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Items: 1 to 50 of 119

1.

A conditionally immortalized Gli1-positive kidney mesenchymal cell line models myofibroblast transition.

Ó hAinmhire E, Wu H, Muto Y, Donnelly EL, G Machado F, Fan LX, Chang-Panesso M, Humphreys BD.

Am J Physiol Renal Physiol. 2018 Oct 10. doi: 10.1152/ajprenal.00460.2018. [Epub ahead of print]

PMID:
30303712
2.

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell. 2018 Aug 2;23(2):308-309. doi: 10.1016/j.stem.2018.07.006. No abstract available.

PMID:
30075132
3.

Single-Cell Transcriptomics of a Human Kidney Allograft Biopsy Specimen Defines a Diverse Inflammatory Response.

Wu H, Malone AF, Donnelly EL, Kirita Y, Uchimura K, Ramakrishnan SM, Gaut JP, Humphreys BD.

J Am Soc Nephrol. 2018 Aug;29(8):2069-2080. doi: 10.1681/ASN.2018020125. Epub 2018 Jul 6.

PMID:
29980650
4.

Efficient Gene Transfer to Kidney Mesenchymal Cells Using a Synthetic Adeno-Associated Viral Vector.

Ikeda Y, Sun Z, Ru X, Vandenberghe LH, Humphreys BD.

J Am Soc Nephrol. 2018 Sep;29(9):2287-2297. doi: 10.1681/ASN.2018040426. Epub 2018 Jul 5.

PMID:
29976586
5.

MicroRNA-132 controls water homeostasis through regulating MECP2-mediated vasopressin synthesis.

Bijkerk R, Trimpert C, van Solingen C, de Bruin RG, Florijn BW, Kooijman S, van den Berg R, van der Veer EP, Bredewold EOW, Rensen PCN, Rabelink TJ, Humphreys BD, Deen PMT, van Zonneveld AJ.

Am J Physiol Renal Physiol. 2018 Oct 1;315(4):F1129-F1138. doi: 10.1152/ajprenal.00087.2018. Epub 2018 May 30.

PMID:
29846108
6.

Mapping kidney cellular complexity.

Humphreys BD.

Science. 2018 May 18;360(6390):709-710. doi: 10.1126/science.aat7271. No abstract available.

PMID:
29773732
7.

Parabiosis and single-cell RNA sequencing reveal a limited contribution of monocytes to myofibroblasts in kidney fibrosis.

Kramann R, Machado F, Wu H, Kusaba T, Hoeft K, Schneider RK, Humphreys BD.

JCI Insight. 2018 May 3;3(9). pii: 99561. doi: 10.1172/jci.insight.99561. [Epub ahead of print]

8.

Meis1 is specifically upregulated in kidney myofibroblasts during aging and injury but is not required for kidney homeostasis or fibrotic response.

Chang-Panesso M, Kadyrov FF, Machado FG, Kumar A, Humphreys BD.

Am J Physiol Renal Physiol. 2018 Aug 1;315(2):F275-F290. doi: 10.1152/ajprenal.00030.2018. Epub 2018 Mar 28.

PMID:
29592525
9.

Overcoming Translational Barriers in Acute Kidney Injury: A Report from an NIDDK Workshop.

Zuk A, Palevsky PM, Fried L, Harrell FE Jr, Khan S, McKay DB, Devey L, Chawla L, de Caestecker M, Kaufman JS, Thompson BT, Agarwal A, Greene T, Okusa MD, Bonventre JV, Dember LM, Liu KD, Humphreys BD, Gossett D, Xie Y, Norton JM, Kimmel PL, Star RA.

Clin J Am Soc Nephrol. 2018 Jul 6;13(7):1113-1123. doi: 10.2215/CJN.06820617. Epub 2018 Mar 9.

PMID:
29523680
10.

Development and Validation of a Risk Prediction Model for Acute Kidney Injury After the First Course of Cisplatin.

Motwani SS, McMahon GM, Humphreys BD, Partridge AH, Waikar SS, Curhan GC.

J Clin Oncol. 2018 Mar 1;36(7):682-688. doi: 10.1200/JCO.2017.75.7161. Epub 2018 Jan 10.

PMID:
29320311
11.

Bringing Renal Biopsy Interpretation Into the Molecular Age With Single-Cell RNA Sequencing.

Malone AF, Wu H, Humphreys BD.

Semin Nephrol. 2018 Jan;38(1):31-39. doi: 10.1016/j.semnephrol.2017.09.005. Review.

PMID:
29291760
12.

Mechanisms of Renal Fibrosis.

Humphreys BD.

Annu Rev Physiol. 2018 Feb 10;80:309-326. doi: 10.1146/annurev-physiol-022516-034227. Epub 2017 Oct 25.

PMID:
29068765
13.

The promise of single-cell RNA sequencing for kidney disease investigation.

Wu H, Humphreys BD.

Kidney Int. 2017 Dec;92(6):1334-1342. doi: 10.1016/j.kint.2017.06.033. Epub 2017 Oct 12. Review.

PMID:
28893418
14.

Targeting Phospholipase D4 Attenuates Kidney Fibrosis.

Trivedi P, Kumar RK, Iyer A, Boswell S, Gerarduzzi C, Dadhania VP, Herbert Z, Joshi N, Luyendyk JP, Humphreys BD, Vaidya VS.

J Am Soc Nephrol. 2017 Dec;28(12):3579-3589. doi: 10.1681/ASN.2016111222. Epub 2017 Aug 16.

PMID:
28814511
15.

Mesenchymal Stem Cells in Fibrotic Disease.

El Agha E, Kramann R, Schneider RK, Li X, Seeger W, Humphreys BD, Bellusci S.

Cell Stem Cell. 2017 Aug 3;21(2):166-177. doi: 10.1016/j.stem.2017.07.011. Review.

16.

Fibrotic Changes Mediating Acute Kidney Injury to Chronic Kidney Disease Transition.

Ó hAinmhire E, Humphreys BD.

Nephron. 2017;137(4):264-267. doi: 10.1159/000474960. Epub 2017 Jun 9.

17.

Endothelial marker-expressing stromal cells are critical for kidney formation.

Mukherjee E, Maringer K, Papke E, Bushnell D, Schaefer C, Kramann R, Ho J, Humphreys BD, Bates C, Sims-Lucas S.

Am J Physiol Renal Physiol. 2017 Sep 1;313(3):F611-F620. doi: 10.1152/ajprenal.00136.2017. Epub 2017 May 24.

18.

Gli1+ Mesenchymal Stromal Cells Are a Key Driver of Bone Marrow Fibrosis and an Important Cellular Therapeutic Target.

Schneider RK, Mullally A, Dugourd A, Peisker F, Hoogenboezem R, Van Strien PMH, Bindels EM, Heckl D, Büsche G, Fleck D, Müller-Newen G, Wongboonsin J, Ventura Ferreira M, Puelles VG, Saez-Rodriguez J, Ebert BL, Humphreys BD, Kramann R.

Cell Stem Cell. 2017 Jun 1;20(6):785-800.e8. doi: 10.1016/j.stem.2017.03.008. Epub 2017 Apr 27. Erratum in: Cell Stem Cell. 2018 Aug 2;23(2):308-309.

19.

The ten barriers for translation of animal data on AKI to the clinical setting.

Liu KD, Humphreys BD, Endre ZH.

Intensive Care Med. 2017 Jun;43(6):898-900. doi: 10.1007/s00134-017-4810-4. Epub 2017 Apr 27. No abstract available.

20.

(Re)Building a Kidney.

Oxburgh L, Carroll TJ, Cleaver O, Gossett DR, Hoshizaki DK, Hubbell JA, Humphreys BD, Jain S, Jensen J, Kaplan DL, Kesselman C, Ketchum CJ, Little MH, McMahon AP, Shankland SJ, Spence JR, Valerius MT, Wertheim JA, Wessely O, Zheng Y, Drummond IA.

J Am Soc Nephrol. 2017 May;28(5):1370-1378. doi: 10.1681/ASN.2016101077. Epub 2017 Jan 17.

21.

Cellular plasticity in kidney injury and repair.

Chang-Panesso M, Humphreys BD.

Nat Rev Nephrol. 2017 Jan;13(1):39-46. doi: 10.1038/nrneph.2016.169. Epub 2016 Nov 28. Review.

PMID:
27890924
22.

ADAM17 substrate release in proximal tubule drives kidney fibrosis.

Kefaloyianni E, Muthu ML, Kaeppler J, Sun X, Sabbisetti V, Chalaris A, Rose-John S, Wong E, Sagi I, Waikar SS, Rennke H, Humphreys BD, Bonventre JV, Herrlich A.

JCI Insight. 2016 Aug 18;1(13). pii: e87023.

23.

Gli1+ Pericyte Loss Induces Capillary Rarefaction and Proximal Tubular Injury.

Kramann R, Wongboonsin J, Chang-Panesso M, Machado FG, Humphreys BD.

J Am Soc Nephrol. 2017 Mar;28(3):776-784. doi: 10.1681/ASN.2016030297. Epub 2016 Sep 13.

24.

Adventitial MSC-like Cells Are Progenitors of Vascular Smooth Muscle Cells and Drive Vascular Calcification in Chronic Kidney Disease.

Kramann R, Goettsch C, Wongboonsin J, Iwata H, Schneider RK, Kuppe C, Kaesler N, Chang-Panesso M, Machado FG, Gratwohl S, Madhurima K, Hutcheson JD, Jain S, Aikawa E, Humphreys BD.

Cell Stem Cell. 2016 Nov 3;19(5):628-642. doi: 10.1016/j.stem.2016.08.001. Epub 2016 Sep 8.

25.

Gene Editing: Powerful New Tools for Nephrology Research and Therapy.

Miyagi A, Lu A, Humphreys BD.

J Am Soc Nephrol. 2016 Oct;27(10):2940-2947. Epub 2016 Jun 29. Review.

26.

Silencing of microRNA-132 reduces renal fibrosis by selectively inhibiting myofibroblast proliferation.

Bijkerk R, de Bruin RG, van Solingen C, van Gils JM, Duijs JM, van der Veer EP, Rabelink TJ, Humphreys BD, van Zonneveld AJ.

Kidney Int. 2016 Jun;89(6):1268-80. doi: 10.1016/j.kint.2016.01.029. Epub 2016 Apr 8.

PMID:
27165825
27.

Clinical Use of the Urine Biomarker [TIMP-2] × [IGFBP7] for Acute Kidney Injury Risk Assessment.

Vijayan A, Faubel S, Askenazi DJ, Cerda J, Fissell WH, Heung M, Humphreys BD, Koyner JL, Liu KD, Mour G, Nolin TD, Bihorac A; American Society of Nephrology Acute Kidney Injury Advisory Group.

Am J Kidney Dis. 2016 Jul;68(1):19-28. doi: 10.1053/j.ajkd.2015.12.033. Epub 2016 Mar 4.

28.

A Plumbing Solution for Stem Cell-Derived Kidneys.

Ó hAinmhire E, Humphreys BD.

Transplantation. 2016 Jan;100(1):3-4. doi: 10.1097/TP.0000000000001049. No abstract available. Erratum in: Transplantation. 2016 Mar;100(3):e16.

PMID:
26674728
29.

CD248/Endosialin: A Novel Pericyte Target in Renal Fibrosis.

Chang-Panesso M, Humphreys BD.

Nephron. 2015;131(4):262-4. doi: 10.1159/000440890. Epub 2015 Dec 11. No abstract available.

30.

Cardio-Oncology: How New Targeted Cancer Therapies and Precision Medicine Can Inform Cardiovascular Discovery.

Bellinger AM, Arteaga CL, Force T, Humphreys BD, Demetri GD, Druker BJ, Moslehi JJ.

Circulation. 2015 Dec 8;132(23):2248-58. doi: 10.1161/CIRCULATIONAHA.115.010484. Review.

31.

Targeting Endogenous Repair Pathways after AKI.

Humphreys BD, Cantaluppi V, Portilla D, Singbartl K, Yang L, Rosner MH, Kellum JA, Ronco C; Acute Dialysis Quality Initiative (ADQI) XIII Work Group.

J Am Soc Nephrol. 2016 Apr;27(4):990-8. doi: 10.1681/ASN.2015030286. Epub 2015 Nov 18. Review.

32.

Bridging Translation by Improving Preclinical Study Design in AKI.

de Caestecker M, Humphreys BD, Liu KD, Fissell WH, Cerda J, Nolin TD, Askenazi D, Mour G, Harrell FE Jr, Pullen N, Okusa MD, Faubel S; ASN AKI Advisory Group.

J Am Soc Nephrol. 2015 Dec;26(12):2905-16. doi: 10.1681/ASN.2015070832. Epub 2015 Nov 4. Review.

33.

Mammalian Target of Rapamycin Mediates Kidney Injury Molecule 1-Dependent Tubule Injury in a Surrogate Model.

Yin W, Naini SM, Chen G, Hentschel DM, Humphreys BD, Bonventre JV.

J Am Soc Nephrol. 2016 Jul;27(7):1943-57. doi: 10.1681/ASN.2015050500. Epub 2015 Nov 4.

34.

Sox9 Activation Highlights a Cellular Pathway of Renal Repair in the Acutely Injured Mammalian Kidney.

Kumar S, Liu J, Pang P, Krautzberger AM, Reginensi A, Akiyama H, Schedl A, Humphreys BD, McMahon AP.

Cell Rep. 2015 Aug 25;12(8):1325-38. doi: 10.1016/j.celrep.2015.07.034. Epub 2015 Aug 13.

35.

Paracrine Wnt1 Drives Interstitial Fibrosis without Inflammation by Tubulointerstitial Cross-Talk.

Maarouf OH, Aravamudhan A, Rangarajan D, Kusaba T, Zhang V, Welborn J, Gauvin D, Hou X, Kramann R, Humphreys BD.

J Am Soc Nephrol. 2016 Mar;27(3):781-90. doi: 10.1681/ASN.2014121188. Epub 2015 Jul 23.

36.

Pharmacological GLI2 inhibition prevents myofibroblast cell-cycle progression and reduces kidney fibrosis.

Kramann R, Fleig SV, Schneider RK, Fabian SL, DiRocco DP, Maarouf O, Wongboonsin J, Ikeda Y, Heckl D, Chang SL, Rennke HG, Waikar SS, Humphreys BD.

J Clin Invest. 2015 Aug 3;125(8):2935-51. doi: 10.1172/JCI74929. Epub 2015 Jul 20.

37.

Perivascular Gli1+ progenitors are key contributors to injury-induced organ fibrosis.

Kramann R, Schneider RK, DiRocco DP, Machado F, Fleig S, Bondzie PA, Henderson JM, Ebert BL, Humphreys BD.

Cell Stem Cell. 2015 Jan 8;16(1):51-66. doi: 10.1016/j.stem.2014.11.004. Epub 2014 Nov 20.

38.

Rationale of mesenchymal stem cell therapy in kidney injury.

Fleig SV, Humphreys BD.

Nephron Clin Pract. 2014;127(1-4):75-80. doi: 10.1159/000363680. Epub 2014 Sep 24. Review.

39.

Cutting to the chase: taking the pulse of label-retaining cells in kidney.

Humphreys BD.

Am J Physiol Renal Physiol. 2015 Jan 1;308(1):F29-30. doi: 10.1152/ajprenal.00538.2014. Epub 2014 Oct 8. No abstract available.

40.

Wnt signaling in kidney tubulointerstitium during disease.

Maarouf OH, Ikeda Y, Humphreys BD.

Histol Histopathol. 2015 Feb;30(2):163-71. doi: 10.14670/HH-30.163. Epub 2014 Oct 9. Review.

PMID:
25297005
41.

Kidney pericytes: roles in regeneration and fibrosis.

Kramann R, Humphreys BD.

Semin Nephrol. 2014 Jul;34(4):374-83. doi: 10.1016/j.semnephrol.2014.06.004. Epub 2014 Jun 13. Review.

42.

Introduction: stem cells and kidney regeneration.

Humphreys BD.

Semin Nephrol. 2014 Jul;34(4):349-50. doi: 10.1016/j.semnephrol.2014.06.001. Epub 2014 Jun 13. No abstract available.

PMID:
25217263
43.

Who regenerates the kidney tubule?

Kramann R, Kusaba T, Humphreys BD.

Nephrol Dial Transplant. 2015 Jun;30(6):903-10. doi: 10.1093/ndt/gfu281. Epub 2014 Aug 25. Review.

44.

Pharmacological and genetic depletion of fibrinogen protects from kidney fibrosis.

Craciun FL, Ajay AK, Hoffmann D, Saikumar J, Fabian SL, Bijol V, Humphreys BD, Vaidya VS.

Am J Physiol Renal Physiol. 2014 Aug 15;307(4):F471-84. doi: 10.1152/ajprenal.00189.2014. Epub 2014 Jul 9.

45.

Discovery of new glomerular disease-relevant genes by translational profiling of podocytes in vivo.

Grgic I, Hofmeister AF, Genovese G, Bernhardy AJ, Sun H, Maarouf OH, Bijol V, Pollak MR, Humphreys BD.

Kidney Int. 2014 Dec;86(6):1116-29. doi: 10.1038/ki.2014.204. Epub 2014 Jun 18.

46.

Report on ISN Forefronts, Florence, Italy, 12-15 September 2013: Stem cells and kidney regeneration.

Romagnani P, Humphreys BD.

Kidney Int. 2014 Jul;86(1):23-7. doi: 10.1038/ki.2014.32. Epub 2014 Jun 4.

47.

The seen and the unseen: clinical guidelines and cost-effective care.

Chang-Panesso M, Humphreys BD.

J Am Soc Nephrol. 2014 Nov;25(11):2390-2. doi: 10.1681/ASN.2014050426. Epub 2014 May 29. No abstract available.

48.

Reply to Corbeil et al.: Dedifferentiation and multipotency.

Kusaba T, Humphreys BD.

Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):E1453. No abstract available.

49.

Fluorescence microangiography for quantitative assessment of peritubular capillary changes after AKI in mice.

Kramann R, Tanaka M, Humphreys BD.

J Am Soc Nephrol. 2014 Sep;25(9):1924-31. doi: 10.1681/ASN.2013101121. Epub 2014 Mar 20.

50.

Translational profiles of medullary myofibroblasts during kidney fibrosis.

Grgic I, Krautzberger AM, Hofmeister A, Lalli M, DiRocco DP, Fleig SV, Liu J, Duffield JS, McMahon AP, Aronow B, Humphreys BD.

J Am Soc Nephrol. 2014 Sep;25(9):1979-90. doi: 10.1681/ASN.2013101143. Epub 2014 Mar 20.

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