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Items: 29

1.

Targeting cancer addiction for SALL4 by shifting its transcriptome with a pharmacologic peptide.

Liu BH, Jobichen C, Chia CSB, Chan THM, Tang JP, Chung TXY, Li J, Poulsen A, Hung AW, Koh-Stenta X, Tan YS, Verma CS, Tan HK, Wu CS, Li F, Hill J, Joy J, Yang H, Chai L, Sivaraman J, Tenen DG.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):E7119-E7128. doi: 10.1073/pnas.1801253115. Epub 2018 Jul 5.

PMID:
29976840
2.

Characterization of molecular interactions between Zika virus protease and peptides derived from the C-terminus of NS2B.

Li Y, Loh YR, Hung AW, Kang C.

Biochem Biophys Res Commun. 2018 Sep 5;503(2):691-696. doi: 10.1016/j.bbrc.2018.06.062. Epub 2018 Jun 21.

PMID:
29908184
3.

Structural and ligand-binding analysis of the YAP-binding domain of transcription factor TEAD4.

Li Y, Liu S, Ng EY, Li R, Poulsen A, Hill J, Pobbati AV, Hung AW, Hong W, Keller TH, Kang C.

Biochem J. 2018 Jun 26;475(12):2043-2055. doi: 10.1042/BCJ20180225.

PMID:
29760238
4.

Fragment-Based Drug Discovery of Potent Protein Kinase C Iota Inhibitors.

Kwiatkowski J, Liu B, Tee DHY, Chen G, Ahmad NHB, Wong YX, Poh ZY, Ang SH, Tan ESW, Ong EH, Nurul Dinie, Poulsen A, Pendharkar V, Sangthongpitag K, Lee MA, Sepramaniam S, Ho SY, Cherian J, Hill J, Keller TH, Hung AW.

J Med Chem. 2018 May 24;61(10):4386-4396. doi: 10.1021/acs.jmedchem.8b00060. Epub 2018 May 4.

PMID:
29688013
5.

Backbone resonance assignments for the SET domain of human methyltransferase NSD3 in complex with its cofactor.

Li Y, Ng HQ, Ngo A, Liu S, Tan YW, Kwek PZ, Hung AW, Joy J, Hill J, Keller TH, Kang C.

Biomol NMR Assign. 2017 Oct;11(2):225-229. doi: 10.1007/s12104-017-9753-8. Epub 2017 Aug 14.

PMID:
28808922
6.

Structural Dynamics of Zika Virus NS2B-NS3 Protease Binding to Dipeptide Inhibitors.

Li Y, Zhang Z, Phoo WW, Loh YR, Wang W, Liu S, Chen MW, Hung AW, Keller TH, Luo D, Kang C.

Structure. 2017 Aug 1;25(8):1242-1250.e3. doi: 10.1016/j.str.2017.06.006. Epub 2017 Jul 6.

7.

Crystal structure of unlinked NS2B-NS3 protease from Zika virus.

Zhang Z, Li Y, Loh YR, Phoo WW, Hung AW, Kang C, Luo D.

Science. 2016 Dec 23;354(6319):1597-1600. doi: 10.1126/science.aai9309. Epub 2016 Dec 8.

PMID:
27940580
8.

Diversity-Oriented Synthesis as a Strategy for Fragment Evolution against GSK3β.

Wang Y, Wach JY, Sheehan P, Zhong C, Zhan C, Harris R, Almo SC, Bishop J, Haggarty SJ, Ramek A, Berry KN, O'Herin C, Koehler AN, Hung AW, Young DW.

ACS Med Chem Lett. 2016 Jul 14;7(9):852-6. doi: 10.1021/acsmedchemlett.6b00230. eCollection 2016 Sep 8.

9.

Escherichia coli Topoisomerase IV E Subunit and an Inhibitor Binding Mode Revealed by NMR Spectroscopy.

Li Y, Wong YL, Ng FM, Liu B, Wong YX, Poh ZY, Liu S, Then SW, Lee MY, Ng HQ, Huang Q, Hung AW, Cherian J, Hill J, Keller TH, Kang C.

J Biol Chem. 2016 Aug 19;291(34):17743-53. doi: 10.1074/jbc.M116.737429. Epub 2016 Jun 30.

10.

Comparison of Planning Quality and Efficiency Between Conventional and Knowledge-based Algorithms in Nasopharyngeal Cancer Patients Using Intensity Modulated Radiation Therapy.

Chang ATY, Hung AWM, Cheung FWK, Lee MCH, Chan OSH, Philips H, Cheng YT, Ng WT.

Int J Radiat Oncol Biol Phys. 2016 Jul 1;95(3):981-990. doi: 10.1016/j.ijrobp.2016.02.017. Epub 2016 Feb 12.

PMID:
27302513
11.

Targeting the Central Pocket in Human Transcription Factor TEAD as a Potential Cancer Therapeutic Strategy.

Pobbati AV, Han X, Hung AW, Weiguang S, Huda N, Chen GY, Kang C, Chia CS, Luo X, Hong W, Poulsen A.

Structure. 2015 Nov 3;23(11):2076-86. doi: 10.1016/j.str.2015.09.009. Epub 2015 Oct 22.

12.

Biophysical Studies of Bacterial Topoisomerases Substantiate Their Binding Modes to an Inhibitor.

Kang C, Li Y, Cherian J, Liu B, Ng HQ, Lee MY, Binte Ahmad NH, Poh ZY, Wong YX, Huang Q, Wong YL, Hung AW, Hill J, Keller TH.

Biophys J. 2015 Nov 3;109(9):1969-77. doi: 10.1016/j.bpj.2015.10.001.

13.

Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis.

Hung AW, Silvestre HL, Wen S, George GP, Boland J, Blundell TL, Ciulli A, Abell C.

ChemMedChem. 2016 Jan 5;11(1):38-42. doi: 10.1002/cmdc.201500414. Epub 2015 Oct 21.

14.

Characterization of the interaction between Escherichia coli topoisomerase IV E subunit and an ATP competitive inhibitor.

Li Y, Wong YL, Ng FM, Liu B, Wong YX, Poh ZY, Then SW, Lee MY, Ng HQ, Hung AW, Cherian J, Hill J, Keller TH, Kang C.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):961-6. doi: 10.1016/j.bbrc.2015.10.036. Epub 2015 Oct 17.

PMID:
26471301
15.

NMR structural characterization of the N-terminal active domain of the gyrase B subunit from Pseudomonas aeruginosa and its complex with an inhibitor.

Li Y, Wong YX, Poh ZY, Wong YL, Lee MY, Ng HQ, Liu B, Hung AW, Cherian J, Hill J, Keller TH, Kang C.

FEBS Lett. 2015 Sep 14;589(19 Pt B):2683-9. doi: 10.1016/j.febslet.2015.07.044. Epub 2015 Aug 10.

16.

Should all nasopharyngeal carcinoma with masticator space involvement be staged as T4?

Sze H, Chan LL, Ng WT, Hung AW, Lee MC, Chang AT, Chan OS, Cheung FY, Yeung RM, Lee AW.

Oral Oncol. 2014 Dec;50(12):1188-95. doi: 10.1016/j.oraloncology.2014.09.001. Epub 2014 Sep 30.

PMID:
25261296
17.

Pantothenic acid biosynthesis in the parasite Toxoplasma gondii: a target for chemotherapy.

Mageed SN, Cunningham F, Hung AW, Silvestre HL, Wen S, Blundell TL, Abell C, McConkey GA.

Antimicrob Agents Chemother. 2014 Nov;58(11):6345-53. doi: 10.1128/AAC.02640-14. Epub 2014 Jul 21.

18.

NMR analysis of a novel enzymatically active unlinked dengue NS2B-NS3 protease complex.

Kim YM, Gayen S, Kang C, Joy J, Huang Q, Chen AS, Wee JL, Ang MJ, Lim HA, Hung AW, Li R, Noble CG, Lee le T, Yip A, Wang QY, Chia CS, Hill J, Shi PY, Keller TH.

J Biol Chem. 2013 May 3;288(18):12891-900. doi: 10.1074/jbc.M112.442723. Epub 2013 Mar 19.

19.

Selective access to trisubstituted macrocyclic E- and Z-alkenes from the ring-closing metathesis of vinylsiloxanes.

Wang Y, Jimenez M, Sheehan P, Zhong C, Hung AW, Tam CP, Young DW.

Org Lett. 2013 Mar 15;15(6):1218-21. doi: 10.1021/ol400134d. Epub 2013 Feb 28.

PMID:
23448432
20.

Stereotactic ablative radiotherapy for medically inoperable early stage lung cancer: early outcomes.

Chan OS, Yeung RM, Hung AW, Lee MC, Chang AT, Chan CC, Lee AW.

Hong Kong Med J. 2012 Oct;18(5):412-8.

21.

Pathway-selective sensitization of Mycobacterium tuberculosis for target-based whole-cell screening.

Abrahams GL, Kumar A, Savvi S, Hung AW, Wen S, Abell C, Barry CE 3rd, Sherman DR, Boshoff HI, Mizrahi V.

Chem Biol. 2012 Jul 27;19(7):844-54. doi: 10.1016/j.chembiol.2012.05.020.

22.

Diastereoselective control of intramolecular aza-Michael reactions using achiral catalysts.

Zhong C, Wang Y, Hung AW, Schreiber SL, Young DW.

Org Lett. 2011 Oct 21;13(20):5556-9. doi: 10.1021/ol202276h. Epub 2011 Sep 14.

PMID:
21916463
23.

The superiority of hybrid-volumetric arc therapy (VMAT) technique over double arcs VMAT and 3D-conformal technique in the treatment of locally advanced non-small cell lung cancer--a planning study.

Chan OS, Lee MC, Hung AW, Chang AT, Yeung RM, Lee AW.

Radiother Oncol. 2011 Nov;101(2):298-302. doi: 10.1016/j.radonc.2011.08.015. Epub 2011 Sep 8.

PMID:
21907438
24.

Route to three-dimensional fragments using diversity-oriented synthesis.

Hung AW, Ramek A, Wang Y, Kaya T, Wilson JA, Clemons PA, Young DW.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6799-804. doi: 10.1073/pnas.1015271108. Epub 2011 Apr 11.

25.

Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase.

Sledz P, Silvestre HL, Hung AW, Ciulli A, Blundell TL, Abell C.

J Am Chem Soc. 2010 Apr 7;132(13):4544-5. doi: 10.1021/ja100595u.

26.

Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase.

Hung AW, Silvestre HL, Wen S, Ciulli A, Blundell TL, Abell C.

Angew Chem Int Ed Engl. 2009;48(45):8452-6. doi: 10.1002/anie.200903821. No abstract available.

PMID:
19780086
27.

Structure-activity relationship studies of phenanthridine-based Bcl-XL inhibitors.

Bernardo PH, Wan KF, Sivaraman T, Xu J, Moore FK, Hung AW, Mok HY, Yu VC, Chai CL.

J Med Chem. 2008 Nov 13;51(21):6699-710. doi: 10.1021/jm8005433. Epub 2008 Oct 17.

PMID:
18925736
28.

Safety and low molecular weight heparin in older people in a hospital with ambulatory care.

Chan DK, Ong B, Almafragy H, Karr M, Hung AW, Liu JG.

Arch Gerontol Geriatr. 2006 Sep-Oct;43(2):233-41. Epub 2005 Dec 15.

PMID:
16359739
29.

Primary tumor volume of nasopharyngeal carcinoma: prognostic significance for local control.

Sze WM, Lee AW, Yau TK, Yeung RM, Lau KY, Leung SK, Hung AW, Lee MC, Chappell R, Chan K.

Int J Radiat Oncol Biol Phys. 2004 May 1;59(1):21-7.

PMID:
15093895

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