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Findings from a Genotyping Study of Over 1000 People with Inherited Retinal Disorders in Ireland.

Whelan L, Dockery A, Wynne N, Zhu J, Stephenson K, Silvestri G, Turner J, O'Byrne JJ, Carrigan M, Humphries P, Keegan D, Kenna PF, Farrar GJ.

Genes (Basel). 2020 Jan 16;11(1). pii: E105. doi: 10.3390/genes11010105.


Dysregulated claudin-5 cycling in the inner retina causes retinal pigment epithelial cell atrophy.

Hudson N, Celkova L, Hopkins A, Greene C, Storti F, Ozaki E, Fahey E, Theodoropoulou S, Kenna PF, Humphries MM, Curtis AM, Demmons E, Browne A, Liddie S, Lawrence MS, Grimm C, Cahill MT, Humphries P, Doyle SL, Campbell M.

JCI Insight. 2019 Aug 8;4(15). pii: 130273. doi: 10.1172/jci.insight.130273. eCollection 2019 Aug 8.


Reduced humidity experienced by mice in vivo coincides with reduced outflow facility measured ex vivo.

Reina-Torres E, Bertrand JA, O'Callaghan J, Sherwood JM, Humphries P, Overby DR.

Exp Eye Res. 2019 Sep;186:107745. doi: 10.1016/j.exer.2019.107745. Epub 2019 Jul 24.


Whole-body magnetic resonance imaging in paediatric Hodgkin lymphoma - evaluation of quantitative magnetic resonance metrics for nodal staging.

Latifoltojar A, Humphries PD, Menezes LJ, Haroon A, Daw S, Shankar A, Punwani S.

Pediatr Radiol. 2019 Sep;49(10):1285-1298. doi: 10.1007/s00247-019-04463-9. Epub 2019 Jul 22.


Commentary on: radiological diagnosis of chronic recurrent multifocal osteomyelitis using whole-body MRI-based lesion distribution patterns.

Ording Müller LS, Humphries P.

Clin Radiol. 2019 Sep;74(9):737.e1-737.e2. doi: 10.1016/j.crad.2019.05.024. Epub 2019 Jul 2. No abstract available.


Biocontrol of Carp: The Australian Plan Does Not Stand Up to a Rational Analysis of Safety and Efficacy.

Boutier M, Donohoe O, Kopf RK, Humphries P, Becker JA, Marshall J, Vanderplasschen A.

Front Microbiol. 2019 Apr 30;10:882. doi: 10.3389/fmicb.2019.00882. eCollection 2019. No abstract available.


Contrast-enhanced ultrasound for multiple liver lesions after bone marrow transplant in a child with leukaemia: Multifocal focal nodular hyperplasia.

Verhagen MV, Ciocarlie O, Humphries P, Watson T.

Ultrasound. 2019 May;27(2):122-126. doi: 10.1177/1742271X18795328. Epub 2018 Aug 13.


Bone age for chronological age determination - statement of the European Society of Paediatric Radiology musculoskeletal task force group.

Ording Müller LS, Offiah A, Adamsbaum C, Barber I, Di Paolo PL, Humphries P, Shelmerdine S, Tanturri De Horatio L, Toma P, Treguier C, Rosendahl K.

Pediatr Radiol. 2019 Jun;49(7):979-982. doi: 10.1007/s00247-019-04379-4. Epub 2019 Mar 26.


Acoustic shadowing in pediatric kidney stone ultrasound: a retrospective study with non-enhanced computed tomography as reference standard.

Verhagen MV, Watson TA, Hickson M, Smeulders N, Humphries PD.

Pediatr Radiol. 2019 May;49(6):777-783. doi: 10.1007/s00247-019-04372-x. Epub 2019 Mar 14.


Intracameral Delivery of AAV to Corneal Endothelium for Expression of Secretory Proteins.

O'Callaghan J, Campbell M, Humphries P.

Methods Mol Biol. 2019;1950:263-270. doi: 10.1007/978-1-4939-9139-6_15.


How to use abdominal X-rays in preterm infants suspected of developing necrotising enterocolitis.

Soni R, Katana A, Curry JI, Humphries PD, Huertas-Ceballos A.

Arch Dis Child Educ Pract Ed. 2020 Feb;105(1):50-57. doi: 10.1136/archdischild-2018-315252. Epub 2019 Feb 18.


Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI.

Crosbie DE, Keaney J, Tam LCS, Daniel Stamer W, Campbell M, Humphries P.

Magn Reson Imaging. 2019 Jun;59:10-16. doi: 10.1016/j.mri.2019.01.016. Epub 2019 Jan 17.


Association of a Competency-Based Assessment System With Identification of and Support for Medical Residents in Difficulty.

Ross S, Binczyk NM, Hamza DM, Schipper S, Humphries P, Nichols D, Donoff MG.

JAMA Netw Open. 2018 Nov 2;1(7):e184581. doi: 10.1001/jamanetworkopen.2018.4581.


Imaging features of extranodal involvement in paediatric Hodgkin lymphoma.

Spijkers S, Littooij AS, Humphries PD, Lam MGEH, Nievelstein RAJ.

Pediatr Radiol. 2019 Feb;49(2):266-276. doi: 10.1007/s00247-018-4280-z. Epub 2018 Dec 5. Review.


Whole-body MRI for staging and interim response monitoring in paediatric and adolescent Hodgkin's lymphoma: a comparison with multi-modality reference standard including 18F-FDG-PET-CT.

Latifoltojar A, Punwani S, Lopes A, Humphries PD, Klusmann M, Menezes LJ, Daw S, Shankar A, Neriman D, Fitzke H, Clifton-Hadley L, Smith P, Taylor SA.

Eur Radiol. 2019 Jan;29(1):202-212. doi: 10.1007/s00330-018-5445-8. Epub 2018 Jun 15.


Introduction of a novel magnetic resonance imaging-based scoring system for assessing disease activity in children with juvenile dermatomyositis.

Thyoka M, Adekunle O, Pilkington C, Walters S, Arthurs OJ, Humphries P, Johnson K, Kraft J, Landes C, Persaud T, Sinha R, Offiah AC.

Rheumatology (Oxford). 2018 Sep 1;57(9):1661-1668. doi: 10.1093/rheumatology/key144.


Partial ablation of the orexin field induces a sub-narcoleptic phenotype in a conditional mouse model of orexin neurodegeneration.

Black SW, Sun JD, Santiago P, Laihsu A, Kimura N, Yamanaka A, Bersot R, Humphries PS.

Sleep. 2018 Sep 1;41(9). doi: 10.1093/sleep/zsy116.


Carbazole-containing amides and ureas: Discovery of cryptochrome modulators as antihyperglycemic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E.

Bioorg Med Chem Lett. 2018 Feb 1;28(3):293-297. doi: 10.1016/j.bmcl.2017.12.051. Epub 2017 Dec 24.


Target 5000: Target Capture Sequencing for Inherited Retinal Degenerations.

Dockery A, Stephenson K, Keegan D, Wynne N, Silvestri G, Humphries P, Kenna PF, Carrigan M, Farrar GJ.

Genes (Basel). 2017 Nov 3;8(11). pii: E304. doi: 10.3390/genes8110304.


Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia.

Greene C, Kealy J, Humphries MM, Gong Y, Hou J, Hudson N, Cassidy LM, Martiniano R, Shashi V, Hooper SR, Grant GA, Kenna PF, Norris K, Callaghan CK, Islam MD, O'Mara SM, Najda Z, Campbell SG, Pachter JS, Thomas J, Williams NM, Humphries P, Murphy KC, Campbell M.

Mol Psychiatry. 2018 Nov;23(11):2156-2166. doi: 10.1038/mp.2017.156. Epub 2017 Oct 10.


A Novel Retinal Ganglion Cell Promoter for Utility in AAV Vectors.

Hanlon KS, Chadderton N, Palfi A, Blanco Fernandez A, Humphries P, Kenna PF, Millington-Ward S, Farrar GJ.

Front Neurosci. 2017 Sep 21;11:521. doi: 10.3389/fnins.2017.00521. eCollection 2017.


Open-angle glaucoma: therapeutically targeting the extracellular matrix of the conventional outflow pathway.

O'Callaghan J, Cassidy PS, Humphries P.

Expert Opin Ther Targets. 2017 Nov;21(11):1037-1050. doi: 10.1080/14728222.2017.1386174. Epub 2017 Oct 5. Review.


Manipulating ocular endothelial tight junctions: Applications in treatment of retinal disease pathology and ocular hypertension.

Campbell M, Cassidy PS, O'Callaghan J, Crosbie DE, Humphries P.

Prog Retin Eye Res. 2018 Jan;62:120-133. doi: 10.1016/j.preteyeres.2017.09.003. Epub 2017 Sep 22. Review.


Confronting the risks of large-scale invasive species control.

Kopf RK, Nimmo DG, Humphries P, Baumgartner LJ, Bode M, Bond NR, Byrom AE, Cucherousset J, Keller RP, King AJ, McGinness HM, Moyle PB, Olden JD.

Nat Ecol Evol. 2017 May 23;1(6):172. doi: 10.1038/s41559-017-0172. No abstract available.


Toward an elucidation of the molecular genetics of inherited retinal degenerations.

Farrar GJ, Carrigan M, Dockery A, Millington-Ward S, Palfi A, Chadderton N, Humphries M, Kiang AS, Kenna PF, Humphries P.

Hum Mol Genet. 2017 Aug 1;26(R1):R2-R11. doi: 10.1093/hmg/ddx185. Review.


Juvenile idiopathic arthritis: what is the utility of ultrasound?

Basra HAS, Humphries PD.

Br J Radiol. 2017 May;90(1073):20160920. doi: 10.1259/bjr.20160920. Epub 2017 Apr 6. Review.


Therapeutic potential of AAV-mediated MMP-3 secretion from corneal endothelium in treating glaucoma.

O'Callaghan J, Crosbie DE, Cassidy PS, Sherwood JM, Flügel-Koch C, Lütjen-Drecoll E, Humphries MM, Reina-Torres E, Wallace D, Kiang AS, Campbell M, Stamer WD, Overby DR, O'Brien C, Tam LCS, Humphries P.

Hum Mol Genet. 2017 Apr 1;26(7):1230-1246. doi: 10.1093/hmg/ddx028.


Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia.

Tam LC, Reina-Torres E, Sherwood JM, Cassidy PS, Crosbie DE, Lütjen-Drecoll E, Flügel-Koch C, Perkumas K, Humphries MM, Kiang AS, O'Callaghan J, Callanan JJ, Read AT, Ethier CR, O'Brien C, Lawrence M, Campbell M, Stamer WD, Overby DR, Humphries P.

Sci Rep. 2017 Jan 16;7:40717. doi: 10.1038/srep40717.


Trait-based prediction of extinction risk of small-bodied freshwater fishes.

Kopf RK, Shaw C, Humphries P.

Conserv Biol. 2017 Jun;31(3):581-591. doi: 10.1111/cobi.12882. Epub 2017 Jan 30.


Panel-Based Population Next-Generation Sequencing for Inherited Retinal Degenerations.

Carrigan M, Duignan E, Malone CP, Stephenson K, Saad T, McDermott C, Green A, Keegan D, Humphries P, Kenna PF, Farrar GJ.

Sci Rep. 2016 Sep 14;6:33248. doi: 10.1038/srep33248.


Discordant inflammatory changes in the apophyseal and sacroiliac joints: serial observations in enthesitis-related arthritis.

Bray TJ, Amies T, Vendhan K, Humphries P, Sen D, Ioannou Y, Hall-Craggs MA.

Br J Radiol. 2016 Sep;89(1065):20160353. doi: 10.1259/bjr.20160353. Epub 2016 Jul 4.


Corrigendum to "Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho-/- mouse".

Palfi A, Chadderton N, O'Reilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, Humphries P, Kenna P, Millington-Ward S, Farrar J.

Mol Ther Methods Clin Dev. 2016 May 25;3:16032. doi: 10.1038/mtm.2016.32. eCollection 2016.


Carbazole-containing sulfonamides and sulfamides: Discovery of cryptochrome modulators as antidiabetic agents.

Humphries PS, Bersot R, Kincaid J, Mabery E, McCluskie K, Park T, Renner T, Riegler E, Steinfeld T, Turtle ED, Wei ZL, Willis E.

Bioorg Med Chem Lett. 2016 Feb 1;26(3):757-760. doi: 10.1016/j.bmcl.2015.12.102. Epub 2015 Dec 30.


Author Response: The Role of IL-18 in the Treatment of AMD.

Doyle SL, López FJ, Humphries P, Adamson P, Campbell M.

Invest Ophthalmol Vis Sci. 2015 Dec;56(13):8237-8. doi: 10.1167/iovs.15-18714. No abstract available.


Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier.

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M.

Sci Adv. 2015 Sep 4;1(8):e1500472.


A novel homozygous truncating GNAT1 mutation implicated in retinal degeneration.

Carrigan M, Duignan E, Humphries P, Palfi A, Kenna PF, Farrar GJ.

Br J Ophthalmol. 2016 Apr;100(4):495-500. doi: 10.1136/bjophthalmol-2015-306939. Epub 2015 Oct 15.


IL-18 Immunotherapy for Neovascular AMD: Tolerability and Efficacy in Nonhuman Primates.

Doyle SL, López FJ, Celkova L, Brennan K, Mulfaul K, Ozaki E, Kenna PF, Kurali E, Hudson N, Doggett T, Ferguson TA, Humphries P, Adamson P, Campbell M.

Invest Ophthalmol Vis Sci. 2015 Aug;56(9):5424-30. doi: 10.1167/iovs.15-17264.


Electroretinographic assessment of rod- and cone-mediated bipolar cell pathways using flicker stimuli in mice.

Tanimoto N, Sothilingam V, Kondo M, Biel M, Humphries P, Seeliger MW.

Sci Rep. 2015 Jun 1;5:10731. doi: 10.1038/srep10731.


Efficient gene delivery to photoreceptors using AAV2/rh10 and rescue of the Rho(-/-) mouse.

Palfi A, Chadderton N, O'Reilly M, Nagel-Wolfrum K, Wolfrum U, Bennett J, Humphries P, Kenna P, Millington-Ward S, Farrar J.

Mol Ther Methods Clin Dev. 2015 May 6;2:15016. doi: 10.1038/mtm.2015.16. eCollection 2015. Erratum in: Mol Ther Methods Clin Dev. 2016;3:16032.


Intra- and interobserver variability of whole-tumour apparent diffusion coefficient measurements in nephroblastoma: a pilot study.

Littooij AS, Humphries PD, Olsen ØE.

Pediatr Radiol. 2015 Oct;45(11):1651-60. doi: 10.1007/s00247-015-3354-4. Epub 2015 May 8.


The joints in juvenile idiopathic arthritis.

Ording Muller LS, Humphries P, Rosendahl K.

Insights Imaging. 2015 Jun;6(3):275-84. doi: 10.1007/s13244-015-0406-0. Epub 2015 Apr 23.


Interleukin-18 bioactivity and dose: data interpretation at a crossroads.

Doyle SL, Adamson P, López FJ, Humphries P, Campbell M.

Invest Ophthalmol Vis Sci. 2014 Dec 23;55(12):8349-50. doi: 10.1167/iovs.14-15786. No abstract available.


Reply to IL-18 is not therapeutic for neovascular age-related macular degeneration.

Doyle SL, Adamson P, López FJ, Humphries P, Campbell M.

Nat Med. 2014 Dec;20(12):1376-7. doi: 10.1038/nm.3741. No abstract available.


Contrasting patterns of larval mortality in two sympatric riverine fish species: a test of the critical period hypothesis.

McCasker N, Humphries P, Meredith S, Klomp N.

PLoS One. 2014 Oct 9;9(10):e109317. doi: 10.1371/journal.pone.0109317. eCollection 2014.


IL-18: a new player in immunotherapy for age-related macular degeneration?

Campbell M, Doyle S, Humphries P.

Expert Rev Clin Immunol. 2014 Oct;10(10):1273-5. doi: 10.1586/1744666X.2014.950231. Epub 2014 Aug 21. Review.


Structure-based design of novel human Pin1 inhibitors (III): optimizing affinity beyond the phosphate recognition pocket.

Guo C, Hou X, Dong L, Marakovits J, Greasley S, Dagostino E, Ferre R, Johnson MC, Humphries PS, Li H, Paderes GD, Piraino J, Kraynov E, Murray BW.

Bioorg Med Chem Lett. 2014 Sep 1;24(17):4187-91. doi: 10.1016/j.bmcl.2014.07.044. Epub 2014 Jul 22.


Perineal lipoma with accessory labioscrotal fold and penis-like phallus in a female infant with unilateral renal agenesis.

Mifsud W, Sambandan N, Humphries P, Sebire NJ, Mushtaq I.

Urology. 2014 Jul;84(1):209-12. doi: 10.1016/j.urology.2014.03.033. Epub 2014 May 22.


Ontogeny of critical and prolonged swimming performance for the larvae of six Australian freshwater fish species.

Kopf SM, Humphries P, Watts RJ.

J Fish Biol. 2014 Jun;84(6):1820-41. doi: 10.1111/jfb.12399. Epub 2014 May 9.


IL-18 attenuates experimental choroidal neovascularization as a potential therapy for wet age-related macular degeneration.

Doyle SL, Ozaki E, Brennan K, Humphries MM, Mulfaul K, Keaney J, Kenna PF, Maminishkis A, Kiang AS, Saunders SP, Hams E, Lavelle EC, Gardiner C, Fallon PG, Adamson P, Humphries P, Campbell M.

Sci Transl Med. 2014 Apr 2;6(230):230ra44. doi: 10.1126/scitranslmed.3007616.


Antioxidant therapy for retinal disease.

Kiang AS, Humphries MM, Campbell M, Humphries P.

Adv Exp Med Biol. 2014;801:783-9. doi: 10.1007/978-1-4614-3209-8_98. Review.


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