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Items: 1 to 50 of 99

1.

Conservation of the structure and function of bacterial tryptophan synthases.

Michalska K, Gale J, Joachimiak G, Chang C, Hatzos-Skintges C, Nocek B, Johnston SE, Bigelow L, Bajrami B, Jedrzejczak RP, Wellington S, Hung DT, Nag PP, Fisher SL, Endres M, Joachimiak A.

IUCrJ. 2019 May 29;6(Pt 4):649-664. doi: 10.1107/S2052252519005955. eCollection 2019 Jul 1.

2.

Mutations in pmrB Confer Cross-Resistance between the LptD Inhibitor POL7080 and Colistin in Pseudomonas aeruginosa.

Romano KP, Warrier T, Poulsen BE, Nguyen PH, Loftis AR, Saebi A, Pentelute BL, Hung DT.

Antimicrob Agents Chemother. 2019 Aug 23;63(9). pii: e00511-19. doi: 10.1128/AAC.00511-19. Print 2019 Sep.

3.

Large-scale chemical-genetics yields new M. tuberculosis inhibitor classes.

Johnson EO, LaVerriere E, Office E, Stanley M, Meyer E, Kawate T, Gomez JE, Audette RE, Bandyopadhyay N, Betancourt N, Delano K, Da Silva I, Davis J, Gallo C, Gardner M, Golas AJ, Guinn KM, Kennedy S, Korn R, McConnell JA, Moss CE, Murphy KC, Nietupski RM, Papavinasasundaram KG, Pinkham JT, Pino PA, Proulx MK, Ruecker N, Song N, Thompson M, Trujillo C, Wakabayashi S, Wallach JB, Watson C, Ioerger TR, Lander ES, Hubbard BK, Serrano-Wu MH, Ehrt S, Fitzgerald M, Rubin EJ, Sassetti CM, Schnappinger D, Hung DT.

Nature. 2019 Jul;571(7763):72-78. doi: 10.1038/s41586-019-1315-z. Epub 2019 Jun 19.

PMID:
31217586
4.

Publisher Correction: Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):460. doi: 10.1038/s41579-019-0207-4.

PMID:
31036919
5.

Defining the core essential genome of Pseudomonas aeruginosa.

Poulsen BE, Yang R, Clatworthy AE, White T, Osmulski SJ, Li L, Penaranda C, Lander ES, Shoresh N, Hung DT.

Proc Natl Acad Sci U S A. 2019 May 14;116(20):10072-10080. doi: 10.1073/pnas.1900570116. Epub 2019 Apr 29.

6.

Definitions and guidelines for research on antibiotic persistence.

Balaban NQ, Helaine S, Lewis K, Ackermann M, Aldridge B, Andersson DI, Brynildsen MP, Bumann D, Camilli A, Collins JJ, Dehio C, Fortune S, Ghigo JM, Hardt WD, Harms A, Heinemann M, Hung DT, Jenal U, Levin BR, Michiels J, Storz G, Tan MW, Tenson T, Van Melderen L, Zinkernagel A.

Nat Rev Microbiol. 2019 Jul;17(7):441-448. doi: 10.1038/s41579-019-0196-3. Review. Erratum in: Nat Rev Microbiol. 2019 Apr 29;:.

PMID:
30980069
7.

Rapid identification and phylogenetic classification of diverse bacterial pathogens in a multiplexed hybridization assay targeting ribosomal RNA.

Bhattacharyya RP, Walker M, Boykin R, Son SS, Liu J, Hachey AC, Ma P, Wu L, Choi K, Cummins KC, Benson M, Skerry J, Ryu H, Wong SY, Goldberg MB, Han J, Pierce VM, Cosimi LA, Shoresh N, Livny J, Beechem J, Hung DT.

Sci Rep. 2019 Mar 14;9(1):4516. doi: 10.1038/s41598-019-40792-3.

8.

Single-Cell RNA Sequencing to Understand Host-Pathogen Interactions.

Penaranda C, Hung DT.

ACS Infect Dis. 2019 Mar 8;5(3):336-344. doi: 10.1021/acsinfecdis.8b00369. Epub 2019 Jan 31.

PMID:
30702856
9.

Discovery of heterocyclic replacements for the coumarin core of anti-tubercular FadD32 inhibitors.

Fang C, Lee KK, Nietupski R, Bates RH, Fernandez-Menendez R, Lopez-Roman EM, Guijarro-Lopez L, Yin Y, Peng Z, Gomez JE, Fisher S, Barros-Aguirre D, Hubbard BK, Serrano-Wu MH, Hung DT.

Bioorg Med Chem Lett. 2018 Dec 1;28(22):3529-3533. doi: 10.1016/j.bmcl.2018.09.037. Epub 2018 Sep 29.

10.

Carbapenem Resistance Caused by High-Level Expression of OXA-663 β-Lactamase in an OmpK36-Deficient Klebsiella pneumoniae Clinical Isolate.

Ma P, Laibinis HH, Ernst CM, Hung DT.

Antimicrob Agents Chemother. 2018 Oct 24;62(11). pii: e01281-18. doi: 10.1128/AAC.01281-18. Print 2018 Nov.

11.

Harnessing CRISPR Effectors for Infectious Disease Diagnostics.

Bhattacharyya RP, Thakku SG, Hung DT.

ACS Infect Dis. 2018 Sep 14;4(9):1278-1282. doi: 10.1021/acsinfecdis.8b00170. Epub 2018 Aug 16.

PMID:
30113801
12.

Whole-organism phenotypic screening for anti-infectives promoting host health.

Clatworthy AE, Romano KP, Hung DT.

Nat Chem Biol. 2018 Apr;14(4):331-341. doi: 10.1038/s41589-018-0018-3. Epub 2018 Mar 19. Review.

PMID:
29556098
13.

The Expanding Diversity of Mycobacterium tuberculosis Drug Targets.

Wellington S, Hung DT.

ACS Infect Dis. 2018 May 11;4(5):696-714. doi: 10.1021/acsinfecdis.7b00255. Epub 2018 Feb 15. Review.

PMID:
29412643
14.

Continuous and High-Throughput Electromechanical Lysis of Bacterial Pathogens Using Ion Concentration Polarization.

Kim M, Wu L, Kim B, Hung DT, Han J.

Anal Chem. 2018 Jan 2;90(1):872-880. doi: 10.1021/acs.analchem.7b03746. Epub 2017 Dec 15.

PMID:
29193960
15.

scDual-Seq: mapping the gene regulatory program of Salmonella infection by host and pathogen single-cell RNA-sequencing.

Avital G, Avraham R, Fan A, Hashimshony T, Hung DT, Yanai I.

Genome Biol. 2017 Oct 27;18(1):200. doi: 10.1186/s13059-017-1340-x.

16.

Loss of Sigma-1 Receptor Chaperone Promotes Astrocytosis and Enhances the Nrf2 Antioxidant Defense.

Weng TY, Hung DT, Su TP, Tsai SA.

Oxid Med Cell Longev. 2017;2017:4582135. doi: 10.1155/2017/4582135. Epub 2017 Aug 14.

17.

Metagenomic Sequencing of an Echovirus 30 Genome From Cerebrospinal Fluid of a Patient With Aseptic Meningitis and Orchitis.

Piantadosi A, Mukerji SS, Chitneni P, Cho TA, Cosimi LA, Hung DT, Goldberg MB, Sabeti PC, Kuritzkes DR, Grad YH.

Open Forum Infect Dis. 2017 Jul 28;4(3):ofx138. doi: 10.1093/ofid/ofx138. eCollection 2017 Summer.

18.

A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase.

Wellington S, Nag PP, Michalska K, Johnston SE, Jedrzejczak RP, Kaushik VK, Clatworthy AE, Siddiqi N, McCarren P, Bajrami B, Maltseva NI, Combs S, Fisher SL, Joachimiak A, Schreiber SL, Hung DT.

Nat Chem Biol. 2017 Sep;13(9):943-950. doi: 10.1038/nchembio.2420. Epub 2017 Jul 3.

PMID:
28671682
19.

Systematic, multiparametric analysis of Mycobacterium tuberculosis intracellular infection offers insight into coordinated virulence.

Barczak AK, Avraham R, Singh S, Luo SS, Zhang WR, Bray MA, Hinman AE, Thompson M, Nietupski RM, Golas A, Montgomery P, Fitzgerald M, Smith RS, White DW, Tischler AD, Carpenter AE, Hung DT.

PLoS Pathog. 2017 May 15;13(5):e1006363. doi: 10.1371/journal.ppat.1006363. eCollection 2017 May.

20.

Nucleic acid detection with CRISPR-Cas13a/C2c2.

Gootenberg JS, Abudayyeh OO, Lee JW, Essletzbichler P, Dy AJ, Joung J, Verdine V, Donghia N, Daringer NM, Freije CA, Myhrvold C, Bhattacharyya RP, Livny J, Regev A, Koonin EV, Hung DT, Sabeti PC, Collins JJ, Zhang F.

Science. 2017 Apr 28;356(6336):438-442. doi: 10.1126/science.aam9321. Epub 2017 Apr 13.

21.

Dual Inhibition of Bruton's Tyrosine Kinase and Phosphoinositide-3-Kinase p110δ as a Therapeutic Approach to Treat Non-Hodgkin's B Cell Malignancies.

Alfaro J, Pérez de Arce F, Belmar S, Fuentealba G, Avila P, Ureta G, Flores C, Acuña C, Delgado L, Gaete D, Pujala B, Barde A, Nayak AK, Upendra TVR, Patel D, Chauhan S, Sharma VK, Kanno S, Almirez RG, Hung DT, Chakravarty S, Rai R, Bernales S, Quinn KP, Pham SM, McCullagh E.

J Pharmacol Exp Ther. 2017 May;361(2):312-321. doi: 10.1124/jpet.116.238022. Epub 2017 Mar 15.

PMID:
28298527
22.

Ribosomal mutations promote the evolution of antibiotic resistance in a multidrug environment.

Gomez JE, Kaufmann-Malaga BB, Wivagg CN, Kim PB, Silvis MR, Renedo N, Ioerger TR, Ahmad R, Livny J, Fishbein S, Sacchettini JC, Carr SA, Hung DT.

Elife. 2017 Feb 21;6. pii: e20420. doi: 10.7554/eLife.20420.

23.

Multi-institute analysis of carbapenem resistance reveals remarkable diversity, unexplained mechanisms, and limited clonal outbreaks.

Cerqueira GC, Earl AM, Ernst CM, Grad YH, Dekker JP, Feldgarden M, Chapman SB, Reis-Cunha JL, Shea TP, Young S, Zeng Q, Delaney ML, Kim D, Peterson EM, O'Brien TF, Ferraro MJ, Hooper DC, Huang SS, Kirby JE, Onderdonk AB, Birren BW, Hung DT, Cosimi LA, Wortman JR, Murphy CI, Hanage WP.

Proc Natl Acad Sci U S A. 2017 Jan 31;114(5):1135-1140. doi: 10.1073/pnas.1616248114. Epub 2017 Jan 17.

24.

Discovery of Pyrazolopyrimidine Derivatives as Novel Dual Inhibitors of BTK and PI3Kδ.

Pujala B, Agarwal AK, Middya S, Banerjee M, Surya A, Nayak AK, Gupta A, Khare S, Guguloth R, Randive NA, Shinde BU, Thakur A, Patel DI, Raja M, Green MJ, Alfaro J, Avila P, Pérez de Arce F, Almirez RG, Kanno S, Bernales S, Hung DT, Chakravarty S, McCullagh E, Quinn KP, Rai R, Pham SM.

ACS Med Chem Lett. 2016 Oct 28;7(12):1161-1166. eCollection 2016 Dec 8.

25.

Novel 3-methylindoline inhibitors of EZH2: Design, synthesis and SAR.

Ansari A, Satalkar S, Patil V, Shete AS, Kaur S, Gupta A, Singh S, Raja M, Severance DL, Bernales S, Chakravarty S, Hung DT, Pham SM, Herrera FJ, Rai R.

Bioorg Med Chem Lett. 2017 Jan 15;27(2):217-222. doi: 10.1016/j.bmcl.2016.11.080. Epub 2016 Nov 25.

PMID:
27923618
26.

A perspective on single cell behavior during infection.

Avraham R, Hung DT.

Gut Microbes. 2016 Nov;7(6):518-525. Epub 2016 Sep 22.

27.

Targeting prostate cancer with compounds possessing dual activity as androgen receptor antagonists and HDAC6 inhibitors.

Jadhavar PS, Ramachandran SA, Riquelme E, Gupta A, Quinn KP, Shivakumar D, Ray S, Zende D, Nayak AK, Miglani SK, Sathe BD, Raja M, Farias O, Alfaro I, Belmar S, Guerrero J, Bernales S, Chakravarty S, Hung DT, Lindquist JN, Rai R.

Bioorg Med Chem Lett. 2016 Nov 1;26(21):5222-5228. doi: 10.1016/j.bmcl.2016.09.058. Epub 2016 Oct 4.

PMID:
27717544
28.

Loss of a Class A Penicillin-Binding Protein Alters β-Lactam Susceptibilities in Mycobacterium tuberculosis.

Wivagg CN, Wellington S, Gomez JE, Hung DT.

ACS Infect Dis. 2016 Feb 12;2(2):104-10. doi: 10.1021/acsinfecdis.5b00119. Epub 2015 Dec 21.

PMID:
27624961
29.

Temozolomide analogs with improved brain/plasma ratios - Exploring the possibility of enhancing the therapeutic index of temozolomide.

Rai R, Banerjee M, Wong DH, McCullagh E, Gupta A, Tripathi S, Riquelme E, Jangir R, Yadav S, Raja M, Melkani P, Dixit V, Patil U, Shrivastava R, Middya S, Olivares F, Guerrero J, Surya A, Pham SM, Bernales S, Protter AA, Hung DT, Chakravarty S.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):5103-5109. doi: 10.1016/j.bmcl.2016.08.064. Epub 2016 Aug 21.

PMID:
27614414
30.

Genomic Analysis of the Evolution of Fluoroquinolone Resistance in Mycobacterium tuberculosis Prior to Tuberculosis Diagnosis.

Zhang D, Gomez JE, Chien JY, Haseley N, Desjardins CA, Earl AM, Hsueh PR, Hung DT.

Antimicrob Agents Chemother. 2016 Oct 21;60(11):6600-6608. doi: 10.1128/AAC.00664-16. Print 2016 Nov.

31.

Accelerating global innovation to address antibacterial resistance: introducing CARB-X.

Outterson K, Rex JH, Jinks T, Jackson P, Hallinan J, Karp S, Hung DT, Franceschi F, Merkeley T, Houchens C, Dixon DM, Kurilla MG, Aurigemma R, Larsen J.

Nat Rev Drug Discov. 2016 Sep;15(9):589-590. doi: 10.1038/nrd.2016.155. Epub 2016 Jul 29.

PMID:
27469032
32.

A highly multiplexed and sensitive RNA-seq protocol for simultaneous analysis of host and pathogen transcriptomes.

Avraham R, Haseley N, Fan A, Bloom-Ackermann Z, Livny J, Hung DT.

Nat Protoc. 2016 Aug;11(8):1477-91. doi: 10.1038/nprot.2016.090. Epub 2016 Jul 21.

PMID:
27442864
33.

Baeyer-Villiger Monooxygenases EthA and MymA Are Required for Activation of Replicating and Non-replicating Mycobacterium tuberculosis Inhibitors.

Grant SS, Wellington S, Kawate T, Desjardins CA, Silvis MR, Wivagg C, Thompson M, Gordon K, Kazyanskaya E, Nietupski R, Haseley N, Iwase N, Earl AM, Fitzgerald M, Hung DT.

Cell Chem Biol. 2016 Jun 23;23(6):666-77. doi: 10.1016/j.chembiol.2016.05.011. Epub 2016 Jun 16.

34.

Pathogen Cell-to-Cell Variability Drives Heterogeneity in Host Immune Responses.

Avraham R, Haseley N, Brown D, Penaranda C, Jijon HB, Trombetta JJ, Satija R, Shalek AK, Xavier RJ, Regev A, Hung DT.

Cell. 2015 Sep 10;162(6):1309-21. doi: 10.1016/j.cell.2015.08.027. Epub 2015 Sep 3. Erratum in: Cell. 2015 Oct 8;163(2):523.

35.

Direct detection and drug-resistance profiling of bacteremias using inertial microfluidics.

Hou HW, Bhattacharyya RP, Hung DT, Han J.

Lab Chip. 2015 May 21;15(10):2297-307. doi: 10.1039/c5lc00311c.

36.

Identification of a chemically validated target in replicating and non-replicating Mycobacterium tuberculosis with the aid of a small molecule probe.

Nag PP, Grant SS, Lewis TA, Gordon K, Kawate T, Fitzgerald M, Nietupski R, Gomez J, White EL, Maddox C, Nebane NM, Tower NA, McKellip S, Sosa M, Rasmussen L, Johnston S, Bittker JA, Dandapani S, Perez J, Munoz B, Palmer M, Schreiber SL, Hung DT.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2014 Apr 15 [updated 2015 Jan 16].

37.

Simultaneous generation of many RNA-seq libraries in a single reaction.

Shishkin AA, Giannoukos G, Kucukural A, Ciulla D, Busby M, Surka C, Chen J, Bhattacharyya RP, Rudy RF, Patel MM, Novod N, Hung DT, Gnirke A, Garber M, Guttman M, Livny J.

Nat Methods. 2015 Apr;12(4):323-5. doi: 10.1038/nmeth.3313. Epub 2015 Mar 2.

38.

Mechanisms of β-lactam killing and resistance in the context of Mycobacterium tuberculosis.

Wivagg CN, Bhattacharyya RP, Hung DT.

J Antibiot (Tokyo). 2014 Sep;67(9):645-54. doi: 10.1038/ja.2014.94. Epub 2014 Jul 23. Review.

PMID:
25052484
39.

Identification of host-targeted small molecules that restrict intracellular Mycobacterium tuberculosis growth.

Stanley SA, Barczak AK, Silvis MR, Luo SS, Sogi K, Vokes M, Bray MA, Carpenter AE, Moore CB, Siddiqi N, Rubin EJ, Hung DT.

PLoS Pathog. 2014 Feb 20;10(2):e1003946. doi: 10.1371/journal.ppat.1003946. eCollection 2014 Feb.

40.

Bacterial toxins and small molecules elucidate endosomal trafficking.

Slater LH, Clatworthy AE, Hung DT.

Trends Microbiol. 2014 Feb;22(2):53-5. doi: 10.1016/j.tim.2013.12.002. Epub 2013 Dec 23.

PMID:
24370463
41.

Elucidation of the physiology of non-replicating, drug tolerant Mycobacterium tuberculosis with the aid of the small molecule probe ML338.

Nag PP, Grant SS, Lewis TA, Gordon K, Kawate T, Iwase N, White EL, Maddox C, Nebane NM, Tower NA, McKellip S, Sosa MI, Rasmussen L, Mosher CM, Anthoine T, Johnston S, Dandapani S, Perez J, Munoz B, Palmer M, Schreiber SL, Hung DT.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Sep 16].

42.

Synthesis and structure-activity relationships of phenyl-substituted coumarins with anti-tubercular activity that target FadD32.

Kawate T, Iwase N, Shimizu M, Stanley SA, Wellington S, Kazyanskaya E, Hung DT.

Bioorg Med Chem Lett. 2013 Nov 15;23(22):6052-9. doi: 10.1016/j.bmcl.2013.09.035. Epub 2013 Sep 19.

PMID:
24103299
43.

Identification of novel inhibitors of nonreplicating Mycobacterium tuberculosis using a carbon starvation model.

Grant SS, Kawate T, Nag PP, Silvis MR, Gordon K, Stanley SA, Kazyanskaya E, Nietupski R, Golas A, Fitzgerald M, Cho S, Franzblau SG, Hung DT.

ACS Chem Biol. 2013 Oct 18;8(10):2224-34. doi: 10.1021/cb4004817. Epub 2013 Aug 13.

44.

Diarylcoumarins inhibit mycolic acid biosynthesis and kill Mycobacterium tuberculosis by targeting FadD32.

Stanley SA, Kawate T, Iwase N, Shimizu M, Clatworthy AE, Kazyanskaya E, Sacchettini JC, Ioerger TR, Siddiqi NA, Minami S, Aquadro JA, Grant SS, Rubin EJ, Hung DT.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11565-70. doi: 10.1073/pnas.1302114110. Epub 2013 Jun 24.

45.

CCT chaperonin complex is required for efficient delivery of anthrax toxin into the cytosol of host cells.

Slater LH, Hett EC, Clatworthy AE, Mark KG, Hung DT.

Proc Natl Acad Sci U S A. 2013 Jun 11;110(24):9932-7. doi: 10.1073/pnas.1302257110. Epub 2013 May 28.

46.

How antibiotics kill bacteria: new models needed?

Wright GD, Hung DT, Helmann JD.

Nat Med. 2013 May;19(5):544-5. doi: 10.1038/nm.3198. No abstract available.

PMID:
23652106
47.

Chemical genetics reveals a kinase-independent role for protein kinase R in pyroptosis.

Hett EC, Slater LH, Mark KG, Kawate T, Monks BG, Stutz A, Latz E, Hung DT.

Nat Chem Biol. 2013 Jun;9(6):398-405. doi: 10.1038/nchembio.1236. Epub 2013 Apr 21. Erratum in: Nat Chem Biol. 2013 Jul;9(7):466.

48.

Persistent bacterial infections, antibiotic tolerance, and the oxidative stress response.

Grant SS, Hung DT.

Virulence. 2013 May 15;4(4):273-83. doi: 10.4161/viru.23987. Epub 2013 Apr 5. Review.

49.

Reply to Guy et al.: Support for a bottleneck in the 2011 Escherichia coli O104:H4 outbreak in Germany.

Grad YH, Lipsitch M, Griggs AD, Haas BJ, Shea TP, McCowan C, Montmayeur A, FitzGerald M, Wortman JR, Krogfelt KA, Bingen E, Weill FX, Tietze E, Flieger A, Lander ES, Nusbaum C, Birren BW, Hung DT, Hanage WP.

Proc Natl Acad Sci U S A. 2012 Dec 26;109(52):E3629-30. No abstract available.

50.

Identification of novel host-targeted compounds that protect from anthrax lethal toxin-induced cell death.

Slater LH, Hett EC, Mark K, Chumbler NM, Patel D, Lacy DB, Collier RJ, Hung DT.

ACS Chem Biol. 2013 Apr 19;8(4):812-22. doi: 10.1021/cb300555n. Epub 2013 Feb 4.

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