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Items: 1 to 50 of 56

1.

TLR4 Promotes and DAP12 Limits Obesity-Induced Osteoarthritis in Aged Female Mice.

Kalaitzoglou E, Lopes EBP, Fu Y, Herron JC, Flaming JM, Donovan EL, Hu Y, Filiberti A, Griffin TM, Humphrey MB.

JBMR Plus. 2018 Oct 4;3(4):e10079. doi: 10.1002/jbm4.10079. eCollection 2019 Apr.

2.

Glucocorticoid-Induced Osteoporosis. Reply.

Humphrey MB, Buckley L.

N Engl J Med. 2019 Apr 4;380(14):1379. doi: 10.1056/NEJMc1901239. No abstract available.

PMID:
30943351
3.

Glucocorticoid-Induced Osteoporosis.

Buckley L, Humphrey MB.

N Engl J Med. 2018 Dec 27;379(26):2547-2556. doi: 10.1056/NEJMcp1800214. Review. No abstract available.

PMID:
30586507
4.

Low-level transcutaneous vagus nerve stimulation attenuates cardiac remodelling in a rat model of heart failure with preserved ejection fraction.

Zhou L, Filiberti A, Humphrey MB, Fleming CD, Scherlag BJ, Po SS, Stavrakis S.

Exp Physiol. 2019 Jan;104(1):28-38. doi: 10.1113/EP087351. Epub 2018 Nov 29.

PMID:
30398289
5.

Low-Level Vagus Nerve Stimulation Suppresses Post-Operative Atrial Fibrillation and Inflammation: A Randomized Study.

Stavrakis S, Humphrey MB, Scherlag B, Iftikhar O, Parwani P, Abbas M, Filiberti A, Fleming C, Hu Y, Garabelli P, McUnu A, Peyton M, Po SS.

JACC Clin Electrophysiol. 2017 Sep;3(9):929-938. doi: 10.1016/j.jacep.2017.02.019. Epub 2017 May 30.

6.

Immune Contributions to Osteoarthritis.

Lopes EBP, Filiberti A, Husain SA, Humphrey MB.

Curr Osteoporos Rep. 2017 Dec;15(6):593-600. doi: 10.1007/s11914-017-0411-y. Review.

PMID:
29098574
7.

Corrigendum to "Utilization of Preventive Measures for Glucocorticoid-Induced Osteoporosis among Veterans with Inflammatory Bowel Disease".

Thanou A, Ali T, Haq O, Kaitha S, Morton J, Stavrakis S, Humphrey MB.

Int Sch Res Notices. 2017 Sep 18;2017:2365840. doi: 10.1155/2017/2365840. eCollection 2017.

8.

A functional genomics predictive network model identifies regulators of inflammatory bowel disease.

Peters LA, Perrigoue J, Mortha A, Iuga A, Song WM, Neiman EM, Llewellyn SR, Di Narzo A, Kidd BA, Telesco SE, Zhao Y, Stojmirovic A, Sendecki J, Shameer K, Miotto R, Losic B, Shah H, Lee E, Wang M, Faith JJ, Kasarskis A, Brodmerkel C, Curran M, Das A, Friedman JR, Fukui Y, Humphrey MB, Iritani BM, Sibinga N, Tarrant TK, Argmann C, Hao K, Roussos P, Zhu J, Zhang B, Dobrin R, Mayer LF, Schadt EE.

Nat Genet. 2017 Oct;49(10):1437-1449. doi: 10.1038/ng.3947. Epub 2017 Sep 11.

9.

Skeletal complications of rheumatoid arthritis.

Heinlen L, Humphrey MB.

Osteoporos Int. 2017 Oct;28(10):2801-2812. doi: 10.1007/s00198-017-4170-5. Epub 2017 Aug 4. Review.

PMID:
28779302
10.

Innate Immune Responses and Osteoarthritis.

Kalaitzoglou E, Griffin TM, Humphrey MB.

Curr Rheumatol Rep. 2017 Aug;19(8):45. doi: 10.1007/s11926-017-0672-6. Review.

PMID:
28718060
11.

DOK3 Modulates Bone Remodeling by Negatively Regulating Osteoclastogenesis and Positively Regulating Osteoblastogenesis.

Cai X, Xing J, Long CL, Peng Q, Humphrey MB.

J Bone Miner Res. 2017 Nov;32(11):2207-2218. doi: 10.1002/jbmr.3205. Epub 2017 Aug 2.

12.

2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.

Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L, Rao M, Byun Robinson A, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T.

Arthritis Care Res (Hoboken). 2017 Aug;69(8):1095-1110. doi: 10.1002/acr.23279. Epub 2017 Jun 6. Review. Erratum in: Arthritis Care Res (Hoboken). 2017 Nov;69(11):1776.

13.

2017 American College of Rheumatology Guideline for the Prevention and Treatment of Glucocorticoid-Induced Osteoporosis.

Buckley L, Guyatt G, Fink HA, Cannon M, Grossman J, Hansen KE, Humphrey MB, Lane NE, Magrey M, Miller M, Morrison L, Rao M, Robinson AB, Saha S, Wolver S, Bannuru RR, Vaysbrot E, Osani M, Turgunbaev M, Miller AS, McAlindon T.

Arthritis Rheumatol. 2017 Aug;69(8):1521-1537. doi: 10.1002/art.40137. Epub 2017 Jun 6. Review. Erratum in: Arthritis Rheumatol. 2017 Nov;69(11):2246.

14.

Parallel mechanisms suppress cochlear bone remodeling to protect hearing.

Jáuregui EJ, Akil O, Acevedo C, Hall-Glenn F, Tsai BS, Bale HA, Liebenberg E, Humphrey MB, Ritchie RO, Lustig LR, Alliston T.

Bone. 2016 Aug;89:7-15. doi: 10.1016/j.bone.2016.04.010. Epub 2016 Apr 13.

15.

Differential effects of IGF-1 deficiency during the life span on structural and biomechanical properties in the tibia of aged mice.

Ashpole NM, Herron JC, Estep PN, Logan S, Hodges EL, Yabluchanskiy A, Humphrey MB, Sonntag WE.

Age (Dordr). 2016 Apr;38(2):38. doi: 10.1007/s11357-016-9902-5. Epub 2016 Mar 11.

16.

A Comprehensive Review of Immunoreceptor Regulation of Osteoclasts.

Humphrey MB, Nakamura MC.

Clin Rev Allergy Immunol. 2016 Aug;51(1):48-58. doi: 10.1007/s12016-015-8521-8. Review.

17.

The TREM2-DAP12 signaling pathway in Nasu-Hakola disease: a molecular genetics perspective.

Xing J, Titus AR, Humphrey MB.

Res Rep Biochem. 2015;5:89-100. Epub 2015 Mar 17.

18.

Reply: Vagal Modulation of Atrial Fibrillation.

Stavrakis S, Humphrey MB, Po SS.

J Am Coll Cardiol. 2015 Aug 25;66(8):978. doi: 10.1016/j.jacc.2015.06.1086. No abstract available.

19.

IGF-1 Regulates Vertebral Bone Aging Through Sex-Specific and Time-Dependent Mechanisms.

Ashpole NM, Herron JC, Mitschelen MC, Farley JA, Logan S, Yan H, Ungvari Z, Hodges EL, Csiszar A, Ikeno Y, Humphrey MB, Sonntag WE.

J Bone Miner Res. 2016 Feb;31(2):443-54. doi: 10.1002/jbmr.2689. Epub 2015 Sep 3.

20.

Low-level transcutaneous electrical vagus nerve stimulation suppresses atrial fibrillation.

Stavrakis S, Humphrey MB, Scherlag BJ, Hu Y, Jackman WM, Nakagawa H, Lockwood D, Lazzara R, Po SS.

J Am Coll Cardiol. 2015 Mar 10;65(9):867-75. doi: 10.1016/j.jacc.2014.12.026.

21.

Medication-induced osteoporosis: screening and treatment strategies.

Panday K, Gona A, Humphrey MB.

Ther Adv Musculoskelet Dis. 2014 Oct;6(5):185-202. doi: 10.1177/1759720X14546350. Review.

22.

Genome-wide DNA methylation study identifies significant epigenomic changes in osteoarthritic cartilage.

Jeffries MA, Donica M, Baker LW, Stevenson ME, Annan AC, Humphrey MB, James JA, Sawalha AH.

Arthritis Rheumatol. 2014 Oct;66(10):2804-15. doi: 10.1002/art.38762.

23.

Editorial: lipid kinases and bone homeostasis: lessons learned from phosphoinositide 3-kinase isoform-specific knockouts.

Xing J, Humphrey MB.

Arthritis Rheumatol. 2014 Aug;66(8):1984-6. doi: 10.1002/art.38661. No abstract available.

24.

A physical interaction between the adaptor proteins DOK3 and DAP12 is required to inhibit lipopolysaccharide signaling in macrophages.

Peng Q, Long CL, Malhotra S, Humphrey MB.

Sci Signal. 2013 Aug 20;6(289):ra72. doi: 10.1126/scisignal.2003801.

25.

A TRPC1 protein-dependent pathway regulates osteoclast formation and function.

Ong EC, Nesin V, Long CL, Bai CX, Guz JL, Ivanov IP, Abramowitz J, Birnbaumer L, Humphrey MB, Tsiokas L.

J Biol Chem. 2013 Aug 2;288(31):22219-32. doi: 10.1074/jbc.M113.459826. Epub 2013 Jun 14.

26.

Utilization of Preventive Measures for Glucocorticoid-Induced Osteoporosis among Veterans with Inflammatory Bowel Disease.

Thanou A, Ali T, Haq O, Kaitha S, Morton J, Stavrakis S, Humphrey MB.

ISRN Gastroenterol. 2013 Apr 21;2013:862312. doi: 10.1155/2013/862312. Print 2013. Erratum in: Int Sch Res Notices. 2017 Sep 18;2017:2365840.

27.

Comparison of titanium soaked in 5 M NaOH or 5 M KOH solutions.

Kim C, Kendall MR, Miller MA, Long CL, Larson PR, Humphrey MB, Madden AS, Tas AC.

Mater Sci Eng C Mater Biol Appl. 2013 Jan 1;33(1):327-39.

28.

Macrophage metalloelastase (MMP-12) deficiency mitigates retinal inflammation and pathological angiogenesis in ischemic retinopathy.

Li J, Wang JJ, Peng Q, Chen C, Humphrey MB, Heinecke J, Zhang SX.

PLoS One. 2012;7(12):e52699. doi: 10.1371/journal.pone.0052699. Epub 2012 Dec 20.

29.

Cardiac myxoma induced paraneoplastic syndromes: a review of the literature.

Smith M, Chaudhry MA, Lozano P, Humphrey MB.

Eur J Intern Med. 2012 Dec;23(8):669-73. doi: 10.1016/j.ejim.2012.05.015. Epub 2012 Jun 30. Review.

PMID:
23122392
30.

E proteins regulate osteoclast maturation and survival.

Long CL, Berry WL, Zhao Y, Sun XH, Humphrey MB.

J Bone Miner Res. 2012 Dec;27(12):2476-89. doi: 10.1002/jbmr.1707.

31.

DOK3 negatively regulates LPS responses and endotoxin tolerance.

Peng Q, O'Loughlin JL, Humphrey MB.

PLoS One. 2012;7(6):e39967. doi: 10.1371/journal.pone.0039967. Epub 2012 Jun 27.

32.
33.

CD73-generated adenosine promotes osteoblast differentiation.

Takedachi M, Oohara H, Smith BJ, Iyama M, Kobashi M, Maeda K, Long CL, Humphrey MB, Stoecker BJ, Toyosawa S, Thompson LF, Murakami S.

J Cell Physiol. 2012 Jun;227(6):2622-31. doi: 10.1002/jcp.23001.

34.

Atrial myxoma and bone changes: a paraneoplastic syndrome?

Smith MJ, Chaudhry MA, Humphrey MB, Lozano PM.

J Card Surg. 2011 Jul;26(4):375-7. doi: 10.1111/j.1540-8191.2011.01277.x.

PMID:
21793924
35.

Chronic exposure to a TLR ligand injures hematopoietic stem cells.

Esplin BL, Shimazu T, Welner RS, Garrett KP, Nie L, Zhang Q, Humphrey MB, Yang Q, Borghesi LA, Kincade PW.

J Immunol. 2011 May 1;186(9):5367-75. doi: 10.4049/jimmunol.1003438. Epub 2011 Mar 25.

36.

Association of a functional variant downstream of TNFAIP3 with systemic lupus erythematosus.

Adrianto I, Wen F, Templeton A, Wiley G, King JB, Lessard CJ, Bates JS, Hu Y, Kelly JA, Kaufman KM, Guthridge JM, Alarcón-Riquelme ME; BIOLUPUS and GENLES Networks, Anaya JM, Bae SC, Bang SY, Boackle SA, Brown EE, Petri MA, Gallant C, Ramsey-Goldman R, Reveille JD, Vila LM, Criswell LA, Edberg JC, Freedman BI, Gregersen PK, Gilkeson GS, Jacob CO, James JA, Kamen DL, Kimberly RP, Martin J, Merrill JT, Niewold TB, Park SY, Pons-Estel BA, Scofield RH, Stevens AM, Tsao BP, Vyse TJ, Langefeld CD, Harley JB, Moser KL, Webb CF, Humphrey MB, Montgomery CG, Gaffney PM.

Nat Genet. 2011 Mar;43(3):253-8. doi: 10.1038/ng.766. Epub 2011 Feb 20.

37.

Tissue-specific calibration of extracellular matrix material properties by transforming growth factor-β and Runx2 in bone is required for hearing.

Chang JL, Brauer DS, Johnson J, Chen CG, Akil O, Balooch G, Humphrey MB, Chin EN, Porter AE, Butcher K, Ritchie RO, Schneider RA, Lalwani A, Derynck R, Marshall GW, Marshall SJ, Lustig L, Alliston T.

EMBO Rep. 2010 Oct;11(10):765-71. doi: 10.1038/embor.2010.135. Epub 2010 Sep 17.

38.

TREM2- and DAP12-dependent activation of PI3K requires DAP10 and is inhibited by SHIP1.

Peng Q, Malhotra S, Torchia JA, Kerr WG, Coggeshall KM, Humphrey MB.

Sci Signal. 2010 May 18;3(122):ra38. doi: 10.1126/scisignal.2000500.

39.

IL-10 suppresses calcium-mediated costimulation of receptor activator NF-kappa B signaling during human osteoclast differentiation by inhibiting TREM-2 expression.

Park-Min KH, Ji JD, Antoniv T, Reid AC, Silver RB, Humphrey MB, Nakamura M, Ivashkiv LB.

J Immunol. 2009 Aug 15;183(4):2444-55. doi: 10.4049/jimmunol.0804165. Epub 2009 Jul 22.

40.

Osteoporosis in inflammatory bowel disease.

Ali T, Lam D, Bronze MS, Humphrey MB.

Am J Med. 2009 Jul;122(7):599-604. doi: 10.1016/j.amjmed.2009.01.022. Review.

41.

Meta-analysis and imputation identifies a 109 kb risk haplotype spanning TNFAIP3 associated with lupus nephritis and hematologic manifestations.

Bates JS, Lessard CJ, Leon JM, Nguyen T, Battiest LJ, Rodgers J, Kaufman KM, James JA, Gilkeson GS, Kelly JA, Humphrey MB, Harley JB, Gray-McGuire C, Moser KL, Gaffney PM.

Genes Immun. 2009 Jul;10(5):470-7. doi: 10.1038/gene.2009.31. Epub 2009 Apr 23.

42.

The innate immune response to Salmonella enterica serovar Typhimurium by macrophages is dependent on TREM2-DAP12.

Charles JF, Humphrey MB, Zhao X, Quarles E, Nakamura MC, Aderem A, Seaman WE, Smith KD.

Infect Immun. 2008 Jun;76(6):2439-47. doi: 10.1128/IAI.00115-08. Epub 2008 Apr 7.

43.

Osteoclasts - the innate immune cells of the bone.

Wu Y, Humphrey MB, Nakamura MC.

Autoimmunity. 2008 Apr;41(3):183-94. doi: 10.1080/08916930701693180. Review.

PMID:
18365831
44.

Bone microenvironment specific roles of ITAM adapter signaling during bone remodeling induced by acute estrogen-deficiency.

Wu Y, Torchia J, Yao W, Lane NE, Lanier LL, Nakamura MC, Humphrey MB.

PLoS One. 2007 Jul 4;2(7):e586.

45.

Cutting edge: inhibition of TLR and FcR responses in macrophages by triggering receptor expressed on myeloid cells (TREM)-2 and DAP12.

Hamerman JA, Jarjoura JR, Humphrey MB, Nakamura MC, Seaman WE, Lanier LL.

J Immunol. 2006 Aug 15;177(4):2051-5.

46.

TREM2, a DAP12-associated receptor, regulates osteoclast differentiation and function.

Humphrey MB, Daws MR, Spusta SC, Niemi EC, Torchia JA, Lanier LL, Seaman WE, Nakamura MC.

J Bone Miner Res. 2006 Feb;21(2):237-45. Epub 2005 Oct 20.

47.

Role of ITAM-containing adapter proteins and their receptors in the immune system and bone.

Humphrey MB, Lanier LL, Nakamura MC.

Immunol Rev. 2005 Dec;208:50-65. Review.

PMID:
16313340
48.

Mice lacking the integrin beta5 subunit have accelerated osteoclast maturation and increased activity in the estrogen-deficient state.

Lane NE, Yao W, Nakamura MC, Humphrey MB, Kimmel D, Huang X, Sheppard D, Ross FP, Teitelbaum SL.

J Bone Miner Res. 2005 Jan;20(1):58-66. Epub 2004 Oct 25.

49.

The immunomodulatory adapter proteins DAP12 and Fc receptor gamma-chain (FcRgamma) regulate development of functional osteoclasts through the Syk tyrosine kinase.

Mócsai A, Humphrey MB, Van Ziffle JA, Hu Y, Burghardt A, Spusta SC, Majumdar S, Lanier LL, Lowell CA, Nakamura MC.

Proc Natl Acad Sci U S A. 2004 Apr 20;101(16):6158-63. Epub 2004 Apr 8.

50.

The signaling adapter protein DAP12 regulates multinucleation during osteoclast development.

Humphrey MB, Ogasawara K, Yao W, Spusta SC, Daws MR, Lane NE, Lanier LL, Nakamura MC.

J Bone Miner Res. 2004 Feb;19(2):224-34. Epub 2003 Dec 16.

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