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Items: 1 to 50 of 789

1.

Comparison of the characteristics at diagnosis and treatment of children with heterozygous familial hypercholesterolaemia (FH) from eight European countries.

Ramaswami U, Futema M, Bogsrud MP, Holven KB, Roeters van Lennep J, Wiegman A, Descamps OS, Vrablik M, Freiberger T, Dieplinger H, Greber-Platzer S, Hanauer-Mader G, Bourbon M, Drogari E, Humphries SE.

Atherosclerosis. 2019 Nov 15;292:178-187. doi: 10.1016/j.atherosclerosis.2019.11.012. [Epub ahead of print]

PMID:
31809987
2.

Familial hypercholesterolaemia workshop for leveraging point-of-care testing and personalised medicine in association with the Lipid and Atherosclerosis Society of Southern Africa.

Marais AD, Kotze MJ, Raal FJ, Khine AA, Talmud PJ, Humphries SE.

Cardiovasc J Afr. 2019 Sep/Oct;30(5):297-304. doi: 10.5830/CVJA-2019-055.

3.

Statins for children with familial hypercholesterolemia.

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E, Ramaswami U.

Cochrane Database Syst Rev. 2019 Nov 7;2019(11). doi: 10.1002/14651858.CD006401.pub5. Review.

PMID:
31696945
4.

Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.

Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C, Valentine D, Fairhurst-Hunter Z, Hartwig FP, Horta BL, Hypponen E, Power C, Moldovan M, van Iperen E, Hovingh K, Demuth I, Norman K, Steinhagen-Thiessen E, Demuth J, Bertram L, Lill CM, Coassin S, Willeit J, Kiechl S, Willeit K, Mason D, Wright J, Morris R, Wanamethee G, Whincup P, Ben-Shlomo Y, McLachlan S, Price JF, Kivimaki M, Welch C, Sanchez-Galvez A, Marques-Vidal P, Nicolaides A, Panayiotou AG, Onland-Moret NC, van der Schouw YT, Matullo G, Fiorito G, Guarrera S, Sacerdote C, Wareham NJ, Langenberg C, Scott RA, Luan J, Bobak M, Malyutina S, Pająk A, Kubinova R, Tamosiunas A, Pikhart H, Grarup N, Pedersen O, Hansen T, Linneberg A, Jess T, Cooper J, Humphries SE, Brilliant M, Kitchner T, Hakonarson H, Carrell DS, McCarty CA, Lester KH, Larson EB, Crosslin DR, de Andrade M, Roden DM, Denny JC, Carty C, Hancock S, Attia J, Holliday E, Scott R, Schofield P, O'Donnell M, Yusuf S, Chong M, Pare G, van der Harst P, Said MA, Eppinga RN, Verweij N, Snieder H; Lifelines Cohort authors, Christen T, Mook-Kanamori DO; ICBP Consortium, Gustafsson S, Lind L, Ingelsson E, Pazoki R, Franco O, Hofman A, Uitterlinden A, Dehghan A, Teumer A, Baumeister S, Dörr M, Lerch MM, Völker U, Völzke H, Ward J, Pell JP, Meade T, Christophersen IE, Maitland-van der Zee AH, Baranova EV, Young R, Ford I, Campbell A, Padmanabhan S, Bots ML, Grobbee DE, Froguel P, Thuillier D, Roussel R, Bonnefond A, Cariou B, Smart M, Bao Y, Kumari M, Mahajan A, Hopewell JC, Seshadri S; METASTROKE Consortium of the ISGC, Dale C, Costa RPE, Ridker PM, Chasman DI, Reiner AP, Ritchie MD, Lange LA, Cornish AJ, Dobbins SE, Hemminki K, Kinnersley B, Sanson M, Labreche K, Simon M, Bondy M, Law P, Speedy H, Allan J, Li N, Went M, Weinhold N, Morgan G, Sonneveld P, Nilsson B, Goldschmidt H, Sud A, Engert A, Hansson M, Hemingway H, Asselbergs FW, Patel RS, Keating BJ, Sattar N, Houlston R, Casas JP, Hingorani AD.

BMC Cardiovasc Disord. 2019 Oct 29;19(1):240. doi: 10.1186/s12872-019-1187-z.

5.

Current management of children and young people with heterozygous familial hypercholesterolaemia - HEART UK statement of care.

Ramaswami U, Humphries SE, Priestley-Barnham L, Green P, Wald DS, Capps N, Anderson M, Dale P, Morris AA.

Atherosclerosis. 2019 Nov;290:1-8. doi: 10.1016/j.atherosclerosis.2019.09.005. Epub 2019 Sep 12. Review.

6.

Data on the association between a simplified Mediterranean diet score and the incidence of combined, cardio and cerebro vascular events.

Veglia F, Baldassarre D, de Faire U, Kurl S, Smit AJ, Rauramaa R, Giral P, Amato M, Di Minno A, Ravani A, Frigerio B, Castelnuovo S, Sansaro D, Coggi D, Bonomi A, Tedesco CC, Mannarino E, Humphries SE, Hamsten A, Tremoli E; IMPROVE study group.

Data Brief. 2019 Feb 28;23:103789. doi: 10.1016/j.dib.2019.103789. eCollection 2019 Apr.

7.

Subclinical atherosclerosis and its progression are modulated by PLIN2 through a feed-forward loop between LXR and autophagy.

Saliba-Gustafsson P, Pedrelli M, Gertow K, Werngren O, Janas V, Pourteymour S, Baldassarre D, Tremoli E, Veglia F, Rauramaa R, Smit AJ, Giral P, Kurl S, Pirro M, de Faire U, Humphries SE, Hamsten A; IMPROVE Study Group, Gonçalves I, Orho-Melander M, Franco-Cereceda A, Borén J, Eriksson P, Magné J, Parini P, Ehrenborg E.

J Intern Med. 2019 Dec;286(6):660-675. doi: 10.1111/joim.12951. Epub 2019 Jul 29.

PMID:
31251843
8.

Risk of cardiovascular disease outcomes in primary care subjects with familial hypercholesterolaemia: A cohort study.

Iyen B, Qureshi N, Kai J, Akyea RK, Leonardi-Bee J, Roderick P, Humphries SE, Weng S.

Atherosclerosis. 2019 Aug;287:8-15. doi: 10.1016/j.atherosclerosis.2019.05.017. Epub 2019 May 24.

9.

Genetic variation in CADM2 as a link between psychological traits and obesity.

Morris J, Bailey MES, Baldassarre D, Cullen B, de Faire U, Ferguson A, Gigante B, Giral P, Goel A, Graham N, Hamsten A, Humphries SE, Johnston KJA, Lyall DM, Lyall LM, Sennblad B, Silveira A, Smit AJ, Tremoli E, Veglia F, Ward J, Watkins H, Smith DJ, Strawbridge RJ.

Sci Rep. 2019 May 14;9(1):7339. doi: 10.1038/s41598-019-43861-9.

10.

Polygenic Hypercholesterolemia and Cardiovascular Disease Risk.

Sharifi M, Futema M, Nair D, Humphries SE.

Curr Cardiol Rep. 2019 Apr 22;21(6):43. doi: 10.1007/s11886-019-1130-z. Review.

11.

A priori-defined Mediterranean-like dietary pattern predicts cardiovascular events better in north Europe than in Mediterranean countries.

Veglia F, Baldassarre D, de Faire U, Kurl S, Smit AJ, Rauramaa R, Giral P, Amato M, Di Minno A, Ravani A, Frigerio B, Castelnuovo S, Sansaro D, Coggi D, Bonomi A, Tedesco CC, Mannarino E, Humphries SE, Hamsten A, Tremoli E; IMPROVE study group.

Int J Cardiol. 2019 May 1;282:88-92. doi: 10.1016/j.ijcard.2018.11.124. Epub 2018 Nov 29.

12.

GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes.

Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM, Winkler TW, Graff M, Kavousi M, Dale C, Smith AV, Hofer E, van Leeuwen EM, Nolte IM, Lu L, Scholz M, Sargurupremraj M, Pitkänen N, Franzén O, Joshi PK, Noordam R, Marioni RE, Hwang SJ, Musani SK, Schminke U, Palmas W, Isaacs A, Correa A, Zonderman AB, Hofman A, Teumer A, Cox AJ, Uitterlinden AG, Wong A, Smit AJ, Newman AB, Britton A, Ruusalepp A, Sennblad B, Hedblad B, Pasaniuc B, Penninx BW, Langefeld CD, Wassel CL, Tzourio C, Fava C, Baldassarre D, O'Leary DH, Teupser D, Kuh D, Tremoli E, Mannarino E, Grossi E, Boerwinkle E, Schadt EE, Ingelsson E, Veglia F, Rivadeneira F, Beutner F, Chauhan G, Heiss G, Snieder H, Campbell H, Völzke H, Markus HS, Deary IJ, Jukema JW, de Graaf J, Price J, Pott J, Hopewell JC, Liang J, Thiery J, Engmann J, Gertow K, Rice K, Taylor KD, Dhana K, Kiemeney LALM, Lind L, Raffield LM, Launer LJ, Holdt LM, Dörr M, Dichgans M, Traylor M, Sitzer M, Kumari M, Kivimaki M, Nalls MA, Melander O, Raitakari O, Franco OH, Rueda-Ochoa OL, Roussos P, Whincup PH, Amouyel P, Giral P, Anugu P, Wong Q, Malik R, Rauramaa R, Burkhardt R, Hardy R, Schmidt R, de Mutsert R, Morris RW, Strawbridge RJ, Wannamethee SG, Hägg S, Shah S, McLachlan S, Trompet S, Seshadri S, Kurl S, Heckbert SR, Ring S, Harris TB, Lehtimäki T, Galesloot TE, Shah T, de Faire U, Plagnol V, Rosamond WD, Post W, Zhu X, Zhang X, Guo X, Saba Y; MEGASTROKE Consortium, Dehghan A, Seldenrijk A, Morrison AC, Hamsten A, Psaty BM, van Duijn CM, Lawlor DA, Mook-Kanamori DO, Bowden DW, Schmidt H, Wilson JF, Wilson JG, Rotter JI, Wardlaw JM, Deanfield J, Halcox J, Lyytikäinen LP, Loeffler M, Evans MK, Debette S, Humphries SE, Völker U, Gudnason V, Hingorani AD, Björkegren JLM, Casas JP, O'Donnell CJ.

Nat Commun. 2018 Dec 3;9(1):5141. doi: 10.1038/s41467-018-07340-5.

13.

Coronary heart disease mortality in severe vs. non-severe familial hypercholesterolaemia in the Simon Broome Register.

Humphries SE, Cooper JA, Capps N, Durrington PN, Jones B, McDowell IFW, Soran H, Neil AHW; Simon Broome Familial Hyperlipidaemia Register Group.

Atherosclerosis. 2019 Feb;281:207-212. doi: 10.1016/j.atherosclerosis.2018.11.014. Epub 2018 Nov 12.

14.

ClinVar database of global familial hypercholesterolemia-associated DNA variants.

Iacocca MA, Chora JR, Carrié A, Freiberger T, Leigh SE, Defesche JC, Kurtz CL, DiStefano MT, Santos RD, Humphries SE, Mata P, Jannes CE, Hooper AJ, Wilemon KA, Benlian P, O'Connor R, Garcia J, Wand H, Tichy L, Sijbrands EJ, Hegele RA, Bourbon M, Knowles JW; ClinGen FH Variant Curation Expert Panel.

Hum Mutat. 2018 Nov;39(11):1631-1640. doi: 10.1002/humu.23634.

15.

Clinical utility of the polygenic LDL-C SNP score in familial hypercholesterolemia.

Futema M, Bourbon M, Williams M, Humphries SE.

Atherosclerosis. 2018 Oct;277:457-463. doi: 10.1016/j.atherosclerosis.2018.06.006. Review.

PMID:
30270085
16.

Estimation of the prevalence of cholesteryl ester storage disorder in a cohort of patients with clinical features of familial hypercholesterolaemia.

Ashfield-Watt P, Haralambos K, Edwards R, Townsend D, Gingell R, Wa Li K, Humphries SE, McDowell I.

Ann Clin Biochem. 2019 Jan;56(1):112-117. doi: 10.1177/0004563218793165. Epub 2018 Aug 8.

PMID:
30056760
17.

Universal screening at age 1-2 years as an adjunct to cascade testing for familial hypercholesterolaemia in the UK: A cost-utility analysis.

McKay AJ, Hogan H, Humphries SE, Marks D, Ray KK, Miners A.

Atherosclerosis. 2018 Aug;275:434-443. doi: 10.1016/j.atherosclerosis.2018.05.047. Epub 2018 Jun 4.

18.

Cost-utility analysis of searching electronic health records and cascade testing to identify and diagnose familial hypercholesterolaemia in England and Wales.

Crosland P, Maconachie R, Buckner S, McGuire H, Humphries SE, Qureshi N.

Atherosclerosis. 2018 Aug;275:80-87. doi: 10.1016/j.atherosclerosis.2018.05.021. Epub 2018 May 17.

19.

Association of circulating metabolites with healthy diet and risk of cardiovascular disease: analysis of two cohort studies.

Akbaraly T, Würtz P, Singh-Manoux A, Shipley MJ, Haapakoski R, Lehto M, Desrumaux C, Kähönen M, Lehtimäki T, Mikkilä V, Hingorani A, Humphries SE, Kangas AJ, Soininen P, Raitakari O, Ala-Korpela M, Kivimäki M.

Sci Rep. 2018 Jun 5;8(1):8620. doi: 10.1038/s41598-018-26441-1.

20.

Coronary heart disease mortality in treated familial hypercholesterolaemia: Update of the UK Simon Broome FH register.

Humphries SE, Cooper JA, Seed M, Capps N, Durrington PN, Jones B, McDowell IFW, Soran H, Neil HAW; Simon Broome Familial Hyperlipidaemia Register Group.

Atherosclerosis. 2018 Jul;274:41-46. doi: 10.1016/j.atherosclerosis.2018.04.040. Epub 2018 May 1.

21.

Personalised medicine in general practice: the example of raised cholesterol.

Qureshi N, Humphries SE, Gray H.

Br J Gen Pract. 2018 Feb;68(667):68-69. doi: 10.3399/bjgp18X694481. No abstract available.

22.

Association of lifelong occupation and educational level with subclinical atherosclerosis in different European regions. Results from the IMPROVE study.

Tedesco CC, Veglia F, de Faire U, Kurl S, Smit AJ, Rauramaa R, Giral P, Amato M, Bonomi A, Ravani A, Frigerio B, Castelnuovo S, Sansaro D, Mannarino E, Humphries SE, Hamsten A, Tremoli E, Baldassarre D; IMPROVE study group.

Atherosclerosis. 2018 Feb;269:129-137. doi: 10.1016/j.atherosclerosis.2017.12.023. Epub 2017 Dec 20.

23.

Increased Levels of Circulating Fatty Acids Are Associated with Protective Effects against Future Cardiovascular Events in Nondiabetics.

Kamleh MA, McLeod O, Checa A, Baldassarre D, Veglia F, Gertow K, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Tremoli E, Silveira A, Örvik J, Hamsten A, Wheelock CE.

J Proteome Res. 2018 Feb 2;17(2):870-878. doi: 10.1021/acs.jproteome.7b00671. Epub 2018 Jan 22.

24.

The Genetic Spectrum of Familial Hypercholesterolemia (FH) in the Iranian Population.

Fairoozy RH, Futema M, Vakili R, Abbaszadegan MR, Hosseini S, Aminzadeh M, Zaeri H, Mobini M, Humphries SE, Sahebkar A.

Sci Rep. 2017 Dec 6;7(1):17087. doi: 10.1038/s41598-017-17181-9.

25.

The UK Paediatric Familial Hypercholesterolaemia Register: Statin-related safety and 1-year growth data.

Humphries SE, Cooper J, Dale P, Ramaswami U; FH Paediatric Register Steering Group.

J Clin Lipidol. 2018 Jan - Feb;12(1):25-32. doi: 10.1016/j.jacl.2017.11.005. Epub 2017 Nov 22.

26.

Genetic Association of Lipids and Lipid Drug Targets With Abdominal Aortic Aneurysm: A Meta-analysis.

Harrison SC, Holmes MV, Burgess S, Asselbergs FW, Jones GT, Baas AF, van 't Hof FN, de Bakker PIW, Blankensteijn JD, Powell JT, Saratzis A, de Borst GJ, Swerdlow DI, van der Graaf Y, van Rij AM, Carey DJ, Elmore JR, Tromp G, Kuivaniemi H, Sayers RD, Samani NJ, Bown MJ, Humphries SE.

JAMA Cardiol. 2018 Jan 1;3(1):26-33. doi: 10.1001/jamacardio.2017.4293. Review. Erratum in: JAMA Cardiol. 2018 Jan 1;3(1):90.

27.

Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation.

Strawbridge RJ, Silveira A, Hoed MD, Gustafsson S, Luan J, Rybin D, Dupuis J, Li-Gao R, Kavousi M, Dehghan A, Haljas K, Lahti J, Gådin JR, Bäcklund A, de Faire U, Gertow K, Giral P, Goel A, Humphries SE, Kurl S, Langenberg C, Lannfelt LL, Lind L, Lindgren CCM, Mannarino E, Mook-Kanamori DO, Morris AP, de Mutsert R, Rauramaa R, Saliba-Gustafsson P, Sennblad B, Smit AJ, Syvänen AC, Tremoli E, Veglia F, Zethelius B, Björck HM, Eriksson JG, Hofman A, Franco OH, Watkins H, Jukema JW, Florez JC, Wareham NJ, Meigs JB, Ingelsson E, Baldassarre D, Hamsten A; IMPROVE study group.

Atherosclerosis. 2017 Nov;266:196-204. doi: 10.1016/j.atherosclerosis.2017.09.031. Epub 2017 Sep 28.

28.

Plasma Concentrations of Afamin Are Associated With Prevalent and Incident Type 2 Diabetes: A Pooled Analysis in More Than 20,000 Individuals.

Kollerits B, Lamina C, Huth C, Marques-Vidal P, Kiechl S, Seppälä I, Cooper J, Hunt SC, Meisinger C, Herder C, Kedenko L, Willeit J, Thorand B, Dähnhardt D, Stöckl D, Willeit K, Roden M, Rathmann W, Paulweber B, Peters A, Kähönen M, Lehtimäki T, Raitakari OT, Humphries SE, Vollenweider P, Dieplinger H, Kronenberg F.

Diabetes Care. 2017 Oct;40(10):1386-1393. doi: 10.2337/dc17-0201. Epub 2017 Sep 6.

29.

How close are we to implementing a genetic risk score for coronary heart disease?

Beaney K, Drenos F, Humphries SE.

Expert Rev Mol Diagn. 2017 Oct;17(10):905-915. doi: 10.1080/14737159.2017.1368388. Epub 2017 Sep 4. Review.

PMID:
28816567
30.

Integrative studies implicate matrix metalloproteinase-12 as a culprit gene for large-artery atherosclerotic stroke.

Mahdessian H, Perisic Matic L, Lengquist M, Gertow K, Sennblad B, Baldassarre D, Veglia F, Humphries SE, Rauramaa R, de Faire U, Smit AJ, Giral P, Kurl S, Mannarino E, Tremoli E, Hamsten A, Eriksson P, Hedin U, Mälarstig A; IMPROVE study group.

J Intern Med. 2017 Nov;282(5):429-444. doi: 10.1111/joim.12655. Epub 2017 Aug 28.

31.

Effect of Coronary Artery Disease risk SNPs on serum cytokine levels and cytokine imbalance in Premature Coronary Artery Disease.

Ansari WM, Humphries SE, Naveed AK, Khan OJ, Khan DA, Khattak EH.

Cytokine. 2019 Oct;122:154060. doi: 10.1016/j.cyto.2017.05.013. Epub 2017 Jul 10.

PMID:
28705542
32.

Statins for children with familial hypercholesterolemia.

Vuorio A, Kuoppala J, Kovanen PT, Humphries SE, Tonstad S, Wiegman A, Drogari E, Ramaswami U.

Cochrane Database Syst Rev. 2017 Jul 7;7:CD006401. doi: 10.1002/14651858.CD006401.pub4. Review.

33.

Carotid plaque-thickness and common carotid IMT show additive value in cardiovascular risk prediction and reclassification.

Amato M, Veglia F, de Faire U, Giral P, Rauramaa R, Smit AJ, Kurl S, Ravani A, Frigerio B, Sansaro D, Bonomi A, Tedesco CC, Castelnuovo S, Mannarino E, Humphries SE, Hamsten A, Tremoli E, Baldassarre D; IMPROVE study group.

Atherosclerosis. 2017 Aug;263:412-419. doi: 10.1016/j.atherosclerosis.2017.05.023. Epub 2017 May 19.

34.

Assessment of the clinical utility of adding common single nucleotide polymorphism genetic scores to classical risk factor algorithms in coronary heart disease risk prediction in UK men.

Beaney KE, Cooper JA, Drenos F, Humphries SE.

Clin Chem Lab Med. 2017 Aug 28;55(10):1605-1613. doi: 10.1515/cclm-2016-0984.

PMID:
28586300
35.

An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans.

Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH, Johnson AD, Eicher JD, Jackson AU, Ferreira T, Lee Y, Ma C, Steinthorsdottir V, Thorleifsson G, Qi L, Van Zuydam NR, Mahajan A, Chen H, Almgren P, Voight BF, Grallert H, Müller-Nurasyid M, Ried JS, Rayner NW, Robertson N, Karssen LC, van Leeuwen EM, Willems SM, Fuchsberger C, Kwan P, Teslovich TM, Chanda P, Li M, Lu Y, Dina C, Thuillier D, Yengo L, Jiang L, Sparso T, Kestler HA, Chheda H, Eisele L, Gustafsson S, Frånberg M, Strawbridge RJ, Benediktsson R, Hreidarsson AB, Kong A, Sigurðsson G, Kerrison ND, Luan J, Liang L, Meitinger T, Roden M, Thorand B, Esko T, Mihailov E, Fox C, Liu CT, Rybin D, Isomaa B, Lyssenko V, Tuomi T, Couper DJ, Pankow JS, Grarup N, Have CT, Jørgensen ME, Jørgensen T, Linneberg A, Cornelis MC, van Dam RM, Hunter DJ, Kraft P, Sun Q, Edkins S, Owen KR, Perry JRB, Wood AR, Zeggini E, Tajes-Fernandes J, Abecasis GR, Bonnycastle LL, Chines PS, Stringham HM, Koistinen HA, Kinnunen L, Sennblad B, Mühleisen TW, Nöthen MM, Pechlivanis S, Baldassarre D, Gertow K, Humphries SE, Tremoli E, Klopp N, Meyer J, Steinbach G, Wennauer R, Eriksson JG, Mӓnnistö S, Peltonen L, Tikkanen E, Charpentier G, Eury E, Lobbens S, Gigante B, Leander K, McLeod O, Bottinger EP, Gottesman O, Ruderfer D, Blüher M, Kovacs P, Tonjes A, Maruthur NM, Scapoli C, Erbel R, Jöckel KH, Moebus S, de Faire U, Hamsten A, Stumvoll M, Deloukas P, Donnelly PJ, Frayling TM, Hattersley AT, Ripatti S, Salomaa V, Pedersen NL, Boehm BO, Bergman RN, Collins FS, Mohlke KL, Tuomilehto J, Hansen T, Pedersen O, Barroso I, Lannfelt L, Ingelsson E, Lind L, Lindgren CM, Cauchi S, Froguel P, Loos RJF, Balkau B, Boeing H, Franks PW, Barricarte Gurrea A, Palli D, van der Schouw YT, Altshuler D, Groop LC, Langenberg C, Wareham NJ, Sijbrands E, van Duijn CM, Florez JC, Meigs JB, Boerwinkle E, Gieger C, Strauch K, Metspalu A, Morris AD, Palmer CNA, Hu FB, Thorsteinsdottir U, Stefansson K, Dupuis J, Morris AP, Boehnke M, McCarthy MI, Prokopenko I; DIAbetes Genetics Replication And Meta-analysis (DIAGRAM) Consortium.

Diabetes. 2017 Nov;66(11):2888-2902. doi: 10.2337/db16-1253. Epub 2017 May 31.

36.

Common Variants for Cardiovascular Disease: Clinical Utility Confirmed.

Humphries SE.

Circulation. 2017 May 30;135(22):2102-2105. doi: 10.1161/CIRCULATIONAHA.117.027798. No abstract available.

PMID:
28559494
37.

Greater preclinical atherosclerosis in treated monogenic familial hypercholesterolemia vs. polygenic hypercholesterolemia.

Sharifi M, Higginson E, Bos S, Gallivan A, Harvey D, Li KW, Abeysekera A, Haddon A, Ashby H, Shipman KE, Cooper JA, Futema M, Roeters van Lennep JE, Sijbrands EJG, Labib M, Nair D, Humphries SE.

Atherosclerosis. 2017 Aug;263:405-411. doi: 10.1016/j.atherosclerosis.2017.05.015. Epub 2017 May 13.

38.

Causal Associations of Adiposity and Body Fat Distribution With Coronary Heart Disease, Stroke Subtypes, and Type 2 Diabetes Mellitus: A Mendelian Randomization Analysis.

Dale CE, Fatemifar G, Palmer TM, White J, Prieto-Merino D, Zabaneh D, Engmann JEL, Shah T, Wong A, Warren HR, McLachlan S, Trompet S, Moldovan M, Morris RW, Sofat R, Kumari M, Hyppönen E, Jefferis BJ, Gaunt TR, Ben-Shlomo Y, Zhou A, Gentry-Maharaj A, Ryan A; UCLEB Consortium; METASTROKE Consortium, Mutsert R, Noordam R, Caulfield MJ, Jukema JW, Worrall BB, Munroe PB, Menon U, Power C, Kuh D, Lawlor DA, Humphries SE, Mook-Kanamori DO, Sattar N, Kivimaki M, Price JF, Davey Smith G, Dudbridge F, Hingorani AD, Holmes MV, Casas JP.

Circulation. 2017 Jun 13;135(24):2373-2388. doi: 10.1161/CIRCULATIONAHA.116.026560. Epub 2017 May 12.

39.

Functional Analysis of the Coronary Heart Disease Risk Locus on Chromosome 21q22.

Beaney KE, Smith AJP, Folkersen L, Palmen J, Wannamethee SG, Jefferis BJ, Whincup P, Gaunt TR, Casas JP, Ben-Shlomo Y, Price JF, Kumari M, Wong A, Ong K, Hardy R, Kuh D, Wareham N, Kivimaki M, Eriksson P, Humphries SE, Consortium U.

Dis Markers. 2017;2017:1096916. doi: 10.1155/2017/1096916. Epub 2017 Mar 28.

40.

Identifying low density lipoprotein cholesterol associated variants in the Annexin A2 (ANXA2) gene.

Fairoozy RH, Cooper J, White J, Giambartolomei C, Folkersen L, Wannamethee SG, Jefferis BJ, Whincup P, Ben-Shlomo Y, Kumari M, Kivimaki M, Wong A, Hardy R, Kuh D, Gaunt TR, Casas JP, McLachlan S, Price JF, Hingorani A, Franco-Cereceda A, Grewal T, Kalea AZ, Humphries SE; UCLEB consortium.

Atherosclerosis. 2017 Jun;261:60-68. doi: 10.1016/j.atherosclerosis.2017.04.010. Epub 2017 Apr 13.

41.

Genetic Architecture of Familial Hypercholesterolaemia.

Sharifi M, Futema M, Nair D, Humphries SE.

Curr Cardiol Rep. 2017 May;19(5):44. doi: 10.1007/s11886-017-0848-8. Review.

42.

Cost effectiveness of cascade testing for familial hypercholesterolaemia, based on data from familial hypercholesterolaemia services in the UK.

Kerr M, Pears R, Miedzybrodzka Z, Haralambos K, Cather M, Watson M, Humphries SE.

Eur Heart J. 2017 Jun 14;38(23):1832-1839. doi: 10.1093/eurheartj/ehx111.

43.

Mapping of 79 loci for 83 plasma protein biomarkers in cardiovascular disease.

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PLoS Genet. 2017 Apr 3;13(4):e1006706. doi: 10.1371/journal.pgen.1006706. eCollection 2017 Apr.

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Screening for familial hypercholesterolaemia in childhood: Avon Longitudinal Study of Parents and Children (ALSPAC).

Futema M, Cooper JA, Charakida M, Boustred C, Sattar N, Deanfield J, Lawlor DA, Timpson NJ; UK10K Consortium, Humphries SE, Hingorani AD.

Atherosclerosis. 2017 May;260:47-55. doi: 10.1016/j.atherosclerosis.2017.03.007. Epub 2017 Mar 8.

45.

Analysis of mutations causing familial hypercholesterolaemia in black South African patients of different ancestr.

Ibe UK, Whittall R, Humphries SE, Pilcher G, Raal F.

S Afr Med J. 2017 Jan 30;107(2):145-148. doi: 10.7196/SAMJ.2017.v107i2.12022.

PMID:
28220743
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Genetic risk analysis of coronary artery disease in Pakistani subjects using a genetic risk score of 21 variants.

Shahid SU, Shabana, Cooper JA, Beaney KE, Li K, Rehman A, Humphries SE.

Atherosclerosis. 2017 Mar;258:1-7. doi: 10.1016/j.atherosclerosis.2017.01.024. Epub 2017 Jan 22.

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Common variants in the genes of triglyceride and HDL-C metabolism lack association with coronary artery disease in the Pakistani subjects.

Shahid SU, Shabana NA, Cooper JA, Rehman A, Humphries SE.

Lipids Health Dis. 2017 Jan 31;16(1):24. doi: 10.1186/s12944-017-0419-4.

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Molecular genetics of familial hypercholesterolemia in Israel-revisited.

Durst R, Ibe UK, Shpitzen S, Schurr D, Eliav O, Futema M, Whittall R, Szalat A, Meiner V, Knobler H, Gavish D, Henkin Y, Ellis A, Rubinstein A, Harats D, Bitzur R, Hershkovitz B, Humphries SE, Leitersdorf E.

Atherosclerosis. 2017 Feb;257:55-63. doi: 10.1016/j.atherosclerosis.2016.12.021. Epub 2016 Dec 18.

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Genetics of CHD in 2016: Common and rare genetic variants and risk of CHD.

Swerdlow DI, Humphries SE.

Nat Rev Cardiol. 2017 Feb;14(2):73-74. doi: 10.1038/nrcardio.2016.209. Epub 2017 Jan 5. No abstract available.

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Identification of the Functional Variant(s) that Explain the Low-Density Lipoprotein Receptor (LDLR) GWAS SNP rs6511720 Association with Lower LDL-C and Risk of CHD.

Fairoozy RH, White J, Palmen J, Kalea AZ, Humphries SE.

PLoS One. 2016 Dec 14;11(12):e0167676. doi: 10.1371/journal.pone.0167676. eCollection 2016.

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