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Consistent detection of 2019 novel coronavirus in saliva.

To KK, Tsang OT, Chik-Yan Yip C, Chan KH, Wu TC, Chan JMC, Leung WS, Chik TS, Choi CY, Kandamby DH, Lung DC, Tam AR, Poon RW, Fung AY, Hung IF, Cheng VC, Chan JF, Yuen KY.

Clin Infect Dis. 2020 Feb 12. pii: ciaa149. doi: 10.1093/cid/ciaa149. [Epub ahead of print]


Innate immune defect predisposing to severe influenza in a Chinese population.

To KKW, Zhou J, Song YQ, Hung IFN, Yuen KY.

Hong Kong Med J. 2019 Oct;25 Suppl 7(5):27-29. No abstract available.


Assessment of population susceptibility to upcoming seasonal influenza epidemic strain using interepidemic emerging influenza virus strains.

Chen LL, Wu WL, Chan WM, Fong CHY, Ng ACK, Ip JD, Lu L, Dissanayake TK, Ding X, Cai JP, Zhang AJX, Tam S, Hung IFN, Chan KH, Yuen KY, To KKW.

Epidemiol Infect. 2019 Sep 26;147:e279. doi: 10.1017/S0950268819001717.


Linked color imaging versus narrow-band imaging for colorectal polyp detection: a prospective randomized tandem colonoscopy study.

Leung WK, Guo CG, Ko MKL, To EWP, Mak LY, Tong TSM, Chen LJ, But DYK, Wong SY, Liu KSH, Tsui V, Lam FYF, Lui TKL, Cheung KS, Lo SH, Hung IFN.

Gastrointest Endosc. 2020 Jan;91(1):104-112.e5. doi: 10.1016/j.gie.2019.06.031. Epub 2019 Jul 2.


Respiratory virus infection among hospitalized adult patients with or without clinically apparent respiratory infection: a prospective cohort study.

To KKW, Chan KH, Ho J, Pang PKP, Ho DTY, Chang ACH, Seng CW, Yip CCY, Cheng VCC, Hung IFN, Yuen KY.

Clin Microbiol Infect. 2019 Dec;25(12):1539-1545. doi: 10.1016/j.cmi.2019.04.012. Epub 2019 Apr 18.


Population-based estimates of the burden of pneumonia hospitalizations in Hong Kong, 2011-2015.

Li X, Blais JE, Wong ICK, Tam AWY, Cowling BJ, Hung IFN, Chan EWY.

Eur J Clin Microbiol Infect Dis. 2019 Mar;38(3):553-561. doi: 10.1007/s10096-018-03459-x. Epub 2019 Jan 25.


Co-stimulation With TLR7 Agonist Imiquimod and Inactivated Influenza Virus Particles Promotes Mouse B Cell Activation, Differentiation, and Accelerated Antigen Specific Antibody Production.

Li C, To KKW, Zhang AJX, Lee ACY, Zhu H, Mak WWN, Hung IFN, Yuen KY.

Front Immunol. 2018 Oct 12;9:2370. doi: 10.3389/fimmu.2018.02370. eCollection 2018.


Rates of metachronous adenoma after curative resection for left-sided or right-sided colon cancer.

Lam YF, Seto WK, Tong T, Cheung KS, Lo O, Hung IF, Law WL, Leung WK.

Intest Res. 2018 Oct;16(4):619-627. doi: 10.5217/ir.2018.00013. Epub 2018 Oct 10.



Hung IFN, Yuen KY.

Chest. 2018 Oct;154(4):999. doi: 10.1016/j.chest.2018.07.022. No abstract available.


Melioidosis in Hong Kong.

Lui G, Tam A, Tso EYK, Wu AKL, Zee J, Choi KW, Lam W, Chan MC, Ting WM, Hung IFN.

Trop Med Infect Dis. 2018 Aug 25;3(3). pii: E91. doi: 10.3390/tropicalmed3030091. Review.


Prostaglandin E2-Mediated Impairment of Innate Immune Response to A(H1N1)pdm09 Infection in Diet-Induced Obese Mice Could Be Restored by Paracetamol.

Zhang AJX, Zhu H, Chen Y, Li C, Li C, Chu H, Gozali L, Lee ACY, To KKW, Hung IFN, Yuen KY.

J Infect Dis. 2019 Feb 15;219(5):795-807. doi: 10.1093/infdis/jiy527.


Saliva as a diagnostic specimen for testing respiratory virus by a point-of-care molecular assay: a diagnostic validity study.

To KKW, Yip CCY, Lai CYW, Wong CKH, Ho DTY, Pang PKP, Ng ACK, Leung KH, Poon RWS, Chan KH, Cheng VCC, Hung IFN, Yuen KY.

Clin Microbiol Infect. 2019 Mar;25(3):372-378. doi: 10.1016/j.cmi.2018.06.009. Epub 2018 Jun 12.


Triple combination of FDA-approved drugs including flufenamic acid, clarithromycin and zanamivir improves survival of severe influenza in mice.

Lee ACY, To KKW, Zhang AJX, Zhu H, Li C, Zhang RR, Hung IFN, Kao RYT, Chan KH, Yuen KY.

Arch Virol. 2018 Sep;163(9):2349-2358. doi: 10.1007/s00705-018-3852-4. Epub 2018 May 7.


Prevention of post-sphincterotomy bleeding by proton pump inhibitor: A randomized controlled trial.

Leung WK, But DY, Wong SY, Tong TS, Liu KS, Cheung KS, Tsang SH, Chok KS, Poon RT, Hung IF.

J Dig Dis. 2018 Jun;19(6):369-376. doi: 10.1111/1751-2980.12604. Epub 2018 May 24.


Low population serum microneutralization antibody titer against the predominating influenza A(H3N2) N121K virus during the severe influenza summer peak of Hong Kong in 2017.

Zhu H, Lee ACY, Li C, Mak WWN, Chen YY, Chan KH, Zhang AJX, Fung WF, Zhang RQ, Fung YF, Poon RWS, Lam JY, Tam S, Hung IFN, Chen H, Yuen KY, To KKW.

Emerg Microbes Infect. 2018 Mar 6;7(1):23. doi: 10.1038/s41426-018-0041-1.


Rhinovirus respiratory tract infection in hospitalized adult patients is associated with TH2 response irrespective of asthma.

To KKW, Lu L, Fong CHY, Wu AKL, Mok KY, Yip CCY, Ke YH, Sze KH, Lau SKP, Hung IFN, Yuen KY.

J Infect. 2018 May;76(5):465-474. doi: 10.1016/j.jinf.2018.02.005. Epub 2018 Feb 15.


Human intestinal tract serves as an alternative infection route for Middle East respiratory syndrome coronavirus.

Zhou J, Li C, Zhao G, Chu H, Wang D, Yan HH, Poon VK, Wen L, Wong BH, Zhao X, Chiu MC, Yang D, Wang Y, Au-Yeung RKH, Chan IH, Sun S, Chan JF, To KK, Memish ZA, Corman VM, Drosten C, Hung IF, Zhou Y, Leung SY, Yuen KY.

Sci Adv. 2017 Nov 15;3(11):eaao4966. doi: 10.1126/sciadv.aao4966. eCollection 2017 Nov.


Genotype 4 hepatitis E virus is a cause of chronic hepatitis in renal transplant recipients in Hong Kong.

Sridhar S, Chan JFW, Yap DYH, Teng JLL, Huang C, Yip CCY, Hung IFN, Tang SCW, Lau SKP, Woo PCY, Yuen KY.

J Viral Hepat. 2018 Feb;25(2):209-213. doi: 10.1111/jvh.12799. Epub 2017 Nov 13. No abstract available.


Immunogenicity, safety and tolerability of intradermal influenza vaccines.

Hung IFN, Yuen KY.

Hum Vaccin Immunother. 2018 Mar 4;14(3):565-570. doi: 10.1080/21645515.2017.1328332. Epub 2017 Jul 6. Review.


Additional molecular testing of saliva specimens improves the detection of respiratory viruses.

To KK, Lu L, Yip CC, Poon RW, Fung AM, Cheng A, Lui DH, Ho DT, Hung IF, Chan KH, Yuen KY.

Emerg Microbes Infect. 2017 Jun 7;6(6):e49. doi: 10.1038/emi.2017.35.


Budget impact and cost-effectiveness analyses of direct-acting antivirals for chronic hepatitis C virus infection in Hong Kong.

Li X, Chan NS, Tam AW, Hung IFN, Chan EW.

Eur J Clin Microbiol Infect Dis. 2017 Oct;36(10):1801-1809. doi: 10.1007/s10096-017-2995-7. Epub 2017 May 17.


Direct health-care cost utilization in Hong Kong inflammatory bowel disease patients in the initial 2 years following diagnosis.

Mak LY, Ng SC, Wong IOL, Li MKK, Lo FH, Wong MTL, Leung CM, Tsang SWC, Chan KH, Sze SF, Shan EHS, Lam BCY, Hui AJ, Hung IFN, Leung WK.

J Gastroenterol Hepatol. 2018 Jan;33(1):141-149. doi: 10.1111/jgh.13817.


Improved detection of Zika virus RNA in human and animal specimens by a novel, highly sensitive and specific real-time RT-PCR assay targeting the 5'-untranslated region of Zika virus.

Chan JF, Yip CC, Tee KM, Zhu Z, Tsang JO, Chik KK, Tsang TG, Chan CC, Poon VK, Sridhar S, Yin F, Hung IF, Chau SK, Zhang AJ, Chan KH, Yuen KY.

Trop Med Int Health. 2017 May;22(5):594-603. doi: 10.1111/tmi.12857. Epub 2017 Mar 16.


Review of first 36 cases of New Delhi metallo-β-lactamase-producing Enterobacteriaceae in Hong Kong.

Lung DC, Tsang OTY, Choi KW, Hung IFN, Chan KM, Wu AKL, Tso EYK, Wu TC, Lam TS, Wong AWY, Ng KHL, Lui SSY, Hsu EK, Wong ATY.

J Glob Antimicrob Resist. 2017 Mar;8:199-201. doi: 10.1016/j.jgar.2017.01.002. Epub 2017 Feb 10. No abstract available.


Unexpectedly Higher Morbidity and Mortality of Hospitalized Elderly Patients Associated with Rhinovirus Compared with Influenza Virus Respiratory Tract Infection.

Hung IF, Zhang AJ, To KK, Chan JF, Zhu SH, Zhang R, Chan TC, Chan KH, Yuen KY.

Int J Mol Sci. 2017 Jan 26;18(2). pii: E259. doi: 10.3390/ijms18020259.


Randomised clinical trial: rifaximin versus placebo for the treatment of functional dyspepsia.

Tan VP, Liu KS, Lam FY, Hung IF, Yuen MF, Leung WK.

Aliment Pharmacol Ther. 2017 Mar;45(6):767-776. doi: 10.1111/apt.13945. Epub 2017 Jan 23.


Effects of nucleoside analogue prescription for hepatitis B on the incidence of liver cancer in Hong Kong: a territory-wide ecological study.

Seto WK, Lau EH, Wu JT, Hung IF, Leung WK, Cheung KS, Fung J, Lai CL, Yuen MF.

Aliment Pharmacol Ther. 2017 Feb;45(4):501-509. doi: 10.1111/apt.13895. Epub 2016 Dec 15.


Efficacy of Clarithromycin-Naproxen-Oseltamivir Combination in the Treatment of Patients Hospitalized for Influenza A(H3N2) Infection: An Open-label Randomized, Controlled, Phase IIb/III Trial.

Hung IFN, To KKW, Chan JFW, Cheng VCC, Liu KSH, Tam A, Chan TC, Zhang AJ, Li P, Wong TL, Zhang R, Cheung MKS, Leung W, Lau JYN, Fok M, Chen H, Chan KH, Yuen KY.

Chest. 2017 May;151(5):1069-1080. doi: 10.1016/j.chest.2016.11.012. Epub 2016 Nov 22.


First detection and complete genome sequence of a phylogenetically distinct human polyomavirus 6 highly prevalent in human bile samples.

Chan JF, Tee KM, Choi GK, Zhu Z, Poon RW, Ng KT, Chan KH, Hung IF, Man K, Yuen KY.

J Infect. 2017 Jan;74(1):50-59. doi: 10.1016/j.jinf.2016.11.002. Epub 2016 Nov 10.


A Novel Risk Factor Associated With Colonization by Carbapenemase-Producing Enterobacteriaceae: Use of Proton Pump Inhibitors in Addition to Antimicrobial Treatment.

Cheng VC, Chen JH, So SY, Wong SC, Chau PH, Wong LM, Ching RH, Ng MM, Lee WM, Hung IF, Ho PL, Yuen KY.

Infect Control Hosp Epidemiol. 2016 Dec;37(12):1418-1425. Epub 2016 Sep 13.


Burden of upper gastrointestinal symptoms in patients prescribed dabigatran for stroke prevention.

Chan PH, Hai JJ, Huang D, Ho MH, Chan EW, Cheung BM, Chan AO, Wong IC, Tse HF, Hung IF, Siu CW.

SAGE Open Med. 2016 Aug 4;4:2050312116662414. doi: 10.1177/2050312116662414. eCollection 2016.


Infection-related hospitalizations in the first year after inflammatory bowel disease diagnosis.

Ko MK, Ng SC, Mak LY, Li MK, Lo FH, Ng CK, Lao WC, Tsang S, Chan KH, Hui YT, Shan EH, Loo CK, Hui AJ, To WP, Hung IF, Leung WK.

J Dig Dis. 2016 Sep;17(9):610-617. doi: 10.1111/1751-2980.12397.


Gastrointestinal haemorrhage in atrial fibrillation patients: impact of quality of anticoagulation control.

Chan PH, Li WH, Hai JJ, Chan KH, Tse HF, Cheung BM, Chan EW, Wong IC, Leung WK, Hung IF, Lip GY, Siu CW.

Eur Heart J Cardiovasc Pharmacother. 2015 Oct;1(4):265-72. doi: 10.1093/ehjcvp/pvv032. Epub 2015 Aug 11.


Epidemiology of Inflammatory Bowel Disease from 1981 to 2014: Results from a Territory-Wide Population-Based Registry in Hong Kong.

Ng SC, Leung WK, Shi HY, Li MK, Leung CM, Ng CK, Lo FH, Hui YT, Tsang SW, Chan YK, Loo CK, Chan KH, Hui AJ, Chow WH, Harbord M, Ching JY, Lee M, Chan V, Tang W, Hung IF, Ho J, Lao WC, Wong MT, Sze SF, Shan EH, Lam BC, Tong RW, Mak LY, Wong SH, Wu JC, Chan FK, Sung JJ.

Inflamm Bowel Dis. 2016 Aug;22(8):1954-60. doi: 10.1097/MIB.0000000000000846.


Low-dose azathioprine is effective in maintaining remission in steroid-dependent ulcerative colitis: results from a territory-wide Chinese population-based IBD registry.

Shi HY, Chan FK, Leung WK, Li MK, Leung CM, Sze SF, Ching JY, Lo FH, Tsang SW, Shan EH, Mak LY, Lam BC, Hui AJ, Chow WH, Wong MT, Hung IF, Hui YT, Chan YK, Chan KH, Loo CK, Ng CK, Lao WC, Harbord M, Wu JC, Sung JJ, Ng SC.

Therap Adv Gastroenterol. 2016 Jul;9(4):449-56. doi: 10.1177/1756283X16643509. Epub 2016 Apr 19.


Middle East Respiratory Syndrome Interpreted: Human Herpesvirus 6B Pneumonia.

Lau SK, Chan JF, Hung IF, Cheng VC, Sridhar S, Yip CC, Chan KH, Woo PC.

Am J Med. 2016 Sep;129(9):945-7. doi: 10.1016/j.amjmed.2016.04.030. Epub 2016 May 20. No abstract available.


Lipid metabolites as potential diagnostic and prognostic biomarkers for acute community acquired pneumonia.

To KK, Lee KC, Wong SS, Sze KH, Ke YH, Lui YM, Tang BS, Li IW, Lau SK, Hung IF, Law CY, Lam CW, Yuen KY.

Diagn Microbiol Infect Dis. 2016 Jun;85(2):249-54. doi: 10.1016/j.diagmicrobio.2016.03.012. Epub 2016 Mar 14.


A 10-year study reveals clinical and laboratory evidence for the 'semi-invasive' properties of chronic pulmonary aspergillosis.

Chan JF, Lau SK, Wong SC, To KK, So SY, Leung SS, Chan SM, Pang CM, Xiao C, Hung IF, Cheng VC, Yuen KY, Woo PC.

Emerg Microbes Infect. 2016 Apr 20;5:e37. doi: 10.1038/emi.2016.31.


Metabolomic Profiling of Plasma from Melioidosis Patients Using UHPLC-QTOF MS Reveals Novel Biomarkers for Diagnosis.

Lau SK, Lee KC, Lo GC, Ding VS, Chow WN, Ke TY, Curreem SO, To KK, Ho DT, Sridhar S, Wong SC, Chan JF, Hung IF, Sze KH, Lam CW, Yuen KY, Woo PC.

Int J Mol Sci. 2016 Feb 27;17(3):307. doi: 10.3390/ijms17030307.


Pulmonary and extrapulmonary complications of human rhinovirus infection in critically ill patients.

To KK, Lau SK, Chan KH, Mok KY, Luk HK, Yip CC, Ma YK, Sinn LH, Lam SH, Ngai CW, Hung IF, Chan KH, Yuen KY.

J Clin Virol. 2016 Apr;77:85-91. doi: 10.1016/j.jcv.2016.02.014. Epub 2016 Feb 20.


Risk Factors and Post-Resection Independent Predictive Score for the Recurrence of Hepatitis B-Related Hepatocellular Carcinoma.

Hung IF, Wong DK, Poon RT, Fong DY, Chui AH, Seto WK, Fung JY, Chan AC, Yuen JC, Tiu R, Choi O, Lai CL, Yuen MF.

PLoS One. 2016 Feb 22;11(2):e0148493. doi: 10.1371/journal.pone.0148493. eCollection 2016.


High recurrence rate supports need for secondary prophylaxis in non-HIV patients with disseminated mycobacterium avium complex infection: a multi-center observational study.

Sridhar S, Fung KS, Chan JF, Lam JY, Yip EK, Hung IF, Wu AK, Que TL, Lau SK, Woo PC.

BMC Infect Dis. 2016 Feb 10;16:74. doi: 10.1186/s12879-016-1411-8.


Ongoing transmission of avian influenza A viruses in Hong Kong despite very comprehensive poultry control measures: A prospective seroepidemiology study.

To KK, Hung IF, Lui YM, Mok FK, Chan AS, Li PT, Wong TL, Ho DT, Chan JF, Chan KH, Yuen KY.

J Infect. 2016 Feb;72(2):207-13. doi: 10.1016/j.jinf.2015.10.013. Epub 2015 Nov 26.


Topical imiquimod before intradermal trivalent influenza vaccine for protection against heterologous non-vaccine and antigenically drifted viruses: a single-centre, double-blind, randomised, controlled phase 2b/3 trial.

Hung IF, Zhang AJ, To KK, Chan JF, Li P, Wong TL, Zhang R, Chan TC, Chan BC, Wai HH, Chan LW, Fong HP, Hui RK, Kong KL, Leung AC, Ngan AH, Tsang LW, Yeung AP, Yiu GC, Yung W, Lau JY, Chen H, Chan KH, Yuen KY.

Lancet Infect Dis. 2016 Feb;16(2):209-18. doi: 10.1016/S1473-3099(15)00354-0. Epub 2015 Nov 9.


Natural History of Elderly-onset Ulcerative Colitis: Results from a Territory-wide Inflammatory Bowel Disease Registry.

Shi HY, Chan FK, Leung WK, Li MK, Leung CM, Sze SF, Ching JY, Lo FH, Tsang SW, Shan EH, Mak LY, Lam BC, Hui AJ, Wong SH, Wong MT, Hung IF, Hui YT, Chan YK, Chan KH, Loo CK, Tong RW, Chow WH, Ng CK, Lao WC, Harbord M, Wu JC, Sung JJ, Ng SC.

J Crohns Colitis. 2016 Feb;10(2):176-85. doi: 10.1093/ecco-jcc/jjv194. Epub 2015 Oct 28.


Suboptimal Humoral Immune Response against Influenza A(H7N9) Virus Is Related to Its Internal Genes.

Lee AC, Zhu H, Zhang AJ, Li C, Wang P, Li C, Chen H, Hung IF, To KK, Yuen KY.

Clin Vaccine Immunol. 2015 Dec;22(12):1235-43. doi: 10.1128/CVI.00443-15. Epub 2015 Oct 7.


Metabolomic Profiling of Plasma from Patients with Tuberculosis by Use of Untargeted Mass Spectrometry Reveals Novel Biomarkers for Diagnosis.

Lau SK, Lee KC, Curreem SO, Chow WN, To KK, Hung IF, Ho DT, Sridhar S, Li IW, Ding VS, Koo EW, Wong CF, Tam S, Lam CW, Yuen KY, Woo PC.

J Clin Microbiol. 2015 Dec;53(12):3750-9. doi: 10.1128/JCM.01568-15. Epub 2015 Sep 16.


Use of fluoroquinolones is the single most important risk factor for the high bacterial load in patients with nasal and gastrointestinal colonization by multidrug-resistant Acinetobacter baumannii.

Cheng VC, Chen JH, So SY, Wong SC, Yan MK, Chau PH, Lee WM, To KK, Chan JF, Hung IF, Ho PL, Yuen KY.

Eur J Clin Microbiol Infect Dis. 2015 Dec;34(12):2359-66. doi: 10.1007/s10096-015-2489-4. Epub 2015 Sep 15.


The association between methicillin resistant staphylococcus aureus colonization and mortality in Chinese nursing home older adults: a 2-year prospective cohort.

Chan TC, Cheng VC, Hung IF, Chan FH, Ng WC, Yuen KY.

J Am Med Dir Assoc. 2015 Sep 1;16(9):796-7. doi: 10.1016/j.jamda.2015.05.020. Epub 2015 Jul 9. No abstract available.


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