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Items: 1 to 50 of 249

1.

Musculoskeletal injuries in real tennis.

Humphrey JA, Humphrey PP, Greenwood AS, Anderson JL, Markus HS, Ajuied A.

Open Access J Sports Med. 2019 May 23;10:81-86. doi: 10.2147/OAJSM.S198500. eCollection 2019.

2.

Discovery, oral pharmacokinetics and in vivo efficacy of velusetrag, a highly selective 5-HT(4) receptor agonist that has achieved proof-of-concept in patients with chronic idiopathic constipation.

Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Genov D, Goldblum AA, Humphrey PP, Jiang L, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG.

Bioorg Med Chem Lett. 2012 Oct 1;22(19):6048-52. doi: 10.1016/j.bmcl.2012.08.051. Epub 2012 Aug 21.

PMID:
22959244
3.

Discovery, oral pharmacokinetics and in vivo efficacy of a highly selective 5-HT4 receptor agonist: clinical compound TD-2749.

Long DD, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum AA, Humphrey PP, Marquess DG, Shaw JP, Smith JA, Derek Turner S, Vickery RG.

Bioorg Med Chem Lett. 2012 Jul 15;22(14):4849-53. doi: 10.1016/j.bmcl.2012.05.034. Epub 2012 May 15.

PMID:
22683222
4.

Specificity of induction of the vanA and vanB operons in vancomycin-resistant enterococci by telavancin.

Hill CM, Krause KM, Lewis SR, Blais J, Benton BM, Mammen M, Humphrey PP, Kinana A, Janc JW.

Antimicrob Agents Chemother. 2010 Jul;54(7):2814-8. doi: 10.1128/AAC.01737-09. Epub 2010 Apr 19.

5.

A multivalent approach to the design and discovery of orally efficacious 5-HT4 receptor agonists.

McKinnell RM, Armstrong SR, Beattie DT, Choi SK, Fatheree PR, Gendron RA, Goldblum A, Humphrey PP, Long DD, Marquess DG, Shaw JP, Smith JA, Turner SD, Vickery RG.

J Med Chem. 2009 Sep 10;52(17):5330-43. doi: 10.1021/jm900881j.

PMID:
19663444
6.

Telavancin disrupts the functional integrity of the bacterial membrane through targeted interaction with the cell wall precursor lipid II.

Lunde CS, Hartouni SR, Janc JW, Mammen M, Humphrey PP, Benton BM.

Antimicrob Agents Chemother. 2009 Aug;53(8):3375-83. doi: 10.1128/AAC.01710-08. Epub 2009 May 26.

7.

The discovery and development of the triptans, a major therapeutic breakthrough.

Humphrey PP.

Headache. 2008 May;48(5):685-7. doi: 10.1111/j.1526-4610.2008.01097.x.

PMID:
18471110
8.

The in vitro pharmacological profile of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Smith JA, Beattie DT, Marquess D, Shaw JP, Vickery RG, Humphrey PP.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):125-37. doi: 10.1007/s00210-008-0282-y. Epub 2008 Apr 16.

PMID:
18415081
9.

The in vivo gastrointestinal activity of TD-5108, a selective 5-HT(4) receptor agonist with high intrinsic activity.

Beattie DT, Armstrong SR, Shaw JP, Marquess D, Sandlund C, Smith JA, Taylor JA, Humphrey PP.

Naunyn Schmiedebergs Arch Pharmacol. 2008 Jul;378(1):139-47. doi: 10.1007/s00210-008-0281-z. Epub 2008 Apr 12.

PMID:
18408918
10.

Efficacy, duration, and onset of immunogenicity of a West Nile virus vaccine, live Flavivirus chimera, in horses with a clinical disease challenge model.

Long MT, Gibbs EP, Mellencamp MW, Bowen RA, Seino KK, Zhang S, Beachboard SE, Humphrey PP.

Equine Vet J. 2007 Nov;39(6):491-7.

PMID:
18065305
11.

Safety of an attenuated West Nile virus vaccine, live Flavivirus chimera in horses.

Long MT, Gibbs EP, Mellencamp MW, Zhang S, Barnett DC, Seino KK, Beachboard SE, Humphrey PP.

Equine Vet J. 2007 Nov;39(6):486-90.

PMID:
18065304
12.

Comparative efficacies of three commercially available vaccines against West Nile Virus (WNV) in a short-duration challenge trial involving an equine WNV encephalitis model.

Seino KK, Long MT, Gibbs EP, Bowen RA, Beachboard SE, Humphrey PP, Dixon MA, Bourgeois MA.

Clin Vaccine Immunol. 2007 Nov;14(11):1465-71. Epub 2007 Aug 8.

13.

The discovery of a new drug class for the acute treatment of migraine.

Humphrey PP.

Headache. 2007 Apr;47 Suppl 1:S10-9. Review.

PMID:
17425704
14.

A comparison of the pharmacological properties of guinea-pig and human recombinant 5-HT4 receptors.

Vickery RG, Mai N, Kaufman E, Beattie DT, Pulido-Rios T, O'Keefe M, Humphrey PP, Smith JA.

Br J Pharmacol. 2007 Mar;150(6):782-91. Epub 2007 Feb 12.

15.

Species and response dependent differences in the effects of MAPK inhibitors on P2X(7) receptor function.

Michel AD, Thompson KM, Simon J, Boyfield I, Fonfria E, Humphrey PP.

Br J Pharmacol. 2006 Dec;149(7):948-57. Epub 2006 Oct 9.

16.

Decavanadate, a P2X receptor antagonist, and its use to study ligand interactions with P2X7 receptors.

Michel AD, Xing M, Thompson KM, Jones CA, Humphrey PP.

Eur J Pharmacol. 2006 Mar 18;534(1-3):19-29. Epub 2006 Feb 17.

PMID:
16487507
17.

Telavancin, a multifunctional lipoglycopeptide, disrupts both cell wall synthesis and cell membrane integrity in methicillin-resistant Staphylococcus aureus.

Higgins DL, Chang R, Debabov DV, Leung J, Wu T, Krause KM, Sandvik E, Hubbard JM, Kaniga K, Schmidt DE Jr, Gao Q, Cass RT, Karr DE, Benton BM, Humphrey PP.

Antimicrob Agents Chemother. 2005 Mar;49(3):1127-34.

18.

The 5-HT4 receptor agonist, tegaserod, is a potent 5-HT2B receptor antagonist in vitro and in vivo.

Beattie DT, Smith JA, Marquess D, Vickery RG, Armstrong SR, Pulido-Rios T, McCullough JL, Sandlund C, Richardson C, Mai N, Humphrey PP.

Br J Pharmacol. 2004 Nov;143(5):549-60. Epub 2004 Oct 4.

19.

Cellular actions of somatostatin on rat periaqueductal grey neurons in vitro.

Connor M, Bagley EE, Mitchell VA, Ingram SL, Christie MJ, Humphrey PP, Vaughan CW.

Br J Pharmacol. 2004 Aug;142(8):1273-80. Epub 2004 Jul 20.

20.

Functional regulation of P2X6 receptors by N-linked glycosylation: identification of a novel alpha beta-methylene ATP-sensitive phenotype.

Jones CA, Vial C, Sellers LA, Humphrey PP, Evans RJ, Chessell IP.

Mol Pharmacol. 2004 Apr;65(4):979-85.

PMID:
15044628
21.

Somatostatin induces striatal dopamine release and contralateral turning behaviour in the mouse.

Hathway GJ, Humphrey PP, Kendrick KM.

Neurosci Lett. 2004 Mar 25;358(2):127-31.

PMID:
15026165
22.

Characterization of bradykinin-induced prostaglandin E2 release from cultured rat trigeminal ganglion neurones.

Jenkins DW, Sellers LA, Feniuk W, Humphrey PP.

Eur J Pharmacol. 2003 May 23;469(1-3):29-36.

PMID:
12782182
23.

Somatostatin receptor 2 knockout/lacZ knockin mice show impaired motor coordination and reveal sites of somatostatin action within the striatum.

Allen JP, Hathway GJ, Clarke NJ, Jowett MI, Topps S, Kendrick KM, Humphrey PP, Wilkinson LS, Emson PC.

Eur J Neurosci. 2003 May;17(9):1881-95.

PMID:
12752788
24.

Identification of cells expressing somatostatin receptor 2 in the gastrointestinal tract of Sstr2 knockout/lacZ knockin mice.

Allen JP, Canty AJ, Schulz S, Humphrey PP, Emson PC, Young HM.

J Comp Neurol. 2002 Dec 16;454(3):329-40.

PMID:
12442323
25.

Excitation of rat colonic afferent fibres by 5-HT(3) receptors.

Hicks GA, Coldwell JR, Schindler M, Ward PA, Jenkins D, Lynn PA, Humphrey PP, Blackshaw LA.

J Physiol. 2002 Nov 1;544(3):861-9.

26.

Study of an adenosine A1 receptor agonist on trigeminally evoked dural blood vessel dilation in the anaesthetized rat.

Honey AC, Bland-Ward PA, Connor HE, Feniuk W, Humphrey PP.

Cephalalgia. 2002 May;22(4):260-4.

PMID:
12100087
27.

Single-nucleotide polymorphism alleles in the insulin receptor gene are associated with typical migraine.

McCarthy LC, Hosford DA, Riley JH, Bird MI, White NJ, Hewett DR, Peroutka SJ, Griffiths LR, Boyd PR, Lea RA, Bhatti SM, Hosking LK, Hood CM, Jones KW, Handley AR, Rallan R, Lewis KF, Yeo AJ, Williams PM, Priest RC, Khan P, Donnelly C, Lumsden SM, O'Sullivan J, See CG, Smart DH, Shaw-Hawkins S, Patel J, Langrish TC, Feniuk W, Knowles RG, Thomas M, Libri V, Montgomery DS, Manasco PK, Xu CF, Dykes C, Humphrey PP, Roses AD, Purvis IJ.

Genomics. 2001 Dec;78(3):135-49. Erratum in: Genomics 2002 Feb;79(2):271.

PMID:
11735220
29.

Somatostatin release by glutamate in vivo is primarily regulated by AMPA receptors.

Hathway GJ, Humphrey PP, Kendrick KM.

Br J Pharmacol. 2001 Nov;134(6):1155-8.

30.

Titrating the expression of a Gi protein-coupled receptor using an ecdysone-inducible system in CHO-K1 cells.

Cole SL, Schindler M, Sellers LA, Humphrey PP.

Receptors Channels. 2001;7(4):289-302.

PMID:
11697234
31.

How it started.

Humphrey PP.

Cephalalgia. 2001;21 Suppl 1:2-5. No abstract available.

PMID:
11678811
32.

Somatostatin sst(2) receptor-mediated inhibition of mesenteric afferent nerves of the jejunum in the anesthetized rat.

Booth CE, Kirkup AJ, Hicks GA, Humphrey PP, Grundy D.

Gastroenterology. 2001 Aug;121(2):358-69.

PMID:
11487545
33.

Craniovascular selectivity of eletriptan and sumatriptan in human isolated blood vessels.

Humphrey PP, Fenvik W, Salonen R.

Neurology. 2001 Jul 10;57(1):162-3. No abstract available.

PMID:
11445657
34.

Species- and agonist-dependent differences in the deactivation-kinetics of P2X7 receptors.

Hibell AD, Thompson KM, Simon J, Xing M, Humphrey PP, Michel AD.

Naunyn Schmiedebergs Arch Pharmacol. 2001 Jun;363(6):639-48.

PMID:
11414659
35.

Adenosine A(1) receptor-mediated inhibition of protein kinase A-induced calcitonin gene-related peptide release from rat trigeminal neurons.

Carruthers AM, Sellers LA, Jenkins DW, Jarvie EM, Feniuk W, Humphrey PP.

Mol Pharmacol. 2001 Jun;59(6):1533-41.

PMID:
11353815
36.

High-intensity p38 kinase activity is critical for p21(cip1) induction and the antiproliferative function of G(i) protein-coupled receptors.

Alderton F, Humphrey PP, Sellers LA.

Mol Pharmacol. 2001 May;59(5):1119-28. Erratum in: Mol Pharmacol 2001 Jul;60(1):233.

PMID:
11306695
37.

Somatostatin activates two types of inwardly rectifying K+ channels in MIN-6 cells.

Smith PA, Sellers LA, Humphrey PP.

J Physiol. 2001 Apr 1;532(Pt 1):127-42.

38.

Adenosine nucleotides acting at the human P2Y1 receptor stimulate mitogen-activated protein kinases and induce apoptosis.

Sellers LA, Simon J, Lundahl TS, Cousens DJ, Humphrey PP, Barnard EA.

J Biol Chem. 2001 May 11;276(19):16379-90. Epub 2001 Jan 25.

39.

Serum constituents can affect 2'-& 3'-O-(4-benzoylbenzoyl)-ATP potency at P2X(7) receptors.

Michel AD, Xing M, Humphrey PP.

Br J Pharmacol. 2001 Apr;132(7):1501-8.

40.
41.

Complexities of measuring antagonist potency at P2X(7) receptor orthologs.

Hibell AD, Thompson KM, Xing M, Humphrey PP, Michel AD.

J Pharmacol Exp Ther. 2001 Mar;296(3):947-57.

PMID:
11181928
42.

International union of pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits.

Khakh BS, Burnstock G, Kennedy C, King BF, North RA, Séguéla P, Voigt M, Humphrey PP.

Pharmacol Rev. 2001 Mar;53(1):107-18. Review.

PMID:
11171941
43.
44.

Activity of adenosine diphosphates and triphosphates on a P2Y(T) -type receptor in brain capillary endothelial cells.

Simon J, Vigne P, Eklund KM, Michel AD, Carruthers AM, Humphrey PP, Frelin C, Barnard EA.

Br J Pharmacol. 2001 Jan;132(1):173-82.

45.

Immunohistochemical localization of adenosine A1 receptors in human brain regions.

Schindler M, Harris CA, Hayes B, Papotti M, Humphrey PP.

Neurosci Lett. 2001 Jan 19;297(3):211-5.

PMID:
11137765
46.

5-HT(3) and histamine H(1) receptors mediate afferent nerve sensitivity to intestinal anaphylaxis in rats.

Jiang W, Kreis ME, Eastwood C, Kirkup AJ, Humphrey PP, Grundy D.

Gastroenterology. 2000 Nov;119(5):1267-75.

PMID:
11054384
47.

First localisation of somatostatin sst(4) receptor protein in selected human brain areas: an immunohistochemical study.

Selmer IS, Schindler M, Humphrey PP, Waldvogel HJ, Faull RL, Emson PC.

Brain Res Mol Brain Res. 2000 Oct 20;82(1-2):114-25.

PMID:
11042364
48.

Receptor isoforms mediate opposing proliferative effects through gbetagamma-activated p38 or Akt pathways.

Sellers LA, Alderton F, Carruthers AM, Schindler M, Humphrey PP.

Mol Cell Biol. 2000 Aug;20(16):5974-85.

49.

Immunohistochemical localization of the somatostatin sst(4) receptor in rat brain.

Selmer IS, Schindler M, Humphrey PP, Emson PC.

Neuroscience. 2000;98(3):523-33.

PMID:
10869846
50.

P2X receptors mediate ATP-induced primary nociceptive neurone activation.

Bland-Ward PA, Humphrey PP.

J Auton Nerv Syst. 2000 Jul 3;81(1-3):146-51. Review.

PMID:
10869713

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