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Items: 1 to 50 of 96

1.

Ankyrin-B dysfunction predisposes to arrhythmogenic cardiomyopathy and is amenable to therapy.

Roberts JD, Murphy NP, Hamilton RM, Lubbers ER, James CA, Kline CF, Gollob MH, Krahn AD, Sturm AC, Musa H, El-Refaey M, Koenig S, Aneq MÅ, Hoorntje ET, Graw SL, Davies RW, Rafiq MA, Koopmann TT, Aafaqi S, Fatah M, Chiasson DA, Taylor MR, Simmons SL, Han M, van Opbergen CJ, Wold LE, Sinagra G, Mittal K, Tichnell C, Murray B, Codima A, Nazer B, Nguyen DT, Marcus FI, Sobriera N, Lodder EM, van den Berg MP, Spears DA, Robinson JF, Ursell PC, Green AK, Skanes AC, Tang AS, Gardner MJ, Hegele RA, van Veen TA, Wilde AA, Healey JS, Janssen PM, Mestroni L, van Tintelen JP, Calkins H, Judge DP, Hund TJ, Scheinman MM, Mohler PJ.

J Clin Invest. 2019 Jul 2;129(8):3171-3184. doi: 10.1172/JCI125538. eCollection 2019 Jul 2.

2.

Defining new mechanistic roles for αII spectrin in cardiac function.

Lubbers ER, Murphy NP, Musa H, Huang CY, Gupta R, Price MV, Han M, Daoud G, Gratz D, El Refaey M, Xu X, Hoeflinger NK, Friel EL, Lancione P, Wallace MJ, Cavus O, Simmons SL, Williams JL, Skaf M, Koenig SN, Janssen PML, Rasband MN, Hund TJ, Mohler PJ.

J Biol Chem. 2019 Jun 14;294(24):9576-9591. doi: 10.1074/jbc.RA119.007714. Epub 2019 May 7.

PMID:
31064843
3.

Response by El Refaey et al to Letter Regarding Article, "Protein Phosphatase 2A Regulates Cardiac Na+ Channels".

El Refaey M, Musa H, Smith SA, Binkley PF, Bradley E, Hund TJ, Mohler PJ.

Circ Res. 2019 Apr 12;124(8):e60-e61. doi: 10.1161/CIRCRESAHA.119.314938. No abstract available.

PMID:
30973807
4.

Protein Phosphatase 2A Regulates Cardiac Na+ Channels.

El Refaey M, Musa H, Murphy NP, Lubbers ER, Skaf M, Han M, Cavus O, Koenig SN, Wallace MJ, Gratz D, Bradley E, Alsina KM, Wehrens XHT, Hund TJ, Mohler PJ.

Circ Res. 2019 Mar;124(5):737-746. doi: 10.1161/CIRCRESAHA.118.314350.

PMID:
30602331
5.

The N6-Methyladenosine mRNA Methylase METTL3 Controls Cardiac Homeostasis and Hypertrophy.

Dorn LE, Lasman L, Chen J, Xu X, Hund TJ, Medvedovic M, Hanna JH, van Berlo JH, Accornero F.

Circulation. 2019 Jan 22;139(4):533-545. doi: 10.1161/CIRCULATIONAHA.118.036146.

6.

Novel Mechanistic Roles for Ankyrin-G in Cardiac Remodeling and Heart Failure.

Makara MA, Curran J, Lubbers ER, Murphy NP, Little SC, Musa H, Smith SA, Unudurthi SD, Rajaram MVS, Janssen PML, Boyden PA, Bradley EA, Hund TJ, Mohler PJ.

JACC Basic Transl Sci. 2018 Nov 12;3(5):675-689. doi: 10.1016/j.jacbts.2018.07.008. eCollection 2018 Oct.

7.

Oxidative stress creates a unique, CaMKII-mediated substrate for atrial fibrillation in heart failure.

Yoo S, Aistrup G, Shiferaw Y, Ng J, Mohler PJ, Hund TJ, Waugh T, Browne S, Gussak G, Gilani M, Knight BP, Passman R, Goldberger JJ, Wasserstrom JA, Arora R.

JCI Insight. 2018 Nov 2;3(21). pii: 120728. doi: 10.1172/jci.insight.120728.

8.

βIV-Spectrin regulates STAT3 targeting to tune cardiac response to pressure overload.

Unudurthi SD, Nassal D, Greer-Short A, Patel N, Howard T, Xu X, Onal B, Satroplus T, Hong D, Lane C, Dalic A, Koenig SN, Lehnig AC, Baer LA, Musa H, Stanford KI, Smith S, Mohler PJ, Hund TJ.

J Clin Invest. 2018 Dec 3;128(12):5561-5572. doi: 10.1172/JCI99245. Epub 2018 Nov 12.

9.

CaMKII-dependent late Na+ current increases electrical dispersion and arrhythmia in ischemia-reperfusion.

Howard T, Greer-Short A, Satroplus T, Patel N, Nassal D, Mohler PJ, Hund TJ.

Am J Physiol Heart Circ Physiol. 2018 Oct 1;315(4):H794-H801. doi: 10.1152/ajpheart.00197.2018. Epub 2018 Jun 22.

PMID:
29932771
10.

Reverse Translation: Using Computational Modeling to Enhance Translational Research.

Gratz D, Hund TJ, Falvo MJ, Wold LE.

Circ Res. 2018 May 25;122(11):1496-1498. doi: 10.1161/CIRCRESAHA.118.313003. No abstract available.

11.

Editorial commentary: Mathematical modeling as a tool to elucidate fundamental principles in cardiac electrophysiology.

Greer-Short A, Hund TJ.

Trends Cardiovasc Med. 2018 May;28(4):243-245. doi: 10.1016/j.tcm.2017.12.001. Epub 2017 Dec 7. No abstract available.

PMID:
29269287
12.

Spectrin-based pathways underlying electrical and mechanical dysfunction in cardiac disease.

Unudurthi SD, Greer-Short A, Patel N, Nassal D, Hund TJ.

Expert Rev Cardiovasc Ther. 2018 Jan;16(1):59-65. doi: 10.1080/14779072.2018.1418664. Epub 2017 Dec 26.

13.

Novel Pathways for Regulation of Sinoatrial Node Plasticity and Heart Rate.

Mohler PJ, Hund TJ.

Circ Res. 2017 Oct 13;121(9):1027-1028. doi: 10.1161/CIRCRESAHA.117.311922. No abstract available.

14.

Ca2+/calmodulin-dependent kinase II-dependent regulation of atrial myocyte late Na+ current, Ca2+ cycling, and excitability: a mathematical modeling study.

Onal B, Gratz D, Hund TJ.

Am J Physiol Heart Circ Physiol. 2017 Dec 1;313(6):H1227-H1239. doi: 10.1152/ajpheart.00185.2017. Epub 2017 Aug 25.

15.

A recessive mutation in beta-IV-spectrin (SPTBN4) associates with congenital myopathy, neuropathy, and central deafness.

Knierim E, Gill E, Seifert F, Morales-Gonzalez S, Unudurthi SD, Hund TJ, Stenzel W, Schuelke M.

Hum Genet. 2017 Jul;136(7):903-910. doi: 10.1007/s00439-017-1814-7. Epub 2017 May 24.

PMID:
28540413
16.

Integrative approaches for prediction of cardiotoxic drug effects and mitigation strategies.

Onal B, Hund TJ.

J Mol Cell Cardiol. 2017 Jan;102:1-2. doi: 10.1016/j.yjmcc.2016.10.003. Epub 2016 Nov 25. No abstract available.

PMID:
27894864
17.

Neuronal Na+ Channels Are Integral Components of Pro-arrhythmic Na+/Ca2+ Signaling Nanodomain That Promotes Cardiac Arrhythmias During β-adrenergic Stimulation.

Radwański PB, Ho HT, Veeraraghavan R, Brunello L, Liu B, Belevych AE, Unudurthi SD, Makara MA, Priori SG, Volpe P, Armoundas AA, Dillmann WH, Knollmann BC, Mohler PJ, Hund TJ, Györke S.

JACC Basic Transl Sci. 2016 Jun;1(4):251-266.

18.

Atrial-specific pathways for control of intracellular signaling and myocyte function.

Hund TJ, Mohler PJ.

J Clin Invest. 2016 Oct 3;126(10):3731-3734. doi: 10.1172/JCI90348. Epub 2016 Sep 19.

19.

Physiological variability and atrial fibrillation therapy: Insights from population-based mathematical modeling.

Onal B, Hund TJ.

Heart Rhythm. 2016 Dec;13(12):2366-2367. doi: 10.1016/j.hrthm.2016.09.003. Epub 2016 Sep 7. No abstract available.

PMID:
27614024
20.

Common human ANK2 variant confers in vivo arrhythmia phenotypes.

Musa H, Murphy NP, Curran J, Higgins JD, Webb TR, Makara MA, Wright P, Lancione PJ, Lubbers ER, Healy JA, Smith SA, Bennett V, Hund TJ, Kline CF, Mohler PJ.

Heart Rhythm. 2016 Sep;13(9):1932-40. doi: 10.1016/j.hrthm.2016.06.012. Epub 2016 Jun 11.

PMID:
27298202
21.

Dysfunction of the β2-spectrin-based pathway in human heart failure.

Smith SA, Hughes LD, Kline CF, Kempton AN, Dorn LE, Curran J, Makara M, Webb TR, Wright P, Voigt N, Binkley PF, Janssen PM, Kilic A, Carnes CA, Dobrev D, Rasband MN, Hund TJ, Mohler PJ.

Am J Physiol Heart Circ Physiol. 2016 Jun 1;310(11):H1583-91. doi: 10.1152/ajpheart.00875.2015. Epub 2016 Apr 22.

22.

Two-Pore K+ Channel TREK-1 Regulates Sinoatrial Node Membrane Excitability.

Unudurthi SD, Wu X, Qian L, Amari F, Onal B, Li N, Makara MA, Smith SA, Snyder J, Fedorov VV, Coppola V, Anderson ME, Mohler PJ, Hund TJ.

J Am Heart Assoc. 2016 Apr 20;5(4):e002865. doi: 10.1161/JAHA.115.002865.

23.

Late sodium current dysregulation as a causal factor in arrhythmia.

Unudurthi SD, Hund TJ.

Expert Rev Cardiovasc Ther. 2016;14(5):545-7. doi: 10.1586/14779072.2016.1155451. Epub 2016 Mar 16. No abstract available.

PMID:
26886049
24.

Ablation of HRC alleviates cardiac arrhythmia and improves abnormal Ca handling in CASQ2 knockout mice prone to CPVT.

Liu B, Ho HT, Brunello L, Unudurthi SD, Lou Q, Belevych AE, Qian L, Kim DH, Cho C, Janssen PM, Hund TJ, Knollmann BC, Kranias EG, Györke S.

Cardiovasc Res. 2015 Nov 1;108(2):299-311. doi: 10.1093/cvr/cvv222. Epub 2015 Sep 25.

25.

SCN5A variant that blocks fibroblast growth factor homologous factor regulation causes human arrhythmia.

Musa H, Kline CF, Sturm AC, Murphy N, Adelman S, Wang C, Yan H, Johnson BL, Csepe TA, Kilic A, Higgins RS, Janssen PM, Fedorov VV, Weiss R, Salazar C, Hund TJ, Pitt GS, Mohler PJ.

Proc Natl Acad Sci U S A. 2015 Oct 6;112(40):12528-33. doi: 10.1073/pnas.1516430112. Epub 2015 Sep 21.

26.

Protein phosphatase 2A regulatory subunit B56α limits phosphatase activity in the heart.

Little SC, Curran J, Makara MA, Kline CF, Ho HT, Xu Z, Wu X, Polina I, Musa H, Meadows AM, Carnes CA, Biesiadecki BJ, Davis JP, Weisleder N, Györke S, Wehrens XH, Hund TJ, Mohler PJ.

Sci Signal. 2015 Jul 21;8(386):ra72. doi: 10.1126/scisignal.aaa5876.

27.

Voltage-Gated Sodium Channel Phosphorylation at Ser571 Regulates Late Current, Arrhythmia, and Cardiac Function In Vivo.

Glynn P, Musa H, Wu X, Unudurthi SD, Little S, Qian L, Wright PJ, Radwanski PB, Gyorke S, Mohler PJ, Hund TJ.

Circulation. 2015 Aug 18;132(7):567-77. doi: 10.1161/CIRCULATIONAHA.114.015218. Epub 2015 Jul 17.

28.

Use of whole exome sequencing for the identification of Ito-based arrhythmia mechanism and therapy.

Sturm AC, Kline CF, Glynn P, Johnson BL, Curran J, Kilic A, Higgins RS, Binkley PF, Janssen PM, Weiss R, Raman SV, Fowler SJ, Priori SG, Hund TJ, Carnes CA, Mohler PJ.

J Am Heart Assoc. 2015 May 26;4(5). pii: e001762. doi: 10.1161/JAHA.114.001762.

29.

Eps15 Homology Domain-containing Protein 3 Regulates Cardiac T-type Ca2+ Channel Targeting and Function in the Atria.

Curran J, Musa H, Kline CF, Makara MA, Little SC, Higgins JD, Hund TJ, Band H, Mohler PJ.

J Biol Chem. 2015 May 8;290(19):12210-21. doi: 10.1074/jbc.M115.646893. Epub 2015 Mar 30.

30.

Na+ channel function, regulation, structure, trafficking and sequestration.

Chen-Izu Y, Shaw RM, Pitt GS, Yarov-Yarovoy V, Sack JT, Abriel H, Aldrich RW, Belardinelli L, Cannell MB, Catterall WA, Chazin WJ, Chiamvimonvat N, Deschenes I, Grandi E, Hund TJ, Izu LT, Maier LS, Maltsev VA, Marionneau C, Mohler PJ, Rajamani S, Rasmusson RL, Sobie EA, Clancy CE, Bers DM.

J Physiol. 2015 Mar 15;593(6):1347-60. doi: 10.1113/jphysiol.2014.281428. Review.

31.

Dysfunction in the βII spectrin-dependent cytoskeleton underlies human arrhythmia.

Smith SA, Sturm AC, Curran J, Kline CF, Little SC, Bonilla IM, Long VP, Makara M, Polina I, Hughes LD, Webb TR, Wei Z, Wright P, Voigt N, Bhakta D, Spoonamore KG, Zhang C, Weiss R, Binkley PF, Janssen PM, Kilic A, Higgins RS, Sun M, Ma J, Dobrev D, Zhang M, Carnes CA, Vatta M, Rasband MN, Hund TJ, Mohler PJ.

Circulation. 2015 Feb 24;131(8):695-708. doi: 10.1161/CIRCULATIONAHA.114.013708. Epub 2015 Jan 28.

32.

Role of CaMKII in cardiac arrhythmias.

Hund TJ, Mohler PJ.

Trends Cardiovasc Med. 2015 Jul;25(5):392-7. doi: 10.1016/j.tcm.2014.12.001. Epub 2014 Dec 6. Review.

33.

Neuronal Na+ channel blockade suppresses arrhythmogenic diastolic Ca2+ release.

Radwański PB, Brunello L, Veeraraghavan R, Ho HT, Lou Q, Makara MA, Belevych AE, Anghelescu M, Priori SG, Volpe P, Hund TJ, Janssen PM, Mohler PJ, Bridge JH, Poelzing S, Györke S.

Cardiovasc Res. 2015 Apr 1;106(1):143-52. doi: 10.1093/cvr/cvu262. Epub 2014 Dec 23.

34.

Role of sinoatrial node architecture in maintaining a balanced source-sink relationship and synchronous cardiac pacemaking.

Unudurthi SD, Wolf RM, Hund TJ.

Front Physiol. 2014 Nov 26;5:446. doi: 10.3389/fphys.2014.00446. eCollection 2014. Review.

35.

Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo.

Makara MA, Curran J, Little SC, Musa H, Polina I, Smith SA, Wright PJ, Unudurthi SD, Snyder J, Bennett V, Hund TJ, Mohler PJ.

Circ Res. 2014 Nov 7;115(11):929-38. doi: 10.1161/CIRCRESAHA.115.305154. Epub 2014 Sep 19.

36.

Mathematical modeling of physiological systems: an essential tool for discovery.

Glynn P, Unudurthi SD, Hund TJ.

Life Sci. 2014 Aug 28;111(1-2):1-5. doi: 10.1016/j.lfs.2014.07.005. Epub 2014 Jul 23. Review.

37.

Nav channel complex heterogeneity: new targets for the treatment of arrhythmia?

Hund TJ, Mohler PJ.

Circulation. 2014 Jul 8;130(2):132-4. doi: 10.1161/CIRCULATIONAHA.114.010867. Epub 2014 Jun 3. No abstract available.

38.

Tubulin polymerization disrupts cardiac β-adrenergic regulation of late INa.

Dybkova N, Wagner S, Backs J, Hund TJ, Mohler PJ, Sowa T, Nikolaev VO, Maier LS.

Cardiovasc Res. 2014 Jul 1;103(1):168-77. doi: 10.1093/cvr/cvu120. Epub 2014 May 8.

39.

EHD3-dependent endosome pathway regulates cardiac membrane excitability and physiology.

Curran J, Makara MA, Little SC, Musa H, Liu B, Wu X, Polina I, Alecusan JS, Wright P, Li J, Billman GE, Boyden PA, Gyorke S, Band H, Hund TJ, Mohler PJ.

Circ Res. 2014 Jun 20;115(1):68-78. doi: 10.1161/CIRCRESAHA.115.304149. Epub 2014 Apr 23.

40.

Assembly of the cardiac intercalated disk during pre- and postnatal development of the human heart.

Vreeker A, van Stuijvenberg L, Hund TJ, Mohler PJ, Nikkels PG, van Veen TA.

PLoS One. 2014 Apr 14;9(4):e94722. doi: 10.1371/journal.pone.0094722. eCollection 2014.

41.

Modeling CaMKII in cardiac physiology: from molecule to tissue.

Onal B, Unudurthi SD, Hund TJ.

Front Pharmacol. 2014 Feb 4;5:9. doi: 10.3389/fphar.2014.00009. eCollection 2014. Review.

42.

Cycle length restitution in sinoatrial node cells: a theory for understanding spontaneous action potential dynamics.

Glynn P, Onal B, Hund TJ.

PLoS One. 2014 Feb 12;9(2):e89049. doi: 10.1371/journal.pone.0089049. eCollection 2014.

43.

β(IV)-Spectrin regulates TREK-1 membrane targeting in the heart.

Hund TJ, Snyder JS, Wu X, Glynn P, Koval OM, Onal B, Leymaster ND, Unudurthi SD, Curran J, Camardo C, Wright PJ, Binkley PF, Anderson ME, Mohler PJ.

Cardiovasc Res. 2014 Apr 1;102(1):166-75. doi: 10.1093/cvr/cvu008. Epub 2014 Jan 20.

44.

Ankyrin-B regulates Cav2.1 and Cav2.2 channel expression and targeting.

Kline CF, Scott J, Curran J, Hund TJ, Mohler PJ.

J Biol Chem. 2014 Feb 21;289(8):5285-95. doi: 10.1074/jbc.M113.523639. Epub 2014 Jan 6.

45.

Ibandronate and ventricular arrhythmia risk.

Bonilla IM, Vargas-Pinto P, Nishijima Y, Pedraza-Toscano A, Ho HT, Long VP 3rd, Belevych AE, Glynn P, Houmsse M, Rhodes T, Weiss R, Hund TJ, Hamlin RL, Györke S, Carnes CA.

J Cardiovasc Electrophysiol. 2014 Mar;25(3):299-306. doi: 10.1111/jce.12327. Epub 2013 Dec 20.

46.

Ankyrin-G participates in INa remodeling in myocytes from the border zones of infarcted canine heart.

Dun W, Lowe JS, Wright P, Hund TJ, Mohler PJ, Boyden PA.

PLoS One. 2013 Oct 14;8(10):e78087. doi: 10.1371/journal.pone.0078087. eCollection 2013.

47.

Ryanodine receptor phosphorylation by oxidized CaMKII contributes to the cardiotoxic effects of cardiac glycosides.

Ho HT, Liu B, Snyder JS, Lou Q, Brundage EA, Velez-Cortes F, Wang H, Ziolo MT, Anderson ME, Sen CK, Wehrens XH, Fedorov VV, Biesiadecki BJ, Hund TJ, Györke S.

Cardiovasc Res. 2014 Jan 1;101(1):165-74. doi: 10.1093/cvr/cvt233. Epub 2013 Oct 8.

48.

βIV-Spectrin and CaMKII facilitate Kir6.2 regulation in pancreatic beta cells.

Kline CF, Wright PJ, Koval OM, Zmuda EJ, Johnson BL, Anderson ME, Hai T, Hund TJ, Mohler PJ.

Proc Natl Acad Sci U S A. 2013 Oct 22;110(43):17576-81. doi: 10.1073/pnas.1314195110. Epub 2013 Oct 7.

49.

Role of late sodium current as a potential arrhythmogenic mechanism in the progression of pressure-induced heart disease.

Toischer K, Hartmann N, Wagner S, Fischer TH, Herting J, Danner BC, Sag CM, Hund TJ, Mohler PJ, Belardinelli L, Hasenfuss G, Maier LS, Sossalla S.

J Mol Cell Cardiol. 2013 Aug;61:111-22. doi: 10.1016/j.yjmcc.2013.03.021. Epub 2013 Apr 6.

50.

A Novel Core-Shell Microcapsule for Encapsulation and 3D Culture of Embryonic Stem Cells.

Zhang W, Zhao S, Rao W, Snyder J, Choi JK, Wang J, Khan IA, Saleh NB, Mohler PJ, Yu J, Hund TJ, Tang C, He X.

J Mater Chem B. 2013;2013(7):1002-1009. Epub 2012 Nov 23.

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