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Items: 1 to 50 of 281

1.

Reticular adhesions are a distinct class of cell-matrix adhesions that mediate attachment during mitosis.

Lock JG, Jones MC, Askari JA, Gong X, Oddone A, Olofsson H, Göransson S, Lakadamyali M, Humphries MJ, Strömblad S.

Nat Cell Biol. 2018 Nov;20(11):1290-1302. doi: 10.1038/s41556-018-0220-2. Epub 2018 Oct 22.

PMID:
30361699
2.

Signal transduction via integrin adhesion complexes.

Humphries JD, Chastney MR, Askari JA, Humphries MJ.

Curr Opin Cell Biol. 2019 Feb;56:14-21. doi: 10.1016/j.ceb.2018.08.004. Epub 2018 Sep 5. Review.

PMID:
30195153
3.

Cell adhesion is regulated by CDK1 during the cell cycle.

Jones MC, Askari JA, Humphries JD, Humphries MJ.

J Cell Biol. 2018 Sep 3;217(9):3203-3218. doi: 10.1083/jcb.201802088. Epub 2018 Jun 21.

4.

Use of N-methyliminodiacetic acid boronate esters in suzuki-miyaura cross-coupling polymerizations of triarylamine and fluorene monomers.

Foster AB, Bagutski V, Ayuso-Carrillo JI, Humphries MJ, Ingleson MJ, Turner ML.

J Polym Sci A Polym Chem. 2017 Sep 1;55(17):2798-2806. doi: 10.1002/pola.28682. Epub 2017 Jul 3.

5.

Post-polymerization C-H Borylation of Donor-Acceptor Materials Gives Highly Efficient Solid State Near-Infrared Emitters for Near-IR-OLEDs and Effective Biological Imaging.

Crossley DL, Urbano L, Neumann R, Bourke S, Jones J, Dailey LA, Green M, Humphries MJ, King SM, Turner ML, Ingleson MJ.

ACS Appl Mater Interfaces. 2017 Aug 30;9(34):28243-28249. doi: 10.1021/acsami.7b08473. Epub 2017 Aug 18.

PMID:
28783304
6.

The Sharpin interactome reveals a role for Sharpin in lamellipodium formation via the Arp2/3 complex.

Khan MH, Salomaa SI, Jacquemet G, Butt U, Miihkinen M, Deguchi T, Kremneva E, Lappalainen P, Humphries MJ, Pouwels J.

J Cell Sci. 2017 Sep 15;130(18):3094-3107. doi: 10.1242/jcs.200329. Epub 2017 Aug 3.

7.

Characterization of the Phospho-Adhesome by Mass Spectrometry-Based Proteomics.

Robertson J, Humphries JD, Paul NR, Warwood S, Knight D, Byron A, Humphries MJ.

Methods Mol Biol. 2017;1636:235-251. doi: 10.1007/978-1-4939-7154-1_15.

PMID:
28730483
8.

Flexible Blade-Coated Multicolor Polymer Light-Emitting Diodes for Optoelectronic Sensors.

Han D, Khan Y, Ting J, King SM, Yaacobi-Gross N, Humphries MJ, Newsome CJ, Arias AC.

Adv Mater. 2017 Jun;29(22). doi: 10.1002/adma.201606206. Epub 2017 Apr 10.

9.

Conformational equilibria and intrinsic affinities define integrin activation.

Li J, Su Y, Xia W, Qin Y, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

EMBO J. 2017 Mar 1;36(5):629-645. doi: 10.15252/embj.201695803. Epub 2017 Jan 25.

10.

Indacaterol/glycopyrronium in symptomatic patients with COPD (GOLD B and GOLD D) versus salmeterol/fluticasone: ILLUMINATE/LANTERN pooled analysis.

Vogelmeier C, Zhong N, Humphries MJ, Mezzi K, Fogel R, Bader G, Patalano F, Banerji D.

Int J Chron Obstruct Pulmon Dis. 2016 Dec 14;11:3189-3197. doi: 10.2147/COPD.S116786. eCollection 2016.

11.

PPFIA1 drives active α5β1 integrin recycling and controls fibronectin fibrillogenesis and vascular morphogenesis.

Mana G, Clapero F, Panieri E, Panero V, Böttcher RT, Tseng HY, Saltarin F, Astanina E, Wolanska KI, Morgan MR, Humphries MJ, Santoro MM, Serini G, Valdembri D.

Nat Commun. 2016 Nov 23;7:13546. doi: 10.1038/ncomms13546.

12.

The integrin adhesome network at a glance.

Horton ER, Humphries JD, James J, Jones MC, Askari JA, Humphries MJ.

J Cell Sci. 2016 Nov 15;129(22):4159-4163. Epub 2016 Oct 31. Review.

13.

Proteomic definitions of basement membrane composition in health and disease.

Randles MJ, Humphries MJ, Lennon R.

Matrix Biol. 2017 Jan;57-58:12-28. doi: 10.1016/j.matbio.2016.08.006. Epub 2016 Aug 20. Review.

PMID:
27553508
14.

Ligand-induced Epitope Masking: DISSOCIATION OF INTEGRIN α5β1-FIBRONECTIN COMPLEXES ONLY BY MONOCLONAL ANTIBODIES WITH AN ALLOSTERIC MODE OF ACTION.

Mould AP, Askari JA, Byron A, Takada Y, Jowitt TA, Humphries MJ.

J Biol Chem. 2016 Sep 30;291(40):20993-21007. Epub 2016 Aug 2.

15.

Highly Emissive Far Red/Near-IR Fluorophores Based on Borylated Fluorene-Benzothiadiazole Donor-Acceptor Materials.

Crossley DL, Vitorica-Yrezabal I, Humphries MJ, Turner ML, Ingleson MJ.

Chemistry. 2016 Aug 22;22(35):12439-48. doi: 10.1002/chem.201602010. Epub 2016 Jul 27.

PMID:
27460768
16.

Allosteric Regulation of Fibronectin/α5β1 Interaction by Fibronectin-Binding MSCRAMMs.

Liang X, Garcia BL, Visai L, Prabhakaran S, Meenan NA, Potts JR, Humphries MJ, Höök M.

PLoS One. 2016 Jul 19;11(7):e0159118. doi: 10.1371/journal.pone.0159118. eCollection 2016.

17.

Relating conformation to function in integrin α5β1.

Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3872-81. doi: 10.1073/pnas.1605074113. Epub 2016 Jun 17.

18.

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition.

Horton ER, Humphries JD, Stutchbury B, Jacquemet G, Ballestrem C, Barry ST, Humphries MJ.

J Cell Biol. 2016 Feb 1;212(3):349-64. doi: 10.1083/jcb.201508080.

19.

Mechanosensitivity of integrin adhesion complexes: role of the consensus adhesome.

Horton ER, Astudillo P, Humphries MJ, Humphries JD.

Exp Cell Res. 2016 Apr 10;343(1):7-13. doi: 10.1016/j.yexcr.2015.10.025. Epub 2015 Oct 26. Review.

PMID:
26515553
20.

Definition of a consensus integrin adhesome and its dynamics during adhesion complex assembly and disassembly.

Horton ER, Byron A, Askari JA, Ng DHJ, Millon-Frémillon A, Robertson J, Koper EJ, Paul NR, Warwood S, Knight D, Humphries JD, Humphries MJ.

Nat Cell Biol. 2015 Dec;17(12):1577-1587. doi: 10.1038/ncb3257. Epub 2015 Oct 19.

21.

Enhancing electron affinity and tuning band gap in donor-acceptor organic semiconductors by benzothiadiazole directed C-H borylation.

Crossley DL, Cade IA, Clark ER, Escande A, Humphries MJ, King SM, Vitorica-Yrezabal I, Ingleson MJ, Turner ML.

Chem Sci. 2015 Sep 1;6(9):5144-5151. doi: 10.1039/c5sc01800e. Epub 2015 Jun 12.

22.

Proteomic analysis of integrin-associated complexes from mesenchymal stem cells.

Ajeian JN, Horton ER, Astudillo P, Byron A, Askari JA, Millon-Frémillon A, Knight D, Kimber SJ, Humphries MJ, Humphries JD.

Proteomics Clin Appl. 2016 Jan;10(1):51-7. doi: 10.1002/prca.201500033. Epub 2015 Sep 17.

23.

Genetic Background is a Key Determinant of Glomerular Extracellular Matrix Composition and Organization.

Randles MJ, Woolf AS, Huang JL, Byron A, Humphries JD, Price KL, Kolatsi-Joannou M, Collinson S, Denny T, Knight D, Mironov A, Starborg T, Korstanje R, Humphries MJ, Long DA, Lennon R.

J Am Soc Nephrol. 2015 Dec;26(12):3021-34. doi: 10.1681/ASN.2014040419. Epub 2015 Apr 20.

24.

Emerging properties of adhesion complexes: what are they and what do they do?

Humphries JD, Paul NR, Humphries MJ, Morgan MR.

Trends Cell Biol. 2015 Jul;25(7):388-97. doi: 10.1016/j.tcb.2015.02.008. Epub 2015 Mar 27. Review.

PMID:
25824971
25.

Isolation of integrin-based adhesion complexes.

Jones MC, Humphries JD, Byron A, Millon-Frémillon A, Robertson J, Paul NR, Ng DH, Askari JA, Humphries MJ.

Curr Protoc Cell Biol. 2015 Mar 2;66:9.8.1-15. doi: 10.1002/0471143030.cb0908s66.

26.

Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling.

Robertson J, Jacquemet G, Byron A, Jones MC, Warwood S, Selley JN, Knight D, Humphries JD, Humphries MJ.

Nat Commun. 2015 Feb 13;6:6265. doi: 10.1038/ncomms7265.

27.

A proteomic approach reveals integrin activation state-dependent control of microtubule cortical targeting.

Byron A, Askari JA, Humphries JD, Jacquemet G, Koper EJ, Warwood S, Choi CK, Stroud MJ, Chen CS, Knight D, Humphries MJ.

Nat Commun. 2015 Jan 22;6:6135. doi: 10.1038/ncomms7135.

28.

Microtubule-dependent modulation of adhesion complex composition.

Ng DH, Humphries JD, Byron A, Millon-Frémillon A, Humphries MJ.

PLoS One. 2014 Dec 19;9(12):e115213. doi: 10.1371/journal.pone.0115213. eCollection 2014.

29.

The importance of podocyte adhesion for a healthy glomerulus.

Lennon R, Randles MJ, Humphries MJ.

Front Endocrinol (Lausanne). 2014 Oct 14;5:160. doi: 10.3389/fendo.2014.00160. eCollection 2014. Review.

30.

Disruption of integrin-fibronectin complexes by allosteric but not ligand-mimetic inhibitors.

Mould AP, Craig SE, Byron SK, Humphries MJ, Jowitt TA.

Biochem J. 2014 Dec 15;464(3):301-13. doi: 10.1042/BJ20141047.

PMID:
25333419
31.

Epimorphin alters the inhibitory effects of SOX9 on Mmp13 in activated hepatic stellate cells.

Pritchett J, Athwal VS, Harvey E, Martin K, Llewellyn J, Ireland P, Nicolaides A, Humphries MJ, Bobola N, Hanley NA, Piper Hanley K.

PLoS One. 2014 Jun 27;9(6):e100091. doi: 10.1371/journal.pone.0100091. eCollection 2014.

32.

Glomerular cell cross-talk influences composition and assembly of extracellular matrix.

Byron A, Randles MJ, Humphries JD, Mironov A, Hamidi H, Harris S, Mathieson PW, Saleem MA, Satchell SC, Zent R, Humphries MJ, Lennon R.

J Am Soc Nephrol. 2014 May;25(5):953-66. doi: 10.1681/ASN.2013070795. Epub 2014 Jan 16.

33.

Global analysis reveals the complexity of the human glomerular extracellular matrix.

Lennon R, Byron A, Humphries JD, Randles MJ, Carisey A, Murphy S, Knight D, Brenchley PE, Zent R, Humphries MJ.

J Am Soc Nephrol. 2014 May;25(5):939-51. doi: 10.1681/ASN.2013030233. Epub 2014 Jan 16.

34.

IQGAP1 is a key node within the small GTPase network.

Jacquemet G, Humphries MJ.

Small GTPases. 2013 Oct-Dec;4(4):199-207. doi: 10.4161/sgtp.27451. Epub 2013 Dec 19.

35.

Distinct biophysical mechanisms of focal adhesion kinase mechanoactivation by different extracellular matrix proteins.

Seong J, Tajik A, Sun J, Guan JL, Humphries MJ, Craig SE, Shekaran A, García AJ, Lu S, Lin MZ, Wang N, Wang Y.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19372-7. doi: 10.1073/pnas.1307405110. Epub 2013 Nov 12.

36.

RCP-driven α5β1 recycling suppresses Rac and promotes RhoA activity via the RacGAP1-IQGAP1 complex.

Jacquemet G, Green DM, Bridgewater RE, von Kriegsheim A, Humphries MJ, Norman JC, Caswell PT.

J Cell Biol. 2013 Sep 16;202(6):917-35. doi: 10.1083/jcb.201302041. Epub 2013 Sep 9.

37.

Rac1 is deactivated at integrin activation sites through an IQGAP1-filamin-A-RacGAP1 pathway.

Jacquemet G, Morgan MR, Byron A, Humphries JD, Choi CK, Chen CS, Caswell PT, Humphries MJ.

J Cell Sci. 2013 Sep 15;126(Pt 18):4121-35. doi: 10.1242/jcs.121988. Epub 2013 Jul 10.

38.

Role of adhesion receptor trafficking in 3D cell migration.

Jacquemet G, Humphries MJ, Caswell PT.

Curr Opin Cell Biol. 2013 Oct;25(5):627-32. doi: 10.1016/j.ceb.2013.05.008. Epub 2013 Jun 21. Review.

39.

The effect of peptide adsorption on signal linearity and a simple approach to improve reliability of quantification.

Warwood S, Byron A, Humphries MJ, Knight D.

J Proteomics. 2013 Jun 24;85:160-4. doi: 10.1016/j.jprot.2013.04.034. Epub 2013 May 9.

40.

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance.

Soteriou D, Iskender B, Byron A, Humphries JD, Borg-Bartolo S, Haddock MC, Baxter MA, Knight D, Humphries MJ, Kimber SJ.

J Biol Chem. 2013 Jun 28;288(26):18716-31. doi: 10.1074/jbc.M113.463372. Epub 2013 May 8.

41.

Syndecan-4 phosphorylation is a control point for integrin recycling.

Morgan MR, Hamidi H, Bass MD, Warwood S, Ballestrem C, Humphries MJ.

Dev Cell. 2013 Mar 11;24(5):472-85. doi: 10.1016/j.devcel.2013.01.027. Epub 2013 Feb 28.

42.

Defining the extracellular matrix using proteomics.

Byron A, Humphries JD, Humphries MJ.

Int J Exp Pathol. 2013 Apr;94(2):75-92. doi: 10.1111/iep.12011. Epub 2013 Feb 19. Review.

43.

Cyclic mechanical reinforcement of integrin-ligand interactions.

Kong F, Li Z, Parks WM, Dumbauld DW, García AJ, Mould AP, Humphries MJ, Zhu C.

Mol Cell. 2013 Mar 28;49(6):1060-8. doi: 10.1016/j.molcel.2013.01.015. Epub 2013 Feb 14.

44.

Activation of beta 1 but not beta 3 integrin increases cell traction forces.

Lin GL, Cohen DM, Desai RA, Breckenridge MT, Gao L, Humphries MJ, Chen CS.

FEBS Lett. 2013 Mar 18;587(6):763-9. doi: 10.1016/j.febslet.2013.01.068. Epub 2013 Feb 8.

45.

Proteomic analysis of extracellular matrix from the hepatic stellate cell line LX-2 identifies CYR61 and Wnt-5a as novel constituents of fibrotic liver.

Rashid ST, Humphries JD, Byron A, Dhar A, Askari JA, Selley JN, Knight D, Goldin RD, Thursz M, Humphries MJ.

J Proteome Res. 2012 Aug 3;11(8):4052-64. doi: 10.1021/pr3000927. Epub 2012 Jun 28.

46.

Opticin exerts its anti-angiogenic activity by regulating extracellular matrix adhesiveness.

Le Goff MM, Sutton MJ, Slevin M, Latif A, Humphries MJ, Bishop PN.

J Biol Chem. 2012 Aug 10;287(33):28027-36. doi: 10.1074/jbc.M111.331157. Epub 2012 Jun 5.

47.

Proteomic analysis of α4β1 integrin adhesion complexes reveals α-subunit-dependent protein recruitment.

Byron A, Humphries JD, Craig SE, Knight D, Humphries MJ.

Proteomics. 2012 Jul;12(13):2107-14. doi: 10.1002/pmic.201100487.

48.

Alternative cellular roles for proteins identified using proteomics.

Byron A, Humphries JD, Humphries MJ.

J Proteomics. 2012 Jul 16;75(13):4184-5. doi: 10.1016/j.jprot.2012.04.049. Epub 2012 May 9. No abstract available.

49.

Fibronectin supports neurite outgrowth and axonal regeneration of adult brain neurons in vitro.

Tonge DA, de Burgh HT, Docherty R, Humphries MJ, Craig SE, Pizzey J.

Brain Res. 2012 May 9;1453:8-16. doi: 10.1016/j.brainres.2012.03.024. Epub 2012 Mar 17.

50.

A syndecan-4 hair trigger initiates wound healing through caveolin- and RhoG-regulated integrin endocytosis.

Bass MD, Williamson RC, Nunan RD, Humphries JD, Byron A, Morgan MR, Martin P, Humphries MJ.

Dev Cell. 2011 Oct 18;21(4):681-93. doi: 10.1016/j.devcel.2011.08.007. Epub 2011 Oct 6. Erratum in: Dev Cell. 2012 Nov 13;23(5):1081-2.

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