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Items: 1 to 50 of 267

1.

Synthetic modeling reveals HOXB genes are critical for the initiation and maintenance of human leukemia.

Kusakabe M, Sun AC, Tyshchenko K, Wong R, Nanda A, Shanna C, Gusscott S, Chavez EA, Lorzadeh A, Zhu A, Hill A, Hung S, Brown S, Babaian A, Wang X, Holt RA, Steidl C, Karsan A, Humphries RK, Eaves CJ, Hirst M, Weng AP.

Nat Commun. 2019 Jul 2;10(1):2913. doi: 10.1038/s41467-019-10510-8.

2.

Lipid nanoparticle-mediated siRNA delivery for safe targeting of human CML in vivo.

Jyotsana N, Sharma A, Chaturvedi A, Budida R, Scherr M, Kuchenbauer F, Lindner R, Noyan F, Sühs KW, Stangel M, Grote-Koska D, Brand K, Vornlocher HP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M.

Ann Hematol. 2019 Aug;98(8):1905-1918. doi: 10.1007/s00277-019-03713-y. Epub 2019 May 18.

PMID:
31104089
3.

Hepatic leukemia factor is a novel leukemic stem cell regulator in DNMT3A, NPM1, and FLT3-ITD triple-mutated AML.

Garg S, Reyes-Palomares A, He L, Bergeron A, Lavallée VP, Lemieux S, Gendron P, Rohde C, Xia J, Jagdhane P, Müller-Tidow C, Lipka DB, Imren S, Humphries RK, Waskow C, Vick B, Jeremias I, Richard-Carpentier G, Hébert J, Sauvageau G, Zaugg JB, Barabé F, Pabst C.

Blood. 2019 Jul 18;134(3):263-276. doi: 10.1182/blood.2018862383. Epub 2019 May 10.

PMID:
31076446
4.

Endothelial Sash1 Is Required for Lung Maturation through Nitric Oxide Signaling.

Coulombe P, Paliouras GN, Clayton A, Hussainkhel A, Fuller M, Jovanovic V, Dauphinee S, Umlandt P, Xiang P, Kyle AH, Minchinton AI, Humphries RK, Hoodless PA, Parker JDK, Wright JL, Karsan A.

Cell Rep. 2019 May 7;27(6):1769-1780.e4. doi: 10.1016/j.celrep.2019.04.039.

5.

UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK.

Mol Ther Methods Clin Dev. 2018 Jul 5;10:156-164. doi: 10.1016/j.omtm.2018.06.009. eCollection 2018 Sep 21.

6.

Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential.

Knapp DJHF, Hammond CA, Hui T, van Loenhout MTJ, Wang F, Aghaeepour N, Miller PH, Moksa M, Rabu GM, Beer PA, Pellacani D, Humphries RK, Hansen C, Hirst M, Eaves CJ.

Nat Cell Biol. 2018 Jun;20(6):710-720. doi: 10.1038/s41556-018-0104-5. Epub 2018 May 25.

PMID:
29802403
7.

Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH.

J Clin Oncol. 2018 Apr 1;36(10):1007-1016. doi: 10.1200/JCO.2017.75.2204. Epub 2018 Feb 12.

PMID:
29432078
8.

A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1.

Xiang P, Wei W, Hofs N, Clemans-Gibbon J, Maetzig T, Lai CK, Dhillon I, May C, Ruschmann J, Schneider E, Rosten P, Hu K, Kuchenbauer F, Hoodless PA, Humphries RK.

Blood Adv. 2017 Nov 7;1(24):2225-2235. doi: 10.1182/bloodadvances.2017010355. eCollection 2017 Nov 14.

9.

Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.

Schneider E, Staffas A, Röhner L, Malmberg ED, Ashouri A, Krowiorz K, Pochert N, Miller C, Wei SY, Arabanian L, Buske C, Döhner H, Bullinger L, Fogelstrand L, Heuser M, Döhner K, Xiang P, Ruschmann J, Petriv OI, Heravi-Moussavi A, Hansen CL, Hirst M, Humphries RK, Rouhi A, Palmqvist L, Kuchenbauer F.

Haematologica. 2018 Feb;103(2):246-255. doi: 10.3324/haematol.2017.177485. Epub 2017 Dec 7.

10.

Meis2 as a critical player in MN1-induced leukemia.

Lai CK, Norddahl GL, Maetzig T, Rosten P, Lohr T, Sanchez Milde L, von Krosigk N, Docking TR, Heuser M, Karsan A, Humphries RK.

Blood Cancer J. 2017 Sep 29;7(9):e613. doi: 10.1038/bcj.2017.86.

11.

RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Sühs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M.

Leukemia. 2018 Jan;32(1):224-226. doi: 10.1038/leu.2017.269. Epub 2017 Aug 22. No abstract available.

12.

Lentiviral Fluorescent Genetic Barcoding for Multiplex Fate Tracking of Leukemic Cells.

Maetzig T, Ruschmann J, Sanchez Milde L, Lai CK, von Krosigk N, Humphries RK.

Mol Ther Methods Clin Dev. 2017 Jun 1;6:54-65. doi: 10.1016/j.omtm.2017.05.007. eCollection 2017 Sep 15.

13.

Vitamin C-induced epigenomic remodelling in IDH1 mutant acute myeloid leukaemia.

Mingay M, Chaturvedi A, Bilenky M, Cao Q, Jackson L, Hui T, Moksa M, Heravi-Moussavi A, Humphries RK, Heuser M, Hirst M.

Leukemia. 2018 Jan;32(1):11-20. doi: 10.1038/leu.2017.171. Epub 2017 Jun 2.

14.

Hoxa9 and Meis1 Cooperatively Induce Addiction to Syk Signaling by Suppressing miR-146a in Acute Myeloid Leukemia.

Mohr S, Doebele C, Comoglio F, Berg T, Beck J, Bohnenberger H, Alexe G, Corso J, Ströbel P, Wachter A, Beissbarth T, Schnütgen F, Cremer A, Haetscher N, Göllner S, Rouhi A, Palmqvist L, Rieger MA, Schroeder T, Bönig H, Müller-Tidow C, Kuchenbauer F, Schütz E, Green AR, Urlaub H, Stegmaier K, Humphries RK, Serve H, Oellerich T.

Cancer Cell. 2017 Apr 10;31(4):549-562.e11. doi: 10.1016/j.ccell.2017.03.001.

15.

A novel AHI-1-BCR-ABL-DNM2 complex regulates leukemic properties of primitive CML cells through enhanced cellular endocytosis and ROS-mediated autophagy.

Liu X, Rothe K, Yen R, Fruhstorfer C, Maetzig T, Chen M, Forrest DL, Humphries RK, Jiang X.

Leukemia. 2017 Nov;31(11):2376-2387. doi: 10.1038/leu.2017.108. Epub 2017 Apr 3.

16.

A Lentiviral Fluorescent Genetic Barcoding System for Flow Cytometry-Based Multiplex Tracking.

Maetzig T, Ruschmann J, Lai CK, Ngom M, Imren S, Rosten P, Norddahl GL, von Krosigk N, Sanchez Milde L, May C, Selich A, Rothe M, Dhillon I, Schambach A, Humphries RK.

Mol Ther. 2017 Mar 1;25(3):606-620. doi: 10.1016/j.ymthe.2016.12.005. Epub 2017 Jan 5.

17.

Editorial.

Humphries RK, Eaves C.

Exp Hematol. 2017 Mar;47:1. doi: 10.1016/j.exphem.2017.01.006. No abstract available.

PMID:
28232028
18.

Analysis of parameters that affect human hematopoietic cell outputs in mutant c-kit-immunodeficient mice.

Miller PH, Rabu G, MacAldaz M, Knapp DJ, Cheung AM, Dhillon K, Nakamichi N, Beer PA, Shultz LD, Humphries RK, Eaves CJ.

Exp Hematol. 2017 Apr;48:41-49. doi: 10.1016/j.exphem.2016.12.012. Epub 2017 Jan 11.

19.

MiR-139-5p is a potent tumor suppressor in adult acute myeloid leukemia.

Krowiorz K, Ruschmann J, Lai C, Ngom M, Maetzig T, Martins V, Scheffold A, Schneider E, Pochert N, Miller C, Palmqvist L, Staffas A, Mulaw M, Bohl SR, Buske C, Heuser M, Kraus J, O'Neill K, Hansen CL, Petriv OI, Kestler H, Döhner H, Bullinger L, Döhner K, Humphries RK, Rouhi A, Kuchenbauer F.

Blood Cancer J. 2016 Dec 9;6(12):e508. doi: 10.1038/bcj.2016.110. No abstract available.

20.

Distinct signaling programs control human hematopoietic stem cell survival and proliferation.

Knapp DJ, Hammond CA, Aghaeepour N, Miller PH, Pellacani D, Beer PA, Sachs K, Qiao W, Wang W, Humphries RK, Sauvageau G, Zandstra PW, Bendall SC, Nolan GP, Hansen C, Eaves CJ.

Blood. 2017 Jan 19;129(3):307-318. doi: 10.1182/blood-2016-09-740654. Epub 2016 Nov 8.

21.

Pyrimethamine as a Potent and Selective Inhibitor of Acute Myeloid Leukemia Identified by High-throughput Drug Screening.

Sharma A, Jyotsana N, Lai CK, Chaturvedi A, Gabdoulline R, Görlich K, Murphy C, Blanchard JE, Ganser A, Brown E, Hassell JA, Humphries RK, Morgan M, Heuser M.

Curr Cancer Drug Targets. 2016;16(9):818-828.

PMID:
27321378
22.

Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion.

Miller ME, Rosten P, Lemieux ME, Lai C, Humphries RK.

PLoS One. 2016 Mar 17;11(3):e0151584. doi: 10.1371/journal.pone.0151584. eCollection 2016.

23.

MicroRNA-223 dose levels fine tune proliferation and differentiation in human cord blood progenitors and acute myeloid leukemia.

Gentner B, Pochert N, Rouhi A, Boccalatte F, Plati T, Berg T, Sun SM, Mah SM, Mirkovic-Hösle M, Ruschmann J, Muranyi A, Leierseder S, Argiropoulos B, Starczynowski DT, Karsan A, Heuser M, Hogge D, Camargo FD, Engelhardt S, Döhner H, Buske C, Jongen-Lavrencic M, Naldini L, Humphries RK, Kuchenbauer F.

Exp Hematol. 2015 Oct;43(10):858-868.e7. doi: 10.1016/j.exphem.2015.05.018. Epub 2015 Jul 8.

24.

Cell fate decisions in malignant hematopoiesis: leukemia phenotype is determined by distinct functional domains of the MN1 oncogene.

Lai CK, Moon Y, Kuchenbauer F, Starzcynowski DT, Argiropoulos B, Yung E, Beer P, Schwarzer A, Sharma A, Park G, Leung M, Lin G, Vollett S, Fung S, Eaves CJ, Karsan A, Weng AP, Humphries RK, Heuser M.

PLoS One. 2014 Nov 17;9(11):e112671. doi: 10.1371/journal.pone.0112671. eCollection 2014.

25.

Modeling de novo leukemogenesis from human cord blood with MN1 and NUP98HOXD13.

Imren S, Heuser M, Gasparetto M, Beer PA, Norddahl GL, Xiang P, Chen L, Berg T, Rhyasen GW, Rosten P, Park G, Moon Y, Weng AP, Eaves CJ, Humphries RK.

Blood. 2014 Dec 4;124(24):3608-12. doi: 10.1182/blood-2014-04-564666. Epub 2014 Oct 22.

26.

Cord blood expansion. Pyrimidoindole derivatives are agonists of human hematopoietic stem cell self-renewal.

Fares I, Chagraoui J, Gareau Y, Gingras S, Ruel R, Mayotte N, Csaszar E, Knapp DJ, Miller P, Ngom M, Imren S, Roy DC, Watts KL, Kiem HP, Herrington R, Iscove NN, Humphries RK, Eaves CJ, Cohen S, Marinier A, Zandstra PW, Sauvageau G.

Science. 2014 Sep 19;345(6203):1509-12. doi: 10.1126/science.1256337.

27.

A regulatory network controls nephrocan expression and midgut patterning.

Hou J, Wei W, Saund RS, Xiang P, Cunningham TJ, Yi Y, Alder O, Lu DY, Savory JG, Krentz NA, Montpetit R, Cullum R, Hofs N, Lohnes D, Humphries RK, Yamanaka Y, Duester G, Saijoh Y, Hoodless PA.

Development. 2014 Oct;141(19):3772-81. doi: 10.1242/dev.108274. Epub 2014 Sep 10.

28.

Genomics and model organisms.

Humphries RK.

Exp Hematol. 2014 Aug;42(8):595-7. doi: 10.1016/j.exphem.2014.07.001. Epub 2014 Jul 3. No abstract available.

PMID:
24998450
29.

Constitutive IRF8 expression inhibits AML by activation of repressed immune response signaling.

Sharma A, Yun H, Jyotsana N, Chaturvedi A, Schwarzer A, Yung E, Lai CK, Kuchenbauer F, Argiropoulos B, Görlich K, Ganser A, Humphries RK, Heuser M.

Leukemia. 2015 Jan;29(1):157-68. doi: 10.1038/leu.2014.162. Epub 2014 May 20.

PMID:
24957708
30.

Impact of MLL5 expression on decitabine efficacy and DNA methylation in acute myeloid leukemia.

Yun H, Damm F, Yap D, Schwarzer A, Chaturvedi A, Jyotsana N, Lübbert M, Bullinger L, Döhner K, Geffers R, Aparicio S, Humphries RK, Ganser A, Heuser M.

Haematologica. 2014 Sep;99(9):1456-64. doi: 10.3324/haematol.2013.101386. Epub 2014 Jun 3.

31.

A transgenic mouse model demonstrating the oncogenic role of mutations in the polycomb-group gene EZH2 in lymphomagenesis.

Berg T, Thoene S, Yap D, Wee T, Schoeler N, Rosten P, Lim E, Bilenky M, Mungall AJ, Oellerich T, Lee S, Lai CK, Umlandt P, Salmi A, Chang H, Yue L, Lai D, Cheng SW, Morin RD, Hirst M, Serve H, Marra MA, Morin GB, Gascoyne RD, Aparicio SA, Humphries RK.

Blood. 2014 Jun 19;123(25):3914-24. doi: 10.1182/blood-2012-12-473439. Epub 2014 May 6.

32.

No evidence of clonal dominance after transplant of HOXB4-expanded cord blood cells in a nonhuman primate model.

Watts KL, Beard BC, Wood BL, Trobridge GD, Humphries RK, Adams AB, Nelson V, Kiem HP.

Exp Hematol. 2014 Jul;42(7):497-504. doi: 10.1016/j.exphem.2014.03.007. Epub 2014 Apr 2.

33.

The methyltransferase G9a regulates HoxA9-dependent transcription in AML.

Lehnertz B, Pabst C, Su L, Miller M, Liu F, Yi L, Zhang R, Krosl J, Yung E, Kirschner J, Rosten P, Underhill TM, Jin J, Hébert J, Sauvageau G, Humphries RK, Rossi FM.

Genes Dev. 2014 Feb 15;28(4):317-27. doi: 10.1101/gad.236794.113.

34.

Clonal analysis via barcoding reveals diverse growth and differentiation of transplanted mouse and human mammary stem cells.

Nguyen LV, Makarem M, Carles A, Moksa M, Kannan N, Pandoh P, Eirew P, Osako T, Kardel M, Cheung AM, Kennedy W, Tse K, Zeng T, Zhao Y, Humphries RK, Aparicio S, Eaves CJ, Hirst M.

Cell Stem Cell. 2014 Feb 6;14(2):253-63. doi: 10.1016/j.stem.2013.12.011. Epub 2014 Jan 16.

35.

Past, present and future horizons for experimental hematology.

Humphries RK.

Exp Hematol. 2014 Feb;42(2):73. doi: 10.1016/j.exphem.2013.12.005. Epub 2013 Dec 27. No abstract available.

PMID:
24374262
36.

A Novel Translocation Involving RUNX1 and HOXA Gene Clusters in a Case of Acute Myeloid Leukemia with t(7;21)(p15;q22).

Moon Y, Horsman DE, Humphries RK, Park G.

Immune Netw. 2013 Oct;13(5):222-6. doi: 10.4110/in.2013.13.5.222. Epub 2013 Oct 26.

37.

The Lin28b-let-7-Hmga2 axis determines the higher self-renewal potential of fetal haematopoietic stem cells.

Copley MR, Babovic S, Benz C, Knapp DJ, Beer PA, Kent DG, Wohrer S, Treloar DQ, Day C, Rowe K, Mader H, Kuchenbauer F, Humphries RK, Eaves CJ.

Nat Cell Biol. 2013 Aug;15(8):916-25. doi: 10.1038/ncb2783. Epub 2013 Jun 30.

PMID:
23811688
38.

Myelosuppressive conditioning using busulfan enables bone marrow cell accumulation in the spinal cord of a mouse model of amyotrophic lateral sclerosis.

Lewis CA, Manning J, Barr C, Peake K, Humphries RK, Rossi F, Krieger C.

PLoS One. 2013 Apr 8;8(4):e60661. doi: 10.1371/journal.pone.0060661. Print 2013.

39.

CD34(+) expansion with Delta-1 and HOXB4 promotes rapid engraftment and transfusion independence in a Macaca nemestrina cord blood transplant model.

Watts KL, Delaney C, Nelson V, Trobridge GD, Beard BC, Humphries RK, Kiem HP.

Mol Ther. 2013 Jun;21(6):1270-8. doi: 10.1038/mt.2013.40. Epub 2013 Apr 16.

40.

Enhanced normal short-term human myelopoiesis in mice engineered to express human-specific myeloid growth factors.

Miller PH, Cheung AM, Beer PA, Knapp DJ, Dhillon K, Rabu G, Rostamirad S, Humphries RK, Eaves CJ.

Blood. 2013 Jan 31;121(5):e1-4. doi: 10.1182/blood-2012-09-456566. Epub 2012 Dec 11.

41.

NOTCH1 promotes T cell leukemia-initiating activity by RUNX-mediated regulation of PKC-θ and reactive oxygen species.

Giambra V, Jenkins CR, Wang H, Lam SH, Shevchuk OO, Nemirovsky O, Wai C, Gusscott S, Chiang MY, Aster JC, Humphries RK, Eaves C, Weng AP.

Nat Med. 2012 Nov;18(11):1693-8. doi: 10.1038/nm.2960. Epub 2012 Oct 21.

42.

Ex vivo expansion of normal and chronic myeloid leukemic stem cells without functional alteration using a NUP98HOXA10homeodomain fusion gene.

Sloma I, Imren S, Beer PA, Zhao Y, Lecault V, Leung D, Raghuram K, Brimacombe C, Lambie K, Piret J, Hansen C, Humphries RK, Eaves CJ.

Leukemia. 2013 Jan;27(1):159-69. doi: 10.1038/leu.2012.196. Epub 2012 Jul 16.

43.

Heterogeneity, self-renewal, and differentiation of hematopoietic stem cells.

Jurecic R, Li L, Humphries RK.

Stem Cells Int. 2012;2012:580165. doi: 10.1155/2012/580165. Epub 2012 May 21. No abstract available.

44.

Varying levels of aldehyde dehydrogenase activity in adult murine marrow hematopoietic stem cells are associated with engraftment and cell cycle status.

Gasparetto M, Sekulovic S, Zakaryan A, Imren S, Kent DG, Humphries RK, Vasiliou V, Smith C.

Exp Hematol. 2012 Oct;40(10):857-66.e5. doi: 10.1016/j.exphem.2012.05.014. Epub 2012 Jun 6.

PMID:
22683567
45.

IGF signaling contributes to malignant transformation of hematopoietic progenitors by the MLL-AF9 oncoprotein.

Jenkins CR, Shevchuk OO, Giambra V, Lam SH, Carboni JM, Gottardis MM, Holzenberger M, Pollak M, Humphries RK, Weng AP.

Exp Hematol. 2012 Sep;40(9):715-723.e6. doi: 10.1016/j.exphem.2012.05.003. Epub 2012 May 18.

PMID:
22613471
46.

Beyond Hox: the role of ParaHox genes in normal and malignant hematopoiesis.

Rawat VP, Humphries RK, Buske C.

Blood. 2012 Jul 19;120(3):519-27. doi: 10.1182/blood-2012-02-385898. Epub 2012 Apr 30. Review.

47.

Notch-mediated repression of miR-223 contributes to IGF1R regulation in T-ALL.

Gusscott S, Kuchenbauer F, Humphries RK, Weng AP.

Leuk Res. 2012 Jul;36(7):905-11. doi: 10.1016/j.leukres.2012.02.013. Epub 2012 Mar 17.

PMID:
22424712
48.

Aldehyde dehydrogenases are regulators of hematopoietic stem cell numbers and B-cell development.

Gasparetto M, Sekulovic S, Brocker C, Tang P, Zakaryan A, Xiang P, Kuchenbauer F, Wen M, Kasaian K, Witty MF, Rosten P, Chen Y, Imren S, Duester G, Thompson DC, Humphries RK, Vasiliou V, Smith C.

Exp Hematol. 2012 Apr;40(4):318-29.e2. doi: 10.1016/j.exphem.2011.12.006. Epub 2011 Dec 20.

PMID:
22198153
49.

Functional regulation of pre-B-cell leukemia homeobox interacting protein 1 (PBXIP1/HPIP) in erythroid differentiation.

Manavathi B, Lo D, Bugide S, Dey O, Imren S, Weiss MJ, Humphries RK.

J Biol Chem. 2012 Feb 17;287(8):5600-14. doi: 10.1074/jbc.M111.289843. Epub 2011 Dec 20.

50.

Hematopoietic stem cell expansion facilitates multilineage engraftment in a nonhuman primate cord blood transplantation model.

Watts KL, Nelson V, Wood BL, Trobridge GD, Beard BC, Humphries RK, Kiem HP.

Exp Hematol. 2012 Mar;40(3):187-96. doi: 10.1016/j.exphem.2011.11.009. Epub 2011 Dec 8.

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