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Sex Differences in Complications and Outcomes of Cardiac Implantable Electronic Devices: Time to Evaluate Our Practice.

Humphries KH, Hawkins N.

Can J Cardiol. 2019 Sep 24. pii: S0828-282X(19)31265-6. doi: 10.1016/j.cjca.2019.09.009. [Epub ahead of print] No abstract available.


Individualizing Revascularization Strategy for Diabetic Patients With Multivessel Coronary Disease.

Qintar M, Humphries KH, Park JE, Arnold SV, Tang Y, Jones P, Salisbury AC, Kureshi F, Farkouh ME, Fuster V, Cohen DJ, Spertus JA.

J Am Coll Cardiol. 2019 Oct 22;74(16):2074-2084. doi: 10.1016/j.jacc.2019.07.083.


Enhancing cardiac glycolysis causes an increase in PDK4 content in response to short-term high-fat diet.

Newhardt MF, Batushansky A, Matsuzaki S, Young ZT, West M, Chin NC, Szweda LI, Kinter M, Humphries KM.

J Biol Chem. 2019 Nov 8;294(45):16831-16845. doi: 10.1074/jbc.RA119.010371. Epub 2019 Sep 27.


Empirical Insights When Defining the Population Burden of Atrial Fibrillation and Oral Anticoagulation Utilization Using Administrative Data.

Hawkins NM, Daniele PR, Humphries KH, Ezekowitz JA, McAlister FA, Sandhu RK, Kaul P.

Can J Cardiol. 2019 Oct;35(10):1412-1415. doi: 10.1016/j.cjca.2019.05.009. Epub 2019 May 15.


Life-threatening bleeding due to persistent dabigatran effect in a patient with sepsis despite idarucizumab therapy and haemodialysis.

Humphries K, Huggan P, Stiles M, Martynoga R.

BMJ Case Rep. 2019 Aug 21;12(8). pii: e230125. doi: 10.1136/bcr-2019-230125.


Premature Atherosclerotic Cardiovascular Disease: Trends in Incidence, Risk Factors, and Sex-Related Differences, 2000 to 2016.

Vikulova DN, Grubisic M, Zhao Y, Lynch K, Humphries KH, Pimstone SN, Brunham LR.

J Am Heart Assoc. 2019 Jul 16;8(14):e012178. doi: 10.1161/JAHA.119.012178. Epub 2019 Jul 8.


GC-MS method for metabolic profiling of mouse femoral head articular cartilage reveals distinct effects of tissue culture and development.

Batushansky A, Lopes EBP, Zhu S, Humphries KM, Griffin TM.

Osteoarthritis Cartilage. 2019 Sep;27(9):1361-1371. doi: 10.1016/j.joca.2019.05.010. Epub 2019 May 25.


Impact of Local Anesthesia Only Versus Procedural Sedation Using the Vancouver Clinical Pathway for TAVR: Insights From the 3M TAVR Study.

Sathananthan J, Webb JG, Lauck SB, Cairns J, Humphries KH, Nazif T, Thourani VH, Cohen DJ, Leon MB, Wood DA; 3M TAVR Study Investigators.

JACC Cardiovasc Interv. 2019 May 27;12(10):1000-1001. doi: 10.1016/j.jcin.2019.02.014. No abstract available.


C-Reactive Protein Levels and the Risk of Incident Cardiovascular and Cerebrovascular Events in Patients with Obstructive Sleep Apnea.

Ayas NT, Hirsch Allen AJ, Fox N, Peres B, Mehrtash M, Humphries KH, Jen R, Taylor CM, van Eeden SF.

Lung. 2019 Aug;197(4):459-464. doi: 10.1007/s00408-019-00237-0. Epub 2019 May 14.


Coronary atheroma regression and adverse cardiac events: A systematic review and meta-regression analysis.

Bhindi R, Guan M, Zhao Y, Humphries KH, Mancini GBJ.

Atherosclerosis. 2019 May;284:194-201. doi: 10.1016/j.atherosclerosis.2019.03.005. Epub 2019 Mar 11. Review.


The Vancouver 3M (Multidisciplinary, Multimodality, But Minimalist) Clinical Pathway Facilitates Safe Next-Day Discharge Home at Low-, Medium-, and High-Volume Transfemoral Transcatheter Aortic Valve Replacement Centers: The 3M TAVR Study.

Wood DA, Lauck SB, Cairns JA, Humphries KH, Cook R, Welsh R, Leipsic J, Genereux P, Moss R, Jue J, Blanke P, Cheung A, Ye J, Dvir D, Umedaly H, Klein R, Rondi K, Poulter R, Stub D, Barbanti M, Fahmy P, Htun N, Murdoch D, Prakash R, Barker M, Nickel K, Thakkar J, Sathananthan J, Tyrell B, Al-Qoofi F, Velianou JL, Natarajan MK, Wijeysundera HC, Radhakrishnan S, Horlick E, Osten M, Buller C, Peterson M, Asgar A, Palisaitis D, Masson JB, Kodali S, Nazif T, Thourani V, Babaliaros VC, Cohen DJ, Park JE, Leon MB, Webb JG.

JACC Cardiovasc Interv. 2019 Mar 11;12(5):459-469. doi: 10.1016/j.jcin.2018.12.020.


GC-MS metabolic profiling reveals fructose-2,6-bisphosphate regulates branched chain amino acid metabolism in the heart during fasting.

Batushansky A, Matsuzaki S, Newhardt MF, West MS, Griffin TM, Humphries KM.

Metabolomics. 2019 Jan 28;15(2):18. doi: 10.1007/s11306-019-1478-5.


The Effect of Canola Oil on Body Weight and Composition: A Systematic Review and Meta-Analysis of Randomized Controlled Clinical Trials.

Raeisi-Dehkordi H, Amiri M, Humphries KH, Salehi-Abargouei A.

Adv Nutr. 2019 May 1;10(3):419-432. doi: 10.1093/advances/nmy108.


Neuroprotective effects of PPARα in retinopathy of type 1 diabetes.

Pearsall EA, Cheng R, Matsuzaki S, Zhou K, Ding L, Ahn B, Kinter M, Humphries KM, Quiambao AB, Farjo RA, Ma JX.

PLoS One. 2019 Feb 4;14(2):e0208399. doi: 10.1371/journal.pone.0208399. eCollection 2019.


Mitochondrial oxidative stress impairs contractile function but paradoxically increases muscle mass via fibre branching.

Ahn B, Ranjit R, Premkumar P, Pharaoh G, Piekarz KM, Matsuzaki S, Claflin DR, Riddle K, Judge J, Bhaskaran S, Satara Natarajan K, Barboza E, Wronowski B, Kinter M, Humphries KM, Griffin TM, Freeman WM, Richardson A, Brooks SV, Van Remmen H.

J Cachexia Sarcopenia Muscle. 2019 Apr;10(2):411-428. doi: 10.1002/jcsm.12375. Epub 2019 Feb 1. Erratum in: J Cachexia Sarcopenia Muscle. 2019 Oct;10(5):1148.


Canadian spontaneous coronary artery dissection cohort study: in-hospital and 30-day outcomes.

Saw J, Starovoytov A, Humphries K, Sheth T, So D, Minhas K, Brass N, Lavoie A, Bishop H, Lavi S, Pearce C, Renner S, Madan M, Welsh RC, Lutchmedial S, Vijayaraghavan R, Aymong E, Har B, Ibrahim R, Gornik HL, Ganesh S, Buller C, Matteau A, Martucci G, Ko D, Mancini GBJ.

Eur Heart J. 2019 Apr 14;40(15):1188-1197. doi: 10.1093/eurheartj/ehz007.


A Mechanistic Investigation of Methylene Blue and Heparin Interactions and Their Photoacoustic Enhancement.

Wang J, Jeevarathinam AS, Humphries K, Jhunjhunwala A, Chen F, Hariri A, Miller BR 3rd, Jokerst JV.

Bioconjug Chem. 2018 Nov 21;29(11):3768-3775. doi: 10.1021/acs.bioconjchem.8b00639. Epub 2018 Oct 16.


Racism Is Not a Factor in Door-to-electrocardiogram Times of Patients With Symptoms of Acute Coronary Syndrome: A Prospective, Observational Study.

Mackay MH, Ratner PA, Veenstra G, Scheuermeyer FX, Grubisic M, Ramanathan K, Murray C, Humphries KH.

Acad Emerg Med. 2019 May;26(5):491-500. doi: 10.1111/acem.13569. Epub 2018 Oct 21.


Sex Differences in Cardiac Troponin Testing in Patients Presenting to the Emergency Department with Chest Pain.

Humphries KH, Gao M, Lee MK, Izadnegahdar M, Holmes DT, Scheuermeyer FX, Mackay M, Mattman A, Grafstein E.

J Womens Health (Larchmt). 2018 Nov;27(11):1327-1334. doi: 10.1089/jwh.2017.6812. Epub 2018 Jul 16.


Ranolazine for Symptomatic Management of Microvascular Angina.

Rayner-Hartley E, Parvand M, Humphries KH, Starovoytov A, Park JE, Sedlak T.

Am J Ther. 2018 May 9. doi: 10.1097/MJT.0000000000000779. [Epub ahead of print]


Nitration of microtubules blocks axonal mitochondrial transport in a human pluripotent stem cell model of Parkinson's disease.

Stykel MG, Humphries K, Kirby MP, Czaniecki C, Wang T, Ryan T, Bamm V, Ryan SD.

FASEB J. 2018 Oct;32(10):5350-5364. doi: 10.1096/fj.201700759RR. Epub 2018 Apr 24.


Determinants of long-term clinical outcomes in patients with angina but without obstructive coronary artery disease: a systematic review and meta-analysis.

Radico F, Zimarino M, Fulgenzi F, Ricci F, Di Nicola M, Jespersen L, Chang SM, Humphries KH, Marzilli M, De Caterina R.

Eur Heart J. 2018 Jun 14;39(23):2135-2146. doi: 10.1093/eurheartj/ehy185.


The design and rationale of SAVE BC: The Study to Avoid CardioVascular Events in British Columbia.

Brunham LR, Lynch K, English A, Sutherland R, Weng J, Cho R, Wong GC, Anis AH, Francis GA, Khan NA, McManus B, Wood D, Walley KR, Leipsic J, Humphries KH, Hoens A, Krahn AD, John Mancini GB, Pimstone S.

Clin Cardiol. 2018 Jul;41(7):888-895. doi: 10.1002/clc.22959. Epub 2018 Jun 11.


Effect of Lowering Diastolic Pressure in Patients With and Without Cardiovascular Disease: Analysis of the SPRINT (Systolic Blood Pressure Intervention Trial).

Khan NA, Rabkin SW, Zhao Y, McAlister FA, Park JE, Guan M, Chan S, Humphries KH.

Hypertension. 2018 May;71(5):840-847. doi: 10.1161/HYPERTENSIONAHA.117.10177. Epub 2018 Mar 26.


Electrolyte minerals intake and cardiovascular health.

Mohammadifard N, Gotay C, Humphries KH, Ignaszewski A, Esmaillzadeh A, Sarrafzadegan N.

Crit Rev Food Sci Nutr. 2019;59(15):2375-2385. doi: 10.1080/10408398.2018.1453474. Epub 2018 Apr 4.


Cardiolipin exposure on the outer mitochondrial membrane modulates α-synuclein.

Ryan T, Bamm VV, Stykel MG, Coackley CL, Humphries KM, Jamieson-Williams R, Ambasudhan R, Mosser DD, Lipton SA, Harauz G, Ryan SD.

Nat Commun. 2018 Feb 26;9(1):817. doi: 10.1038/s41467-018-03241-9.


Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance.

Bhaskaran S, Pharaoh G, Ranjit R, Murphy A, Matsuzaki S, Nair BC, Forbes B, Gispert S, Auburger G, Humphries KM, Kinter M, Griffin TM, Deepa SS.

EMBO Rep. 2018 Mar;19(3). pii: e45009. doi: 10.15252/embr.201745009. Epub 2018 Feb 2.


Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-β uptake in astrocytes.

Logan S, Pharaoh GA, Marlin MC, Masser DR, Matsuzaki S, Wronowski B, Yeganeh A, Parks EE, Premkumar P, Farley JA, Owen DB, Humphries KM, Kinter M, Freeman WM, Szweda LI, Van Remmen H, Sonntag WE.

Mol Metab. 2018 Mar;9:141-155. doi: 10.1016/j.molmet.2018.01.013. Epub 2018 Feb 2.


Reply: Should We Recommend Cardiac Rehabilitation in Patients With Spontaneous Coronary Artery Dissection?

Saw J, Humphries K, Mancini GBJ.

J Am Coll Cardiol. 2018 Jan 30;71(4):473. doi: 10.1016/j.jacc.2017.10.058. No abstract available.


Research in Women's Cardiovascular Health-Progress at Last?

Humphries KH, Pilote L.

Can J Cardiol. 2018 Apr;34(4):349-353. doi: 10.1016/j.cjca.2017.10.019. Epub 2017 Dec 29. No abstract available.


Investigation of Nascent Base Pair and Polymerase Behavior in the Presence of Mismatches in DNA Polymerase I Using Molecular Dynamics.

Yeager A, Humphries K, Farmer E, Cline G, Miller BR 3rd.

J Chem Inf Model. 2018 Feb 26;58(2):338-349. doi: 10.1021/acs.jcim.7b00516. Epub 2018 Jan 12.


Sex Differences in Diagnoses, Treatment, and Outcomes for Emergency Department Patients With Chest Pain and Elevated Cardiac Troponin.

Humphries KH, Lee MK, Izadnegahdar M, Gao M, Holmes DT, Scheuermeyer FX, Mackay M, Mattman A, Grafstein E.

Acad Emerg Med. 2018 Apr;25(4):413-424. doi: 10.1111/acem.13371. Epub 2018 Feb 8.


Setting up a cohort study in speech and language therapy: lessons from The UK Cleft Collective Speech and Language (CC-SL) study.

Wren Y, Humphries K, Stock NM, Rumsey N, Lewis S, Davies A, Bennett R, Sandy J.

Int J Lang Commun Disord. 2018 May;53(3):421-430. doi: 10.1111/1460-6984.12364. Epub 2017 Dec 18.


Surgical Versus Percutaneous Coronary Revascularization in Patients With Diabetes and Acute Coronary Syndromes.

Ramanathan K, Abel JG, Park JE, Fung A, Mathew V, Taylor CM, Mancini GBJ, Gao M, Ding L, Verma S, Humphries KH, Farkouh ME.

J Am Coll Cardiol. 2017 Dec 19;70(24):2995-3006. doi: 10.1016/j.jacc.2017.10.029.


Trace minerals intake: Risks and benefits for cardiovascular health.

Mohammadifard N, Humphries KH, Gotay C, Mena-Sánchez G, Salas-Salvadó J, Esmaillzadeh A, Ignaszewski A, Sarrafzadegan N.

Crit Rev Food Sci Nutr. 2019;59(8):1334-1346. doi: 10.1080/10408398.2017.1406332. Epub 2017 Dec 13. Review.


Cardiac Insulin Signaling Regulates Glycolysis Through Phosphofructokinase 2 Content and Activity.

Bockus LB, Matsuzaki S, Vadvalkar SS, Young ZT, Giorgione JR, Newhardt MF, Kinter M, Humphries KM.

J Am Heart Assoc. 2017 Dec 4;6(12). pii: e007159. doi: 10.1161/JAHA.117.007159.


Recruiting to cohort studies in specialist healthcare services: Lessons learned from clinical research nurses in UK cleft services.

Zucchelli F, Rumsey N, Humphries K, Bennett R, Davies A, Sandy J, Stock NM.

J Clin Nurs. 2018 Mar;27(5-6):e787-e797. doi: 10.1111/jocn.14188. Epub 2018 Jan 11.


PPARα is essential for retinal lipid metabolism and neuronal survival.

Pearsall EA, Cheng R, Zhou K, Takahashi Y, Matlock HG, Vadvalkar SS, Shin Y, Fredrick TW, Gantner ML, Meng S, Fu Z, Gong Y, Kinter M, Humphries KM, Szweda LI, Smith LEH, Ma JX.

BMC Biol. 2017 Nov 28;15(1):113. doi: 10.1186/s12915-017-0451-x.


Spontaneous Coronary Artery Dissection: Clinical Outcomes and Risk of Recurrence.

Saw J, Humphries K, Aymong E, Sedlak T, Prakash R, Starovoytov A, Mancini GBJ.

J Am Coll Cardiol. 2017 Aug 29;70(9):1148-1158. doi: 10.1016/j.jacc.2017.06.053.


Longitudinal changes in visceral and subcutaneous adipose tissue and metabolic syndrome: Results from the Multicultural Community Health Assessment Trial (M-CHAT).

Tu AW, Humphries KH, Lear SA.

Diabetes Metab Syndr. 2017 Dec;11 Suppl 2:S957-S961. doi: 10.1016/j.dsx.2017.07.022. Epub 2017 Jul 8.


The pharyngeal contractile integral is a useful indicator of pharyngeal swallowing impairment.

O'Rourke A, Humphries K, Lazar A, Martin-Harris B.

Neurogastroenterol Motil. 2017 Dec;29(12). doi: 10.1111/nmo.13144. Epub 2017 Jul 11.


Distinct DNA methylation profiles in subtypes of orofacial cleft.

Sharp GC, Ho K, Davies A, Stergiakouli E, Humphries K, McArdle W, Sandy J, Davey Smith G, Lewis SJ, Relton CL.

Clin Epigenetics. 2017 Jun 8;9:63. doi: 10.1186/s13148-017-0362-2. eCollection 2017.


Reduction of LDL-C-related residual cardiovascular risk with ezetimibe: are mechanistic considerations warranted in practice?

Humphries KH, Mancini GBJ.

Eur Heart J. 2017 Aug 1;38(29):2276-2278. doi: 10.1093/eurheartj/ehx275. No abstract available.


Sex differences in cardiovascular disease - Impact on care and outcomes.

Humphries KH, Izadnegahdar M, Sedlak T, Saw J, Johnston N, Schenck-Gustafsson K, Shah RU, Regitz-Zagrosek V, Grewal J, Vaccarino V, Wei J, Bairey Merz CN.

Front Neuroendocrinol. 2017 Jul;46:46-70. doi: 10.1016/j.yfrne.2017.04.001. Epub 2017 Apr 18. Review. No abstract available.


Outcomes following percutaneous coronary revascularization among South Asian and Chinese Canadians.

Mackay MH, Singh R, Boone RH, Park JE, Humphries KH.

BMC Cardiovasc Disord. 2017 Apr 19;17(1):101. doi: 10.1186/s12872-017-0535-0.


Cardiac Medication Use in Patients with Acute Myocardial Infarction and Nonobstructive Coronary Artery Disease.

Adatia F, Galway S, Grubisic M, Lee M, Daniele P, Humphries KH, Sedlak TL.

J Womens Health (Larchmt). 2017 Nov;26(11):1185-1192. doi: 10.1089/jwh.2016.5984. Epub 2017 Apr 6.


Sex Differences in Cardiac Medication Use Post-Catheterization in Patients Undergoing Coronary Angiography for Stable Angina with Nonobstructive Coronary Artery Disease.

Galway S, Adatia F, Grubisic M, Lee M, Daniele P, Humphries KH, Sedlak TL.

J Womens Health (Larchmt). 2017 Sep;26(9):976-983. doi: 10.1089/jwh.2016.5983. Epub 2017 Apr 6.


Early non-persistence with dabigatran and rivaroxaban in patients with atrial fibrillation.

Jackevicius CA, Tsadok MA, Essebag V, Atzema C, Eisenberg MJ, Tu JV, Lu L, Rahme E, Ho PM, Turakhia M, Humphries KH, Behlouli H, Zhou L, Pilote L.

Heart. 2017 Sep;103(17):1331-1338. doi: 10.1136/heartjnl-2016-310672. Epub 2017 Mar 12.


Targeted therapy for a subset of acute myeloid leukemias that lack expression of aldehyde dehydrogenase 1A1.

Gasparetto M, Pei S, Minhajuddin M, Khan N, Pollyea DA, Myers JR, Ashton JM, Becker MW, Vasiliou V, Humphries KR, Jordan CT, Smith CA.

Haematologica. 2017 Jun;102(6):1054-1065. doi: 10.3324/haematol.2016.159053. Epub 2017 Mar 9.


Progression of paroxysmal to persistent atrial fibrillation: 10-year follow-up in the Canadian Registry of Atrial Fibrillation.

Padfield GJ, Steinberg C, Swampillai J, Qian H, Connolly SJ, Dorian P, Green MS, Humphries KH, Klein GJ, Sheldon R, Talajic M, Kerr CR.

Heart Rhythm. 2017 Jun;14(6):801-807. doi: 10.1016/j.hrthm.2017.01.038. Epub 2017 Feb 21.


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