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Induced Chromosomal Aneuploidy Results in Global and Consistent Deregulation of the Transcriptome of Cancer Cells.

Wangsa D, Braun R, Stuelten CH, Brown M, Bauer KM, Emons G, Weston LA, Hu Y, Yang HH, Vila-Casades├║s M, Lee MP, Brauer P, Warner L, Upender M, Hummon AB, Camps J, Ried T.

Neoplasia. 2019 Jul;21(7):721-729. doi: 10.1016/j.neo.2019.04.009. Epub 2019 Jun 4.


Capillary Zone Electrophoresis-Tandem Mass Spectrometry for Large-Scale Phosphoproteomics with the Production of over 11,000 Phosphopeptides from the Colon Carcinoma HCT116 Cell Line.

Chen D, Ludwig KR, Krokhin OV, Spicer V, Yang Z, Shen X, Hummon AB, Sun L.

Anal Chem. 2019 Feb 5;91(3):2201-2208. doi: 10.1021/acs.analchem.8b04770. Epub 2019 Jan 23.


MALDI-MSI of Immunotherapy: Mapping the EGFR-Targeting Antibody Cetuximab in 3D Colon-Cancer Cell Cultures.

Liu X, Lukowski JK, Flinders C, Kim S, Georgiadis RA, Mumenthaler SM, Hummon AB.

Anal Chem. 2018 Dec 18;90(24):14156-14164. doi: 10.1021/acs.analchem.8b02151. Epub 2018 Dec 7.


Electronic Cigarettes and the Lung Proteome.

Shields PG, Song MA, Freudenheim JL, Brasky TM, Mathe E, McElroy JP, Hummon AB, Wewers MD.

Am J Respir Crit Care Med. 2018 Nov 15;198(10):1350-1351. doi: 10.1164/rccm.201806-1151LE. No abstract available.


Combined Short-Term Glucose Starvation and Chemotherapy in 3D Colorectal Cancer Cell Culture Decreases 14-3-3 Family Protein Expression and Phenotypic Response to Therapy.

Schroll MM, Ludwig KR, LaBonia GJ, Herring EL, Hummon AB.

J Am Soc Mass Spectrom. 2018 Oct;29(10):2012-2022. doi: 10.1007/s13361-018-2013-z. Epub 2018 Jul 17.


Employing proteomics to understand the effects of nutritional intervention in cancer treatment.

Schroll MM, Hummon AB.

Anal Bioanal Chem. 2018 Oct;410(25):6371-6386. doi: 10.1007/s00216-018-1219-z. Epub 2018 Jul 4. Review.


Comparison of In-Solution, FASP, and S-Trap Based Digestion Methods for Bottom-Up Proteomic Studies.

Ludwig KR, Schroll MM, Hummon AB.

J Proteome Res. 2018 Jul 6;17(7):2480-2490. doi: 10.1021/acs.jproteome.8b00235. Epub 2018 May 24.


Quantitative proteomic analysis of murine white adipose tissue for peritoneal cancer metastasis.

Feist PE, Loughran EA, Stack MS, Hummon AB.

Anal Bioanal Chem. 2018 Feb;410(5):1583-1594. doi: 10.1007/s00216-017-0813-9. Epub 2017 Dec 27.


iTRAQ Quantitative Proteomic Profiling and MALDI-MSI of Colon Cancer Spheroids Treated with Combination Chemotherapies in a 3D Printed Fluidic Device.

LaBonia GJ, Ludwig KR, Mousseau CB, Hummon AB.

Anal Chem. 2018 Jan 16;90(2):1423-1430. doi: 10.1021/acs.analchem.7b04969. Epub 2017 Dec 21.


MALDI Mass Spectrometry Imaging for Evaluation of Therapeutics in Colorectal Tumor Organoids.

Liu X, Flinders C, Mumenthaler SM, Hummon AB.

J Am Soc Mass Spectrom. 2018 Mar;29(3):516-526. doi: 10.1007/s13361-017-1851-4. Epub 2017 Dec 5.


Chemical Analysis of Morphological Changes in Lysophosphatidic Acid-Treated Ovarian Cancer Cells.

Bailey KA, Klymenko Y, Feist PE, Hummon AB, Stack MS, Schultz ZD.

Sci Rep. 2017 Nov 10;7(1):15295. doi: 10.1038/s41598-017-15547-7.


Magnetic bead-based peptide extraction methodology for tissue imaging.

Andrews WT, Skube SB, Hummon AB.

Analyst. 2017 Dec 18;143(1):133-140. doi: 10.1039/c7an00757d.


Discovery of leucokinin-like neuropeptides that modulate a specific parameter of feeding motor programs in the molluscan model, Aplysia.

Zhang G, Vilim FS, Liu DD, Romanova EV, Yu K, Yuan WD, Xiao H, Hummon AB, Chen TT, Alexeeva V, Yin SY, Chen SA, Cropper EC, Sweedler JV, Weiss KR, Jing J.

J Biol Chem. 2017 Nov 17;292(46):18775-18789. doi: 10.1074/jbc.M117.795450. Epub 2017 Sep 18.


Analyzing Liposomal Drug Delivery Systems in Three-Dimensional Cell Culture Models Using MALDI Imaging Mass Spectrometry.

Lukowski JK, Weaver EM, Hummon AB.

Anal Chem. 2017 Aug 15;89(16):8453-8458. doi: 10.1021/acs.analchem.7b02006. Epub 2017 Aug 4.


Assessing chemotherapeutic effectiveness using a paper-based tumor model.

Boyce MW, LaBonia GJ, Hummon AB, Lockett MR.

Analyst. 2017 Jul 24;142(15):2819-2827. doi: 10.1039/c7an00806f.


Glucose Restriction Combined with Autophagy Inhibition and Chemotherapy in HCT 116 Spheroids Decreases Cell Clonogenicity and Viability Regulated by Tumor Suppressor Genes.

Schroll MM, LaBonia GJ, Ludwig KR, Hummon AB.

J Proteome Res. 2017 Aug 4;16(8):3009-3018. doi: 10.1021/acs.jproteome.7b00293. Epub 2017 Jul 3.


Mass spectrometry for the discovery of biomarkers of sepsis.

Ludwig KR, Hummon AB.

Mol Biosyst. 2017 Mar 28;13(4):648-664. doi: 10.1039/c6mb00656f. Review.


Multicellular Tumor Spheroids Combined with Mass Spectrometric Histone Analysis To Evaluate Epigenetic Drugs.

Feist PE, Sidoli S, Liu X, Schroll MM, Rahmy S, Fujiwara R, Garcia BA, Hummon AB.

Anal Chem. 2017 Mar 7;89(5):2773-2781. doi: 10.1021/acs.analchem.6b03602. Epub 2017 Feb 21.


Phosphoproteomics of colon cancer metastasis: comparative mass spectrometric analysis of the isogenic primary and metastatic cell lines SW480 and SW620.

Schunter AJ, Yue X, Hummon AB.

Anal Bioanal Chem. 2017 Mar;409(7):1749-1763. doi: 10.1007/s00216-016-0125-5. Epub 2016 Dec 16.


Chemical Imaging of Platinum-Based Drugs and their Metabolites.

Liu X, Hummon AB.

Sci Rep. 2016 Dec 5;6:38507. doi: 10.1038/srep38507.


Nutrient restriction of glucose or serum results in similar proteomic expression changes in 3D colon cancer cell cultures.

Schroll MM, Liu X, Herzog SK, Skube SB, Hummon AB.

Nutr Res. 2016 Oct;36(10):1068-1080. doi: 10.1016/j.nutres.2016.08.002. Epub 2016 Aug 14.


Quantitative Proteomic and Phosphoproteomic Comparison of 2D and 3D Colon Cancer Cell Culture Models.

Yue X, Lukowski JK, Weaver EM, Skube SB, Hummon AB.

J Proteome Res. 2016 Dec 2;15(12):4265-4276. Epub 2016 Oct 10.


Drug penetration and metabolism in 3D cell cultures treated in a 3D printed fluidic device: assessment of irinotecan via MALDI imaging mass spectrometry.

LaBonia GJ, Lockwood SY, Heller AA, Spence DM, Hummon AB.

Proteomics. 2016 Jun;16(11-12):1814-21. doi: 10.1002/pmic.201500524.


Evaluation of the mirn23a Cluster through an iTRAQ-based Quantitative Proteomic Approach.

Ludwig KR, Dahl R, Hummon AB.

J Proteome Res. 2016 May 6;15(5):1497-505. doi: 10.1021/acs.jproteome.5b01101. Epub 2016 Apr 6.


Chemometric analysis of MALDI mass spectrometric images of three-dimensional cell culture systems.

Weaver EM, Hummon AB, Keithley RB.

Anal Methods. 2015 Sep 7;7(17):7208-7219. Epub 2015 Mar 24.


Over 2300 phosphorylated peptide identifications with single-shot capillary zone electrophoresis-tandem mass spectrometry in a 100 min separation.

Ludwig KR, Sun L, Zhu G, Dovichi NJ, Hummon AB.

Anal Chem. 2015 Oct 6;87(19):9532-7. doi: 10.1021/acs.analchem.5b02457.


Comparing multistep immobilized metal affinity chromatography and multistep TiO2 methods for phosphopeptide enrichment.

Yue X, Schunter A, Hummon AB.

Anal Chem. 2015 Sep 1;87(17):8837-44. doi: 10.1021/acs.analchem.5b01833. Epub 2015 Aug 11.


Bottom-up proteomic analysis of single HCT 116 colon carcinoma multicellular spheroids.

Feist PE, Sun L, Liu X, Dovichi NJ, Hummon AB.

Rapid Commun Mass Spectrom. 2015 Apr 15;29(7):654-8. doi: 10.1002/rcm.7150.


Mass spectrometry imaging of therapeutics from animal models to three-dimensional cell cultures.

Liu X, Hummon AB.

Anal Chem. 2015 Oct 6;87(19):9508-19. doi: 10.1021/acs.analchem.5b00419. Epub 2015 Jul 2. Review.


Proteomic challenges: sample preparation techniques for microgram-quantity protein analysis from biological samples.

Feist P, Hummon AB.

Int J Mol Sci. 2015 Feb 5;16(2):3537-63. doi: 10.3390/ijms16023537. Review.


Sample preparation strategies for mass spectrometry imaging of 3D cell culture models.

Ahlf Wheatcraft DR, Liu X, Hummon AB.

J Vis Exp. 2014 Dec 5;(94). doi: 10.3791/52313.


Proteomic and functional investigation of the colon cancer relapse-associated genes NOX4 and ITGA3.

Bauer KM, Watts TN, Buechler S, Hummon AB.

J Proteome Res. 2014 Nov 7;13(11):4910-8. doi: 10.1021/pr500557n. Epub 2014 Aug 18.


Correlated mass spectrometry imaging and confocal Raman microscopy for studies of three-dimensional cell culture sections.

Ahlf DR, Masyuko RN, Hummon AB, Bohn PW.

Analyst. 2014 Sep 21;139(18):4578-85. doi: 10.1039/c4an00826j.


Comparison of bottom-up proteomic approaches for LC-MS analysis of complex proteomes.

Weston LA, Bauer KM, Hummon AB.

Anal Methods. 2013 Sep 21;5(18). doi: 10.1039/C3AY40853A.


Selective, bead-based global peptide capture using a bifunctional cross-linker.

Weston LA, Bauer KM, Skube SB, Hummon AB.

Anal Chem. 2013 Nov 19;85(22):10675-9. doi: 10.1021/ac401825m. Epub 2013 Oct 28.


Comparative LC-MS/MS analysis of optimal cutting temperature (OCT) compound removal for the study of mammalian proteomes.

Weston LA, Hummon AB.

Analyst. 2013 Nov 7;138(21):6380-4. doi: 10.1039/c3an01121f.


Single cell metabolic profiling of tumor mimics.

Keithley RB, Weaver EM, Rosado AM, Metzinger MP, Hummon AB, Dovichi NJ.

Anal Chem. 2013 Oct 1;85(19):8910-8. doi: 10.1021/ac402262e. Epub 2013 Sep 12.


Combination of multistep IMAC enrichment with high-pH reverse phase separation for in-depth phosphoproteomic profiling.

Yue XS, Hummon AB.

J Proteome Res. 2013 Sep 6;12(9):4176-86. doi: 10.1021/pr4005234. Epub 2013 Aug 8.


Evaluation of therapeutics in three-dimensional cell culture systems by MALDI imaging mass spectrometry.

Liu X, Weaver EM, Hummon AB.

Anal Chem. 2013 Jul 2;85(13):6295-302. doi: 10.1021/ac400519c. Epub 2013 Jun 11.


Aneuploidy, oncogene amplification and epithelial to mesenchymal transition define spontaneous transformation of murine epithelial cells.

Padilla-Nash HM, McNeil NE, Yi M, Nguyen QT, Hu Y, Wangsa D, Mack DL, Hummon AB, Case C, Cardin E, Stephens R, Difilippantonio MJ, Ried T.

Carcinogenesis. 2013 Aug;34(8):1929-39. doi: 10.1093/carcin/bgt138. Epub 2013 Apr 25.


Imaging mass spectrometry: from tissue sections to cell cultures.

Weaver EM, Hummon AB.

Adv Drug Deliv Rev. 2013 Jul;65(8):1039-55. doi: 10.1016/j.addr.2013.03.006. Epub 2013 Apr 6. Review.


Genetic amplification of the NOTCH modulator LNX2 upregulates the WNT/╬▓-catenin pathway in colorectal cancer.

Camps J, Pitt JJ, Emons G, Hummon AB, Case CM, Grade M, Jones TL, Nguyen QT, Ghadimi BM, Beissbarth T, Difilippantonio MJ, Caplen NJ, Ried T.

Cancer Res. 2013 Mar 15;73(6):2003-13. doi: 10.1158/0008-5472.CAN-12-3159. Epub 2013 Jan 14.


Effects of the miR-143/-145 microRNA cluster on the colon cancer proteome and transcriptome.

Bauer KM, Hummon AB.

J Proteome Res. 2012 Sep 7;11(9):4744-54. doi: 10.1021/pr300600r. Epub 2012 Aug 27.


Comparative label-free LC-MS/MS analysis of colorectal adenocarcinoma and metastatic cells treated with 5-fluorouracil.

Bauer KM, Lambert PA, Hummon AB.

Proteomics. 2012 Jun;12(12):1928-37. doi: 10.1002/pmic.201200041.


Systems-wide RNAi analysis of CASP8AP2/FLASH shows transcriptional deregulation of the replication-dependent histone genes and extensive effects on the transcriptome of colorectal cancer cells.

Hummon AB, Pitt JJ, Camps J, Emons G, Skube SB, Huppi K, Jones TL, Beissbarth T, Kramer F, Grade M, Difilippantonio MJ, Ried T, Caplen NJ.

Mol Cancer. 2012 Jan 4;11:1. doi: 10.1186/1476-4598-11-1.


Imaging mass spectrometry of three-dimensional cell culture systems.

Li H, Hummon AB.

Anal Chem. 2011 Nov 15;83(22):8794-801. doi: 10.1021/ac202356g. Epub 2011 Oct 25.


Right-side and left-side colon cancer follow different pathways to relapse.

Bauer KM, Hummon AB, Buechler S.

Mol Carcinog. 2012 May;51(5):411-21. doi: 10.1002/mc.20804. Epub 2011 Jun 7.


A genomic strategy for the functional validation of colorectal cancer genes identifies potential therapeutic targets.

Grade M, Hummon AB, Camps J, Emons G, Spitzner M, Gaedcke J, Hoermann P, Ebner R, Becker H, Difilippantonio MJ, Ghadimi BM, Beissbarth T, Caplen NJ, Ried T.

Int J Cancer. 2011 Mar 1;128(5):1069-79. doi: 10.1002/ijc.25453.

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