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Clinical delineation of GTPBP2-associated neuro-ectodermal syndrome: Report of two new families and review of the literature.

Carter MT, Venkateswaran S, Shapira-Zaltsberg G, Davila J, Humphreys P; Care4Rare Canada Consortium, Kernohan KD, Boycott KM.

Clin Genet. 2019 Feb 20. doi: 10.1111/cge.13523. [Epub ahead of print]


Genomic Insights Into A Novel, Alkalitolerant Nitrogen Fixing Bacteria, Azonexus sp. Strain ZS02.

Salah ZB, Charles CJ, Humphreys PN, Laws AP, Rout SP.

J Genomics. 2019 Jan 1;7:1-6. doi: 10.7150/jgen.28153. eCollection 2019.


Advancements in the Development of non-BET Bromodomain Chemical Probes.

Clegg MA, Tomkinson NCO, Prinjha RK, Humphreys PG.

ChemMedChem. 2019 Feb 19;14(4):362-385. doi: 10.1002/cmdc.201800738. Epub 2019 Feb 4. Review.


Modulating PCAF/GCN5 Immune Cell Function through a PROTAC Approach.

Bassi ZI, Fillmore MC, Miah AH, Chapman TD, Maller C, Roberts EJ, Davis LC, Lewis DE, Galwey NW, Waddington KE, Parravicini V, Macmillan-Jones AL, Gongora C, Humphreys PG, Churcher I, Prinjha RK, Tough DF.

ACS Chem Biol. 2018 Oct 19;13(10):2862-2867. doi: 10.1021/acschembio.8b00705. Epub 2018 Sep 18.


Atypical Rett Syndrome and Intractable Epilepsy With Novel GRIN2B Mutation.

Kyriakopoulos P, McNiven V, Carter MT, Humphreys P, Dyment D, Fantaneanu TA.

Child Neurol Open. 2018 Aug 23;5:2329048X18787946. doi: 10.1177/2329048X18787946. eCollection 2018. No abstract available.


Publisher Correction: Deterministic delivery of remote entanglement on a quantum network.

Humphreys PC, Kalb N, Morits JPJ, Schouten RN, Vermeulen RFL, Twitchen DJ, Markham M, Hanson R.

Nature. 2018 Oct;562(7725):E2. doi: 10.1038/s41586-018-0314-9.


Deterministic delivery of remote entanglement on a quantum network.

Humphreys PC, Kalb N, Morits JPJ, Schouten RN, Vermeulen RFL, Twitchen DJ, Markham M, Hanson R.

Nature. 2018 Jun;558(7709):268-273. doi: 10.1038/s41586-018-0200-5. Epub 2018 Jun 13. Erratum in: Nature. 2018 Oct;562(7725):E2.


BET bromodomain ligands: Probing the WPF shelf to improve BRD4 bromodomain affinity and metabolic stability.

Jennings LE, Schiedel M, Hewings DS, Picaud S, Laurin CMC, Bruno PA, Bluck JP, Scorah AR, See L, Reynolds JK, Moroglu M, Mistry IN, Hicks A, Guzanov P, Clayton J, Evans CNG, Stazi G, Biggin PC, Mapp AK, Hammond EM, Humphreys PG, Filippakopoulos P, Conway SJ.

Bioorg Med Chem. 2018 Jul 15;26(11):2937-2957. doi: 10.1016/j.bmc.2018.05.003. Epub 2018 May 15.


Extraction of the same novel homoglycan mixture from two different strains of Bifidobacterium animalis and three strains of Bifidobacterium breve.

Alhudhud M, Sadiq S, Ngo HN, Hidalgo-Cantabrana C, Ruas-Madiedo P, van Sinderen D, Humphreys PN, Laws AP.

Benef Microbes. 2018 Jun 15;9(4):663-674. doi: 10.3920/BM2017.0145. Epub 2018 Apr 26.


Disinfection of artificially contaminated gloved hands reduces transmission of Staphylococcus epidermidis to catheter valves.

Assadian O, Humphreys PN, Ousey KJ.

J Hosp Infect. 2018 Nov;100(3):e57-e59. doi: 10.1016/j.jhin.2018.03.010. Epub 2018 Mar 16.


The Impact of Alkaliphilic Biofilm Formation on the Release and Retention of Carbon Isotopes from Nuclear Reactor Graphite.

Rout SP, Payne L, Walker S, Scott T, Heard P, Eccles H, Bond G, Shah P, Bills P, Jackson BR, Boxall SA, Laws AP, Charles C, Williams SJ, Humphreys PN.

Sci Rep. 2018 Mar 13;8(1):4455. doi: 10.1038/s41598-018-22833-5.


Association of Early-Onset Spasticity and Risk for Cognitive Impairment With Mutations at Amino Acid 499 in SPAST.

Gillespie MK, Humphreys P, McMillan HJ, Boycott KM.

J Child Neurol. 2018 Apr;33(5):329-332. doi: 10.1177/0883073818756680. Epub 2018 Feb 8.


Optimal Measurements for Simultaneous Quantum Estimation of Multiple Phases.

Pezzè L, Ciampini MA, Spagnolo N, Humphreys PC, Datta A, Walmsley IA, Barbieri M, Sciarrino F, Smerzi A.

Phys Rev Lett. 2017 Sep 29;119(13):130504. doi: 10.1103/PhysRevLett.119.130504. Epub 2017 Sep 29.


Developing cellulosic waste products as platform chemicals: protecting group chemistry of α-glucoisosaccharinic acid.

Almond M, Suleiman MG, Hawkins M, Winder D, Robshaw T, Waddoups M, Humphreys PN, Laws AP.

Carbohydr Res. 2018 Jan 2;455:97-105. doi: 10.1016/j.carres.2017.11.013. Epub 2017 Nov 26.


Sustained Bauxite Residue Rehabilitation with Gypsum and Organic Matter 16 years after Initial Treatment.

Bray AW, Stewart DI, Courtney R, Rout SP, Humphreys PN, Mayes WM, Burke IT.

Environ Sci Technol. 2018 Jan 2;52(1):152-161. doi: 10.1021/acs.est.7b03568. Epub 2017 Dec 12.


Whole-Genome Sequence of the Anaerobic Isosaccharinic Acid Degrading Isolate, Macellibacteroides fermentans Strain HH-ZS.

Rout SP, Salah ZB, Charles CJ, Humphreys PN.

Genome Biol Evol. 2017 Aug 1;9(8):2140-2144. doi: 10.1093/gbe/evx151.


Small molecules and their role in effective preclinical target validation.

Clegg MA, Tomkinson NC, Prinjha RK, Humphreys PG.

Future Med Chem. 2017 Sep;9(14):1579-1582. doi: 10.4155/fmc-2017-0121. Epub 2017 Aug 22. No abstract available.


Entanglement distillation between solid-state quantum network nodes.

Kalb N, Reiserer AA, Humphreys PC, Bakermans JJW, Kamerling SJ, Nickerson NH, Benjamin SC, Twitchen DJ, Markham M, Hanson R.

Science. 2017 Jun 2;356(6341):928-932. doi: 10.1126/science.aan0070. Epub 2017 Jun 1.


Commensal-derived OMVs elicit a mild proinflammatory response in intestinal epithelial cells.

Patten DA, Hussein E, Davies SP, Humphreys PN, Collett A.

Microbiology. 2017 May;163(5):702-711. doi: 10.1099/mic.0.000468. Epub 2017 May 22.


Epidemiology and Outcomes of Arterial Ischemic Stroke in Children: The Canadian Pediatric Ischemic Stroke Registry.

deVeber GA, Kirton A, Booth FA, Yager JY, Wirrell EC, Wood E, Shevell M, Surmava AM, McCusker P, Massicotte MP, MacGregor D, MacDonald EA, Meaney B, Levin S, Lemieux BG, Jardine L, Humphreys P, David M, Chan AK, Buckley DJ, Bjornson BH.

Pediatr Neurol. 2017 Apr;69:58-70. doi: 10.1016/j.pediatrneurol.2017.01.016. Epub 2017 Jan 26.


Floc Formation Reduces the pH Stress Experienced by Microorganisms Living in Alkaline Environments.

Charles CJ, Rout SP, Patel KA, Akbar S, Laws AP, Jackson BR, Boxall SA, Humphreys PN.

Appl Environ Microbiol. 2017 Mar 2;83(6). pii: e02985-16. doi: 10.1128/AEM.02985-16. Print 2017 Mar 15.


Draft Whole-Genome Sequence of the Alkaliphilic Alishewanella aestuarii Strain HH-ZS, Isolated from Historical Lime Kiln Waste-Contaminated Soil.

Salah ZB, Rout SP, Humphreys PN.

Genome Announc. 2016 Dec 29;4(6). pii: e01447-16. doi: 10.1128/genomeA.01447-16.


Discovery of a Potent, Cell Penetrant, and Selective p300/CBP-Associated Factor (PCAF)/General Control Nonderepressible 5 (GCN5) Bromodomain Chemical Probe.

Humphreys PG, Bamborough P, Chung CW, Craggs PD, Gordon L, Grandi P, Hayhow TG, Hussain J, Jones KL, Lindon M, Michon AM, Renaux JF, Suckling CJ, Tough DF, Prinjha RK.

J Med Chem. 2017 Jan 26;60(2):695-709. doi: 10.1021/acs.jmedchem.6b01566. Epub 2017 Jan 9.


A Novel Rhamnose-Rich Hetero-exopolysaccharide Isolated from Lactobacillus paracasei DG Activates THP-1 Human Monocytic Cells.

Balzaretti S, Taverniti V, Guglielmetti S, Fiore W, Minuzzo M, Ngo HN, Ngere JB, Sadiq S, Humphreys PN, Laws AP.

Appl Environ Microbiol. 2017 Jan 17;83(3). pii: e02702-16. doi: 10.1128/AEM.02702-16. Print 2017 Feb 1.


Microbial Community Evolution Is Significantly Impacted by the Use of Calcium Isosaccharinic Acid as an Analogue for the Products of Alkaline Cellulose Degradation.

Kyeremeh IA, Charles CJ, Rout SP, Laws AP, Humphreys PN.

PLoS One. 2016 Nov 2;11(11):e0165832. doi: 10.1371/journal.pone.0165832. eCollection 2016.


Activity and MeCP2-dependent regulation of nNOS levels in enteric neurons.

Wahba G, Schock SC, Cudd S, Grynspan D, Humphreys P, Staines WA.

Neurogastroenterol Motil. 2016 Nov;28(11):1723-1730. doi: 10.1111/nmo.12873. Epub 2016 Jun 2.


Quantum memories: emerging applications and recent advances.

Heshami K, England DG, Humphreys PC, Bustard PJ, Acosta VM, Nunn J, Sussman BJ.

J Mod Opt. 2016 Nov 12;63(20):2005-2028. Epub 2016 Mar 16. Review.


Viability of Lucilia sericata maggots after exposure to wound antiseptics.

Daeschlein G, Napp M, Assadian O, von Podewils S, Reese K, Hinz P, Matiasek J, Spitzmueller R, Humphreys P, Jünger M, Kramer A.

Int Wound J. 2017 Jun;14(3):512-515. doi: 10.1111/iwj.12637. Epub 2016 Jul 11.


Evolution of an audit and monitoring tool into an infection prevention and control process.

Denton A, Topping A, Humphreys P.

J Hosp Infect. 2016 Sep;94(1):32-40. doi: 10.1016/j.jhin.2016.04.017. Epub 2016 May 12.


Clinical progress and pharmacology of small molecule bromodomain inhibitors.

Theodoulou NH, Tomkinson NC, Prinjha RK, Humphreys PG.

Curr Opin Chem Biol. 2016 Aug;33:58-66. doi: 10.1016/j.cbpa.2016.05.028. Epub 2016 Jun 10. Review.


Interrogating the Druggability of the 2-Oxoglutarate-Dependent Dioxygenase Target Class by Chemical Proteomics.

Joberty G, Boesche M, Brown JA, Eberhard D, Garton NS, Humphreys PG, Mathieson T, Muelbaier M, Ramsden NG, Reader V, Rueger A, Sheppard RJ, Westaway SM, Bantscheff M, Lee K, Wilson DM, Prinjha RK, Drewes G.

ACS Chem Biol. 2016 Jul 15;11(7):2002-10. doi: 10.1021/acschembio.6b00080. Epub 2016 May 19.


The Incidence and Evolution of Parkinsonian Rigidity in Rett Syndrome: A Pilot Study.

Humphreys P, Barrowman N.

Can J Neurol Sci. 2016 Jul;43(4):567-73. doi: 10.1017/cjn.2016.8. Epub 2016 Apr 6.


Clinical Guidelines for Management of Bone Health in Rett Syndrome Based on Expert Consensus and Available Evidence.

Jefferson A, Leonard H, Siafarikas A, Woodhead H, Fyfe S, Ward LM, Munns C, Motil K, Tarquinio D, Shapiro JR, Brismar T, Ben-Zeev B, Bisgaard AM, Coppola G, Ellaway C, Freilinger M, Geerts S, Humphreys P, Jones M, Lane J, Larsson G, Lotan M, Percy A, Pineda M, Skinner S, Syhler B, Thompson S, Weiss B, Witt Engerström I, Downs J.

PLoS One. 2016 Feb 5;11(2):e0146824. doi: 10.1371/journal.pone.0146824. eCollection 2016.


Isolation of sophorose during sophorolipid production and studies of its stability in aqueous alkali: epimerisation of sophorose to 2-O-β-D-glucopyranosyl-D-mannose.

Al-Jasim A, Davis M, Cossar D, Miller T, Humphreys P, Laws AP.

Carbohydr Res. 2016 Feb 8;421:46-54. doi: 10.1016/j.carres.2015.12.001. Epub 2016 Jan 7.


Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 2. Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Drewes G, Eagle R, Garton N, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Pemberton M, Rioja I, Seal GA, Shipley T, Singh O, Suckling CJ, Taylor J, Thomas P, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1370-87. doi: 10.1021/acs.jmedchem.5b01538. Epub 2016 Jan 15.


Cell Penetrant Inhibitors of the KDM4 and KDM5 Families of Histone Lysine Demethylases. 1. 3-Amino-4-pyridine Carboxylate Derivatives.

Westaway SM, Preston AG, Barker MD, Brown F, Brown JA, Campbell M, Chung CW, Diallo H, Douault C, Drewes G, Eagle R, Gordon L, Haslam C, Hayhow TG, Humphreys PG, Joberty G, Katso R, Kruidenier L, Leveridge M, Liddle J, Mosley J, Muelbaier M, Randle R, Rioja I, Rueger A, Seal GA, Sheppard RJ, Singh O, Taylor J, Thomas P, Thomson D, Wilson DM, Lee K, Prinjha RK.

J Med Chem. 2016 Feb 25;59(4):1357-69. doi: 10.1021/acs.jmedchem.5b01537. Epub 2016 Jan 15.


Progress in the Development of non-BET Bromodomain Chemical Probes.

Theodoulou NH, Tomkinson NC, Prinjha RK, Humphreys PG.

ChemMedChem. 2016 Mar 4;11(5):477-87. doi: 10.1002/cmdc.201500540. Epub 2016 Jan 8. Review.


What are the reasons for improved survival following spine fusion for severe scoliosis in Rett syndrome?

Humphreys P.

Dev Med Child Neurol. 2016 Jun;58(6):538-9. doi: 10.1111/dmcn.12993. Epub 2015 Dec 11. No abstract available.


Selection and dynamics of embryonic stem cell integration into early mouse embryos.

Alexandrova S, Kalkan T, Humphreys P, Riddell A, Scognamiglio R, Trumpp A, Nichols J.

Development. 2016 Jan 1;143(1):24-34. doi: 10.1242/dev.124602. Epub 2015 Nov 19.


Role of an organic carbon-rich soil and Fe(III) reduction in reducing the toxicity and environmental mobility of chromium(VI) at a COPR disposal site.

Ding W, Stewart DI, Humphreys PN, Rout SP, Burke IT.

Sci Total Environ. 2016 Jan 15;541:1191-1199. doi: 10.1016/j.scitotenv.2015.09.150. Epub 2015 Nov 11.


A systematic comparison of antimicrobial wound dressings using a planktonic cell and an immobilized cell model.

Shoukat K, Pilling S, Rout S, Bradbury J, Humphreys PN.

J Appl Microbiol. 2015 Dec;119(6):1552-60. doi: 10.1111/jam.12967.


Alkene anti-Dihydroxylation with Malonoyl Peroxides.

Alamillo-Ferrer C, Davidson SC, Rawling MJ, Theodoulou NH, Campbell M, Humphreys PG, Kennedy AR, Tomkinson NC.

Org Lett. 2015 Oct 16;17(20):5132-5. doi: 10.1021/acs.orglett.5b02674. Epub 2015 Oct 1.


Patients' perception of leg length discrepancy post total hip arthroplasty.

Sykes A, Hill J, Orr J, Humphreys P, Rooney A, Morrow E, Beverland D.

Hip Int. 2015 Sep-Oct;25(5):452-6. doi: 10.5301/hipint.5000276. Epub 2015 Sep 9.


Anoxic Biodegradation of Isosaccharinic Acids at Alkaline pH by Natural Microbial Communities.

Rout SP, Charles CJ, Doulgeris C, McCarthy AJ, Rooks DJ, Loughnane JP, Laws AP, Humphreys PN.

PLoS One. 2015 Sep 14;10(9):e0137682. doi: 10.1371/journal.pone.0137682. eCollection 2015.


Measuring gross motor activities in Rett syndrome.

Humphreys P.

Dev Med Child Neurol. 2015 Dec;57(12):1086-7. doi: 10.1111/dmcn.12848. Epub 2015 Jul 22. No abstract available.


The enrichment of an alkaliphilic biofilm consortia capable of the anaerobic degradation of isosaccharinic acid from cellulosic materials incubated within an anthropogenic, hyperalkaline environment.

Charles CJ, Rout SP, Garratt EJ, Patel K, Laws AP, Humphreys PN.

FEMS Microbiol Ecol. 2015 Aug;91(8):fiv085. doi: 10.1093/femsec/fiv085. Epub 2015 Jul 20.


Draft Genome Sequences of Pseudomonas aeruginosa Strain PS3 and Citrobacter freundii Strain SA79 Obtained from a Wound Dressing-Associated Biofilm.

Akbar S, Rout SP, Humphreys PN.

Genome Announc. 2015 Jun 4;3(3). pii: e00561-15. doi: 10.1128/genomeA.00561-15.


MeCP2 in the enteric nervous system.

Wahba G, Schock SC, Claridge E, Bettolli M, Grynspan D, Humphreys P, Staines WA.

Neurogastroenterol Motil. 2015 Aug;27(8):1156-61. doi: 10.1111/nmo.12605. Epub 2015 May 31.


Brain malformations in a patient with deletion 2p16.1: A refinement of the phenotype to BCL11A.

Balci TB, Sawyer SL, Davila J, Humphreys P, Dyment DA.

Eur J Med Genet. 2015 Jun-Jul;58(6-7):351-4. doi: 10.1016/j.ejmg.2015.04.006. Epub 2015 May 13.


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