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Items: 1 to 50 of 248

1.

Whole-body MRI for staging and interim response monitoring in paediatric and adolescent Hodgkin's lymphoma: a comparison with multi-modality reference standard including 18F-FDG-PET-CT.

Latifoltojar A, Punwani S, Lopes A, Humphries PD, Klusmann M, Menezes LJ, Daw S, Shankar A, Neriman D, Fitzke H, Clifton-Hadley L, Smith P, Taylor SA.

Eur Radiol. 2018 Jun 15. doi: 10.1007/s00330-018-5445-8. [Epub ahead of print]

PMID:
29948084
2.

Introduction of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis.

Thyoka M, Adekunle O, Pilkington C, Walters S, Arthurs OJ, Humphries P, Johnson K, Kraft J, Landes C, Persaud T, Sinha R, Offiah AC.

Rheumatology (Oxford). 2018 Sep 1;57(9):1661-1668. doi: 10.1093/rheumatology/key144.

3.

Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.

Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS.

Sleep. 2018 Sep 1;41(9). doi: 10.1093/sleep/zsy116.

PMID:
29860347
4.

Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E.

Bioorg Med Chem Lett. 2017 Dec 24. pii: S0960-894X(17)31225-8. doi: 10.1016/j.bmcl.2017.12.051. [Epub ahead of print]

PMID:
29292223
5.

Target 5000: Target Capture Sequencing for Inherited Retinal Degenerations.

Dockery A, Stephenson K, Keegan D, Wynne N, Silvestri G, Humphries P, Kenna PF, Carrigan M, Farrar GJ.

Genes (Basel). 2017 Nov 3;8(11). pii: E304. doi: 10.3390/genes8110304.

6.

Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.

Greene C, Kealy J, Humphries MM, Gong Y, Hou J, Hudson N, Cassidy LM, Martiniano R, Shashi V, Hooper SR, Grant GA, Kenna PF, Norris K, Callaghan CK, Islam MD, O'Mara SM, Najda Z, Campbell SG, Pachter JS, Thomas J, Williams NM, Humphries P, Murphy KC, Campbell M.

Mol Psychiatry. 2017 Oct 10. doi: 10.1038/mp.2017.156. [Epub ahead of print]

PMID:
28993710
7.

A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors.

Hanlon KS, Chadderton N, Palfi A, Blanco Fernandez A, Humphries P, Kenna PF, Millington-Ward S, Farrar GJ.

Front Neurosci. 2017 Sep 21;11:521. doi: 10.3389/fnins.2017.00521. eCollection 2017.

8.

Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway.

O'Callaghan J, Cassidy PS, Humphries P.

Expert Opin Ther Targets. 2017 Nov;21(11):1037-1050. doi: 10.1080/14728222.2017.1386174. Epub 2017 Oct 5. Review.

PMID:
28952395
9.

Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension.

Campbell M, Cassidy PS, O'Callaghan J, Crosbie DE, Humphries P.

Prog Retin Eye Res. 2018 Jan;62:120-133. doi: 10.1016/j.preteyeres.2017.09.003. Epub 2017 Sep 22. Review.

10.

Confronting the risks of large-scale invasive species control.

Kopf RK, Nimmo DG, Humphries P, Baumgartner LJ, Bode M, Bond NR, Byrom AE, Cucherousset J, Keller RP, King AJ, McGinness HM, Moyle PB, Olden JD.

Nat Ecol Evol. 2017 May 23;1(6):172. doi: 10.1038/s41559-017-0172. No abstract available.

PMID:
28812629
11.

Toward an elucidation of the molecular genetics of inherited retinal degenerations.

Farrar GJ, Carrigan M, Dockery A, Millington-Ward S, Palfi A, Chadderton N, Humphries M, Kiang AS, Kenna PF, Humphries P.

Hum Mol Genet. 2017 Aug 1;26(R1):R2-R11. doi: 10.1093/hmg/ddx185. Review.

12.

Juvenile idiopathic arthritis: what is the utility of ultrasound?

Basra HAS, Humphries PD.

Br J Radiol. 2017 May;90(1073):20160920. doi: 10.1259/bjr.20160920. Epub 2017 Apr 6. Review.

13.

Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.

O'Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Stamer WD, Overby DR, O'Brien C, Tam LCS, Humphries P.

Hum Mol Genet. 2017 Apr 1;26(7):1230-1246. doi: 10.1093/hmg/ddx028.

14.

Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.

Tam LC, Reina-Torres E, Sherwood JM, Cassidy PS, Crosbie DE, Lütjen-Drecoll E, Flügel-Koch C, Perkumas K, Humphries MM, Kiang AS, O'Callaghan J, Callanan JJ, Read AT, Ethier CR, O'Brien C, Lawrence M, Campbell M, Stamer WD, Overby DR, Humphries P.

Sci Rep. 2017 Jan 16;7:40717. doi: 10.1038/srep40717.

15.

Trait-based prediction of extinction risk of small-bodied freshwater fishes.

Kopf RK, Shaw C, Humphries P.

Conserv Biol. 2017 Jun;31(3):581-591. doi: 10.1111/cobi.12882. Epub 2017 Jan 30.

PMID:
27976421
16.

Panel-Based Population Next-Generation Sequencing for Inherited Retinal Degenerations.

Carrigan M, Duignan E, Malone CP, Stephenson K, Saad T, McDermott C, Green A, Keegan D, Humphries P, Kenna PF, Farrar GJ.

Sci Rep. 2016 Sep 14;6:33248. doi: 10.1038/srep33248.

17.

Discordant inflammatory changes in the apophyseal and sacroiliac joints: serial observations in enthesitis-related arthritis.

Bray TJ, Amies T, Vendhan K, Humphries P, Sen D, Ioannou Y, Hall-Craggs MA.

Br J Radiol. 2016 Sep;89(1065):20160353. doi: 10.1259/bjr.20160353. Epub 2016 Jul 4.

18.

Corrigendum to "Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho-/- mouse".

Palfi A, Chadderton N, O'Reilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, Humphries P, Kenna P, Millington-Ward S, Farrar J.

Mol Ther Methods Clin Dev. 2016 May 25;3:16032. doi: 10.1038/mtm.2016.32. eCollection 2016.

19.

Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):757-760. doi: 10.1016/j.bmcl.2015.12.102. Epub 2015 Dec 30.

PMID:
26778255
20.

Author Response: The Role of IL-18 in the Treatment of AMD.

Doyle SL, López FJ, Humphries P, Adamson P, Campbell M.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8237-8. doi: 10.1167/iovs.15-18714. No abstract available.

PMID:
26720477
21.

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier.

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M.

Sci Adv. 2015 Sep 4;1(8):e1500472.

22.

A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration.

Carrigan M, Duignan E, Humphries P, Palfi A, Kenna PF, Farrar GJ.

Br J Ophthalmol. 2016 Apr;100(4):495-500. doi: 10.1136/bjophthalmol-2015-306939. Epub 2015 Oct 15.

23.

IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates.

Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5424-30. doi: 10.1167/iovs.15-17264.

PMID:
26284546
24.

Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.

Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger MW.

Sci Rep. 2015 Jun 1;5:10731. doi: 10.1038/srep10731.

25.

Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(-/-) mouse.

Palfi A, Chadderton N, O'Reilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, Humphries P, Kenna P, Millington-Ward S, Farrar J.

Mol Ther Methods Clin Dev. 2015 May 6;2:15016. doi: 10.1038/mtm.2015.16. eCollection 2015. Erratum in: Mol Ther Methods Clin Dev. 2016;3:16032.

26.

Intra- and interobserver variability of whole-tumour apparent diffusion coefficient measurements in nephroblastoma: a pilot study.

Littooij AS, Humphries PD, Olsen ØE.

Pediatr Radiol. 2015 Oct;45(11):1651-60. doi: 10.1007/s00247-015-3354-4. Epub 2015 May 8.

27.

The joints in juvenile idiopathic arthritis.

Ording Muller LS, Humphries P, Rosendahl K.

Insights Imaging. 2015 Jun;6(3):275-84. doi: 10.1007/s13244-015-0406-0. Epub 2015 Apr 23.

28.

Interleukin-18 bioactivity and dose: data interpretation at a crossroads.

Doyle SL, Adamson P, López FJ, Humphries P, Campbell M.

Invest Ophthalmol Vis Sci. 2014 Dec 23;55(12):8349-50. doi: 10.1167/iovs.14-15786. No abstract available.

PMID:
25538010
29.

Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration.

Doyle SL, Adamson P, López FJ, Humphries P, Campbell M.

Nat Med. 2014 Dec;20(12):1376-7. doi: 10.1038/nm.3741. No abstract available.

PMID:
25473915
30.

Contrasting patterns of larval mortality in two sympatric riverine fish species: a test of the critical period hypothesis.

McCasker N, Humphries P, Meredith S, Klomp N.

PLoS One. 2014 Oct 9;9(10):e109317. doi: 10.1371/journal.pone.0109317. eCollection 2014.

31.

IL-18: a new player in immunotherapy for age-related macular degeneration?

Campbell M, Doyle S, Humphries P.

Expert Rev Clin Immunol. 2014 Oct;10(10):1273-5. doi: 10.1586/1744666X.2014.950231. Epub 2014 Aug 21. Review.

PMID:
25142147
32.

Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.

Guo C, Hou X, Dong L, Marakovits J, Greasley S, Dagostino E, Ferre R, Johnson MC, Humphries PS, Li H, Paderes GD, Piraino J, Kraynov E, Murray BW.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4187-91. doi: 10.1016/j.bmcl.2014.07.044. Epub 2014 Jul 22.

PMID:
25091930
33.

Perineal lipoma with accessory labioscrotal fold and penis-like phallus in a female infant with unilateral renal agenesis.

Mifsud W, Sambandan N, Humphries P, Sebire NJ, Mushtaq I.

Urology. 2014 Jul;84(1):209-12. doi: 10.1016/j.urology.2014.03.033. Epub 2014 May 22.

34.

Ontogeny of critical and prolonged swimming performance for the larvae of six Australian freshwater fish species.

Kopf SM, Humphries P, Watts RJ.

J Fish Biol. 2014 Jun;84(6):1820-41. doi: 10.1111/jfb.12399. Epub 2014 May 9.

PMID:
24814314
35.

IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M.

Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616.

36.

Antioxidant therapy for retinal disease.

Kiang AS, Humphries MM, Campbell M, Humphries P.

Adv Exp Med Biol. 2014;801:783-9. doi: 10.1007/978-1-4614-3209-8_98. Review.

PMID:
24664771
37.

Current therapeutic strategies for P23H RHO-linked RP.

Nguyen AT, Campbell M, Kiang AS, Humphries MM, Humphries P.

Adv Exp Med Biol. 2014;801:471-6. doi: 10.1007/978-1-4614-3209-8_60. Review.

PMID:
24664733
38.

An overview of the involvement of interleukin-18 in degenerative retinopathies.

Campbell M, Doyle SL, Ozaki E, Kenna PF, Kiang AS, Humphries MM, Humphries P.

Adv Exp Med Biol. 2014;801:409-15. doi: 10.1007/978-1-4614-3209-8_52. Review.

PMID:
24664725
39.

Inflammation in age-related macular degeneration.

Ozaki E, Campbell M, Kiang AS, Humphries M, Doyle SL, Humphries P.

Adv Exp Med Biol. 2014;801:229-35. doi: 10.1007/978-1-4614-3209-8_30. Review.

PMID:
24664703
40.

Application of next-generation sequencing to identify genes and mutations causing autosomal dominant retinitis pigmentosa (adRP).

Daiger SP, Bowne SJ, Sullivan LS, Blanton SH, Weinstock GM, Koboldt DC, Fulton RS, Larsen D, Humphries P, Humphries MM, Pierce EA, Chen R, Li Y.

Adv Exp Med Biol. 2014;801:123-9. doi: 10.1007/978-1-4614-3209-8_16.

41.

Auditory event-related signals in mouse ERG recordings.

Tanimoto N, Sothilingam V, Gloeckner G, Bryda EC, Humphries P, Biel M, Seeliger MW.

Doc Ophthalmol. 2014 Feb;128(1):25-32. doi: 10.1007/s10633-013-9417-7. Epub 2013 Nov 13.

PMID:
24221507
42.

On the neighborhoods of trees.

Humphries PJ, Wu T.

IEEE/ACM Trans Comput Biol Bioinform. 2013 May-Jun;10(3):721-8. doi: 10.1109/TCBB.2013.66.

PMID:
24091404
43.

Cherry picking: a characterization of the temporal hybridization number for a set of phylogenies.

Humphries PJ, Linz S, Semple C.

Bull Math Biol. 2013 Oct;75(10):1879-90. doi: 10.1007/s11538-013-9874-x. Epub 2013 Aug 8.

PMID:
23925727
44.

Pyrimidone-based series of glucokinase activators with alternative donor-acceptor motif.

Filipski KJ, Guzman-Perez A, Bian J, Perreault C, Aspnes GE, Didiuk MT, Dow RL, Hank RF, Jones CS, Maguire RJ, Tu M, Zeng D, Liu S, Knafels JD, Litchfield J, Atkinson K, Derksen DR, Bourbonais F, Gajiwala KS, Hickey M, Johnson TO, Humphries PS, Pfefferkorn JA.

Bioorg Med Chem Lett. 2013 Aug 15;23(16):4571-8. doi: 10.1016/j.bmcl.2013.06.036. Epub 2013 Jun 20.

PMID:
23831135
45.

Accuracy of ADC estimates: response to letter by Priola et al. re Diffusion-weighted MRI of lymphoma: prognostic utility and implications for PET/MRI?

Punwani S, Bainbridge A, Humphries P.

Eur J Nucl Med Mol Imaging. 2013 Jul;40(7):1110-1. doi: 10.1007/s00259-013-2392-0. No abstract available.

PMID:
23539176
46.

River regulation and recruitment in a protracted-spawning riverine fish.

Humphries P, Richardson A, Wilson G, Ellison T.

Ecol Appl. 2013 Jan;23(1):208-25.

PMID:
23495647
47.

The blood-retina barrier: tight junctions and barrier modulation.

Campbell M, Humphries P.

Adv Exp Med Biol. 2012;763:70-84.

PMID:
23397619
48.

Dynamic contrast-enhanced MRI improves accuracy for detecting focal splenic involvement in children and adolescents with Hodgkin disease.

Punwani S, Cheung KK, Skipper N, Bell N, Bainbridge A, Taylor SA, Groves AM, Hain SF, Ben-Haim S, Shankar A, Daw S, Halligan S, Humphries PD.

Pediatr Radiol. 2013 Aug;43(8):941-9. doi: 10.1007/s00247-012-2616-7. Epub 2013 Feb 3.

PMID:
23377561
49.

Diffusion-weighted MRI of lymphoma: prognostic utility and implications for PET/MRI?

Punwani S, Taylor SA, Saad ZZ, Bainbridge A, Groves A, Daw S, Shankar A, Halligan S, Humphries PD.

Eur J Nucl Med Mol Imaging. 2013 Feb;40(3):373-85. doi: 10.1007/s00259-012-2293-7. Epub 2012 Nov 30.

PMID:
23197155
50.

Barrier modulation in drug delivery to the retina.

Campbell M, Humphries MM, Humphries P.

Methods Mol Biol. 2013;935:371-80. doi: 10.1007/978-1-62703-080-9_26.

PMID:
23150382

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