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Items: 1 to 50 of 52

1.

Activation of anti-oxidant Nrf2 signaling by enone analogues of curcumin.

Deck LM, Hunsaker LA, Vander Jagt TA, Whalen LJ, Royer RE, Vander Jagt DL.

Eur J Med Chem. 2018 Jan 1;143:854-865. doi: 10.1016/j.ejmech.2017.11.048. Epub 2017 Nov 21.

PMID:
29223100
2.

Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes.

Deck LM, Whalen LJ, Hunsaker LA, Royer RE, Vander Jagt DL.

Bioorg Med Chem. 2017 Feb 15;25(4):1423-1430. doi: 10.1016/j.bmc.2017.01.005. Epub 2017 Jan 6.

PMID:
28126440
3.

Natural products inhibit LPS-induced activation of pro-inflammatory cytokines in peripheral blood mononuclear cells.

Shah VO, Ferguson JE, Hunsaker LA, Deck LM, Vander Jagt DL.

Nat Prod Res. 2010 Jul;24(12):1177-88. doi: 10.1080/14786410903112680.

PMID:
20582811
4.

Inhibition of nuclear factor kappaB activation and cyclooxygenase-2 expression by aqueous extracts of Hispanic medicinal herbs.

Orlando RA, Gonzales AM, Hunsaker LA, Franco CR, Royer RE, Vander Jagt DL, Vander Jagt DJ.

J Med Food. 2010 Aug;13(4):888-95. doi: 10.1089/jmf.2009.1128.

5.

Substituted trans-stilbenes can inhibit or enhance the TPA-induced up-regulation of activator protein-1.

Deck LM, Hunsaker LA, Gonzales AM, Orlando RA, Vander Jagt DL.

BMC Pharmacol. 2008 Nov 10;8:19. doi: 10.1186/1471-2210-8-19.

6.

Efficient calculation of molecular properties from simulation using kernel molecular dynamics.

Brown WM, Sasson A, Bellew DR, Hunsaker LA, Martin S, Leitao A, Deck LM, Vander Jagt DL, Oprea TI.

J Chem Inf Model. 2008 Aug;48(8):1626-37. doi: 10.1021/ci8001233. Epub 2008 Aug 2.

PMID:
18672870
7.

Isocoumarin-based inhibitors of pancreatic cholesterol esterase.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2008 May 1;16(9):5285-94. doi: 10.1016/j.bmc.2008.03.016. Epub 2008 Mar 6.

8.
9.

TPA-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.

Weber WM, Hunsaker LA, Gonzales AM, Heynekamp JJ, Orlando RA, Deck LM, Vander Jagt DL.

Biochem Pharmacol. 2006 Oct 16;72(8):928-40. Epub 2006 Aug 28.

PMID:
16934760
10.

Uncharged isocoumarin-based inhibitors of urokinase-type plasminogen activator.

Heynekamp JJ, Hunsaker LA, Vander Jagt TA, Deck LM, Vander Jagt DL.

BMC Chem Biol. 2006 Feb 8;6:1.

11.

Activation of NFkappaB is inhibited by curcumin and related enones.

Weber WM, Hunsaker LA, Roybal CN, Bobrovnikova-Marjon EV, Abcouwer SF, Royer RE, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2006 Apr 1;14(7):2450-61. Epub 2005 Dec 7.

PMID:
16338138
12.

Anti-oxidant activities of curcumin and related enones.

Weber WM, Hunsaker LA, Abcouwer SF, Deck LM, Vander Jagt DL.

Bioorg Med Chem. 2005 Jun 1;13(11):3811-20.

PMID:
15863007
13.

The oxidative stressor arsenite activates vascular endothelial growth factor mRNA transcription by an ATF4-dependent mechanism.

Roybal CN, Hunsaker LA, Barbash O, Vander Jagt DL, Abcouwer SF.

J Biol Chem. 2005 May 27;280(21):20331-9. Epub 2005 Mar 23.

14.

Comparative structural analysis and kinetic properties of lactate dehydrogenases from the four species of human malarial parasites.

Brown WM, Yowell CA, Hoard A, Vander Jagt TA, Hunsaker LA, Deck LM, Royer RE, Piper RC, Dame JB, Makler MT, Vander Jagt DL.

Biochemistry. 2004 May 25;43(20):6219-29.

PMID:
15147206
15.

Inhibition of pancreatic cholesterol esterase reduces cholesterol absorption in the hamster.

Heidrich JE, Contos LM, Hunsaker LA, Deck LM, Vander Jagt DL.

BMC Pharmacol. 2004 Apr 19;4:5.

16.

17-beta-Hydroxysteroid dehydrogenase type 1: computational design of active site inhibitors targeted to the Rossmann fold.

Brown WM, Metzger LE, Barlow JP, Hunsaker LA, Deck LM, Royer RE, Vander Jagt DL.

Chem Biol Interact. 2003 Feb 1;143-144:481-91.

PMID:
12604234
18.

Inhibition of yeast lipase (CRL1) and cholesterol esterase (CRL3) by 6-chloro-2-pyrones: comparison with porcine cholesterol esterase.

Stoddard Hatch M, Brown WM, Deck JA, Hunsaker LA, Deck LM, Vander Jagt DL.

Biochim Biophys Acta. 2002 Apr 29;1596(2):381-91.

PMID:
12007617
19.

The kinetic properties and sensitivities to inhibitors of lactate dehydrogenases (LDH1 and LDH2) from Toxoplasma gondii: comparisons with pLDH from Plasmodium falciparum.

Dando C, Schroeder ER, Hunsaker LA, Deck LM, Royer RE, Zhou X, Parmley SF, Vander Jagt DL.

Mol Biochem Parasitol. 2001 Nov;118(1):23-32.

PMID:
11704270
20.

Oxidative stress indices in IDDM subjects with and without long-term diabetic complications.

VanderJagt DJ, Harrison JM, Ratliff DM, Hunsaker LA, Vander Jagt DL.

Clin Biochem. 2001 Jun;34(4):265-70.

PMID:
11440725
21.

Selective active site inhibitors of human lactate dehydrogenases A4, B4, and C4.

Yu Y, Deck JA, Hunsaker LA, Deck LM, Royer RE, Goldberg E, Vander Jagt DL.

Biochem Pharmacol. 2001 Jul 1;62(1):81-9.

PMID:
11377399
22.

Metabolism of the 2-oxoaldehyde methylglyoxal by aldose reductase and by glyoxalase-I: roles for glutathione in both enzymes and implications for diabetic complications.

Vander Jagt DL, Hassebrook RK, Hunsaker LA, Brown WM, Royer RE.

Chem Biol Interact. 2001 Jan 30;130-132(1-3):549-62.

PMID:
11306074
23.

Relationship of oxidative stress indices to decreased LDL-cholesterol after acute myocardial infarction.

Chamblee BB, Timm TC, Hunsaker LA, Vander Jagt DL.

Clin Biochem. 2000 Jul;33(5):423-6. No abstract available.

PMID:
11018697
24.

3-Alkyl-6-chloro-2-pyrones: selective inhibitors of pancreatic cholesterol esterase.

Deck LM, Baca ML, Salas SL, Hunsaker LA, Vander Jagt DL.

J Med Chem. 1999 Oct 7;42(20):4250-6.

PMID:
10514295
25.

Inhibition of human aldose and aldehyde reductases by non-steroidal anti-inflammatory drugs.

Ratliff DM, Martinez FJ, Vander Jagt TJ, Schimandle CM, Robinson B, Hunsaker LA, Vander Jagt DL.

Adv Exp Med Biol. 1999;463:493-9. No abstract available.

PMID:
10352724
26.

Inhibition of aldose reductase by gossypol and gossypol-related compounds.

Deck LM, Chamblee BB, Royer RE, Hunsaker LA, Vander Jagt DL.

Adv Exp Med Biol. 1999;463:487-92. No abstract available.

PMID:
10352723
27.

Selective inhibitors of human lactate dehydrogenases and lactate dehydrogenase from the malarial parasite Plasmodium falciparum.

Deck LM, Royer RE, Chamblee BB, Hernandez VM, Malone RR, Torres JE, Hunsaker LA, Piper RC, Makler MT, Vander Jagt DL.

J Med Chem. 1998 Sep 24;41(20):3879-87.

PMID:
9748363
28.

Substrate and cofactor specificity and selective inhibition of lactate dehydrogenase from the malarial parasite P. falciparum.

Gomez MS, Piper RC, Hunsaker LA, Royer RE, Deck LM, Makler MT, Vander Jagt DL.

Mol Biochem Parasitol. 1997 Dec 1;90(1):235-46.

PMID:
9497046
29.

Inactivation of glutathione reductase by 4-hydroxynonenal and other endogenous aldehydes.

Vander Jagt DL, Hunsaker LA, Vander Jagt TJ, Gomez MS, Gonzales DM, Deck LM, Royer RE.

Biochem Pharmacol. 1997 Apr 25;53(8):1133-40.

PMID:
9175718
30.

Physiological substrates of human aldose and aldehyde reductases.

Vander Jagt DL, Torres JE, Hunsaker LA, Deck LM, Royer RE.

Adv Exp Med Biol. 1997;414:491-7. No abstract available.

PMID:
9059654
31.

Substrate specificity of human aldose reductase: identification of 4-hydroxynonenal as an endogenous substrate.

Vander Jagt DL, Kolb NS, Vander Jagt TJ, Chino J, Martinez FJ, Hunsaker LA, Royer RE.

Biochim Biophys Acta. 1995 Jun 12;1249(2):117-26.

PMID:
7599164
32.

Polyol and water accumulation in muscle of galactose-fed rats.

Griffey RH, Sibbitt WL Jr, Sibbitt RR, Griffey BV, Eaton RP, Hunsaker LA, Vander Jagt DL.

Biochem Pharmacol. 1994 Nov 1;48(9):1839-41.

PMID:
7980654
33.

Aldose reductase-catalyzed reduction of acrolein: implications in cyclophosphamide toxicity.

Kolb NS, Hunsaker LA, Vander Jagt DL.

Mol Pharmacol. 1994 Apr;45(4):797-801.

PMID:
8183257
34.

Aldose and aldehyde reductases from human kidney cortex and medulla.

Robinson B, Hunsaker LA, Stangebye LA, Vander Jagt DL.

Biochim Biophys Acta. 1993 Dec 8;1203(2):260-6.

PMID:
8268209
35.

Substrate specificity of reduced and oxidized forms of human aldose reductase.

Vander Jagt DL, Hunsaker LA.

Adv Exp Med Biol. 1993;328:279-88. No abstract available.

PMID:
8493905
36.

Localization and characterization of hemoglobin-degrading aspartic proteinases from the malarial parasite Plasmodium falciparum.

vander Jagt DL, Hunsaker LA, Campos NM, Scaletti JV.

Biochim Biophys Acta. 1992 Aug 21;1122(3):256-64.

PMID:
1504087
37.

Reduction of trioses by NADPH-dependent aldo-keto reductases. Aldose reductase, methylglyoxal, and diabetic complications.

Vander Jagt DL, Robinson B, Taylor KK, Hunsaker LA.

J Biol Chem. 1992 Mar 5;267(7):4364-9.

38.

Aldose reductase from human skeletal and heart muscle. Interconvertible forms related by thiol-disulfide exchange.

Vander Jagt DL, Robinson B, Taylor KK, Hunsaker LA.

J Biol Chem. 1990 Dec 5;265(34):20982-7.

39.

D-lactate production in erythrocytes infected with Plasmodium falciparum.

Vander Jagt DL, Hunsaker LA, Campos NM, Baack BR.

Mol Biochem Parasitol. 1990 Sep-Oct;42(2):277-84.

PMID:
2270109
40.

Aldehyde and aldose reductases from human placenta. Heterogeneous expression of multiple enzyme forms.

Vander Jagt DL, Hunsaker LA, Robinson B, Stangebye LA, Deck LM.

J Biol Chem. 1990 Jul 5;265(19):10912-8.

41.

NADPH production by the malarial parasite Plasmodium falciparum.

Vander Jagt DL, Hunsaker LA, Kibirige M, Campos NM.

Blood. 1989 Jul;74(1):471-4.

PMID:
2665841
42.

Parasite proteases and antimalarial activities of protease inhibitors.

Vander Jagt DL, Caughey WS, Campos NM, Hunsaker LA, Zanner MA.

Prog Clin Biol Res. 1989;313:105-18. No abstract available.

PMID:
2675111
43.

Purification of aldose reductase from human placenta and stabilization of the inhibitor binding site.

Vander Jagt DL, Stangebye LA, Hunsaker LA, Eaton RP, Sibbitt WL Jr.

Biochem Pharmacol. 1988 Mar 15;37(6):1051-6.

PMID:
3128293
44.

Comparison of proteases from chloroquine-sensitive and chloroquine-resistant strains of Plasmodium falciparum.

Vander Jagt DL, Hunsaker LA, Campos NM.

Biochem Pharmacol. 1987 Oct 1;36(19):3285-91.

PMID:
3311049
45.

Biologically active derivatives of gossypol: synthesis and antimalarial activities of peri-acylated gossylic nitriles.

Royer RE, Deck LM, Campos NM, Hunsaker LA, Vander Jagt DL.

J Med Chem. 1986 Sep;29(9):1799-801.

PMID:
3528492
46.

Characterization of a hemoglobin-degrading, low molecular weight protease from Plasmodium falciparum.

Vander Jagt DL, Hunsaker LA, Campos NM.

Mol Biochem Parasitol. 1986 Mar;18(3):389-400.

PMID:
3515180
47.

Isolation and characterization of the multiple glutathione S-transferases from human liver. Evidence for unique heme-binding sites.

Vander Jagt DL, Hunsaker LA, Garcia KB, Royer RE.

J Biol Chem. 1985 Sep 25;260(21):11603-10.

48.

Purification and characterization of an aminopeptidase from Plasmodium falciparum.

Vander Jagt DL, Baack BR, Hunsaker LA.

Mol Biochem Parasitol. 1984 Jan;10(1):45-54.

PMID:
6363922
49.

Nutritional status in a healthy elderly population: vitamin D.

Omdahl JL, Garry PJ, Hunsaker LA, Hunt WC, Goodwin JS.

Am J Clin Nutr. 1982 Dec;36(6):1225-33.

PMID:
7148741
50.

Partial purification and characterization of lactate dehydrogenase from Plasmodium falciparum.

Vander Jagt DL, Hunsaker LA, Heidrich JE.

Mol Biochem Parasitol. 1981 Dec 31;4(5-6):255-64.

PMID:
7038478

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