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Items: 1 to 50 of 88

1.

Cohort Profile: The Oxford Biobank.

Karpe F, Vasan SK, Humphreys SM, Miller J, Cheeseman J, Dennis AL, Neville MJ.

Int J Epidemiol. 2018 Feb 1;47(1):21-21g. doi: 10.1093/ije/dyx132. No abstract available.

2.

The storage stability and concentration of acetoacetate differs between blood fractions.

McNeil CA, Pramfalk C, Humphreys SM, Hodson L.

Clin Chim Acta. 2014 Jun 10;433:278-83. doi: 10.1016/j.cca.2014.03.033. Epub 2014 Apr 8.

PMID:
24721643
3.

Metabolic signatures of human adipose tissue hypoxia in obesity.

Hodson L, Humphreys SM, Karpe F, Frayn KN.

Diabetes. 2013 May;62(5):1417-25. doi: 10.2337/db12-1032. Epub 2012 Dec 28.

4.

Metabolic characteristics of human subcutaneous abdominal adipose tissue after overnight fast.

Frayn KN, Humphreys SM.

Am J Physiol Endocrinol Metab. 2012 Feb 15;302(4):E468-75. doi: 10.1152/ajpendo.00527.2011. Epub 2011 Dec 13.

5.

Secretion of adipokines by human adipose tissue in vivo: partitioning between capillary and lymphatic transport.

Miller NE, Michel CC, Nanjee MN, Olszewski WL, Miller IP, Hazell M, Olivecrona G, Sutton P, Humphreys SM, Frayn KN.

Am J Physiol Endocrinol Metab. 2011 Oct;301(4):E659-67. doi: 10.1152/ajpendo.00058.2011. Epub 2011 Jul 12.

6.

Downregulation of adipose tissue fatty acid trafficking in obesity: a driver for ectopic fat deposition?

McQuaid SE, Hodson L, Neville MJ, Dennis AL, Cheeseman J, Humphreys SM, Ruge T, Gilbert M, Fielding BA, Frayn KN, Karpe F.

Diabetes. 2011 Jan;60(1):47-55. doi: 10.2337/db10-0867. Epub 2010 Oct 13.

7.

Femoral adipose tissue may accumulate the fat that has been recycled as VLDL and nonesterified fatty acids.

McQuaid SE, Humphreys SM, Hodson L, Fielding BA, Karpe F, Frayn KN.

Diabetes. 2010 Oct;59(10):2465-73. doi: 10.2337/db10-0678. Epub 2010 Aug 3.

8.

Greater dietary fat oxidation in obese compared with lean men: an adaptive mechanism to prevent liver fat accumulation?

Hodson L, McQuaid SE, Humphreys SM, Milne R, Fielding BA, Frayn KN, Karpe F.

Am J Physiol Endocrinol Metab. 2010 Oct;299(4):E584-92. doi: 10.1152/ajpendo.00272.2010. Epub 2010 Jul 13.

9.

Regulation of human metabolism by hypoxia-inducible factor.

Formenti F, Constantin-Teodosiu D, Emmanuel Y, Cheeseman J, Dorrington KL, Edwards LM, Humphreys SM, Lappin TR, McMullin MF, McNamara CJ, Mills W, Murphy JA, O'Connor DF, Percy MJ, Ratcliffe PJ, Smith TG, Treacy M, Frayn KN, Greenhaff PL, Karpe F, Clarke K, Robbins PA.

Proc Natl Acad Sci U S A. 2010 Jul 13;107(28):12722-7. doi: 10.1073/pnas.1002339107. Epub 2010 Jun 28.

10.

Substrate utilization by the failing human heart by direct quantification using arterio-venous blood sampling.

Funada J, Betts TR, Hodson L, Humphreys SM, Timperley J, Frayn KN, Karpe F.

PLoS One. 2009 Oct 21;4(10):e7533. doi: 10.1371/journal.pone.0007533.

11.

Effects of growth hormone and free fatty acids on insulin sensitivity in patients with type 1 diabetes.

Salgin B, Marcovecchio ML, Williams RM, Jackson SJ, Bluck LJ, Humphreys SM, Acerini CL, Dunger DB.

J Clin Endocrinol Metab. 2009 Sep;94(9):3297-305. doi: 10.1210/jc.2009-0378. Epub 2009 Jun 30.

12.

Markers of de novo lipogenesis in adipose tissue: associations with small adipocytes and insulin sensitivity in humans.

Roberts R, Hodson L, Dennis AL, Neville MJ, Humphreys SM, Harnden KE, Micklem KJ, Frayn KN.

Diabetologia. 2009 May;52(5):882-90. doi: 10.1007/s00125-009-1300-4. Epub 2009 Feb 28.

PMID:
19252892
13.

Fasted to fed trafficking of Fatty acids in human adipose tissue reveals a novel regulatory step for enhanced fat storage.

Ruge T, Hodson L, Cheeseman J, Dennis AL, Fielding BA, Humphreys SM, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2009 May;94(5):1781-8. doi: 10.1210/jc.2008-2090. Epub 2009 Feb 17.

PMID:
19223522
14.

Effects of prolonged fasting and sustained lipolysis on insulin secretion and insulin sensitivity in normal subjects.

Salgin B, Marcovecchio ML, Humphreys SM, Hill N, Chassin LJ, Lunn DJ, Hovorka R, Dunger DB.

Am J Physiol Endocrinol Metab. 2009 Mar;296(3):E454-61. doi: 10.1152/ajpendo.90613.2008. Epub 2008 Dec 23.

15.

Intramyocellular lipid levels are associated with peripheral, but not hepatic, insulin sensitivity in normal healthy subjects.

Salgin B, Sleigh AJ, Williams RM, Jackson SJ, Bluck LJ, Murgatroyd PR, Humphreys SM, Harding S, Carpenter TA, Dunger DB.

Clin Sci (Lond). 2009 Jul 2;117(3):111-8. doi: 10.1042/CS20080563.

PMID:
19093914
16.

Fatty acid metabolism in patients with PPARgamma mutations.

Tan GD, Savage DB, Fielding BA, Collins J, Hodson L, Humphreys SM, O'Rahilly S, Chatterjee K, Frayn KN, Karpe F.

J Clin Endocrinol Metab. 2008 Nov;93(11):4462-70. doi: 10.1210/jc.2007-2356. Epub 2008 Aug 19.

PMID:
18713822
17.

Adipose tissue fatty acid metabolism in insulin-resistant men.

Bickerton AS, Roberts R, Fielding BA, Tornqvist H, Blaak EE, Wagenmakers AJ, Gilbert M, Humphreys SM, Karpe F, Frayn KN.

Diabetologia. 2008 Aug;51(8):1466-74. doi: 10.1007/s00125-008-1040-x. Epub 2008 May 27. Erratum in: Diabetologia. 2008 Oct;51(10):1936.

PMID:
18504545
18.

Activation of peroxisome proliferator-activated receptor (PPAR)delta promotes reversal of multiple metabolic abnormalities, reduces oxidative stress, and increases fatty acid oxidation in moderately obese men.

Risérus U, Sprecher D, Johnson T, Olson E, Hirschberg S, Liu A, Fang Z, Hegde P, Richards D, Sarov-Blat L, Strum JC, Basu S, Cheeseman J, Fielding BA, Humphreys SM, Danoff T, Moore NR, Murgatroyd P, O'Rahilly S, Sutton P, Willson T, Hassall D, Frayn KN, Karpe F.

Diabetes. 2008 Feb;57(2):332-9. Epub 2007 Nov 16.

19.

The in vivo effects of the Pro12Ala PPARgamma2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank.

Tan GD, Neville MJ, Liverani E, Humphreys SM, Currie JM, Dennis L, Fielding BA, Karpe F.

Diabetologia. 2006 Jan;49(1):158-68. Epub 2005 Dec 17.

PMID:
16362285
20.

Changes in adiponectin receptor expression in muscle and adipose tissue of type 2 diabetic patients during rosiglitazone therapy.

Tan GD, Debard C, Funahashi T, Humphreys SM, Matsuzawa Y, Frayn KN, Karpe F, Vidal H.

Diabetologia. 2005 Aug;48(8):1585-9. Epub 2005 Jul 1.

PMID:
15991021
21.

The effects of rosiglitazone on fatty acid and triglyceride metabolism in type 2 diabetes.

Tan GD, Fielding BA, Currie JM, Humphreys SM, Désage M, Frayn KN, Laville M, Vidal H, Karpe F.

Diabetologia. 2005 Jan;48(1):83-95. Epub 2004 Dec 24.

PMID:
15619071
22.

Upper and lower body adipose tissue function: a direct comparison of fat mobilization in humans.

Tan GD, Goossens GH, Humphreys SM, Vidal H, Karpe F.

Obes Res. 2004 Jan;12(1):114-8.

23.

Inhibition of cholesterol absorption associated with a PPAR alpha-dependent increase in ABC binding cassette transporter A1 in mice.

Knight BL, Patel DD, Humphreys SM, Wiggins D, Gibbons GF.

J Lipid Res. 2003 Nov;44(11):2049-58. Epub 2003 Aug 1.

24.

Plasma leptin is influenced by diet composition and exercise.

Koutsari C, Karpe F, Humphreys SM, Frayn KN, Hardman AE.

Int J Obes Relat Metab Disord. 2003 Aug;27(8):901-6.

PMID:
12861230
25.

A "futile cycle" induced by thiazolidinediones in human adipose tissue?

Tan GD, Debard C, Tiraby C, Humphreys SM, Frayn KN, Langin D, Vidal H, Karpe F.

Nat Med. 2003 Jul;9(7):811-2; author reply 812. No abstract available.

PMID:
12835685
26.

Physiological, metabolic, and performance implications of a prolonged hill walk: influence of energy intake.

Ainslie PN, Campbell IT, Frayn KN, Humphreys SM, MacLaren DP, Reilly T.

J Appl Physiol (1985). 2003 Mar;94(3):1075-83. Epub 2002 Nov 27.

27.

Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjects.

Ulahannan TJ, Karpe F, Humphreys SM, Matthews DR, Frayn KN.

Horm Metab Res. 2002 Sep;34(9):499-503.

PMID:
12384826
28.

Energy balance, metabolism, hydration, and performance during strenuous hill walking: the effect of age.

Ainslie PN, Campbell IT, Frayn KN, Humphreys SM, MacLaren DP, Reilly T, Westerterp KR.

J Appl Physiol (1985). 2002 Aug;93(2):714-23.

29.

Monitoring adipose tissue blood flow in man: a comparison between the (133)xenon washout method and microdialysis.

Karpe F, Fielding BA, Ilic V, Humphreys SM, Frayn KN.

Int J Obes Relat Metab Disord. 2002 Jan;26(1):1-5.

PMID:
11791140
30.

Physiological and metabolic responses to a hill walk.

Ainslie PN, Campbell IT, Frayn KN, Humphreys SM, Maclaren DP, Reilly T.

J Appl Physiol (1985). 2002 Jan;92(1):179-87.

31.

Exercise prevents the accumulation of triglyceride-rich lipoproteins and their remnants seen when changing to a high-carbohydrate diet.

Koutsari C, Karpe F, Humphreys SM, Frayn KN, Hardman AE.

Arterioscler Thromb Vasc Biol. 2001 Sep;21(9):1520-5.

PMID:
11557682
32.

Disturbances in the normal regulation of SREBP-sensitive genes in PPAR alpha-deficient mice.

Patel DD, Knight BL, Wiggins D, Humphreys SM, Gibbons GF.

J Lipid Res. 2001 Mar;42(3):328-37.

33.

Selection of oral microbial adhesion antagonists using biotinylated Streptococcus sanguis and a human mixed oral microflora.

Guan YH, de Graaf T, Lath DL, Humphreys SM, Marlow I, Brook AH.

Arch Oral Biol. 2001 Feb;46(2):129-38.

PMID:
11163320
34.

Prior exercise and postprandial substrate extraction across the human leg.

Malkova D, Evans RD, Frayn KN, Humphreys SM, Jones PR, Hardman AE.

Am J Physiol Endocrinol Metab. 2000 Nov;279(5):E1020-8.

35.

Determinants of within-subject variation of fasting serum leptin concentrations in healthy subjects.

Widjaja A, Levy JC, Morris RJ, Frayn KN, Humphreys SM, Horn R, von zur Mühlen A, Turner RC, Brabant G.

Exp Clin Endocrinol Diabetes. 2000;108(3):208-13.

PMID:
10926318
36.

Ethanol with a mixed meal increases postprandial triacylglycerol but decreases postprandial non-esterified fatty acid concentrations.

Fielding BA, Reid G, Grady M, Humphreys SM, Evans K, Frayn KN.

Br J Nutr. 2000 Jun;83(6):597-604.

PMID:
10911767
37.

Uptake of individual fatty acids into adipose tissue in relation to their presence in the diet.

Summers LK, Barnes SC, Fielding BA, Beysen C, Ilic V, Humphreys SM, Frayn KN.

Am J Clin Nutr. 2000 Jun;71(6):1470-7.

PMID:
10837287
38.

Co-ordination of hepatic and adipose tissue lipid metabolism after oral glucose.

Bülow J, Simonsen L, Wiggins D, Humphreys SM, Frayn KN, Powell D, Gibbons GF.

J Lipid Res. 1999 Nov;40(11):2034-43.

39.

Suppression of the nocturnal rise in growth hormone reduces subsequent lipolysis in subcutaneous adipose tissue.

Samra JS, Clark ML, Humphreys SM, MacDonald IA, Bannister PA, Matthews DR, Frayn KN.

Eur J Clin Invest. 1999 Dec;29(12):1045-52.

PMID:
10583453
40.

The use of microdialysis to monitor rapid changes in glucose concentration.

Summers LK, Clark ML, Humphreys SM, Bugler J, Frayn KN.

Horm Metab Res. 1999 Jul;31(7):424-8.

PMID:
10450834
41.

Lipoprotein lipase transport in plasma: role of muscle and adipose tissues in regulation of plasma lipoprotein lipase concentrations.

Karpe F, Olivecrona T, Olivecrona G, Samra JS, Summers LK, Humphreys SM, Frayn KN.

J Lipid Res. 1998 Dec;39(12):2387-93.

42.

Acute effect of fructose on postprandial lipaemia in diabetic and non-diabetic subjects.

Abraha A, Humphreys SM, Clark ML, Matthews DR, Frayn KN.

Br J Nutr. 1998 Aug;80(2):169-75.

PMID:
9828758
43.

Peripheral fat metabolism during infusion of an exogenous triacylglycerol emulsion.

Samra JS, Giles SL, Summers LK, Evans RD, Arner P, Humphreys SM, Clark ML, Frayn KN.

Int J Obes Relat Metab Disord. 1998 Aug;22(8):806-12.

PMID:
9725642
44.

Metabolic and performance responses during endurance exercise after high-fat and high-carbohydrate meals.

Whitley HA, Humphreys SM, Campbell IT, Keegan MA, Jayanetti TD, Sperry DA, MacLaren DP, Reilly T, Frayn KN.

J Appl Physiol (1985). 1998 Aug;85(2):418-24.

45.

Adipose tissue metabolism in the postprandial period: microdialysis and arteriovenous techniques compared.

Summers LK, Arner P, Ilic V, Clark ML, Humphreys SM, Frayn KN.

Am J Physiol. 1998 Apr;274(4):E651-5. doi: 10.1152/ajpendo.1998.274.4.E651.

PMID:
9575826
46.

Effects of physiological hypercortisolemia on the regulation of lipolysis in subcutaneous adipose tissue.

Samra JS, Clark ML, Humphreys SM, MacDonald IA, Bannister PA, Frayn KN.

J Clin Endocrinol Metab. 1998 Feb;83(2):626-31.

PMID:
9467584
47.

Clearance of lipoprotein remnant particles in adipose tissue and muscle in humans.

Karpe F, Humphreys SM, Samra JS, Summers LK, Frayn KN.

J Lipid Res. 1997 Nov;38(11):2335-43.

48.

Metabolic responses to isoenergetic meals containing different proportions of carbohydrate and fat.

Whitley HA, Humphreys SM, Samra JS, Campbell IT, Maclaren DP, Reilly T, Frayn KN.

Br J Nutr. 1997 Jul;78(1):15-26.

PMID:
9292756
49.

Effects of morning rise in cortisol concentration on regulation of lipolysis in subcutaneous adipose tissue.

Samra JS, Clark ML, Humphreys SM, Macdonald IA, Matthews DR, Frayn KN.

Am J Physiol. 1996 Dec;271(6 Pt 1):E996-1002.

PMID:
8997217
50.

Subcutaneous abdominal adipose tissue blood flow: variation within and between subjects and relationship to obesity.

Summers LK, Samra JS, Humphreys SM, Morris RJ, Frayn KN.

Clin Sci (Lond). 1996 Dec;91(6):679-83.

PMID:
8976802

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