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Items: 25

1.

The TYK2-P1104A Autoimmune Protective Variant Limits Coordinate Signals Required to Generate Specialized T Cell Subsets.

Gorman JA, Hundhausen C, Kinsman M, Arkatkar T, Allenspach EJ, Clough C, West SE, Thomas K, Eken A, Khim S, Hale M, Oukka M, Jackson SW, Cerosaletti K, Buckner JH, Rawlings DJ.

Front Immunol. 2019 Jan 25;10:44. doi: 10.3389/fimmu.2019.00044. eCollection 2019.

2.

Abatacept Targets T Follicular Helper and Regulatory T Cells, Disrupting Molecular Pathways That Regulate Their Proliferation and Maintenance.

Glatigny S, Höllbacher B, Motley SJ, Tan C, Hundhausen C, Buckner JH, Smilek D, Khoury SJ, Ding L, Qin T, Pardo J, Nepom GT, Turka LA, Harris KM, Campbell DJ, Bettelli E.

J Immunol. 2019 Mar 1;202(5):1373-1382. doi: 10.4049/jimmunol.1801425. Epub 2019 Jan 25.

PMID:
30683697
3.

Iterative Design of Visual Analytics for a Clinician-in-the-Loop Smart Home.

Ghods A, Caffrey K, Lin B, Fraga K, Fritz R, Schmitter-Edgecombe M, Hundhausen C, Cook DJ.

IEEE J Biomed Health Inform. 2019 Jul;23(4):1742-1748. doi: 10.1109/JBHI.2018.2864287. Epub 2018 Aug 8.

4.

The A946T variant of the RNA sensor IFIH1 mediates an interferon program that limits viral infection but increases the risk for autoimmunity.

Gorman JA, Hundhausen C, Errett JS, Stone AE, Allenspach EJ, Ge Y, Arkatkar T, Clough C, Dai X, Khim S, Pestal K, Liggitt D, Cerosaletti K, Stetson DB, James RG, Oukka M, Concannon P, Gale M Jr, Buckner JH, Rawlings DJ.

Nat Immunol. 2017 Jul;18(7):744-752. doi: 10.1038/ni.3766. Epub 2017 May 29.

5.

Enhanced T cell responses to IL-6 in type 1 diabetes are associated with early clinical disease and increased IL-6 receptor expression.

Hundhausen C, Roth A, Whalen E, Chen J, Schneider A, Long SA, Wei S, Rawlings R, Kinsman M, Evanko SP, Wight TN, Greenbaum CJ, Cerosaletti K, Buckner JH.

Sci Transl Med. 2016 Sep 14;8(356):356ra119. doi: 10.1126/scitranslmed.aad9943.

6.

Integrative biology approach identifies cytokine targeting strategies for psoriasis.

Perera GK, Ainali C, Semenova E, Hundhausen C, Barinaga G, Kassen D, Williams AE, Mirza MM, Balazs M, Wang X, Rodriguez RS, Alendar A, Barker J, Tsoka S, Ouyang W, Nestle FO.

Sci Transl Med. 2014 Feb 12;6(223):223ra22. doi: 10.1126/scitranslmed.3007217.

7.

An in-depth characterization of the major psoriasis susceptibility locus identifies candidate susceptibility alleles within an HLA-C enhancer element.

Clop A, Bertoni A, Spain SL, Simpson MA, Pullabhatla V, Tonda R, Hundhausen C, Di Meglio P, De Jong P, Hayday AC, Nestle FO, Barker JN, Bell RJ, Capon F, Trembath RC.

PLoS One. 2013 Aug 19;8(8):e71690. doi: 10.1371/journal.pone.0071690. eCollection 2013.

8.

Allele-specific cytokine responses at the HLA-C locus: implications for psoriasis.

Hundhausen C, Bertoni A, Mak RK, Botti E, Di Meglio P, Clop A, Laggner U, Chimenti S, Hayday AC, Barker JN, Trembath RC, Capon F, Nestle FO.

J Invest Dermatol. 2012 Mar;132(3 Pt 1):635-41. doi: 10.1038/jid.2011.378. Epub 2011 Nov 24.

9.

Computational modelling elucidates the mechanism of ciliary regulation in health and disease.

Kotov NV, Bates DG, Gizatullina AN, Gilaziev B, Khairullin RN, Chen MZ, Drozdov I, Umezawa Y, Hundhausen C, Aleksandrov A, Yan XG, Spurgeon SK, Smales CM, Valeyev NV.

BMC Syst Biol. 2011 Sep 15;5:143. doi: 10.1186/1752-0509-5-143.

10.

Identification of a novel proinflammatory human skin-homing Vγ9Vδ2 T cell subset with a potential role in psoriasis.

Laggner U, Di Meglio P, Perera GK, Hundhausen C, Lacy KE, Ali N, Smith CH, Hayday AC, Nickoloff BJ, Nestle FO.

J Immunol. 2011 Sep 1;187(5):2783-93. doi: 10.4049/jimmunol.1100804. Epub 2011 Aug 3.

11.

A systems model for immune cell interactions unravels the mechanism of inflammation in human skin.

Valeyev NV, Hundhausen C, Umezawa Y, Kotov NV, Williams G, Clop A, Ainali C, Ouzounis C, Tsoka S, Nestle FO.

PLoS Comput Biol. 2010 Dec 2;6(12):e1001024. doi: 10.1371/journal.pcbi.1001024.

12.

Progress in understanding the immunopathogenesis of psoriasis.

Mak RK, Hundhausen C, Nestle FO.

Actas Dermosifiliogr. 2009 Dec;100 Suppl 2:2-13. Review.

13.

Ochratoxin a lowers mRNA levels of genes encoding for key proteins of liver cell metabolism.

Hundhausen C, Boesch-Saadatmandi C, Matzner N, Lang F, Blank R, Wolffram S, Blaschek W, Rimbach G.

Cancer Genomics Proteomics. 2008 Nov-Dec;5(6):319-32. Erratum in: Cancer Genomics Proteomics. 2009 Mar-Apr;6(2):129.

14.

Ochratoxin A impairs Nrf2-dependent gene expression in porcine kidney tubulus cells.

Boesch-Saadatmandi C, Wagner AE, Graeser AC, Hundhausen C, Wolffram S, Rimbach G.

J Anim Physiol Anim Nutr (Berl). 2009 Oct;93(5):547-54. doi: 10.1111/j.1439-0396.2008.00838.x. Epub 2008 Jun 10.

PMID:
18547363
15.

Regulated shedding of transmembrane chemokines by the disintegrin and metalloproteinase 10 facilitates detachment of adherent leukocytes.

Hundhausen C, Schulte A, Schulz B, Andrzejewski MG, Schwarz N, von Hundelshausen P, Winter U, Paliga K, Reiss K, Saftig P, Weber C, Ludwig A.

J Immunol. 2007 Jun 15;178(12):8064-72.

16.

Sequential processing of the transmembrane chemokines CX3CL1 and CXCL16 by alpha- and gamma-secretases.

Schulte A, Schulz B, Andrzejewski MG, Hundhausen C, Mletzko S, Achilles J, Reiss K, Paliga K, Weber C, John SR, Ludwig A.

Biochem Biophys Res Commun. 2007 Jun 22;358(1):233-40. Epub 2007 Apr 24.

PMID:
17467666
17.

Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin.

Scholz F, Schulte A, Adamski F, Hundhausen C, Mittag J, Schwarz A, Kruse ML, Proksch E, Ludwig A.

J Invest Dermatol. 2007 Jun;127(6):1444-55. Epub 2007 Mar 15.

18.

Effect of Vitamin E on Cytochrome P450 mRNA Levels in Cultured Hepatocytes (HepG2) and in Rat Liver.

Hundhausen C, Frank J, Rimbach G, Stoecklin E, Muller PY, Barella L.

Cancer Genomics Proteomics. 2006 May-Aug;3(3-4):183-190. Epub 2006 Jan 1.

19.

Effect of vitamin E and polyphenols on ochratoxin A-induced cytotoxicity in liver (HepG2) cells.

Hundhausen C, Bösch-Saadatmandi C, Augustin K, Blank R, Wolffram S, Rimbach G.

J Plant Physiol. 2005 Jul;162(7):818-22.

PMID:
16008110
20.

Enhanced expression and shedding of the transmembrane chemokine CXCL16 by reactive astrocytes and glioma cells.

Ludwig A, Schulte A, Schnack C, Hundhausen C, Reiss K, Brodway N, Held-Feindt J, Mentlein R.

J Neurochem. 2005 Jun;93(5):1293-303.

21.

Metalloproteinase inhibitors for the disintegrin-like metalloproteinases ADAM10 and ADAM17 that differentially block constitutive and phorbol ester-inducible shedding of cell surface molecules.

Ludwig A, Hundhausen C, Lambert MH, Broadway N, Andrews RC, Bickett DM, Leesnitzer MA, Becherer JD.

Comb Chem High Throughput Screen. 2005 Mar;8(2):161-71. Review.

PMID:
15777180
22.

Nitric oxide specifically reduces the permeability of Cx37-containing gap junctions to small molecules.

Kameritsch P, Khandoga N, Nagel W, Hundhausen C, Lidington D, Pohl U.

J Cell Physiol. 2005 Apr;203(1):233-42.

PMID:
15481066
23.

The transmembrane CXC-chemokine ligand 16 is induced by IFN-gamma and TNF-alpha and shed by the activity of the disintegrin-like metalloproteinase ADAM10.

Abel S, Hundhausen C, Mentlein R, Schulte A, Berkhout TA, Broadway N, Hartmann D, Sedlacek R, Dietrich S, Muetze B, Schuster B, Kallen KJ, Saftig P, Rose-John S, Ludwig A.

J Immunol. 2004 May 15;172(10):6362-72.

24.

Cellular cholesterol depletion triggers shedding of the human interleukin-6 receptor by ADAM10 and ADAM17 (TACE).

Matthews V, Schuster B, Schütze S, Bussmeyer I, Ludwig A, Hundhausen C, Sadowski T, Saftig P, Hartmann D, Kallen KJ, Rose-John S.

J Biol Chem. 2003 Oct 3;278(40):38829-39. Epub 2003 Jun 27.

25.

The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion.

Hundhausen C, Misztela D, Berkhout TA, Broadway N, Saftig P, Reiss K, Hartmann D, Fahrenholz F, Postina R, Matthews V, Kallen KJ, Rose-John S, Ludwig A.

Blood. 2003 Aug 15;102(4):1186-95. Epub 2003 Apr 24.

PMID:
12714508

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