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Antimicrob Agents Chemother. 2002 Sep;46(9):3045-9.

Beta-lactamases of Kluyvera ascorbata, probable progenitors of some plasmid-encoded CTX-M types.

Author information

1
Service de Bactériologie, CHU Cochin, Paris, France.

Abstract

Kluyvera ascorbata produces a beta-lactamase that results in an atypical susceptibility pattern, including low-level resistance to penicillins, cephalothin, and cefuroxime, but this resistance is reversed by clavulanate. Ten nucleotide sequences of the corresponding gene, bla(KLUA), were obtained and were found to have minor variations (96 to 100%). Otherwise, bla(KLUA) was found to be similar (95 to 100%) to some plasmid-encoded CTX-M-type beta-lactamases. Finally, mobilization of bla(KLUA) on a plasmid was found to be mediated probably by a genetic mobile element like ISEcp1.

PMID:
12183268
PMCID:
PMC127423
DOI:
10.1128/aac.46.9.3045-3049.2002
[Indexed for MEDLINE]
Free PMC Article

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