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Items: 20


Pathogenic Escherichia coli Hijacks GTPase-Activated p21-Activated Kinase for Actin Pedestal Formation.

Singh V, Davidson A, Hume PJ, Koronakis V.

mBio. 2019 Aug 20;10(4). pii: e01876-19. doi: 10.1128/mBio.01876-19.


Swiss Army Pathogen: The Salmonella Entry Toolkit.

Hume PJ, Singh V, Davidson AC, Koronakis V.

Front Cell Infect Microbiol. 2017 Aug 9;7:348. doi: 10.3389/fcimb.2017.00348. eCollection 2017. Review.


Arf GTPase interplay with Rho GTPases in regulation of the actin cytoskeleton.

Singh V, Davidson AC, Hume PJ, Humphreys D, Koronakis V.

Small GTPases. 2019 Nov;10(6):411-418. doi: 10.1080/21541248.2017.1329691. Epub 2017 Nov 3.


Wearing American Football helmets increases cervicocephalic kinaesthetic awareness in "elite" American Football players but not controls.

McCarthy PW, Hume PJ, Heusch AI, Lark SD.

Chiropr Man Therap. 2015 Nov 16;23:32. doi: 10.1186/s12998-015-0077-4. eCollection 2015.


The Arf GTPase-activating protein family is exploited by Salmonella enterica serovar Typhimurium to invade nonphagocytic host cells.

Davidson AC, Humphreys D, Brooks AB, Hume PJ, Koronakis V.

mBio. 2015 Feb 10;6(1). pii: e02253-14. doi: 10.1128/mBio.02253-14.


WAVE regulatory complex activation.

Hume PJ, Humphreys D, Koronakis V.

Methods Enzymol. 2014;540:363-79. doi: 10.1016/B978-0-12-397924-7.00020-0.


Arf6 coordinates actin assembly through the WAVE complex, a mechanism usurped by Salmonella to invade host cells.

Humphreys D, Davidson AC, Hume PJ, Makin LE, Koronakis V.

Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):16880-5. doi: 10.1073/pnas.1311680110. Epub 2013 Oct 1.


The Drosophila Arf1 homologue Arf79F is essential for lamellipodium formation.

Humphreys D, Liu T, Davidson AC, Hume PJ, Koronakis V.

J Cell Sci. 2012 Dec 1;125(Pt 23):5630-5. doi: 10.1242/jcs.108092. Epub 2012 Sep 19.


Salmonella virulence effector SopE and Host GEF ARNO cooperate to recruit and activate WAVE to trigger bacterial invasion.

Humphreys D, Davidson A, Hume PJ, Koronakis V.

Cell Host Microbe. 2012 Feb 16;11(2):129-39. doi: 10.1016/j.chom.2012.01.006.


WAVE regulatory complex activation by cooperating GTPases Arf and Rac1.

Koronakis V, Hume PJ, Humphreys D, Liu T, Hørning O, Jensen ON, McGhie EJ.

Proc Natl Acad Sci U S A. 2011 Aug 30;108(35):14449-54. doi: 10.1073/pnas.1107666108. Epub 2011 Aug 15.


Enteropathogenic Escherichia coli recruits the cellular inositol phosphatase SHIP2 to regulate actin-pedestal formation.

Smith K, Humphreys D, Hume PJ, Koronakis V.

Cell Host Microbe. 2010 Jan 21;7(1):13-24. doi: 10.1016/j.chom.2009.12.004.


The Salmonella effector SptP dephosphorylates host AAA+ ATPase VCP to promote development of its intracellular replicative niche.

Humphreys D, Hume PJ, Koronakis V.

Cell Host Microbe. 2009 Mar 19;5(3):225-33. doi: 10.1016/j.chom.2009.01.010.


Salmonella takes control: effector-driven manipulation of the host.

McGhie EJ, Brawn LC, Hume PJ, Humphreys D, Koronakis V.

Curr Opin Microbiol. 2009 Feb;12(1):117-24. doi: 10.1016/j.mib.2008.12.001. Epub 2009 Jan 20. Review.


Clustering transfers the translocated Escherichia coli receptor into lipid rafts to stimulate reversible activation of c-Fyn.

Hayward RD, Hume PJ, Humphreys D, Phillips N, Smith K, Koronakis V.

Cell Microbiol. 2009 Mar;11(3):433-41. doi: 10.1111/j.1462-5822.2008.01265.x. Epub 2008 Nov 7.


Mimicry is the sincerest form of flattery?

Hume PJ, Koronakis V.

Cell Host Microbe. 2008 Nov 13;4(5):411-2. doi: 10.1016/j.chom.2008.10.006.


The purified Shigella IpaB and Salmonella SipB translocators share biochemical properties and membrane topology.

Hume PJ, McGhie EJ, Hayward RD, Koronakis V.

Mol Microbiol. 2003 Jul;49(2):425-39.


A Salmonella SipB-derived polypeptide blocks the 'trigger' mechanism of bacterial entry into eukaryotic cells.

Hayward RD, Hume PJ, McGhie EJ, Koronakis V.

Mol Microbiol. 2002 Sep;45(6):1715-27.


Topology of the Salmonella invasion protein SipB in a model bilayer.

McGhie EJ, Hume PJ, Hayward RD, Torres J, Koronakis V.

Mol Microbiol. 2002 Jun;44(5):1309-21.


Motion analysis in two dimensions of radial-ulnar deviation of type I versus type II lunates.

Nakamura K, Beppu M, Patterson RM, Hanson CA, Hume PJ, Viegas SF.

J Hand Surg Am. 2000 Sep;25(5):877-88.


Perspectives in nursing the mentally handicapped.

Hume PJ.

World Ir Nurs. 1975 Jun;4(6):6-7. No abstract available.


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