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Items: 42

1.

Stated-preference research in HIV: A scoping review.

Humphrey JM, Naanyu V, MacDonald KR, Wools-Kaloustian K, Zimet GD.

PLoS One. 2019 Oct 30;14(10):e0224566. doi: 10.1371/journal.pone.0224566. eCollection 2019.

2.

Viral suppression among children and their caregivers living with HIV in western Kenya.

Humphrey JM, Genberg BL, Keter A, Musick B, Apondi E, Gardner A, Hogan JW, Wools-Kaloustian K.

J Int AIDS Soc. 2019 Apr;22(4):e25272. doi: 10.1002/jia2.25272.

3.

Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar.

Humphrey JM, Al-Absi ES, Hamdan MM, Okasha SS, Al-Trmanini DM, El-Dous HG, Dargham SR, Schieffelin J, Abu-Raddad LJ, Nasrallah GK.

PLoS One. 2019 Jan 31;14(1):e0211574. doi: 10.1371/journal.pone.0211574. eCollection 2019.

4.

Synthesis of Pyridopyrazine-1,6-dione γ-Secretase Modulators via Selective 4-Methylimidazole N1-Buchwald Arylation.

Xie L, Am Ende CW, Pettersson M, Rankic DA, Sach NW, Sakya S, Humphrey JM.

J Org Chem. 2019 Apr 19;84(8):4921-4925. doi: 10.1021/acs.joc.8b02953. Epub 2019 Jan 23.

PMID:
30620601
5.

Achieving UNAIDS 90-90-90 targets for pregnant and postpartum women in sub-Saharan Africa: progress, gaps and research needs.

Abuogi LL, Humphrey JM, Mpody C, Yotebieng M, Murnane PM, Clouse K, Otieno L, Cohen CR, Wools-Kaloustian K.

J Virus Erad. 2018 Nov 15;4(Suppl 2):33-39.

6.

Implementing a mobile diagnostic unit to increase access to imaging and laboratory services in western Kenya.

Dhoot R, Humphrey JM, O'Meara P, Gardner A, McDonald CJ, Ogot K, Antani S, Abuya J, Kohli M.

BMJ Glob Health. 2018 Oct 8;3(5):e000947. doi: 10.1136/bmjgh-2018-000947. eCollection 2018.

7.

2,2,2-Trifluoroethoxy Aromatic Heterocycles: Hydrolytically Stable Alternatives to Heteroaryl Chlorides.

Fisher EL, Am Ende CW, Humphrey JM.

J Org Chem. 2019 Apr 19;84(8):4904-4909. doi: 10.1021/acs.joc.8b02453. Epub 2018 Oct 29.

PMID:
30339369
8.

Trends Over Time for Adolescents Enrolling in HIV Care in Kenya, Tanzania, and Uganda From 2001-2014.

Apondi E, Humphrey JM, Sang E, Mwangi A, Keter A, Musick BS, Nalugoda FK, Ssali J, Bukusi E, Yiannoutsos CT, Wools-Kaloustian K, Ayaya S.

J Acquir Immune Defic Syndr. 2018 Oct 1;79(2):164-172. doi: 10.1097/QAI.0000000000001796.

9.

Sulfonamide Synthesis via Calcium Triflimide Activation of Sulfonyl Fluorides.

Mukherjee P, Woroch CP, Cleary L, Rusznak M, Franzese RW, Reese MR, Tucker JW, Humphrey JM, Etuk SM, Kwan SC, Am Ende CW, Ball ND.

Org Lett. 2018 Jul 6;20(13):3943-3947. doi: 10.1021/acs.orglett.8b01520. Epub 2018 Jun 11.

10.

Discovery of Potent and Selective Periphery-Restricted Quinazoline Inhibitors of the Cyclic Nucleotide Phosphodiesterase PDE1.

Humphrey JM, Movsesian M, Am Ende CW, Becker SL, Chappie TA, Jenkinson S, Liras JL, Liras S, Orozco C, Pandit J, Vajdos FF, Vandeput F, Yang E, Menniti FS.

J Med Chem. 2018 May 24;61(10):4635-4640. doi: 10.1021/acs.jmedchem.8b00374. Epub 2018 May 10.

PMID:
29718668
11.

Correction to Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, LaChapelle EA, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.

J Med Chem. 2018 Apr 26;61(8):3753. doi: 10.1021/acs.jmedchem.8b00475. Epub 2018 Apr 6. No abstract available.

PMID:
29624389
12.

Introduction of a Crystalline, Shelf-Stable Reagent for the Synthesis of Sulfur(VI) Fluorides.

Zhou H, Mukherjee P, Liu R, Evrard E, Wang D, Humphrey JM, Butler TW, Hoth LR, Sperry JB, Sakata SK, Helal CJ, Am Ende CW.

Org Lett. 2018 Feb 2;20(3):812-815. doi: 10.1021/acs.orglett.7b03950. Epub 2018 Jan 12.

PMID:
29327935
13.

Identification of a Potent, Highly Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor Clinical Candidate.

Helal CJ, Arnold E, Boyden T, Chang C, Chappie TA, Fisher E, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Pandit J, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, McGinnis D, O'Connor RE, O'Donnell CJ, Ogden A, Piotrowski M, Schmidt CJ, Seymour PA, Ueno H, Vansell N, Verhoest PR, Yang EX.

J Med Chem. 2018 Feb 8;61(3):1001-1018. doi: 10.1021/acs.jmedchem.7b01466. Epub 2018 Jan 16.

PMID:
29293004
14.

Protocol for the Direct Conversion of Lactones to Lactams Mediated by 1,5,7-Triazabicyclo[4.4.0]dec-5-ene: Synthesis of Pyridopyrazine-1,6-diones.

Rankic DA, Stiff CM, Am Ende CW, Humphrey JM.

J Org Chem. 2017 Dec 1;82(23):12791-12797. doi: 10.1021/acs.joc.7b02079. Epub 2017 Nov 1.

PMID:
29049875
15.

The Discovery of a Novel Phosphodiesterase (PDE) 4B-Preferring Radioligand for Positron Emission Tomography (PET) Imaging.

Zhang L, Chen L, Beck EM, Chappie TA, Coelho RV, Doran SD, Fan KH, Helal CJ, Humphrey JM, Hughes Z, Kuszpit K, Lachapelle EA, Lazzaro JT, Lee C, Mather RJ, Patel NC, Skaddan MB, Sciabola S, Verhoest PR, Young JM, Zasadny K, Villalobos A.

J Med Chem. 2017 Oct 26;60(20):8538-8551. doi: 10.1021/acs.jmedchem.7b01050. Epub 2017 Oct 9.

PMID:
28957634
16.

Urban Chikungunya in the Middle East and North Africa: A systematic review.

Humphrey JM, Cleton NB, Reusken CBEM, Glesby MJ, Koopmans MPG, Abu-Raddad LJ.

PLoS Negl Trop Dis. 2017 Jun 26;11(6):e0005707. doi: 10.1371/journal.pntd.0005707. eCollection 2017 Jun. Review.

17.

Application of Structure-Based Design and Parallel Chemistry to Identify a Potent, Selective, and Brain Penetrant Phosphodiesterase 2A Inhibitor.

Helal CJ, Arnold EP, Boyden TL, Chang C, Chappie TA, Fennell KF, Forman MD, Hajos M, Harms JF, Hoffman WE, Humphrey JM, Kang Z, Kleiman RJ, Kormos BL, Lee CW, Lu J, Maklad N, McDowell L, Mente S, O'Connor RE, Pandit J, Piotrowski M, Schmidt AW, Schmidt CJ, Ueno H, Verhoest PR, Yang EX.

J Med Chem. 2017 Jul 13;60(13):5673-5698. doi: 10.1021/acs.jmedchem.7b00397. Epub 2017 Jun 16. Erratum in: J Med Chem. 2018 Apr 26;61(8):3753.

PMID:
28574706
18.

Multiplex Polymerase Chain Reaction for Detection of Gastrointestinal Pathogens in Migrant Workers in Qatar.

Humphrey JM, Ranbhise S, Ibrahim E, Al-Romaihi HE, Farag E, Abu-Raddad LJ, Glesby MJ.

Am J Trop Med Hyg. 2016 Dec 7;95(6):1330-1337. doi: 10.4269/ajtmh.16-0464. Epub 2016 Oct 10.

19.

Dengue in the Middle East and North Africa: A Systematic Review.

Humphrey JM, Cleton NB, Reusken CB, Glesby MJ, Koopmans MP, Abu-Raddad LJ.

PLoS Negl Trop Dis. 2016 Dec 7;10(12):e0005194. doi: 10.1371/journal.pntd.0005194. eCollection 2016 Dec. Review.

20.

Invasive Aspergillus Sinusitis in Human Immunodeficiency Virus Infection: Case Report and Review of the Literature.

Humphrey JM, Walsh TJ, Gulick RM.

Open Forum Infect Dis. 2016 Jul 26;3(3):ofw135. eCollection 2016 Sep. Review.

21.

Discovery of cyclopropyl chromane-derived pyridopyrazine-1,6-dione γ-secretase modulators with robust central efficacy.

Pettersson M, Johnson DS, Rankic DA, Kauffman GW, Am Ende CW, Butler TW, Boscoe B, Evrard E, Helal CJ, Humphrey JM, Stepan AF, Stiff CM, Yang E, Xie L, Bales KR, Hajos-Korcsok E, Jenkinson S, Pettersen B, Pustilnik LR, Ramirez DS, Steyn SJ, Wood KM, Verhoest PR.

Medchemcomm. 2016 Nov 2;8(4):730-743. doi: 10.1039/c6md00406g. eCollection 2017 Apr 1.

22.

Luteinizing Hormone Causes Phosphorylation and Activation of the cGMP Phosphodiesterase PDE5 in Rat Ovarian Follicles, Contributing, Together with PDE1 Activity, to the Resumption of Meiosis.

Egbert JR, Uliasz TF, Shuhaibar LC, Geerts A, Wunder F, Kleiman RJ, Humphrey JM, Lampe PD, Artemyev NO, Rybalkin SD, Beavo JA, Movsesian MA, Jaffe LA.

Biol Reprod. 2016 May;94(5):110. doi: 10.1095/biolreprod.115.135897. Epub 2016 Mar 23.

23.

Prosthetic-Joint-Associated Bordetella holmesii Infection.

Humphrey JM, Lacaille SN, Patel K, Thompson E, Tulumba S, Healey JH, Gilhuley KA, Babady NE, Kamboj M, Mead PA.

Open Forum Infect Dis. 2015 Nov 13;2(4):ofv169. doi: 10.1093/ofid/ofv169. eCollection 2015 Dec.

24.

Design of Pyridopyrazine-1,6-dione γ-Secretase Modulators that Align Potency, MDR Efflux Ratio, and Metabolic Stability.

Pettersson M, Johnson DS, Humphrey JM, Butler TW, Am Ende CW, Fish BA, Green ME, Kauffman GW, Mullins PB, O'Donnell CJ, Stepan AF, Stiff CM, Subramanyam C, Tran TP, Vetelino BC, Yang E, Xie L, Bales KR, Pustilnik LR, Steyn SJ, Wood KM, Verhoest PR.

ACS Med Chem Lett. 2015 Apr 3;6(5):596-601. doi: 10.1021/acsmedchemlett.5b00070. eCollection 2015 May 14.

25.

Discovery of indole-derived pyridopyrazine-1,6-dione γ-secretase modulators that target presenilin.

Pettersson M, Johnson DS, Humphrey JM, Am Ende CW, Evrard E, Efremov I, Kauffman GW, Stepan AF, Stiff CM, Xie L, Bales KR, Hajos-Korcsok E, Murrey HE, Pustilnik LR, Steyn SJ, Wood KM, Verhoest PR.

Bioorg Med Chem Lett. 2015 Feb 15;25(4):908-13. doi: 10.1016/j.bmcl.2014.12.059. Epub 2014 Dec 25.

PMID:
25582600
26.

High-degree atrioventricular block in a child with acute myocarditis.

Caughey RW, Humphrey JM, Thomas PE.

Ochsner J. 2014 Summer;14(2):244-7.

27.

Design and selection parameters to accelerate the discovery of novel central nervous system positron emission tomography (PET) ligands and their application in the development of a novel phosphodiesterase 2A PET ligand.

Zhang L, Villalobos A, Beck EM, Bocan T, Chappie TA, Chen L, Grimwood S, Heck SD, Helal CJ, Hou X, Humphrey JM, Lu J, Skaddan MB, McCarthy TJ, Verhoest PR, Wager TT, Zasadny K.

J Med Chem. 2013 Jun 13;56(11):4568-79. doi: 10.1021/jm400312y. Epub 2013 May 28.

PMID:
23651455
28.

Synthesis of α,α-difluoroethyl aryl and heteroaryl ethers.

Yang E, Reese MR, Humphrey JM.

Org Lett. 2012 Aug 3;14(15):3944-7. doi: 10.1021/ol301696x. Epub 2012 Jul 20.

PMID:
22817683
29.

Use of structure-based design to discover a potent, selective, in vivo active phosphodiesterase 10A inhibitor lead series for the treatment of schizophrenia.

Helal CJ, Kang Z, Hou X, Pandit J, Chappie TA, Humphrey JM, Marr ES, Fennell KF, Chenard LK, Fox C, Schmidt CJ, Williams RD, Chapin DS, Siuciak J, Lebel L, Menniti F, Cianfrogna J, Fonseca KR, Nelson FR, O'Connor R, MacDougall M, McDowell L, Liras S.

J Med Chem. 2011 Jul 14;54(13):4536-47. doi: 10.1021/jm2001508. Epub 2011 Jun 8.

PMID:
21650160
30.

Diastereoselective synthesis of 2,3,6-trisubstituted piperidines.

Humphrey JM, Arnold EP, Chappie TA, Feltenberger JB, Nagel A, Simon W, Suarez-Contreras M, Tom NJ, O'Neill BT.

J Org Chem. 2009 Jun 19;74(12):4525-36. doi: 10.1021/jo9003184.

PMID:
19441779
31.

Phosphodiesterase 10A inhibitors: a novel approach to the treatment of the symptoms of schizophrenia.

Menniti FS, Chappie TA, Humphrey JM, Schmidt CJ.

Curr Opin Investig Drugs. 2007 Jan;8(1):54-9. Review.

PMID:
17263185
32.

Discovery of a series of 6,7-dimethoxy-4-pyrrolidylquinazoline PDE10A inhibitors.

Chappie TA, Humphrey JM, Allen MP, Estep KG, Fox CB, Lebel LA, Liras S, Marr ES, Menniti FS, Pandit J, Schmidt CJ, Tu M, Williams RD, Yang FV.

J Med Chem. 2007 Jan 25;50(2):182-5.

PMID:
17228859
33.

Clinical outcomes for permanent incisor luxations in a pediatric population. I. Intrusions.

Humphrey JM, Kenny DJ, Barrett EJ.

Dent Traumatol. 2003 Oct;19(5):266-73.

PMID:
14708651
34.

Medicinal chemistry of selective neurokinin-1 antagonists.

Humphrey JM.

Curr Top Med Chem. 2003;3(12):1423-35. Review.

PMID:
12871173
35.

Enantioselective total syntheses of manzamine a and related alkaloids.

Humphrey JM, Liao Y, Ali A, Rein T, Wong YL, Chen HJ, Courtney AK, Martin SF.

J Am Chem Soc. 2002 Jul 24;124(29):8584-92.

PMID:
12121099
36.

Chemical Synthesis of Natural Product Peptides: Coupling Methods for the Incorporation of Noncoded Amino Acids into Peptides.

Humphrey JM, Chamberlin AR.

Chem Rev. 1997 Oct 1;97(6):2243-2266. No abstract available.

PMID:
11848900
37.

The synthesis of homoallylic amines utilizing a cuprate-based 1,2-metalate rearrangement.

Neipp CE, Humphrey JM, Martin SF.

J Org Chem. 2001 Jan 26;66(2):531-7.

PMID:
11429825
38.

Differentiation of substrate and nonsubstrate inhibitors of the high-affinity, sodium-dependent glutamate transporters.

Koch HP, Kavanaugh MP, Esslinger CS, Zerangue N, Humphrey JM, Amara SG, Chamberlin AR, Bridges RJ.

Mol Pharmacol. 1999 Dec;56(6):1095-104.

PMID:
10570036
39.
40.

Methylation of the NMDA receptor agonist L-trans-2,3-pyrrolidine-dicarboxylate: enhanced excitotoxic potency and selectivity.

Willis CL, Dauenhauer DL, Humphrey JM, Chamberlin AR, Buller AL, Monaghan DT, Bridges RJ.

Toxicol Appl Pharmacol. 1997 May;144(1):45-55.

PMID:
9169068
41.

L-trans-2,3-pyrrolidine dicarboxylate: characterization of a novel excitotoxin.

Willis CL, Humphrey JM, Koch HP, Hart JA, Blakely T, Ralston L, Baker CA, Shim S, Kadri M, Chamberlin AR, Bridges RJ.

Neuropharmacology. 1996 May;35(5):531-9.

PMID:
8887961
42.

Parasites of man and domestic animals in vietnam, Thailand, Laos, and Cambodia.

Segal DB, Humphrey JM, Edwards SJ, Kirby MD.

Exp Parasitol. 1968 Dec;23(3):412-64. Review. No abstract available.

PMID:
4882998

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