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Ceftazidime/avibactam resistance associated with L169P mutation in the omega loop of KPC-2.

Hemarajata P, Humphries RM.

J Antimicrob Chemother. 2019 Feb 7. doi: 10.1093/jac/dkz026. [Epub ahead of print]


A multisite implementation of a real-time polymerase chain reaction assay to predict ciprofloxacin susceptibility in Neisseria gonorrhoeae.

Ellis O, Hemarajata P, Shahkolahi A, Masinde G, Buchs K, Humphries RM, Klausner JD.

Diagn Microbiol Infect Dis. 2019 Jan 14. pii: S0732-8893(19)30028-8. doi: 10.1016/j.diagmicrobio.2018.12.018. [Epub ahead of print]


Effective implementation of the Accelerate Pheno™ system for positive blood cultures.

Humphries R, Di Martino T.

J Antimicrob Chemother. 2019 Jan 1;74(Supplement_1):i40-i43. doi: 10.1093/jac/dky534.


Evaluation of the Accelerate Pheno™ System for identification of Acinetobacter clinical isolates and minocycline susceptibility testing.

Bowler SL, Towne J, Humphries RM, Doi Y.

J Clin Microbiol. 2019 Jan 16. pii: JCM.01711-18. doi: 10.1128/JCM.01711-18. [Epub ahead of print]


Public Health Efforts Can Impact Adoption of Current Susceptibility Breakpoints, But Closer Attention from Regulatory Bodies is Needed.

McKinnell JA, Bhaurla S, Marquez-Sung P, Pucci A, Baron M, Kamali T, Bugante J, Schwartz B, Balter S, Terashita D, Butler-Wu S, Gunzenhauser J, Hindler J, Humphries RM.

J Clin Microbiol. 2018 Dec 19. pii: JCM.01488-18. doi: 10.1128/JCM.01488-18. [Epub ahead of print]


Evaluation of Ciprofloxacin and Levofloxacin disk and Etest using the 2019 Enterobacteriaceae CLSI Breakpoints.

Humphries RM, Hindler JA, Shaffer K, Campeau SA.

J Clin Microbiol. 2018 Dec 19. pii: JCM.01797-18. doi: 10.1128/JCM.01797-18. [Epub ahead of print]


Performance of ceftazidime/avibactam susceptibility testing methods against clinically relevant Gram-negative organisms.

Wenzler E, Lee M, Wu TJ, Meyer KA, Shields RK, Nguyen MH, Clancy CJ, Humphries RM, Harrington AT.

J Antimicrob Chemother. 2019 Mar 1;74(3):633-638. doi: 10.1093/jac/dky483.


Two-Site Evaluation of the Colistin Broth Disk Elution Test To Determine Colistin In Vitro Activity against Gram-Negative Bacilli.

Simner PJ, Bergman Y, Trejo M, Roberts AA, Marayan R, Tekle T, Campeau S, Kazmi AQ, Bell DT, Lewis S, Tamma PD, Humphries R, Hindler JA.

J Clin Microbiol. 2019 Jan 30;57(2). pii: e01163-18. doi: 10.1128/JCM.01163-18. Print 2019 Feb.


Fluoroquinolone prophylaxis selects for meropenem non-susceptible Pseudomonas aeruginosa in patients with hematologic malignancies and hematopoietic-cell transplant recipients.

Hakki M, Humphries RM, Hemarajata P, Tallman GB, Shields RK, Mettus RT, Doi Y, Lewis JS 2nd.

Clin Infect Dis. 2018 Sep 26. doi: 10.1093/cid/ciy825. [Epub ahead of print]


The Frequency of Discordant Gyrase A Genotypes Among Cases of Multiple Neisseria gonorrhoeae Infections at Different Anatomic Sites.

Allan-Blitz LT, Ellis OL, Bolan R, Hemarajata P, Humphries RM, Shahkolahi A, McGrath M, Klausner JD.

Sex Transm Dis. 2019 Jan;46(1):e3-e4. doi: 10.1097/OLQ.0000000000000912.


Practical methods for effective vancomycin-resistant enterococci (VRE) surveillance: experience in a liver transplant surgical intensive care unit.

Linfield RY, Campeau S, Injean P, Gregson A, Kaldas F, Rubin Z, Kim T, Kunz D, Chan A, Lee DJ, Humphries RM, McKinnell JA.

Infect Control Hosp Epidemiol. 2018 Oct;39(10):1178-1182. doi: 10.1017/ice.2018.178. Epub 2018 Sep 4.


UM171 Enhances Lentiviral Gene Transfer and Recovery of Primitive Human Hematopoietic Cells.

Ngom M, Imren S, Maetzig T, Adair JE, Knapp DJHF, Chagraoui J, Fares I, Bordeleau ME, Sauvageau G, Leboulch P, Eaves C, Humphries RK.

Mol Ther Methods Clin Dev. 2018 Jul 5;10:156-164. doi: 10.1016/j.omtm.2018.06.009. eCollection 2018 Sep 21.


Pharmacodynamics of Daptomycin against Enterococcus faecium and Enterococcus faecalis in the Murine Thigh Infection Model.

Kidd JM, Abdelraouf K, Asempa TE, Humphries RM, Nicolau DP.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00506-18. doi: 10.1128/AAC.00506-18. Print 2018 Oct.


Risk Factors for Colistin Resistance among Gram-Negative Rods and Klebsiella pneumoniae Isolates.

Richter SE, Miller L, Uslan DZ, Bell D, Watson K, Humphries R, McKinnell JA.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00149-18. doi: 10.1128/JCM.00149-18. Print 2018 Sep.


Multicenter Evaluation of the Etest Gradient Diffusion Method for Ceftolozane-Tazobactam Susceptibility Testing of Enterobacteriaceae and Pseudomonas aeruginosa.

Bailey AL, Armstrong T, Dwivedi HP, Denys GA, Hindler J, Campeau S, Traczewski M, Humphries R, Burnham CA.

J Clin Microbiol. 2018 Aug 27;56(9). pii: e00717-18. doi: 10.1128/JCM.00717-18. Print 2018 Sep.


Variability of Daptomycin MIC Values for Enterococcus faecium When Measured by Reference Broth Microdilution and Gradient Diffusion Tests.

Campeau SA, Schuetz AN, Kohner P, Arias CA, Hemarajata P, Bard JD, Humphries RM.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e00745-18. doi: 10.1128/AAC.00745-18. Print 2018 Sep.


Single-cell analysis identifies a CD33+ subset of human cord blood cells with high regenerative potential.

Knapp DJHF, Hammond CA, Hui T, van Loenhout MTJ, Wang F, Aghaeepour N, Miller PH, Moksa M, Rabu GM, Beer PA, Pellacani D, Humphries RK, Hansen C, Hirst M, Eaves CJ.

Nat Cell Biol. 2018 Jun;20(6):710-720. doi: 10.1038/s41556-018-0104-5. Epub 2018 May 25.


Twenty-first Century Cures Act and Antimicrobial Susceptibility Testing: Clinical Implications in the Era of Multidrug Resistance.

Humphries RM, Hindler J, Jane Ferraro M, Mathers A.

Clin Infect Dis. 2018 Sep 14;67(7):1132-1138. doi: 10.1093/cid/ciy432.


How to better monitor and clean irregular surfaces in operating rooms: Insights gained by using both ATP luminescence and RODAC assays.

Ellis O, Godwin H, David M, Morse DJ, Humphries R, Uslan DZ.

Am J Infect Control. 2018 Aug;46(8):906-912. doi: 10.1016/j.ajic.2018.03.024. Epub 2018 May 18.


The Continued Value of Disk Diffusion for Assessing Antimicrobial Susceptibility in Clinical Laboratories: Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group.

Humphries RM, Kircher S, Ferrell A, Krause KM, Malherbe R, Hsiung A, Burnham CA.

J Clin Microbiol. 2018 Jul 26;56(8). pii: e00437-18. doi: 10.1128/JCM.00437-18. Print 2018 Aug. Review.


Hepcidin Protects against Lethal Escherichia coli Sepsis in Mice Inoculated with Isolates from Septic Patients.

Stefanova D, Raychev A, Deville J, Humphries R, Campeau S, Ruchala P, Nemeth E, Ganz T, Bulut Y.

Infect Immun. 2018 Jun 21;86(7). pii: e00253-18. doi: 10.1128/IAI.00253-18. Print 2018 Jul.


A screen of Crohn's disease-associated microbial metabolites identifies ascorbate as a novel metabolic inhibitor of activated human T cells.

Chang YL, Rossetti M, Vlamakis H, Casero D, Sunga G, Harre N, Miller S, Humphries R, Stappenbeck T, Simpson KW, Sartor RB, Wu G, Lewis J, Bushman F, McGovern DPB, Salzman N, Borneman J, Xavier R, Huttenhower C, Braun J.

Mucosal Immunol. 2019 Mar;12(2):457-467. doi: 10.1038/s41385-018-0022-7. Epub 2018 Apr 25.


Duodenoscope-Related Outbreak of a Carbapenem-Resistant Klebsiella pneumoniae Identified Using Advanced Molecular Diagnostics.

Humphries RM, Yang S, Kim S, Muthusamy VR, Russell D, Trout AM, Zaroda T, Cheng QJ, Aldrovandi G, Uslan DZ, Hemarajata P, Rubin ZA.

Clin Infect Dis. 2017 Oct 1;65(7):1159-1166. doi: 10.1093/cid/cix527.


Selection of hyperproduction of AmpC and SME-1 in a carbapenem-resistant Serratia marcescens isolate during antibiotic therapy.

Hemarajata P, Amick T, Yang S, Gregson A, Holzmeyer C, Bush K, Humphries RM.

J Antimicrob Chemother. 2018 May 1;73(5):1256-1262. doi: 10.1093/jac/dky028.


Ciprofloxacin May be Efficacious in Treating Wild-Type Gyrase A Genotype Neisseria gonorrhoeae Infections.

Allan-Blitz LT, Hemarajata P, Humphries RM, Kimble M, Elias S, Klausner JD.

Sex Transm Dis. 2018 Apr;45(4):e18. doi: 10.1097/OLQ.0000000000000758. No abstract available.


Impact of 21st Century Cures Act on Breakpoints and Commercial Antimicrobial Susceptibility Test Systems: Progress and Pitfalls.

Humphries RM, Ferraro MJ, Hindler JA.

J Clin Microbiol. 2018 Apr 25;56(5). pii: e00139-18. doi: 10.1128/JCM.00139-18. Print 2018 May. Review.


Endogenous Tumor Suppressor microRNA-193b: Therapeutic and Prognostic Value in Acute Myeloid Leukemia.

Bhayadia R, Krowiorz K, Haetscher N, Jammal R, Emmrich S, Obulkasim A, Fiedler J, Schwarzer A, Rouhi A, Heuser M, Wingert S, Bothur S, Döhner K, Mätzig T, Ng M, Reinhardt D, Döhner H, Zwaan CM, van den Heuvel Eibrink M, Heckl D, Fornerod M, Thum T, Humphries RK, Rieger MA, Kuchenbauer F, Klusmann JH.

J Clin Oncol. 2018 Apr 1;36(10):1007-1016. doi: 10.1200/JCO.2017.75.2204. Epub 2018 Feb 12.


CLSI Methods Development and Standardization Working Group Best Practices for Evaluation of Antimicrobial Susceptibility Tests.

Humphries RM, Ambler J, Mitchell SL, Castanheira M, Dingle T, Hindler JA, Koeth L, Sei K; CLSI Methods Development and Standardization Working Group of the Subcommittee on Antimicrobial Susceptibility Testing.

J Clin Microbiol. 2018 Mar 26;56(4). pii: e01934-17. doi: 10.1128/JCM.01934-17. Print 2018 Apr. Review.


A Cost Analysis of Gyrase A Testing and Targeted Ciprofloxacin Therapy Versus Recommended 2-Drug Therapy for Neisseria gonorrhoeae Infection.

Allan-Blitz LT, Hemarajata P, Humphries RM, Wynn A, Segura ER, Klausner JD.

Sex Transm Dis. 2018 Feb;45(2):87-91. doi: 10.1097/OLQ.0000000000000698.


Multicenter Evaluation of the Accelerate PhenoTest BC Kit for Rapid Identification and Phenotypic Antimicrobial Susceptibility Testing Using Morphokinetic Cellular Analysis.

Pancholi P, Carroll KC, Buchan BW, Chan RC, Dhiman N, Ford B, Granato PA, Harrington AT, Hernandez DR, Humphries RM, Jindra MR, Ledeboer NA, Miller SA, Mochon AB, Morgan MA, Patel R, Schreckenberger PC, Stamper PD, Simner PJ, Tucci NE, Zimmerman C, Wolk DM.

J Clin Microbiol. 2018 Mar 26;56(4). pii: e01329-17. doi: 10.1128/JCM.01329-17. Print 2018 Apr.


Direct-from-Blood-Culture Disk Diffusion To Determine Antimicrobial Susceptibility of Gram-Negative Bacteria: Preliminary Report from the Clinical and Laboratory Standards Institute Methods Development and Standardization Working Group.

Chandrasekaran S, Abbott A, Campeau S, Zimmer BL, Weinstein M, Thrupp L, Hejna J, Walker L, Ammann T, Kirn T, Patel R, Humphries RM.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01678-17. doi: 10.1128/JCM.01678-17. Print 2018 Mar.


A knock-in mouse strain facilitates dynamic tracking and enrichment of MEIS1.

Xiang P, Wei W, Hofs N, Clemans-Gibbon J, Maetzig T, Lai CK, Dhillon I, May C, Ruschmann J, Schneider E, Rosten P, Hu K, Kuchenbauer F, Hoodless PA, Humphries RK.

Blood Adv. 2017 Nov 7;1(24):2225-2235. doi: 10.1182/bloodadvances.2017010355. eCollection 2017 Nov 14.


Micro-ribonucleic acid-155 is a direct target of Meis1, but not a driver in acute myeloid leukemia.

Schneider E, Staffas A, Röhner L, Malmberg ED, Ashouri A, Krowiorz K, Pochert N, Miller C, Wei SY, Arabanian L, Buske C, Döhner H, Bullinger L, Fogelstrand L, Heuser M, Döhner K, Xiang P, Ruschmann J, Petriv OI, Heravi-Moussavi A, Hansen CL, Hirst M, Humphries RK, Rouhi A, Palmqvist L, Kuchenbauer F.

Haematologica. 2018 Feb;103(2):246-255. doi: 10.3324/haematol.2017.177485. Epub 2017 Dec 7.


Performance of Ceftolozane-Tazobactam Etest, MIC Test Strips, and Disk Diffusion Compared to Reference Broth Microdilution for β-Lactam-Resistant Pseudomonas aeruginosa Isolates.

Humphries RM, Hindler JA, Magnano P, Wong-Beringer A, Tibbetts R, Miller SA.

J Clin Microbiol. 2018 Feb 22;56(3). pii: e01633-17. doi: 10.1128/JCM.01633-17. Print 2018 Mar.


Unusual carbapenem resistant but ceftriaxone and cefepime susceptible Klebsiella oxytoca isolated from a blood culture: Case report and whole-genome sequencing investigation.

Yang S, Hemarajata P, Shevy L, Maciariello M, Culbreath K, Bush K, Humphries R.

IDCases. 2017 Nov 23;11:9-11. doi: 10.1016/j.idcr.2017.11.007. eCollection 2018.


Evaluation of Oxacillin and Cefoxitin Disk Diffusion and MIC Breakpoints Established by the Clinical and Laboratory Standards Institute for Detection of mecA-Mediated Oxacillin Resistance in Staphylococcus schleiferi.

Huse HK, Miller SA, Chandrasekaran S, Hindler JA, Lawhon SD, Bemis DA, Westblade LF, Humphries RM.

J Clin Microbiol. 2018 Jan 24;56(2). pii: e01653-17. doi: 10.1128/JCM.01653-17. Print 2018 Feb.


Carbapenem-Resistant Enterobacteriaceae Detection Practices in California: What Are We Missing?

Humphries RM, Hindler JA, Epson E, Horwich-Scholefield S, Miller LG, Mendez J, Martinez JB, Sinkowitz J, Sinkowtiz D, Hershey C, Marquez P, Bhaurla S, Moran M, Pandes L, Terashita D, McKinnell JA.

Clin Infect Dis. 2018 Mar 19;66(7):1061-1067. doi: 10.1093/cid/cix942.


Activity of Ceftolozane-Tazobactam and Ceftazidime-Avibactam against Beta-Lactam-Resistant Pseudomonas aeruginosa Isolates.

Humphries RM, Hindler JA, Wong-Beringer A, Miller SA.

Antimicrob Agents Chemother. 2017 Nov 22;61(12). pii: e01858-17. doi: 10.1128/AAC.01858-17. Print 2017 Dec.


Rapid pathogen-specific phenotypic antibiotic susceptibility testing using digital LAMP quantification in clinical samples.

Schoepp NG, Schlappi TS, Curtis MS, Butkovich SS, Miller S, Humphries RM, Ismagilov RF.

Sci Transl Med. 2017 Oct 4;9(410). pii: eaal3693. doi: 10.1126/scitranslmed.aal3693.


Meis2 as a critical player in MN1-induced leukemia.

Lai CK, Norddahl GL, Maetzig T, Rosten P, Lohr T, Sanchez Milde L, von Krosigk N, Docking TR, Heuser M, Karsan A, Humphries RK.

Blood Cancer J. 2017 Sep 29;7(9):e613. doi: 10.1038/bcj.2017.86.


Diagnosis of Fatal Human Case of St. Louis Encephalitis Virus Infection by Metagenomic Sequencing, California, 2016.

Chiu CY, Coffey LL, Murkey J, Symmes K, Sample HA, Wilson MR, Naccache SN, Arevalo S, Somasekar S, Federman S, Stryke D, Vespa P, Schiller G, Messenger S, Humphries R, Miller S, Klausner JD.

Emerg Infect Dis. 2017 Oct;23(10):1964-1968. doi: 10.3201/eid2310.161986.


Corrigendum: Digital Quantification of DNA Replication and Chromosome Segregation Enables Determination of Antimicrobial Susceptibility after only 15 Minutes of Antibiotic Exposure.

Schoepp NG, Khorosheva EM, Schlappi TS, Curtis MS, Humphries RM, Hindler JA, Ismagilov RF.

Angew Chem Int Ed Engl. 2017 Sep 18;56(39):11675. doi: 10.1002/anie.201707742. No abstract available.


Real-Time PCR Targeting the penA Mosaic XXXIV Type for Prediction of Extended-Spectrum-Cephalosporin Susceptibility in Clinical Neisseria gonorrhoeae Isolates.

Wong LK, Hemarajata P, Soge OO, Humphries RM, Klausner JD.

Antimicrob Agents Chemother. 2017 Oct 24;61(11). pii: e01339-17. doi: 10.1128/AAC.01339-17. Print 2017 Nov.


Assessing Clinical Microbiology Practice Guidelines: American Society for Microbiology Ad Hoc Committee on Evidence-Based Laboratory Medicine Practice Guidelines Assessment.

Nachamkin I, Kirn TJ, Westblade LF, Humphries R.

J Clin Microbiol. 2017 Nov;55(11):3183-3193. doi: 10.1128/JCM.01124-17. Epub 2017 Aug 23. Review.


RNA interference efficiently targets human leukemia driven by a fusion oncogene in vivo.

Jyotsana N, Sharma A, Chaturvedi A, Scherr M, Kuchenbauer F, Sajti L, Barchanski A, Lindner R, Noyan F, Sühs KW, Grote-Koska D, Brand K, Vornlocher HP, Stanulla M, Bornhauser B, Bourquin JP, Eder M, Thol F, Ganser A, Humphries RK, Ramsay E, Cullis P, Heuser M.

Leukemia. 2018 Jan;32(1):224-226. doi: 10.1038/leu.2017.269. Epub 2017 Aug 22. No abstract available.


Epidemiology of Neisseria gonorrhoeae Gyrase A Genotype, Los Angeles, California, USA.

Bhatti AA, Allan-Blitz LT, Castrejon M, Humphries RM, Hemarajata P, Klausner JD.

Emerg Infect Dis. 2017 Sep;23(9):1581-1584. doi: 10.3201/eid2309.170215.


Implementation of a Large System-Wide Hepatitis C Virus Screening and Linkage to Care Program for Baby Boomers.

Castrejón M, Chew KW, Javanbakht M, Humphries R, Saab S, Klausner JD.

Open Forum Infect Dis. 2017 May 27;4(3):ofx109. doi: 10.1093/ofid/ofx109. eCollection 2017 Summer.


Induction of β-Lactamase Activity and Decreased β-Lactam Susceptibility by CO2 in Clinical Bacterial Isolates.

Mullen N, Raposo H, Gudis P, Barker L, Humphries RM, Schmitt BH, Relich RF, May M.

mSphere. 2017 Jul 19;2(4). pii: e00266-17. doi: 10.1128/mSphere.00266-17. eCollection 2017 Jul-Aug.


Resistance to Ceftazidime-Avibactam Is Due to Transposition of KPC in a Porin-Deficient Strain of Klebsiella pneumoniae with Increased Efflux Activity.

Nelson K, Hemarajata P, Sun D, Rubio-Aparicio D, Tsivkovski R, Yang S, Sebra R, Kasarskis A, Nguyen H, Hanson BM, Leopold S, Weinstock G, Lomovskaya O, Humphries RM.

Antimicrob Agents Chemother. 2017 Sep 22;61(10). pii: e00989-17. doi: 10.1128/AAC.00989-17. Print 2017 Oct.


Hepatitis E Virus-Associated Meningoencephalitis in a Lung Transplant Recipient Diagnosed by Clinical Metagenomic Sequencing.

Murkey JA, Chew KW, Carlson M, Shannon CL, Sirohi D, Sample HA, Wilson MR, Vespa P, Humphries RM, Miller S, Klausner JD, Chiu CY.

Open Forum Infect Dis. 2017 Jun 13;4(3):ofx121. doi: 10.1093/ofid/ofx121. eCollection 2017 Summer.

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