ.

Infect Immun. 2015 Apr;83(4):1406-17. doi: 10.1128/IAI.02701-14. Epub 2015 Feb 2.


Synthesis of gallinamide A analogues as potent falcipain inhibitors and antimalarials.

Conroy T, Guo JT, Elias N, Cergol KM, Gut J, Legac J, Khatoon L, Liu Y, McGowan S, Rosenthal PJ, Hunt NH, Payne RJ.

J Med Chem. 2014 Dec 26;57(24):10557-63. doi: 10.1021/jm501439w. Epub 2014 Dec 8.


Tryptophan-catabolizing enzymes - party of three.

Ball HJ, Jusof FF, Bakmiwewa SM, Hunt NH, Yuasa HJ.

Front Immunol. 2014 Oct 9;5:485. doi: 10.3389/fimmu.2014.00485. eCollection 2014. Review.


The kynurenine pathway of tryptophan degradation is activated during osteoblastogenesis.

Vidal C, Li W, Santner-Nanan B, Lim CK, Guillemin GJ, Ball HJ, Hunt NH, Nanan R, Duque G.

Stem Cells. 2015 Jan;33(1):111-21. doi: 10.1002/stem.1836.


Cerebral malaria: gamma-interferon redux.

Hunt NH, Ball HJ, Hansen AM, Khaw LT, Guo J, Bakmiwewa S, Mitchell AJ, Combes V, Grau GE.

Front Cell Infect Microbiol. 2014 Aug 15;4:113. doi: 10.3389/fcimb.2014.00113. eCollection 2014. Review.


Brain endothelial cells increase the proliferation of Plasmodium falciparum through production of soluble factors.

Khaw LT, Ball HJ, Mitchell AJ, Grau GE, Stocker R, Golenser J, Hunt NH.

Exp Parasitol. 2014 Oct;145:34-41. doi: 10.1016/j.exppara.2014.07.002. Epub 2014 Jul 18.


Real-time imaging reveals the dynamics of leukocyte behaviour during experimental cerebral malaria pathogenesis.

Pai S, Qin J, Cavanagh L, Mitchell A, El-Assaad F, Jain R, Combes V, Hunt NH, Grau GE, Weninger W.

PLoS Pathog. 2014 Jul 17;10(7):e1004236. doi: 10.1371/journal.ppat.1004236. eCollection 2014 Jul.


Treatment of murine cerebral malaria by artemisone in combination with conventional antimalarial drugs: antiplasmodial effects and immune responses.

Guiguemde WA, Hunt NH, Guo J, Marciano A, Haynes RK, Clark J, Guy RK, Golenser J.

Antimicrob Agents Chemother. 2014 Aug;58(8):4745-54. doi: 10.1128/AAC.01553-13. Epub 2014 Jun 9.


The Fe-heme structure of met-indoleamine 2,3-dioxygenase-2 determined by X-ray absorption fine structure.

Aitken JB, Austin CJ, Hunt NH, Ball HJ, Lay PA.

Biochem Biophys Res Commun. 2014 Jul 18;450(1):25-9. doi: 10.1016/j.bbrc.2014.05.054. Epub 2014 May 22.


The kynurenine pathway contributes to long-term neuropsychological changes in experimental pneumococcal meningitis.

Too LK, McQuillan JA, Ball HJ, Kanai M, Nakamura T, Funakoshi H, McGregor IS, Hunt NH.

Behav Brain Res. 2014 Aug 15;270:179-95. doi: 10.1016/j.bbr.2014.05.018. Epub 2014 May 17.


Production, fate and pathogenicity of plasma microparticles in murine cerebral malaria.

El-Assaad F, Wheway J, Hunt NH, Grau GE, Combes V.

PLoS Pathog. 2014 Mar 20;10(3):e1003839. doi: 10.1371/journal.ppat.1003839. eCollection 2014 Mar. Erratum in: PLoS Pathog. 2014 Apr;10(4):e1004119.


The pro-inflammatory cytokine interferon-gamma is an important driver of neuropathology and behavioural sequelae in experimental pneumococcal meningitis.

Too LK, Ball HJ, McGregor IS, Hunt NH.

Brain Behav Immun. 2014 Aug;40:252-68. doi: 10.1016/j.bbi.2014.02.020. Epub 2014 Mar 7.


Interleukin-18 deficiency and its long-term behavioural and cognitive impacts in a murine model of pneumococcal meningitis.

Too LK, Mitchell AJ, Yau B, Ball HJ, McGregor IS, Hunt NH.

Behav Brain Res. 2014 Apr 15;263:176-89. doi: 10.1016/j.bbr.2014.01.035. Epub 2014 Feb 3.


Indoleamine 2,3-dioxygenase 2 (IDO2) and the kynurenine pathway: characteristics and potential roles in health and disease.

Fatokun AA, Hunt NH, Ball HJ.

Amino Acids. 2013 Dec;45(6):1319-29. doi: 10.1007/s00726-013-1602-1. Epub 2013 Oct 9. Review.


A novel automated test battery reveals enduring behavioural alterations and cognitive impairments in survivors of murine pneumococcal meningitis.

Too LK, Ball HJ, McGregor IS, Hunt NH.

Brain Behav Immun. 2014 Jan;35:107-24. doi: 10.1016/j.bbi.2013.09.007. Epub 2013 Sep 21.


Cytoadherence of Plasmodium berghei-infected red blood cells to murine brain and lung microvascular endothelial cells in vitro.

El-Assaad F, Wheway J, Mitchell AJ, Lou J, Hunt NH, Combes V, Grau GE.

Infect Immun. 2013 Nov;81(11):3984-91. doi: 10.1128/IAI.00428-13. Epub 2013 Aug 12.


Endothelial cells potentiate interferon-γ production in a novel tripartite culture model of human cerebral malaria.

Khaw LT, Ball HJ, Golenser J, Combes V, Grau GE, Wheway J, Mitchell AJ, Hunt NH.

PLoS One. 2013 Jul 12;8(7):e69521. doi: 10.1371/journal.pone.0069521. Print 2013.


Improved spectrophotometric human interferon-gamma bioassay.

Jusof FF, Khaw LT, Ball HJ, Hunt NH.

J Immunol Methods. 2013 Aug 30;394(1-2):115-20. doi: 10.1016/j.jim.2013.05.011. Epub 2013 May 31.


FTIR imaging of brain tissue reveals crystalline creatine deposits are an ex vivo marker of localized ischemia during murine cerebral malaria: general implications for disease neurochemistry.

Hackett MJ, Lee J, El-Assaad F, McQuillan JA, Carter EA, Grau GE, Hunt NH, Lay PA.

ACS Chem Neurosci. 2012 Dec 19;3(12):1017-24. doi: 10.1021/cn300093g. Epub 2012 Sep 11.


Identification of selective inhibitors of indoleamine 2,3-dioxygenase 2.

Bakmiwewa SM, Fatokun AA, Tran A, Payne RJ, Hunt NH, Ball HJ.

Bioorg Med Chem Lett. 2012 Dec 15;22(24):7641-6. doi: 10.1016/j.bmcl.2012.10.010. Epub 2012 Oct 11.


Inflammasome-dependent IFN-γ drives pathogenesis in Streptococcus pneumoniae meningitis.

Mitchell AJ, Yau B, McQuillan JA, Ball HJ, Too LK, Abtin A, Hertzog P, Leib SL, Jones CA, Gerega SK, Weninger W, Hunt NH.

J Immunol. 2012 Nov 15;189(10):4970-80. doi: 10.4049/jimmunol.1201687. Epub 2012 Oct 15.


The crossroads of neuroinflammation in infectious diseases: endothelial cells and astrocytes.

Combes V, Guillemin GJ, Chan-Ling T, Hunt NH, Grau GE.

Trends Parasitol. 2012 Aug;28(8):311-9. doi: 10.1016/ Epub 2012 Jun 22. Review.


Increased gut permeability and microbiota change associate with mesenteric fat inflammation and metabolic dysfunction in diet-induced obese mice.

Lam YY, Ha CW, Campbell CR, Mitchell AJ, Dinudom A, Oscarsson J, Cook DI, Hunt NH, Caterson ID, Holmes AJ, Storlien LH.

PLoS One. 2012;7(3):e34233. doi: 10.1371/journal.pone.0034233. Epub 2012 Mar 23.


Total synthesis, stereochemical assignment, and antimalarial activity of gallinamide A.

Conroy T, Guo JT, Linington RG, Hunt NH, Payne RJ.

Chemistry. 2011 Nov 25;17(48):13544-52. doi: 10.1002/chem.201102538. Epub 2011 Oct 18.


Synthesis of artemiside and its effects in combination with conventional drugs against severe murine malaria.

Guo J, Guiguemde AW, Bentura-Marciano A, Clark J, Haynes RK, Chan WC, Wong HN, Hunt NH, Guy RK, Golenser J.

Antimicrob Agents Chemother. 2012 Jan;56(1):163-73. doi: 10.1128/AAC.05006-11. Epub 2011 Oct 17.


Quantitation of brain edema and localisation of aquaporin 4 expression in relation to susceptibility to experimental cerebral malaria.

Ampawong S, Combes V, Hunt NH, Radford J, Chan-Ling T, Pongponratn E, Grau GE.

Int J Clin Exp Pathol. 2011 Aug 15;4(6):566-74. Epub 2011 Jul 23.


Role of the gut in visceral fat inflammation and metabolic disorders.

Lam YY, Mitchell AJ, Holmes AJ, Denyer GS, Gummesson A, Caterson ID, Hunt NH, Storlien LH.

Obesity (Silver Spring). 2011 Nov;19(11):2113-20. doi: 10.1038/oby.2011.68. Epub 2011 Sep 1. Review. No abstract available.


CNS hypoxia is more pronounced in murine cerebral than noncerebral malaria and is reversed by erythropoietin.

Hempel C, Combes V, Hunt NH, Kurtzhals JA, Grau GE.

Am J Pathol. 2011 Oct;179(4):1939-50. doi: 10.1016/j.ajpath.2011.06.027. Epub 2011 Aug 18.


Chemical alterations to murine brain tissue induced by formalin fixation: implications for biospectroscopic imaging and mapping studies of disease pathogenesis.

Hackett MJ, McQuillan JA, El-Assaad F, Aitken JB, Levina A, Cohen DD, Siegele R, Carter EA, Grau GE, Hunt NH, Lay PA.

Analyst. 2011 Jul 21;136(14):2941-52. doi: 10.1039/c0an00269k. Epub 2011 May 31.


Redox pioneer: professor Roland Stocker.

Hunt NH.

Antioxid Redox Signal. 2011 Dec 15;15(12):3101-5. doi: 10.1089/ars.2010.3842. Epub 2011 Jul 19.


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