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Items: 35


Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.

Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD.

Nat Commun. 2018 Feb 26;9(1):817. doi: 10.1038/s41467-018-03241-9.


Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.

Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS.

EMBO Rep. 2018 Mar;19(3). pii: e45009. doi: 10.15252/embr.201745009. Epub 2018 Feb 2.


Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.

Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE.

Mol Metab. 2018 Mar;9:141-155. doi: 10.1016/j.molmet.2018.01.013. Epub 2018 Feb 2.


Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity.

Bockus LB, Matsuzaki S, Vadvalkar SS, Young ZT, Giorgione JR, Newhardt MF, Kinter M, Humphries KM.

J Am Heart Assoc. 2017 Dec 4;6(12). pii: e007159. doi: 10.1161/JAHA.117.007159.


PPARα is essential for retinal lipid metabolism and neuronal survival.

Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX.

BMC Biol. 2017 Nov 28;15(1):113. doi: 10.1186/s12915-017-0451-x.


Decreased Mitochondrial Pyruvate Transport Activity in the Diabetic Heart: ROLE OF MITOCHONDRIAL PYRUVATE CARRIER 2 (MPC2) ACETYLATION.

Vadvalkar SS, Matsuzaki S, Eyster CA, Giorgione JR, Bockus LB, Kinter CS, Kinter M, Humphries KM.

J Biol Chem. 2017 Mar 17;292(11):4423-4433. doi: 10.1074/jbc.M116.753509. Epub 2017 Feb 1.


AG311, a small molecule inhibitor of complex I and hypoxia-induced HIF-1α stabilization.

Bastian A, Matsuzaki S, Humphries KM, Pharaoh GA, Doshi A, Zaware N, Gangjee A, Ihnat MA.

Cancer Lett. 2017 Mar 1;388:149-157. doi: 10.1016/j.canlet.2016.11.040. Epub 2016 Dec 8.


Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism.

Gurley JM, Ilkayeva O, Jackson RM, Griesel BA, White P, Matsuzaki S, Qaisar R, Van Remmen H, Humphries KM, Newgard CB, Olson AL.

Diabetes. 2016 Dec;65(12):3585-3597. Epub 2016 Sep 27.


Aging Promotes Sirtuin 3-Dependent Cartilage Superoxide Dismutase 2 Acetylation and Osteoarthritis.

Fu Y, Kinter M, Hudson J, Humphries KM, Lane RS, White JR, Hakim M, Pan Y, Verdin E, Griffin TM.

Arthritis Rheumatol. 2016 Aug;68(8):1887-98. doi: 10.1002/art.39618.


Nutrient sensing and utilization: Getting to the heart of metabolic flexibility.

Griffin TM, Humphries KM, Kinter M, Lim HY, Szweda LI.

Biochimie. 2016 May;124:74-83. doi: 10.1016/j.biochi.2015.10.013. Epub 2015 Oct 22. Review.


cAMP-dependent Protein Kinase (PKA) Signaling Is Impaired in the Diabetic Heart.

Bockus LB, Humphries KM.

J Biol Chem. 2015 Dec 4;290(49):29250-8. doi: 10.1074/jbc.M115.681767. Epub 2015 Oct 14.


Lysine Acetylation Activates Mitochondrial Aconitase in the Heart.

Fernandes J, Weddle A, Kinter CS, Humphries KM, Mather T, Szweda LI, Kinter M.

Biochemistry. 2015 Jun 30;54(25):4008-18. doi: 10.1021/acs.biochem.5b00375. Epub 2015 Jun 19.


Mitochondrial respiration and redox coupling in articular chondrocytes.

Lane RS, Fu Y, Matsuzaki S, Kinter M, Humphries KM, Griffin TM.

Arthritis Res Ther. 2015 Mar 10;17:54. doi: 10.1186/s13075-015-0566-9.


A small molecule with anticancer and antimetastatic activities induces rapid mitochondrial-associated necrosis in breast cancer.

Bastian A, Thorpe JE, Disch BC, Bailey-Downs LC, Gangjee A, Devambatla RK, Henthorn J, Humphries KM, Vadvalkar SS, Ihnat MA.

J Pharmacol Exp Ther. 2015 May;353(2):392-404. doi: 10.1124/jpet.114.220335. Epub 2015 Feb 26. Erratum in: J Pharmacol Exp Ther. 2017 Jan;360(1):225.


Selective inhibition of deactivated mitochondrial complex I by biguanides.

Matsuzaki S, Humphries KM.

Biochemistry. 2015 Mar 24;54(11):2011-21. doi: 10.1021/bi501473h. Epub 2015 Mar 9.


Peroxisome proliferator-activated receptor α protects capillary pericytes in the retina.

Ding L, Cheng R, Hu Y, Takahashi Y, Jenkins AJ, Keech AC, Humphries KM, Gu X, Elliott MH, Xia X, Ma JX.

Am J Pathol. 2014 Oct;184(10):2709-20. doi: 10.1016/j.ajpath.2014.06.021. Epub 2014 Aug 7.


Immediate effects of lower cervical spine manipulation on handgrip strength and free-throw accuracy of asymptomatic basketball players: a pilot study.

Humphries KM, Ward J, Coats J, Nobert J, Amonette W, Dyess S.

J Chiropr Med. 2013 Sep;12(3):153-9. doi: 10.1016/j.jcm.2013.10.008.


Metabolic inflexibility and protein lysine acetylation in heart mitochondria of a chronic model of type 1 diabetes.

Vadvalkar SS, Baily CN, Matsuzaki S, West M, Tesiram YA, Humphries KM.

Biochem J. 2013 Jan 1;449(1):253-61. doi: 10.1042/BJ20121038.


MicroRNA-214 protects the mouse heart from ischemic injury by controlling Ca²⁺ overload and cell death.

Aurora AB, Mahmoud AI, Luo X, Johnson BA, van Rooij E, Matsuzaki S, Humphries KM, Hill JA, Bassel-Duby R, Sadek HA, Olson EN.

J Clin Invest. 2012 Apr;122(4):1222-32. doi: 10.1172/JCI59327. Epub 2012 Mar 19.


Identification of mitochondrial electron transport chain-mediated NADH radical formation by EPR spin-trapping techniques.

Matsuzaki S, Kotake Y, Humphries KM.

Biochemistry. 2011 Dec 20;50(50):10792-803. doi: 10.1021/bi201714w. Epub 2011 Nov 28.


Inhibition of mitochondrial respiration by phosphoenolpyruvate.

Baily CN, Cason RW, Vadvalkar SS, Matsuzaki S, Humphries KM.

Arch Biochem Biophys. 2011 Oct;514(1-2):68-74. doi: 10.1016/ Epub 2011 Aug 16.


Regulated production of free radicals by the mitochondrial electron transport chain: Cardiac ischemic preconditioning.

Matsuzaki S, Szweda PA, Szweda LI, Humphries KM.

Adv Drug Deliv Rev. 2009 Nov 30;61(14):1324-31. doi: 10.1016/j.addr.2009.05.008. Epub 2009 Aug 26. Review.


Inhibition of succinate-linked respiration and complex II activity by hydrogen peroxide.

Moser MD, Matsuzaki S, Humphries KM.

Arch Biochem Biophys. 2009 Aug 1;488(1):69-75. doi: 10.1016/ Epub 2009 Jun 18.


Mitochondrial superoxide production and respiratory activity: biphasic response to ischemic duration.

Matsuzaki S, Szweda LI, Humphries KM.

Arch Biochem Biophys. 2009 Apr 1;484(1):87-93. doi: 10.1016/ Epub 2009 Jan 14.


Maintenance of cardiac energy metabolism by histone deacetylase 3 in mice.

Montgomery RL, Potthoff MJ, Haberland M, Qi X, Matsuzaki S, Humphries KM, Richardson JA, Bassel-Duby R, Olson EN.

J Clin Invest. 2008 Nov;118(11):3588-97. doi: 10.1172/JCI35847. Epub 2008 Oct 1.


Reversible inhibition of alpha-ketoglutarate dehydrogenase by hydrogen peroxide: glutathionylation and protection of lipoic acid.

Applegate MA, Humphries KM, Szweda LI.

Biochemistry. 2008 Jan 8;47(1):473-8. Epub 2007 Dec 15.


Redox regulation of cAMP-dependent protein kinase signaling: kinase versus phosphatase inactivation.

Humphries KM, Pennypacker JK, Taylor SS.

J Biol Chem. 2007 Jul 27;282(30):22072-9. Epub 2007 Jun 4.


Aging: a shift from redox regulation to oxidative damage.

Humphries KM, Szweda PA, Szweda LI.

Free Radic Res. 2006 Dec;40(12):1239-43. Review.


Enhanced dephosphorylation of cAMP-dependent protein kinase by oxidation and thiol modification.

Humphries KM, Deal MS, Taylor SS.

J Biol Chem. 2005 Jan 28;280(4):2750-8. Epub 2004 Nov 8.


Selective inactivation of redox-sensitive mitochondrial enzymes during cardiac reperfusion.

Sadek HA, Humphries KM, Szweda PA, Szweda LI.

Arch Biochem Biophys. 2002 Oct 15;406(2):222-8.


Regulation of cAMP-dependent protein kinase activity by glutathionylation.

Humphries KM, Juliano C, Taylor SS.

J Biol Chem. 2002 Nov 8;277(45):43505-11. Epub 2002 Aug 19.


Oxidative modification and inactivation of the proteasome during coronary occlusion/reperfusion.

Bulteau AL, Lundberg KC, Humphries KM, Sadek HA, Szweda PA, Friguet B, Szweda LI.

J Biol Chem. 2001 Aug 10;276(32):30057-63. Epub 2001 May 25.


Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic.

Sasaki M, Ansari A, Pumford N, van de Water J, Leung PS, Humphries KM, Szweda LI, Nakanuma Y, Roche TE, Coppel RL, Bach JF, Gershwin ME.

J Autoimmun. 2000 Aug;15(1):51-60.


Inhibition of NADH-linked mitochondrial respiration by 4-hydroxy-2-nonenal.

Humphries KM, Yoo Y, Szweda LI.

Biochemistry. 1998 Jan 13;37(2):552-7.


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