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Items: 33


Ularcirc: visualization and enhanced analysis of circular RNAs via back and canonical forward splicing.

Humphreys DT, Fossat N, Demuth M, Tam PPL, Ho JWK.

Nucleic Acids Res. 2019 Aug 22. pii: gkz718. doi: 10.1093/nar/gkz718. [Epub ahead of print]


Identification of clinically actionable variants from genome sequencing of families with congenital heart disease.

Alankarage D, Ip E, Szot JO, Munro J, Blue GM, Harrison K, Cuny H, Enriquez A, Troup M, Humphreys DT, Wilson M, Harvey RP, Sholler GF, Graham RM, Ho JWK, Kirk EP, Pachter N, Chapman G, Winlaw DS, Giannoulatou E, Dunwoodie SL.

Genet Med. 2019 May;21(5):1111-1120. doi: 10.1038/s41436-018-0296-x. Epub 2018 Oct 8.


Orphan receptor GPR37L1 contributes to the sexual dimorphism of central cardiovascular control.

Coleman JLJ, Mouat MA, Wu J, Jancovski N, Bassi JK, Chan AY, Humphreys DT, Mrad N, Yu ZY, Ngo T, Iismaa S, Dos Remedios CG, Feneley MP, Allen AM, Graham RM, Smith NJ.

Biol Sex Differ. 2018 Apr 6;9(1):14. doi: 10.1186/s13293-018-0173-y.


A Screening Approach to Identify Clinically Actionable Variants Causing Congenital Heart Disease in Exome Data.

Szot JO, Cuny H, Blue GM, Humphreys DT, Ip E, Harrison K, Sholler GF, Giannoulatou E, Leo P, Duncan EL, Sparrow DB, Ho JWK, Graham RM, Pachter N, Chapman G, Winlaw DS, Dunwoodie SL.

Circ Genom Precis Med. 2018 Mar;11(3):e001978. doi: 10.1161/CIRCGEN.117.001978.


NAD Deficiency, Congenital Malformations, and Niacin Supplementation.

Shi H, Enriquez A, Rapadas M, Martin EMMA, Wang R, Moreau J, Lim CK, Szot JO, Ip E, Hughes JN, Sugimoto K, Humphreys DT, McInerney-Leo AM, Leo PJ, Maghzal GJ, Halliday J, Smith J, Colley A, Mark PR, Collins F, Sillence DO, Winlaw DS, Ho JWK, Guillemin GJ, Brown MA, Kikuchi K, Thomas PQ, Stocker R, Giannoulatou E, Chapman G, Duncan EL, Sparrow DB, Dunwoodie SL.

N Engl J Med. 2017 Aug 10;377(6):544-552. doi: 10.1056/NEJMoa1616361.


Male-lineage transmission of an acquired metabolic phenotype induced by grand-paternal obesity.

Cropley JE, Eaton SA, Aiken A, Young PE, Giannoulatou E, Ho JWK, Buckland ME, Keam SP, Hutvagner G, Humphreys DT, Langley KG, Henstridge DC, Martin DIK, Febbraio MA, Suter CM.

Mol Metab. 2016 Jun 23;5(8):699-708. doi: 10.1016/j.molmet.2016.06.008. eCollection 2016 Aug.


Longitudinal structural, functional, and cellular myocardial alterations with chronic centrifugal continuous-flow left ventricular assist device support.

Muthiah K, Humphreys DT, Robson D, Dhital K, Spratt P, Jansz P, Macdonald PS, Hayward CS.

J Heart Lung Transplant. 2017 Jul;36(7):722-731. doi: 10.1016/j.healun.2016.05.017. Epub 2016 May 20.


Role of miRNAs and alternative mRNA 3'-end cleavage and polyadenylation of their mRNA targets in cardiomyocyte hypertrophy.

Soetanto R, Hynes CJ, Patel HR, Humphreys DT, Evers M, Duan G, Parker BJ, Archer SK, Clancy JL, Graham RM, Beilharz TH, Smith NJ, Preiss T.

Biochim Biophys Acta. 2016 May;1859(5):744-56. doi: 10.1016/j.bbagrm.2016.03.010. Epub 2016 Mar 24.


Impact of maternal undernutrition around the time of conception on factors regulating hepatic lipid metabolism and microRNAs in singleton and twin fetuses.

Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC.

Am J Physiol Endocrinol Metab. 2016 Jan 15;310(2):E148-59. doi: 10.1152/ajpendo.00600.2014. Epub 2015 Oct 20.


Impact of periconceptional and preimplantation undernutrition on factors regulating myogenesis and protein synthesis in muscle of singleton and twin fetal sheep.

Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC.

Physiol Rep. 2015 Aug;3(8). pii: e12495. doi: 10.14814/phy2.12495.


Decoding the complex genetic causes of heart diseases using systems biology.

Djordjevic D, Deshpande V, Szczesnik T, Yang A, Humphreys DT, Giannoulatou E, Ho JWK.

Biophys Rev. 2015 Mar;7(1):141-159. doi: 10.1007/s12551-014-0145-3. Epub 2014 Dec 10.


Verification and validation of bioinformatics software without a gold standard: a case study of BWA and Bowtie.

Giannoulatou E, Park SH, Humphreys DT, Ho JW.

BMC Bioinformatics. 2014;15 Suppl 16:S15. doi: 10.1186/1471-2105-15-S16-S15. Epub 2014 Dec 8.


The human Piwi protein Hiwi2 associates with tRNA-derived piRNAs in somatic cells.

Keam SP, Young PE, McCorkindale AL, Dang TH, Clancy JL, Humphreys DT, Preiss T, Hutvagner G, Martin DI, Cropley JE, Suter CM.

Nucleic Acids Res. 2014 Aug;42(14):8984-95. doi: 10.1093/nar/gku620. Epub 2014 Jul 18.


Computational analysis, biochemical purification, and detection of tRNA-derived small RNA fragments.

Keam SP, Sobala A, Humphreys DT, Suter CM, Hutvagner G.

Methods Mol Biol. 2014;1173:157-67. doi: 10.1007/978-1-4939-0931-5_14.


Impact of embryo number and maternal undernutrition around the time of conception on insulin signaling and gluconeogenic factors and microRNAs in the liver of fetal sheep.

Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, MacLaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC.

Am J Physiol Endocrinol Metab. 2014 May 1;306(9):E1013-24. doi: 10.1152/ajpendo.00553.2013. Epub 2014 Feb 4.


Periconceptional undernutrition programs changes in insulin-signaling molecules and microRNAs in skeletal muscle in singleton and twin fetal sheep.

Lie S, Morrison JL, Williams-Wyss O, Suter CM, Humphreys DT, Ozanne SE, Zhang S, Maclaughlin SM, Kleemann DO, Walker SK, Roberts CT, McMillen IC.

Biol Reprod. 2014 Jan 9;90(1):5. doi: 10.1095/biolreprod.113.109751. Print 2014 Jan.


Glioma microvesicles carry selectively packaged coding and non-coding RNAs which alter gene expression in recipient cells.

Li CC, Eaton SA, Young PE, Lee M, Shuttleworth R, Humphreys DT, Grau GE, Combes V, Bebawy M, Gong J, Brammah S, Buckland ME, Suter CM.

RNA Biol. 2013 Aug;10(8):1333-44. doi: 10.4161/rna.25281. Epub 2013 Jun 17.


miRspring: a compact standalone research tool for analyzing miRNA-seq data.

Humphreys DT, Suter CM.

Nucleic Acids Res. 2013 Aug;41(15):e147. doi: 10.1093/nar/gkt485. Epub 2013 Jun 17.


Modeling and analysis of repeat RNA toxicity in Drosophila.

Samaraweera SE, O'Keefe LV, van Eyk CL, Lawlor KT, Humphreys DT, Suter CM, Richards RI.

Methods Mol Biol. 2013;1017:173-92. doi: 10.1007/978-1-62703-438-8_13.


A heterozygous variant in the human cardiac miR-133 gene, MIR133A2, alters miRNA duplex processing and strand abundance.

Ohanian M, Humphreys DT, Anderson E, Preiss T, Fatkin D.

BMC Genet. 2013 Mar 6;14:18. doi: 10.1186/1471-2156-14-18.


Insights into RNA biology from an atlas of mammalian mRNA-binding proteins.

Castello A, Fischer B, Eichelbaum K, Horos R, Beckmann BM, Strein C, Davey NE, Humphreys DT, Preiss T, Steinmetz LM, Krijgsveld J, Hentze MW.

Cell. 2012 Jun 8;149(6):1393-406. doi: 10.1016/j.cell.2012.04.031. Epub 2012 May 31.


Widespread occurrence of 5-methylcytosine in human coding and non-coding RNA.

Squires JE, Patel HR, Nousch M, Sibbritt T, Humphreys DT, Parker BJ, Suter CM, Preiss T.

Nucleic Acids Res. 2012 Jun;40(11):5023-33. doi: 10.1093/nar/gks144. Epub 2012 Feb 16.


Complexity of murine cardiomyocyte miRNA biogenesis, sequence variant expression and function.

Humphreys DT, Hynes CJ, Patel HR, Wei GH, Cannon L, Fatkin D, Suter CM, Clancy JL, Preiss T.

PLoS One. 2012;7(2):e30933. doi: 10.1371/journal.pone.0030933. Epub 2012 Feb 3.


Target gene repression mediated by miRNAs miR-181c and miR-9 both of which are down-regulated by amyloid-β.

Schonrock N, Humphreys DT, Preiss T, Götz J.

J Mol Neurosci. 2012 Feb;46(2):324-35. doi: 10.1007/s12031-011-9587-2. Epub 2011 Jul 1.


mRNA isoform diversity can obscure detection of miRNA-mediated control of translation.

Clancy JL, Wei GH, Echner N, Humphreys DT, Beilharz TH, Preiss T.

RNA. 2011 Jun;17(6):1025-31. doi: 10.1261/rna.2567611. Epub 2011 Apr 5.


Global phosphoproteomics identifies a major role for AKT and 14-3-3 in regulating EDC3.

Larance M, Rowland AF, Hoehn KL, Humphreys DT, Preiss T, Guilhaus M, James DE.

Mol Cell Proteomics. 2010 Apr;9(4):682-94. doi: 10.1074/mcp.M900435-MCP200. Epub 2010 Jan 5.


miRNA Effects on mRNA closed-loop formation during translation initiation.

Beilharz TH, Humphreys DT, Preiss T.

Prog Mol Subcell Biol. 2010;50:99-112. doi: 10.1007/978-3-642-03103-8_7. Review.


microRNA-mediated messenger RNA deadenylation contributes to translational repression in mammalian cells.

Beilharz TH, Humphreys DT, Clancy JL, Thermann R, Martin DI, Hentze MW, Preiss T.

PLoS One. 2009 Aug 27;4(8):e6783. doi: 10.1371/journal.pone.0006783.


Methods to analyze microRNA-mediated control of mRNA translation.

Clancy JL, Nousch M, Humphreys DT, Westman BJ, Beilharz TH, Preiss T.

Methods Enzymol. 2007;431:83-111. Review.


MicroRNAs control translation initiation by inhibiting eukaryotic initiation factor 4E/cap and poly(A) tail function.

Humphreys DT, Westman BJ, Martin DI, Preiss T.

Proc Natl Acad Sci U S A. 2005 Nov 22;102(47):16961-6. Epub 2005 Nov 15.


PCR-based expression analysis and identification of microRNAs.

Lu DP, Read RL, Humphreys DT, Battah FM, Martin DI, Rasko JE.

J RNAi Gene Silencing. 2005 Jul 28;1(1):44-9.


Modes of L929 cell death induced by TNF-alpha and other cytotoxic agents.

Humphreys DT, Wilson MR.

Cytokine. 1999 Oct;11(10):773-82.


Clusterin has chaperone-like activity similar to that of small heat shock proteins.

Humphreys DT, Carver JA, Easterbrook-Smith SB, Wilson MR.

J Biol Chem. 1999 Mar 12;274(11):6875-81.

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