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Toll-Like Receptor 8 Agonist GS-9688 Induces Sustained Efficacy in the Woodchuck Model of Chronic Hepatitis B.

Daffis S, Balsitis S, Chamberlain J, Zheng J, Santos R, Rowe W, Ramakrishnan D, Pattabiraman D, Spurlock S, Chu R, Kang D, Mish M, Ramirez R, Li L, Li B, Ma S, Hung M, Voitenleitner C, Yon C, Suresh M, Menne S, Cote P, Delaney WE 4th, Mackman R, Fletcher SP.

Hepatology. 2020 Apr 4. doi: 10.1002/hep.31255. [Epub ahead of print]


Optimal Connection for Tiotropium SMI Delivery through Mechanical Ventilation: An In Vitro Study.

Fang TP, Chen YJ, Yang TM, Wang SH, Hung MS, Chiu SH, Li HH, Fink JB, Lin HL.

Pharmaceutics. 2020 Mar 24;12(3). pii: E291. doi: 10.3390/pharmaceutics12030291.


Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer.

Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, Hung MC.

Am J Cancer Res. 2020 Feb 1;10(2):648-661. eCollection 2020.


Inhibition of c-MET upregulates PD-L1 expression in lung adenocarcinoma.

Sun X, Li CW, Wang WJ, Chen MK, Li H, Lai YJ, Hsu JL, Koller PB, Chan LC, Lee PC, Cheng FJ, Yam C, Chen GY, Hung MC.

Am J Cancer Res. 2020 Feb 1;10(2):564-571. eCollection 2020.


ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis.

Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X, Hung MC, Chen X.

Cancer Cell. 2020 Mar 16;37(3):324-339.e8. doi: 10.1016/j.ccell.2020.02.006.


Family Experience With Pierre Robin Sequence: A Qualitative Study.

Skirko JR, Pollard SH, Slager S, Hung M, Weir C.

Cleft Palate Craniofac J. 2020 Mar 16:1055665620910331. doi: 10.1177/1055665620910331. [Epub ahead of print]


Cohnella fermenti sp. nov., isolated from a fermentation process.

Lin SY, Chen WM, Hameed A, Huang GH, Hung MH, Young CC.

Int J Syst Evol Microbiol. 2020 Mar 11. doi: 10.1099/ijsem.0.004080. [Epub ahead of print]


Targeting glycosylated PD-1 induces potent anti-tumor immunity.

Sun L, Li CW, Chung EM, Yang R, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, Khoo KH, Yao J, Hsu JL, Cha JH, Chan LC, Hsu JM, Lee HH, Yoo SS, Hung MC.

Cancer Res. 2020 Mar 10. pii: canres.3133.2019. doi: 10.1158/0008-5472.CAN-19-3133. [Epub ahead of print]


Molecular Alterations and Heterogeneity in Hepatocellular Carcinoma.

Hung MH, Wang XW.

In: Hoshida Y, editor. Hepatocellular Carcinoma: Translational Precision Medicine Approaches [Internet]. Cham (CH): Humana Press; 2019. Chapter 14.
2019 Aug 6.


Preventing hypoxemia during nonintubated thoracoscopic surgery.

Hung MH, Wang YP.

Ann Thorac Surg. 2020 Feb 16. pii: S0003-4975(20)30204-6. doi: 10.1016/j.athoracsur.2019.12.076. [Epub ahead of print] No abstract available.


Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies.

Chou CK, Liu YL, Chen YI, Huang PJ, Tsou PH, Chen CT, Lee HH, Wang YN, Hsu JL, Lee JF, Yankeelov TE, Kameoka J, Yeh HC, Hung MC.

ACS Sens. 2020 Feb 28;5(2):296-302. doi: 10.1021/acssensors.9b01736. Epub 2020 Feb 19.


Hepatitis B core-specific memory B cell responses associate with clinical parameters in patients with chronic HBV.

Vanwolleghem T, Groothuismink ZMA, Kreefft K, Hung M, Novikov N, Boonstra A.

J Hepatol. 2020 Feb 12. pii: S0168-8278(20)30071-4. doi: 10.1016/j.jhep.2020.01.024. [Epub ahead of print]


Favorable pleiotropic effects of sodium glucose cotransporter 2 inhibitors: head-to-head comparisons with dipeptidyl peptidase-4 inhibitors in type 2 diabetes patients.

Shao SC, Chang KC, Lin SJ, Chien RN, Hung MJ, Chan YY, Kao Yang YH, Lai EC.

Cardiovasc Diabetol. 2020 Feb 12;19(1):17. doi: 10.1186/s12933-020-0990-2.


Sodium glucose co-transporter 2 inhibitors and cardiovascular event protections: how applicable are clinical trials and observational studies to real-world patients?

Shao SC, Lin YH, Chang KC, Chan YY, Hung MJ, Kao Yang YH, Lai EC.

BMJ Open Diabetes Res Care. 2019 Dec;7(1). pii: e000742. doi: 10.1136/bmjdrc-2019-000742.


Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.

Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC.

Nat Commun. 2020 Jan 29;11(1):673. doi: 10.1038/s41467-020-14429-3.


Alarm Settings of Continuous Glucose Monitoring Systems and Associations to Glucose Outcomes in Type 1 Diabetes.

Lin YK, Groat D, Chan O, Hung M, Sharma A, Varner MW, Gouripeddi R, Facelli JC, Fisher SJ.

J Endocr Soc. 2019 Nov 19;4(1):bvz005. doi: 10.1210/jendso/bvz005. eCollection 2020 Jan 1.


Extra-Curricular Activities Improved Reproductive Health Knowledge of Ethnic Minority High School Students in Vietnam.

Van Hung M, Van Khoa D, Tinh HQ, Thuy TH, Hung NP.

J Family Reprod Health. 2019 Jun;13(2):80-84.


Emergency nurses' perceptions regarding the risks appraisal of the threat of the emerging infectious disease situation in emergency departments.

Lam SKK, Kwong EWY, Hung MSY, Chien WT.

Int J Qual Stud Health Well-being. 2020 Dec;15(1):e1718468. doi: 10.1080/17482631.2020.1718468.


Unique Sulfur-Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors.

Peng YH, Liao FY, Tseng CT, Kuppusamy R, Li AS, Chen CH, Fan YS, Wang SY, Wu MH, Hsueh CC, Chang JY, Lee LC, Shih C, Shia KS, Yeh TK, Hung MS, Kuo CC, Song JS, Wu SY, Ueng SH.

J Med Chem. 2020 Feb 27;63(4):1642-1659. doi: 10.1021/acs.jmedchem.9b01549. Epub 2020 Feb 10.


Tunable Aryl Imidazolium Recyclable Ionic Liquid with Dual Brønsted-Lewis Acid as Green Catalyst for Friedel-Crafts Acylation and Thioesterification.

Lin YJ, Wu YP, Thul M, Hung MW, Chou SH, Chen WT, Lin W, Lin M, Reddy DM, Wu HR, Ho WY, Luo SY.

Molecules. 2020 Jan 15;25(2). pii: E352. doi: 10.3390/molecules25020352.


Boundaries of the Construct of Unemployment in the Preretirement Years: Exploring an Expanded Measurement of Lost-Work Opportunity.

Voss MW, Al Snih S, Li W, Hung M, Richards LG.

Work Aging Retire. 2020 Jan;6(1):59-63. doi: 10.1093/workar/waz006. Epub 2019 Jun 27.


Drug-eluting versus bare-metal stents for first myocardial infarction in patients with atrial fibrillation: A nationwide population-based cohort study.

Chang NC, Hu P, Chen TH, Mao CT, Hung MJ, Yeh CT, Hung MY.

PLoS One. 2020 Jan 10;15(1):e0227571. doi: 10.1371/journal.pone.0227571. eCollection 2020.


The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors.

Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H.

Am J Cancer Res. 2019 Dec 1;9(12):2719-2729. eCollection 2019.


PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo.

Yen YT, Chien M, Lai YC, Chen DP, Chuong CM, Hung MC, Hung SC.

Cells. 2019 Dec 30;9(1). pii: E90. doi: 10.3390/cells9010090.


One-year outcomes of a suture-less laparoscopic sacral hysteropexy using polypropylene Y-mesh grafts and fibrin sealant spray: A prospective comparative study.

Tsai CP, Kao HF, Liu CK, Shen PS, Chen MJ, Hung MJ.

J Chin Med Assoc. 2020 Jan 2. doi: 10.1097/JCMA.0000000000000253. [Epub ahead of print]


Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2.

Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH.

Theranostics. 2020 Jan 1;10(1):201-217. doi: 10.7150/thno.35895. eCollection 2020.


Elucidating molecular interactions of L-nucleotides with HIV-1 reverse transcriptase and mechanism of M184V-caused drug resistance.

Hung M, Tokarsky EJ, Lagpacan L, Zhang L, Suo Z, Lansdon EB.

Commun Biol. 2019 Dec 13;2:469. doi: 10.1038/s42003-019-0706-x. eCollection 2019.


Thoracoscopic Surgery Without Drainage Tube Placement for Peripheral Lung Nodules.

Liao HC, Yang SM, Hung MH, Cheng YJ, Hsu HH, Chen JS.

Ann Thorac Surg. 2020 Mar;109(3):887-893. doi: 10.1016/j.athoracsur.2019.10.048. Epub 2019 Dec 13.


Progerin in muscle leads to thermogenic and metabolic defects via impaired calcium homeostasis.

Wang WP, Wang JY, Lin WH, Kao CH, Hung MC, Teng YC, Tsai TF, Chi YH.

Aging Cell. 2020 Feb;19(2):e13090. doi: 10.1111/acel.13090. Epub 2019 Dec 12.


Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death.

Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA.

Nat Commun. 2019 Dec 11;10(1):5654. doi: 10.1038/s41467-019-13508-4.


Man Hung replies to Dr Terwee.

Hung M.

J Hand Surg Am. 2019 Dec;44(12):e5-e6. doi: 10.1016/j.jhsa.2019.10.028. No abstract available.


Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer.

McCleary-Wheeler AL, Carr RM, Palmer SR, Smyrk TC, Allred JB, Almada LL, Tolosa EJ, Lamberti MJ, Marks DL, Borad MJ, Molina JR, Qi Y, Lingle WL, Grothey A, Pitot HC, Jatoi A, Northfelt DW, Bryce AH, McWilliams RR, Okuno SH, Haluska P, Kim GP, Colon-Otero G, Lowe VJ, Callstrom MR, Ma WW, Bekaii-Saab T, Hung MC, Erlichman C, Fernandez-Zapico ME.

Pancreatology. 2020 Jan;20(1):101-109. doi: 10.1016/j.pan.2019.11.011. Epub 2019 Nov 21.


A novel PCR-based point-of-care method enables rapid, sensitive and reliable diagnosis of Babesia gibsoni infection in dogs.

Liu IL, Chi NY, Chang CL, Hung ML, Chiu CT, Chen HW.

BMC Vet Res. 2019 Nov 29;15(1):428. doi: 10.1186/s12917-019-2181-5.


Highly Efficient Solution-Processed Thermally Activated Delayed Fluorescence Bluish-Green and Hybrid White Organic Light-Emitting Diodes Using Novel Bipolar Host Materials.

Ngo PS, Hung MK, Tsai KW, Sharma S, Chen SA.

ACS Appl Mater Interfaces. 2019 Dec 11;11(49):45939-45948. doi: 10.1021/acsami.9b14168. Epub 2019 Dec 2.


CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer.

Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC.

Nat Commun. 2019 Nov 8;10(1):5114. doi: 10.1038/s41467-019-13105-5. Erratum in: Nat Commun. 2020 Jan 29;11(1):673.


ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis.

Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Bai X, Sun B, Hung MC, Liu L, Wands J, Dong X.

Mol Cancer. 2019 Nov 7;18(1):156. doi: 10.1186/s12943-019-1077-0.


Mechanisms Controlling PD-L1 Expression in Cancer.

Cha JH, Chan LC, Li CW, Hsu JL, Hung MC.

Mol Cell. 2019 Nov 7;76(3):359-370. doi: 10.1016/j.molcel.2019.09.030. Epub 2019 Oct 24. Review.


New Approaches on Cancer Immunotherapy.

Cha JH, Chan LC, Song MS, Hung MC.

Cold Spring Harb Perspect Med. 2019 Oct 15. pii: a036863. doi: 10.1101/cshperspect.a036863. [Epub ahead of print]


Viral etiologies of acute respiratory tract infections among hospitalized children - A comparison between single and multiple viral infections.

Yen CY, Wu WT, Chang CY, Wong YC, Lai CC, Chan YJ, Wu KG, Hung MC.

J Microbiol Immunol Infect. 2019 Dec;52(6):902-910. doi: 10.1016/j.jmii.2019.08.013. Epub 2019 Sep 30.


Correction to A Novel Covalent mTOR Inhibitor, DHM25, Shows in Vivo Antitumor Activity against Triple-Negative Breast Cancer Cells.

Fouqué A, Delalande O, Jean M, Castellano R, Josselin E, Malleter M, Shoji KF, Hung MD, Rampanarivo H, Collette Y, van de Weghe P, Legembre P.

J Med Chem. 2019 Oct 24;62(20):9339-9340. doi: 10.1021/acs.jmedchem.9b01578. Epub 2019 Oct 11. No abstract available.


Pediatric Patient-Reported Outcomes Measurement Information System is Equivalent to Scoliosis Research Society-22 in Assessing Health Status in Adolescent Idiopathic Scoliosis.

Fedorak GT, Larkin K, Heflin JA, Xu J, Hung M.

Spine (Phila Pa 1976). 2019 Oct 15;44(20):E1206-E1210. doi: 10.1097/BRS.0000000000003112. Erratum in: Spine (Phila Pa 1976). 2019 Dec 15;44(24):E1473.


Concurrent proton-pump inhibitors increase risk of death for lung cancer patients receiving 1st-line gefitinib treatment - a nationwide population-based study.

Fang YH, Yang YH, Hsieh MJ, Hung MS, Lin YC.

Cancer Manag Res. 2019 Sep 19;11:8539-8546. doi: 10.2147/CMAR.S222278. eCollection 2019.


Role of Transjugular Intrahepatic Portosystemic Shunt in the Management of Portal Hypertension: Review and Update of the Literature.

Hung ML, Lee EW.

Clin Liver Dis. 2019 Nov;23(4):737-754. doi: 10.1016/j.cld.2019.07.004. Epub 2019 Aug 31. Review.


Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells.

Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG.

Oncogene. 2020 Jan;39(4):801-813. doi: 10.1038/s41388-019-1010-4. Epub 2019 Sep 25.


Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling.

Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, Chen J, Lin SH.

Nat Commun. 2019 Sep 25;10(1):4363. doi: 10.1038/s41467-019-12377-1.


Comparative risk evaluation for cardiovascular events associated with dapagliflozin vs. empagliflozin in real-world type 2 diabetes patients: a multi-institutional cohort study.

Shao SC, Chang KC, Hung MJ, Yang NI, Chan YY, Chen HY, Kao Yang YH, Lai EC.

Cardiovasc Diabetol. 2019 Sep 24;18(1):120. doi: 10.1186/s12933-019-0919-9.


Correction: Deacetylation of HSPA5 by HDAC6 leads to GP78-mediated HSPA5 ubiquitination at K447 and suppresses metastasis of breast cancer.

Chang YW, Tseng CF, Wang MY, Chang WC, Lee CC, Chen LT, Hung MC, Su JL.

Oncogene. 2020 Jan;39(4):946-949. doi: 10.1038/s41388-019-0981-5.


Optoelectronic Properties of High Triplet σ-π-Conjugated Poly[(biphenyl group IV-A atom (C, Si, Ge, Sn)] Backbones.

Hung MK, Tsai KW, Sharma S, Lei J, Wu JY, Chen SA.

ACS Appl Mater Interfaces. 2019 Oct 9;11(40):36895-36904. doi: 10.1021/acsami.9b11496. Epub 2019 Sep 26.


A highly potent long-acting small-molecule HIV-1 capsid inhibitor with efficacy in a humanized mouse model.

Yant SR, Mulato A, Hansen D, Tse WC, Niedziela-Majka A, Zhang JR, Stepan GJ, Jin D, Wong MH, Perreira JM, Singer E, Papalia GA, Hu EY, Zheng J, Lu B, Schroeder SD, Chou K, Ahmadyar S, Liclican A, Yu H, Novikov N, Paoli E, Gonik D, Ram RR, Hung M, McDougall WM, Brass AL, Sundquist WI, Cihlar T, Link JO.

Nat Med. 2019 Sep;25(9):1377-1384. doi: 10.1038/s41591-019-0560-x. Epub 2019 Sep 9.


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