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Genetic and Pharmacological Targeting of Heat Shock Protein 70 in the Mouse Amygdala-Kindling Model.

von Rüden EL, Wolf F, Gualtieri F, Keck M, Hunt CR, Pandita TK, Potschka H.

ACS Chem Neurosci. 2019 Mar 20;10(3):1434-1444. doi: 10.1021/acschemneuro.8b00475. Epub 2018 Nov 16.


The small heat shock protein HSPB1 protects mice from sepsis.

Breed ER, Hilliard CA, Yoseph B, Mittal R, Liang Z, Chen CW, Burd EM, Brewster LP, Hansen LM, Gleason RL Jr, Pandita TK, Ford ML, Hunt CR, Coopersmith CM.

Sci Rep. 2018 Aug 21;8(1):12493. doi: 10.1038/s41598-018-30752-8.


SMARCAD1 Phosphorylation and Ubiquitination Are Required for Resection during DNA Double-Strand Break Repair.

Chakraborty S, Pandita RK, Hambarde S, Mattoo AR, Charaka V, Ahmed KM, Iyer SP, Hunt CR, Pandita TK.

iScience. 2018 Apr 27;2:123-135. doi: 10.1016/j.isci.2018.03.016.


Harnessing and Optimizing the Interplay between Immunotherapy and Radiotherapy to Improve Survival Outcomes.

Mujoo K, Hunt CR, Pandita RK, Ferrari M, Krishnan S, Cooke JP, Hahn S, Pandita TK.

Mol Cancer Res. 2018 Aug;16(8):1209-1214. doi: 10.1158/1541-7786.MCR-17-0743. Epub 2018 Mar 28. Review.


β1-Integrin Impacts Rad51 Stability and DNA Double-Strand Break Repair by Homologous Recombination.

Ahmed KM, Pandita RK, Singh DK, Hunt CR, Pandita TK.

Mol Cell Biol. 2018 Apr 16;38(9). pii: e00672-17. doi: 10.1128/MCB.00672-17. Print 2018 May 1.


MOF Suppresses Replication Stress and Contributes to Resolution of Stalled Replication Forks.

Singh DK, Pandita RK, Singh M, Chakraborty S, Hambarde S, Ramnarain D, Charaka V, Ahmed KM, Hunt CR, Pandita TK.

Mol Cell Biol. 2018 Feb 27;38(6). pii: e00484-17. doi: 10.1128/MCB.00484-17. Print 2018 Mar 15.


Cross Talk between Radiation and Immunotherapy: The Twain Shall Meet.

Iyer SP, Hunt CR, Pandita TK.

Radiat Res. 2018 Mar;189(3):219-224. doi: 10.1667/RR14941.1. Epub 2017 Dec 20. Review.


Differentiation of Human Induced Pluripotent or Embryonic Stem Cells Decreases the DNA Damage Repair by Homologous Recombination.

Mujoo K, Pandita RK, Tiwari A, Charaka V, Chakraborty S, Singh DK, Hambarde S, Hittelman WN, Horikoshi N, Hunt CR, Khanna KK, Kots AY, Butler EB, Murad F, Pandita TK.

Stem Cell Reports. 2017 Nov 14;9(5):1660-1674. doi: 10.1016/j.stemcr.2017.10.002. Epub 2017 Nov 2.


Nuclear functions of β2-Spectrin in genomic stability.

Mujoo K, Hunt CR, Pandita TK.

Aging (Albany NY). 2016 Dec 14;8(12):3151-3152. doi: 10.18632/aging.101147. No abstract available.


MCL-1 Depletion Impairs DNA Double-Strand Break Repair and Reinitiation of Stalled DNA Replication Forks.

Mattoo AR, Pandita RK, Chakraborty S, Charaka V, Mujoo K, Hunt CR, Pandita TK.

Mol Cell Biol. 2017 Jan 19;37(3). pii: e00535-16. doi: 10.1128/MCB.00535-16. Print 2017 Feb 1.


Pluripotent Stem Cells and DNA Damage Response to Ionizing Radiations.

Mujoo K, Butler EB, Pandita RK, Hunt CR, Pandita TK.

Radiat Res. 2016 Jul;186(1):17-26. doi: 10.1667/RR14417.1. Epub 2016 Jun 22. Review.


β2-spectrin depletion impairs DNA damage repair.

Horikoshi N, Pandita RK, Mujoo K, Hambarde S, Sharma D, Mattoo AR, Chakraborty S, Charaka V, Hunt CR, Pandita TK.

Oncotarget. 2016 Jun 7;7(23):33557-70. doi: 10.18632/oncotarget.9677.


Torin2 Suppresses Ionizing Radiation-Induced DNA Damage Repair.

Udayakumar D, Pandita RK, Horikoshi N, Liu Y, Liu Q, Wong KK, Hunt CR, Gray NS, Minna JD, Pandita TK, Westover KD.

Radiat Res. 2016 May;185(5):527-38. doi: 10.1667/RR14373.1. Epub 2016 May 2.


Emerging therapeutic targets in esophageal adenocarcinoma.

Gaur P, Hunt CR, Pandita TK.

Oncotarget. 2016 Jul 26;7(30):48644-48655. doi: 10.18632/oncotarget.8777. Review.


A multifaceted role for MOF histone modifying factor in genome maintenance.

Mujoo K, Hunt CR, Horikoshi N, Pandita TK.

Mech Ageing Dev. 2017 Jan;161(Pt A):177-180. doi: 10.1016/j.mad.2016.03.012. Epub 2016 Mar 30. Review.


More complex transcriptional regulation and stress response by MOF.

Horikoshi N, Hunt CR, Pandita TK.

Oncogene. 2016 May;35(21):2681-3. doi: 10.1038/onc.2015.373. Epub 2015 Oct 5.


Role of the Exocyst Complex Component Sec6/8 in Genomic Stability.

Torres MJ, Pandita RK, Kulak O, Kumar R, Formstecher E, Horikoshi N, Mujoo K, Hunt CR, Zhao Y, Lum L, Zaman A, Yeaman C, White MA, Pandita TK.

Mol Cell Biol. 2015 Nov;35(21):3633-45. doi: 10.1128/MCB.00768-15. Epub 2015 Aug 17.


Single-strand DNA-binding protein SSB1 facilitates TERT recruitment to telomeres and maintains telomere G-overhangs.

Pandita RK, Chow TT, Udayakumar D, Bain AL, Cubeddu L, Hunt CR, Shi W, Horikoshi N, Zhao Y, Wright WE, Khanna KK, Shay JW, Pandita TK.

Cancer Res. 2015 Mar 1;75(5):858-69. doi: 10.1158/0008-5472.CAN-14-2289. Epub 2015 Jan 14.


MOF phosphorylation by ATM regulates 53BP1-mediated double-strand break repair pathway choice.

Gupta A, Hunt CR, Hegde ML, Chakraborty S, Chakraborty S, Udayakumar D, Horikoshi N, Singh M, Ramnarain DB, Hittelman WN, Namjoshi S, Asaithamby A, Hazra TK, Ludwig T, Pandita RK, Tyler JK, Pandita TK.

Cell Rep. 2014 Jul 10;8(1):177-89. doi: 10.1016/j.celrep.2014.05.044. Epub 2014 Jun 19. Erratum in: Cell Rep. 2014 Jul 10;8(1):319.


Optically enhanced coherent transport in YBa2Cu3O6.5 by ultrafast redistribution of interlayer coupling.

Hu W, Kaiser S, Nicoletti D, Hunt CR, Gierz I, Hoffmann MC, Le Tacon M, Loew T, Keimer B, Cavalleri A.

Nat Mater. 2014 Jul;13(7):705-11. doi: 10.1038/nmat3963. Epub 2014 May 11.


Effect of HSP25 loss on muscle contractile function and running wheel activity in young and old mice.

Huey KA, Hilliard CA, Hunt CR.

Front Physiol. 2013 Dec 31;4:398. doi: 10.3389/fphys.2013.00398. eCollection 2013.


Role of 53BP1 in the regulation of DNA double-strand break repair pathway choice.

Gupta A, Hunt CR, Chakraborty S, Pandita RK, Yordy J, Ramnarain DB, Horikoshi N, Pandita TK.

Radiat Res. 2014 Jan;181(1):1-8. doi: 10.1667/RR13572.1. Epub 2013 Dec 9. Review.


Argonaute-1 functions as a mitotic regulator by controlling Cyclin B during Drosophila early embryogenesis.

Pushpavalli SN, Sarkar A, Bag I, Hunt CR, Ramaiah MJ, Pandita TK, Bhadra U, Pal-Bhadra M.

FASEB J. 2014 Feb;28(2):655-66. doi: 10.1096/fj.13-231167. Epub 2013 Oct 28.


A protective Hsp70-TLR4 pathway in lethal oxidant lung injury.

Zhang Y, Zhang X, Shan P, Hunt CR, Pandita TK, Lee PJ.

J Immunol. 2013 Aug 1;191(3):1393-403. doi: 10.4049/jimmunol.1300052. Epub 2013 Jul 1.


Genome-wide distribution of histone H4 Lysine 16 acetylation sites and their relationship to gene expression.

Horikoshi N, Kumar P, Sharma GG, Chen M, Hunt CR, Westover K, Chowdhury S, Pandita TK.

Genome Integr. 2013 Apr 12;4(1):3. doi: 10.1186/2041-9414-4-3.


T-cell-specific deletion of Mof blocks their differentiation and results in genomic instability in mice.

Gupta A, Hunt CR, Pandita RK, Pae J, Komal K, Singh M, Shay JW, Kumar R, Ariizumi K, Horikoshi N, Hittelman WN, Guha C, Ludwig T, Pandita TK.

Mutagenesis. 2013 May;28(3):263-70. doi: 10.1093/mutage/ges080. Epub 2013 Feb 5.


Histone modifications and DNA double-strand break repair after exposure to ionizing radiations.

Hunt CR, Ramnarain D, Horikoshi N, Iyengar P, Pandita RK, Shay JW, Pandita TK.

Radiat Res. 2013 Apr;179(4):383-92. doi: 10.1667/RR3308.2. Epub 2013 Feb 1. Review.


Chromatin modifications and the DNA damage response to ionizing radiation.

Kumar R, Horikoshi N, Singh M, Gupta A, Misra HS, Albuquerque K, Hunt CR, Pandita TK.

Front Oncol. 2013 Jan 22;2:214. doi: 10.3389/fonc.2012.00214. eCollection 2012.


Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest.

Singh M, Hunt CR, Pandita RK, Kumar R, Yang CR, Horikoshi N, Bachoo R, Serag S, Story MD, Shay JW, Powell SN, Gupta A, Jeffery J, Pandita S, Chen BP, Deckbar D, Löbrich M, Yang Q, Khanna KK, Worman HJ, Pandita TK.

Mol Cell Biol. 2013 Mar;33(6):1210-22. doi: 10.1128/MCB.01676-12. Epub 2013 Jan 14. Erratum in: Mol Cell Biol. 2013 Aug;33(16):3390.


Does PTEN loss impair DNA double-strand break repair by homologous recombination?

Hunt CR, Gupta A, Horikoshi N, Pandita TK.

Clin Cancer Res. 2012 Feb 15;18(4):920-2. doi: 10.1158/1078-0432.CCR-11-3131. Epub 2011 Dec 16.


Inhibition of heat shock transcription factor binding by a linear polyamide binding in an unusual 1:1 mode.

Wang RE, Pandita RK, Cai J, Hunt CR, Taylor JS.

Chembiochem. 2012 Jan 2;13(1):97-104. doi: 10.1002/cbic.201100524. Epub 2011 Dec 1.


Biotinylated quercetin as an intrinsic photoaffinity proteomics probe for the identification of quercetin target proteins.

Wang RE, Hunt CR, Chen J, Taylor JS.

Bioorg Med Chem. 2011 Aug 15;19(16):4710-20. doi: 10.1016/j.bmc.2011.07.005. Epub 2011 Jul 13.


Purkinje cell-specific males absent on the first (mMof) gene deletion results in an ataxia-telangiectasia-like neurological phenotype and backward walking in mice.

Kumar R, Hunt CR, Gupta A, Nannepaga S, Pandita RK, Shay JW, Bachoo R, Ludwig T, Burns DK, Pandita TK.

Proc Natl Acad Sci U S A. 2011 Mar 1;108(9):3636-41. doi: 10.1073/pnas.1016524108. Epub 2011 Feb 14.


The role of heat shock protein 70 in mediating age-dependent mortality in sepsis.

McConnell KW, Fox AC, Clark AT, Chang NY, Dominguez JA, Farris AB, Buchman TG, Hunt CR, Coopersmith CM.

J Immunol. 2011 Mar 15;186(6):3718-25. doi: 10.4049/jimmunol.1003652. Epub 2011 Feb 4.


Induction of heat shock protein 70 inhibits ischemic renal injury.

Wang Z, Gall JM, Bonegio RG, Havasi A, Hunt CR, Sherman MY, Schwartz JH, Borkan SC.

Kidney Int. 2011 Apr;79(8):861-70. doi: 10.1038/ki.2010.527. Epub 2011 Jan 26.


TSPO targeted dendrimer imaging agent: synthesis, characterization, and cellular internalization.

Samuelson LE, Dukes MJ, Hunt CR, Casey JD, Bornhop DJ.

Bioconjug Chem. 2009 Nov;20(11):2082-9. doi: 10.1021/bc9002053.


Geldanamycin and its anti-cancer activities.

Fukuyo Y, Hunt CR, Horikoshi N.

Cancer Lett. 2010 Apr 1;290(1):24-35. doi: 10.1016/j.canlet.2009.07.010. Epub 2009 Oct 21. Review.


Phosphorylation-dependent Lys63-linked polyubiquitination of Daxx is essential for sustained TNF-{alpha}-induced ASK1 activation.

Fukuyo Y, Kitamura T, Inoue M, Horikoshi NT, Higashikubo R, Hunt CR, Usheva A, Horikoshi N.

Cancer Res. 2009 Oct 1;69(19):7512-7. doi: 10.1158/0008-5472.CAN-09-2148. Epub 2009 Sep 29.


Nucleophosmin redistribution following heat shock: a role in heat-induced radiosensitization.

Vanderwaal RP, Maggi LB Jr, Weber JD, Hunt CR, Roti Roti JL.

Cancer Res. 2009 Aug 15;69(16):6454-62. doi: 10.1158/0008-5472.CAN-08-4896. Epub 2009 Jul 28.


Absence of IFN-beta impairs antigen presentation capacity of splenic dendritic cells via down-regulation of heat shock protein 70.

Zietara N, Łyszkiewicz M, Gekara N, Puchałka J, Dos Santos VA, Hunt CR, Pandita TK, Lienenklaus S, Weiss S.

J Immunol. 2009 Jul 15;183(2):1099-109. doi: 10.4049/jimmunol.0803214.


Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair.

Gupta A, Yang Q, Pandita RK, Hunt CR, Xiang T, Misri S, Zeng S, Pagan J, Jeffery J, Puc J, Kumar R, Feng Z, Powell SN, Bhat A, Yaguchi T, Wadhwa R, Kaul SC, Parsons R, Khanna KK, Pandita TK.

Cell Cycle. 2009 Jul 15;8(14):2198-210. Epub 2009 Jul 7.


Inhibition of heat shock induction of heat shock protein 70 and enhancement of heat shock protein 27 phosphorylation by quercetin derivatives.

Wang RE, Kao JL, Hilliard CA, Pandita RK, Roti Roti JL, Hunt CR, Taylor JS.

J Med Chem. 2009 Apr 9;52(7):1912-21. doi: 10.1021/jm801445c.


Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization.

Agarwal M, Pandita S, Hunt CR, Gupta A, Yue X, Khan S, Pandita RK, Pratt D, Shay JW, Taylor JS, Pandita TK.

Cancer Res. 2008 May 1;68(9):3370-8. doi: 10.1158/0008-5472.CAN-07-5831.


9 years of recurrent dysphagia.

Basavaraju KP, Hunt CR, Ahluwalia NK.

Lancet. 2007 May 26;369(9575):1814. doi: 10.1016/S0140-6736(07)60819-8. No abstract available.


Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status.

Hunt CR, Pandita RK, Laszlo A, Higashikubo R, Agarwal M, Kitamura T, Gupta A, Rief N, Horikoshi N, Baskaran R, Lee JH, Löbrich M, Paull TT, Roti Roti JL, Pandita TK.

Cancer Res. 2007 Apr 1;67(7):3010-7.


Anti-apoptotic peptides protect against radiation-induced cell death.

McConnell KW, Muenzer JT, Chang KC, Davis CG, McDunn JE, Coopersmith CM, Hilliard CA, Hotchkiss RS, Grigsby PW, Hunt CR.

Biochem Biophys Res Commun. 2007 Apr 6;355(2):501-7. Epub 2007 Feb 8.


Regulation of telomere movement by telomere chromatin structure.

Pandita TK, Hunt CR, Sharma GG, Yang Q.

Cell Mol Life Sci. 2007 Jan;64(2):131-8. Review.


An unusual cause of melena.

Basavaraju KP, Armitage K, Hunt CR, Ahluwalia NK.

Gut. 2005 Aug;54(8):1180, 1193. No abstract available.


Nitric oxide-induced resistance to hydrogen peroxide stress is a glutamate cysteine ligase activity-dependent process.

Ridnour LA, Sim JE, Choi J, Dickinson DA, Forman HJ, Ahmad IM, Coleman MC, Hunt CR, Goswami PC, Spitz DR.

Free Radic Biol Med. 2005 May 15;38(10):1361-71.


HSP70 and genomic stability.

Pandita TK, Higashikubo R, Hunt CR.

Cell Cycle. 2004 May;3(5):591-2. Epub 2004 May 15.


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