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Items: 8


Oncogenic KRAS Induces NIX-Mediated Mitophagy to Promote Pancreatic Cancer.

Humpton TJ, Alagesan B, DeNicola GM, Lu D, Yordanov GN, Leonhardt CS, Yao MA, Alagesan P, Zaatari MN, Park Y, Skepper JN, Macleod KF, Perez-Mancera PA, Murphy MP, Evan GI, Vousden KH, Tuveson DA.

Cancer Discov. 2019 Sep;9(9):1268-1287. doi: 10.1158/2159-8290.CD-18-1409. Epub 2019 Jul 1.


p53-mediated adaptation to serine starvation is retained by a common tumour-derived mutant.

Humpton TJ, Hock AK, Maddocks ODK, Vousden KH.

Cancer Metab. 2018 Dec 3;6:18. doi: 10.1186/s40170-018-0191-6. eCollection 2018.


A Role for p53 in the Adaptation to Glutamine Starvation through the Expression of SLC1A3.

Tajan M, Hock AK, Blagih J, Robertson NA, Labuschagne CF, Kruiswijk F, Humpton TJ, Adams PD, Vousden KH.

Cell Metab. 2018 Nov 6;28(5):721-736.e6. doi: 10.1016/j.cmet.2018.07.005. Epub 2018 Aug 16.


Development of an inducible mouse model of iRFP713 to track recombinase activity and tumour development in vivo.

Hock AK, Cheung EC, Humpton TJ, Monteverde T, Paulus-Hock V, Lee P, McGhee E, Scopelliti A, Murphy DJ, Strathdee D, Blyth K, Vousden KH.

Sci Rep. 2017 May 12;7(1):1837. doi: 10.1038/s41598-017-01741-0.


Regulation of Cellular Metabolism and Hypoxia by p53.

Humpton TJ, Vousden KH.

Cold Spring Harb Perspect Med. 2016 Jul 1;6(7). pii: a026146. doi: 10.1101/cshperspect.a026146. Review.


Aneuploidy drives genomic instability in yeast.

Sheltzer JM, Blank HM, Pfau SJ, Tange Y, George BM, Humpton TJ, Brito IL, Hiraoka Y, Niwa O, Amon A.

Science. 2011 Aug 19;333(6045):1026-30. doi: 10.1126/science.1206412.


Oncogene-induced Nrf2 transcription promotes ROS detoxification and tumorigenesis.

DeNicola GM, Karreth FA, Humpton TJ, Gopinathan A, Wei C, Frese K, Mangal D, Yu KH, Yeo CJ, Calhoun ES, Scrimieri F, Winter JM, Hruban RH, Iacobuzio-Donahue C, Kern SE, Blair IA, Tuveson DA.

Nature. 2011 Jul 6;475(7354):106-9. doi: 10.1038/nature10189.


Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop.

Oliver TG, Meylan E, Chang GP, Xue W, Burke JR, Humpton TJ, Hubbard D, Bhutkar A, Jacks T.

Mol Cell. 2011 Jul 8;43(1):57-71. doi: 10.1016/j.molcel.2011.06.012.

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