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Items: 1 to 50 of 70

1.

NanoBlow: A Simple Device To Limit Contaminants during NanoLC-MS.

Humphrey SJ, Crossett B, Parker BL.

J Proteome Res. 2019 Aug 2;18(8):3219-3222. doi: 10.1021/acs.jproteome.9b00175. Epub 2019 Jul 3.

PMID:
31268342
2.

ABHD15 regulates adipose tissue lipolysis and hepatic lipid accumulation.

Stöckli J, Zadoorian A, Cooke KC, Deshpande V, Yau B, Herrmann G, Kebede MA, Humphrey SJ, James DE.

Mol Metab. 2019 Jul;25:83-94. doi: 10.1016/j.molmet.2019.05.002. Epub 2019 May 6.

3.

QCMAP: An Interactive Web-Tool for Performance Diagnosis and Prediction of LC-MS Systems.

Kim T, Chen IR, Parker BL, Humphrey SJ, Crossett B, Cordwell SJ, Yang P, Yang JYH.

Proteomics. 2019 Jul;19(13):e1900068. doi: 10.1002/pmic.201900068. Epub 2019 Jun 13.

PMID:
31099962
4.

Multi-omic Profiling Reveals Dynamics of the Phased Progression of Pluripotency.

Yang P, Humphrey SJ, Cinghu S, Pathania R, Oldfield AJ, Kumar D, Perera D, Yang JYH, James DE, Mann M, Jothi R.

Cell Syst. 2019 May 22;8(5):427-445.e10. doi: 10.1016/j.cels.2019.03.012. Epub 2019 May 8.

5.

Proteomic Analysis of Human Plasma during Intermittent Fasting.

Harney DJ, Hutchison AT, Hatchwell L, Humphrey SJ, James DE, Hocking S, Heilbronn LK, Larance M.

J Proteome Res. 2019 May 3;18(5):2228-2240. doi: 10.1021/acs.jproteome.9b00090. Epub 2019 Apr 1.

6.

Phosphoproteomics Reveals the GSK3-PDX1 Axis as a Key Pathogenic Signaling Node in Diabetic Islets.

Sacco F, Seelig A, Humphrey SJ, Krahmer N, Volta F, Reggio A, Marchetti P, Gerdes J, Mann M.

Cell Metab. 2019 Jun 4;29(6):1422-1432.e3. doi: 10.1016/j.cmet.2019.02.012. Epub 2019 Mar 14.

PMID:
30879985
7.

Illuminating the dark phosphoproteome.

Needham EJ, Parker BL, Burykin T, James DE, Humphrey SJ.

Sci Signal. 2019 Jan 22;12(565). pii: eaau8645. doi: 10.1126/scisignal.aau8645. Review.

PMID:
30670635
8.

RagC phosphorylation autoregulates mTOR complex 1.

Yang G, Humphrey SJ, Murashige DS, Francis D, Wang QP, Cooke KC, Neely GG, James DE.

EMBO J. 2019 Feb 1;38(3). pii: e99548. doi: 10.15252/embj.201899548. Epub 2018 Dec 14.

PMID:
30552228
9.

High-throughput and high-sensitivity phosphoproteomics with the EasyPhos platform.

Humphrey SJ, Karayel O, James DE, Mann M.

Nat Protoc. 2018 Sep;13(9):1897-1916. doi: 10.1038/s41596-018-0014-9.

PMID:
30190555
10.

In vivo brain GPCR signaling elucidated by phosphoproteomics.

Liu JJ, Sharma K, Zangrandi L, Chen C, Humphrey SJ, Chiu YT, Spetea M, Liu-Chen LY, Schwarzer C, Mann M.

Science. 2018 Jun 22;360(6395). pii: eaao4927. doi: 10.1126/science.aao4927.

11.

Mitochondrial CoQ deficiency is a common driver of mitochondrial oxidants and insulin resistance.

Fazakerley DJ, Chaudhuri R, Yang P, Maghzal GJ, Thomas KC, Krycer JR, Humphrey SJ, Parker BL, Fisher-Wellman KH, Meoli CC, Hoffman NJ, Diskin C, Burchfield JG, Cowley MJ, Kaplan W, Modrusan Z, Kolumam G, Yang JY, Chen DL, Samocha-Bonet D, Greenfield JR, Hoehn KL, Stocker R, James DE.

Elife. 2018 Feb 6;7. pii: e32111. doi: 10.7554/eLife.32111.

12.

Dynamic Metabolomics Reveals that Insulin Primes the Adipocyte for Glucose Metabolism.

Krycer JR, Yugi K, Hirayama A, Fazakerley DJ, Quek LE, Scalzo R, Ohno S, Hodson MP, Ikeda S, Shoji F, Suzuki K, Domanova W, Parker BL, Nelson ME, Humphrey SJ, Turner N, Hoehn KL, Cooney GJ, Soga T, Kuroda S, James DE.

Cell Rep. 2017 Dec 19;21(12):3536-3547. doi: 10.1016/j.celrep.2017.11.085.

13.

Correction: Unraveling Kinase Activation Dynamics Using Kinase-Substrate Relationships from Temporal Large-Scale Phosphoproteomics Studies.

Domanova W, Krycer JR, Chaudhuri R, Yang P, Vafaee F, Fazakerley DJ, Humphrey SJ, James DE, Kuncic Z.

PLoS One. 2017 Sep 28;12(9):e0185871. doi: 10.1371/journal.pone.0185871. eCollection 2017.

14.

The amino acid transporter, SLC1A3, is plasma membrane-localised in adipocytes and its activity is insensitive to insulin.

Krycer JR, Fazakerley DJ, Cater RJ, C Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE.

FEBS Lett. 2017 Jan;591(2):322-330. doi: 10.1002/1873-3468.12549. Epub 2017 Jan 13.

15.

Glucose-regulated and drug-perturbed phosphoproteome reveals molecular mechanisms controlling insulin secretion.

Sacco F, Humphrey SJ, Cox J, Mischnik M, Schulte A, Klabunde T, Schäfer M, Mann M.

Nat Commun. 2016 Nov 14;7:13250. doi: 10.1038/ncomms13250.

16.

Phosphorylation Is a Central Mechanism for Circadian Control of Metabolism and Physiology.

Robles MS, Humphrey SJ, Mann M.

Cell Metab. 2017 Jan 10;25(1):118-127. doi: 10.1016/j.cmet.2016.10.004. Epub 2016 Nov 3.

17.

Hyperactivation of the Insulin Signaling Pathway Improves Intracellular Proteostasis by Coordinately Up-regulating the Proteostatic Machinery in Adipocytes.

Minard AY, Wong MK, Chaudhuri R, Tan SX, Humphrey SJ, Parker BL, Yang JY, Laybutt DR, Cooney GJ, Coster AC, Stöckli J, James DE.

J Biol Chem. 2016 Dec 2;291(49):25629-25640. Epub 2016 Oct 13.

18.

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.

Minard AY, Tan SX, Yang P, Fazakerley DJ, Domanova W, Parker BL, Humphrey SJ, Jothi R, Stöckli J, James DE.

Cell Rep. 2016 Sep 27;17(1):29-36. doi: 10.1016/j.celrep.2016.08.086.

19.

KinasePA: Phosphoproteomics data annotation using hypothesis driven kinase perturbation analysis.

Yang P, Patrick E, Humphrey SJ, Ghazanfar S, James DE, Jothi R, Yang JY.

Proteomics. 2016 Jul;16(13):1868-71. doi: 10.1002/pmic.201600068. Epub 2016 May 27.

20.

Mechanism of Regulation of Intrachromatid Recombination and Long-Range Chromosome Interactions in Saccharomyces cerevisiae.

Zaman S, Choudhury M, Jiang JC, Srivastava P, Mohanty BK, Danielson C, Humphrey SJ, Jazwinski SM, Bastia D.

Mol Cell Biol. 2016 May 2;36(10):1451-63. doi: 10.1128/MCB.01100-15. Print 2016 May 15.

21.

Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation.

Humphrey SJ, James DE, Mann M.

Trends Endocrinol Metab. 2015 Dec;26(12):676-687. doi: 10.1016/j.tem.2015.09.013. Epub 2015 Oct 20. Review.

PMID:
26498855
22.

Global Phosphoproteomic Analysis of Human Skeletal Muscle Reveals a Network of Exercise-Regulated Kinases and AMPK Substrates.

Hoffman NJ, Parker BL, Chaudhuri R, Fisher-Wellman KH, Kleinert M, Humphrey SJ, Yang P, Holliday M, Trefely S, Fazakerley DJ, Stöckli J, Burchfield JG, Jensen TE, Jothi R, Kiens B, Wojtaszewski JF, Richter EA, James DE.

Cell Metab. 2015 Nov 3;22(5):922-35. doi: 10.1016/j.cmet.2015.09.001. Epub 2015 Oct 1. Erratum in: Cell Metab. 2015 Nov 3;22(5):948.

23.

Positive-unlabeled ensemble learning for kinase substrate prediction from dynamic phosphoproteomics data.

Yang P, Humphrey SJ, James DE, Yang YH, Jothi R.

Bioinformatics. 2016 Jan 15;32(2):252-9. doi: 10.1093/bioinformatics/btv550. Epub 2015 Sep 22.

24.

PhosphOrtholog: a web-based tool for cross-species mapping of orthologous protein post-translational modifications.

Chaudhuri R, Sadrieh A, Hoffman NJ, Parker BL, Humphrey SJ, Stöckli J, Hill AP, James DE, Yang JY.

BMC Genomics. 2015 Aug 19;16:617. doi: 10.1186/s12864-015-1820-x.

25.

High-throughput phosphoproteomics reveals in vivo insulin signaling dynamics.

Humphrey SJ, Azimifar SB, Mann M.

Nat Biotechnol. 2015 Sep;33(9):990-5. doi: 10.1038/nbt.3327. Epub 2015 Aug 17.

PMID:
26280412
26.

A Positive Feedback Loop between Akt and mTORC2 via SIN1 Phosphorylation.

Yang G, Murashige DS, Humphrey SJ, James DE.

Cell Rep. 2015 Aug 11;12(6):937-43. doi: 10.1016/j.celrep.2015.07.016. Epub 2015 Jul 30.

27.

Targeted phosphoproteomics of insulin signaling using data-independent acquisition mass spectrometry.

Parker BL, Yang G, Humphrey SJ, Chaudhuri R, Ma X, Peterman S, James DE.

Sci Signal. 2015 Jun 9;8(380):rs6. doi: 10.1126/scisignal.aaa3139.

PMID:
26060331
28.

Dynamic adipocyte phosphoproteome reveals that Akt directly regulates mTORC2.

Humphrey SJ, Yang G, Yang P, Fazakerley DJ, Stöckli J, Yang JY, James DE.

Cell Metab. 2013 Jun 4;17(6):1009-20. doi: 10.1016/j.cmet.2013.04.010. Epub 2013 May 16.

29.

TBC1D13 is a RAB35 specific GAP that plays an important role in GLUT4 trafficking in adipocytes.

Davey JR, Humphrey SJ, Junutula JR, Mishra AK, Lambright DG, James DE, Stöckli J.

Traffic. 2012 Oct;13(10):1429-41. doi: 10.1111/j.1600-0854.2012.01397.x. Epub 2012 Jul 29.

30.

Uncaging akt.

Humphrey SJ, James DE.

Sci Signal. 2012 May 8;5(223):pe20. doi: 10.1126/scisignal.2003085. Erratum in: Sci Signal. 2012 May 29;5(226):er4.

PMID:
22569332
31.

Re-fraction: a machine learning approach for deterministic identification of protein homologues and splice variants in large-scale MS-based proteomics.

Yang P, Humphrey SJ, Fazakerley DJ, Prior MJ, Yang G, James DE, Yang JY.

J Proteome Res. 2012 May 4;11(5):3035-45. doi: 10.1021/pr300072j. Epub 2012 Mar 30.

PMID:
22428558
32.
33.

Cardiovascular effects of the R- and S-enantiomers of ibutilide in conscious beagle dogs.

Humphrey SJ, Smith MP, Hsu CY, Walters RR.

Methods Find Exp Clin Pharmacol. 2001 Oct;23(8):449-55.

PMID:
11838320
34.
35.
36.

K-ATP-blocking diuretic PNU-37883A reduces plasma renin activity in dogs.

Humphrey SJ, Ludens JH.

J Cardiovasc Pharmacol. 1998 Jun;31(6):894-903.

PMID:
9641474
37.

Cardiovascular effects of the K-ATP channel blocker U-37883A and structurally related morpholinoguanidines.

Humphrey SJ, Smith MP, Cimini MG, Buchanan LV, Gibson JK, Khan SA, Meisheri KD.

Methods Find Exp Clin Pharmacol. 1996 May;18(4):247-60.

PMID:
8803957
38.

Cardiovascular interactions characterizing the vasodilator components of nicorandil in conscious dogs.

Humphrey SJ, Schwende FJ.

J Cardiovasc Pharmacol. 1995 Nov;26(5):810-21.

PMID:
8637197
39.

Effects of K-ATP blocking guanidine diuretics during experimental kaliuresis in rats and dogs.

Humphrey SJ.

Methods Find Exp Clin Pharmacol. 1995 Oct;17(8):519-28.

PMID:
8749224
40.

Diuretic activity of N'-disubstituted morpholinoguanidine analogs of U-37883A in rats and dogs.

Humphrey SJ, Ludens JH, Perricone SC, Skaletzky LL, Graham BE, Zins GR.

Methods Find Exp Clin Pharmacol. 1995 May;17(4):255-66.

PMID:
7475512
41.

Renal and vascular effects of chemically distinct ATP-sensitive K+ channel blockers in rats.

Ludens JH, Clark MA, Smith MP, Humphrey SJ.

J Cardiovasc Pharmacol. 1995 Mar;25(3):404-9.

PMID:
7769805
42.

Selective in vivo antagonism of pinacidil-induced hypotension by the guanidine U37883A in anesthetized rats.

Smith MP, Humphrey SJ, Jackson WF.

Pharmacology. 1994 Dec;49(6):363-75.

PMID:
7878074
43.

Synthesis and diuretic activity of alkyl- and arylguanidine analogs of N,N'-dicyclohexyl-4-morpholinecarboxamidine in rats and dogs.

Perricone SC, Humphrey SJ, Skaletzky LL, Graham BE, Zandt RA, Zins GR.

J Med Chem. 1994 Oct 28;37(22):3693-700.

PMID:
7966129
44.

In vitro and in vivo inhibition of rat vascular smooth muscle cell migration and proliferation by a 2-aminochromone U-86983.

Erickson LA, Bonin PD, Wishka DG, Morris J, Dalga RJ, Williams DJ, Wilson GJ, Hoover JL, Simmons CA, Humphrey SJ, et al.

J Pharmacol Exp Ther. 1994 Oct;271(1):415-21.

PMID:
7965742
45.

In vitro vasorelaxant and in vivo cardiovascular effects of S-nitrosothiols: comparison to and cross tolerance with standard nitrovasodilators.

Smith MP, Humphrey SJ, Kerr SW, Mathews WR.

Methods Find Exp Clin Pharmacol. 1994 Jun;16(5):323-35.

PMID:
7934311
46.

4-morpholinecarboximidine-N-1-adamantyl-N'-cyclohexylhydrochloride (U-37883A): pharmacological characterization of a novel antagonist of vascular ATP-sensitive K+ channel openers.

Meisheri KD, Humphrey SJ, Khan SA, Cipkus-Dubray LA, Smith MP, Jones AW.

J Pharmacol Exp Ther. 1993 Aug;266(2):655-65.

PMID:
8355199
47.

Unique natriuretic properties of the ATP-sensitive K(+)-channel blocker glyburide in conscious rats.

Clark MA, Humphrey SJ, Smith MP, Ludens JH.

J Pharmacol Exp Ther. 1993 May;265(2):933-7.

PMID:
8496833
48.

Gait on a shoestring: falls and foot separation in parkinsonism.

Weller C, Humphrey SJ, Kirollos C, Bowes SG, Charlett A, Dobbs SM, Dobbs RJ.

Age Ageing. 1992 Jul;21(4):242-4.

PMID:
1514451
49.

Salmonellosis associated with 'Combi-oven' cooked egg.

Ahmed S, Jephcott AE, Stanwell-Smith RE, Humphrey SJ.

J Public Health Med. 1992 Mar;14(1):68-71.

PMID:
1599745
50.

Evaluation of the Lamtec anaesthetic agent monitor.

Humphrey SJ, Luff NP, White DC.

Anaesthesia. 1991 Jun;46(6):478-81.

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