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Items: 44


Nucleotide exchange factor Rab3GEP requires DENN and non-DENN elements for activation and targeting of Rab27a.

Sanzà P, Evans RD, Briggs DA, Cantero M, Montoliu L, Patel S, Sviderskaya EV, Itzen A, Figueiredo AC, Seabra MC, Hume AN.

J Cell Sci. 2019 Apr 30;132(9). pii: jcs212035. doi: 10.1242/jcs.212035.


The adaptor protein melanophilin regulates dynamic myosin-Va:cargo interaction and dendrite development in melanocytes.

Robinson CL, Evans RD, Sivarasa K, Ramalho JS, Briggs DA, Hume AN.

Mol Biol Cell. 2019 Mar 15;30(6):742-752. doi: 10.1091/mbc.E18-04-0237. Epub 2019 Jan 30.


Myosin Va's adaptor protein melanophilin enforces track selection on the microtubule and actin networks in vitro.

Oberhofer A, Spieler P, Rosenfeld Y, Stepp WL, Cleetus A, Hume AN, Mueller-Planitz F, Ökten Z.

Proc Natl Acad Sci U S A. 2017 Jun 13;114(24):E4714-E4723. doi: 10.1073/pnas.1619473114. Epub 2017 May 30.


Inefficient recruitment of kinesin-1 to melanosomes precludes it from facilitating their transport.

Robinson CL, Evans RD, Briggs DA, Ramalho JS, Hume AN.

J Cell Sci. 2017 Jun 15;130(12):2056-2065. doi: 10.1242/jcs.186064. Epub 2017 May 10.


Correction: A Role for Na+,K+-ATPase α1 in Regulating Rab27a Localisation on Melanosomes.

Booth AE, Tarafder AK, Hume AN, Recchi C, Seabra MC.

PLoS One. 2016 Feb 3;11(2):e0148719. doi: 10.1371/journal.pone.0148719. eCollection 2016. No abstract available.


Myosin--a monarch of pigment transport?

Hume AN.

Pigment Cell Melanoma Res. 2015 Mar;28(2):126-7. doi: 10.1111/pcmr.12339. Epub 2014 Dec 29. No abstract available.


A role for Rab27 in neutrophil chemotaxis and lung recruitment.

Singh RK, Furze RC, Birrell MA, Rankin SM, Hume AN, Seabra MC.

BMC Cell Biol. 2014 Oct 31;15:39. doi: 10.1186/s12860-014-0039-z.


Melanoma goes on a diet to get moving: toning down phagocytic Rab7 expression helps melanoma to metastasise.

Hume AN, Seabra MC.

Pigment Cell Melanoma Res. 2014 Nov;27(6):1012-3. doi: 10.1111/pcmr.12310. Epub 2014 Sep 18. No abstract available.


Myosin-Va and dynamic actin oppose microtubules to drive long-range organelle transport.

Evans RD, Robinson C, Briggs DA, Tooth DJ, Ramalho JS, Cantero M, Montoliu L, Patel S, Sviderskaya EV, Hume AN.

Curr Biol. 2014 Aug 4;24(15):1743-50. doi: 10.1016/j.cub.2014.06.019. Epub 2014 Jul 24.


A role for Na+,K+-ATPase α1 in regulating Rab27a localisation on melanosomes.

Booth AE, Tarafder AK, Hume AN, Recchi C, Seabra MC.

PLoS One. 2014 Jul 22;9(7):e102851. doi: 10.1371/journal.pone.0102851. eCollection 2014. Erratum in: PLoS One. 2016;11(2):e0148719.


Rab11b mediates melanin transfer between donor melanocytes and acceptor keratinocytes via coupled exo/endocytosis.

Tarafder AK, Bolasco G, Correia MS, Pereira FJC, Iannone L, Hume AN, Kirkpatrick N, Picardo M, Torrisi MR, Rodrigues IP, Ramalho JS, Futter CE, Barral DC, Seabra MC.

J Invest Dermatol. 2014 Apr;134(4):1056-1066. doi: 10.1038/jid.2013.432. Epub 2013 Oct 18.


Distinct and opposing roles for Rab27a/Mlph/MyoVa and Rab27b/Munc13-4 in mast cell secretion.

Singh RK, Mizuno K, Wasmeier C, Wavre-Shapton ST, Recchi C, Catz SD, Futter C, Tolmachova T, Hume AN, Seabra MC.

FEBS J. 2013 Feb;280(3):892-903. doi: 10.1111/febs.12081. Epub 2013 Jan 2.


Rab27a and melanosomes: a model to investigate the membrane targeting of Rabs.

Booth AE, Seabra MC, Hume AN.

Biochem Soc Trans. 2012 Dec 1;40(6):1383-8. doi: 10.1042/BST20120200.


Retention in the endoplasmic reticulum is the underlying mechanism of some hereditary haemorrhagic telangiectasia type 2 ALK1 missense mutations.

Hume AN, John A, Akawi NA, Al-Awadhi AM, Al-Suwaidi SS, Al-Gazali L, Ali BR.

Mol Cell Biochem. 2013 Jan;373(1-2):247-57. doi: 10.1007/s11010-012-1496-3. Epub 2012 Nov 4.


Rab27a-mediated protease release regulates neutrophil recruitment by allowing uropod detachment.

Singh RK, Liao W, Tracey-White D, Recchi C, Tolmachova T, Rankin SM, Hume AN, Seabra MC.

J Cell Sci. 2012 Apr 1;125(Pt 7):1652-6. doi: 10.1242/jcs.100438. Epub 2012 Feb 28.


Exosome signaling in mammary gland development and cancer.

Hendrix A, Hume AN.

Int J Dev Biol. 2011;55(7-9):879-87. doi: 10.1387/ijdb.113391ah. Review.


Melanosomes on the move: a model to understand organelle dynamics.

Hume AN, Seabra MC.

Biochem Soc Trans. 2011 Oct;39(5):1191-6. doi: 10.1042/BST0391191. Review.


Semi-automated analysis of organelle movement and membrane content: understanding rab-motor complex transport function.

Hume AN, Wilson MS, Ushakov DS, Ferenczi MA, Seabra MC.

Traffic. 2011 Dec;12(12):1686-701. doi: 10.1111/j.1600-0854.2011.01283.x. Epub 2011 Oct 11.


Rab27a targeting to melanosomes requires nucleotide exchange but not effector binding.

Tarafder AK, Wasmeier C, Figueiredo AC, Booth AE, Orihara A, Ramalho JS, Hume AN, Seabra MC.

Traffic. 2011 Aug;12(8):1056-66. doi: 10.1111/j.1600-0854.2011.01216.x. Epub 2011 Jun 15.


Rab27b regulates exocytosis of secretory vesicles in acinar epithelial cells from the lacrimal gland.

Chiang L, Ngo J, Schechter JE, Karvar S, Tolmachova T, Seabra MC, Hume AN, Hamm-Alvarez SF.

Am J Physiol Cell Physiol. 2011 Aug;301(2):C507-21. doi: 10.1152/ajpcell.00355.2010. Epub 2011 Apr 27. Erratum in: Am J Physiol Cell Physiol. 2011 Dec;301(6):C1480.


Loss of Rab27 function results in abnormal lung epithelium structure in mice.

Bolasco G, Tracey-White DC, Tolmachova T, Thorley AJ, Tetley TD, Seabra MC, Hume AN.

Am J Physiol Cell Physiol. 2011 Mar;300(3):C466-76. doi: 10.1152/ajpcell.00446.2010. Epub 2010 Dec 15.


A novel statin-mediated "prenylation block-and-release" assay provides insight into the membrane targeting mechanisms of small GTPases.

Ali BR, Nouvel I, Leung KF, Hume AN, Seabra MC.

Biochem Biophys Res Commun. 2010 Jun 18;397(1):34-41. doi: 10.1016/j.bbrc.2010.05.045. Epub 2010 May 13.


Rab27a and Rab27b control different steps of the exosome secretion pathway.

Ostrowski M, Carmo NB, Krumeich S, Fanget I, Raposo G, Savina A, Moita CF, Schauer K, Hume AN, Freitas RP, Goud B, Benaroch P, Hacohen N, Fukuda M, Desnos C, Seabra MC, Darchen F, Amigorena S, Moita LF, Thery C.

Nat Cell Biol. 2010 Jan;12(1):19-30; sup pp 1-13. doi: 10.1038/ncb2000. Epub 2009 Dec 6.


Myrip uses distinct domains in the cellular activation of myosin VA and myosin VIIA in melanosome transport.

Ramalho JS, Lopes VS, Tarafder AK, Seabra MC, Hume AN.

Pigment Cell Melanoma Res. 2009 Aug;22(4):461-73. doi: 10.1111/j.1755-148X.2009.00567.x. Epub 2009 Mar 21.


Rab27a and MyRIP regulate the amount and multimeric state of VWF released from endothelial cells.

Nightingale TD, Pattni K, Hume AN, Seabra MC, Cutler DF.

Blood. 2009 May 14;113(20):5010-8. doi: 10.1182/blood-2008-09-181206. Epub 2009 Mar 6. Erratum in: Blood. 2011 Mar 24;117(12):3476.


Melanosomes at a glance.

Wasmeier C, Hume AN, Bolasco G, Seabra MC.

J Cell Sci. 2008 Dec 15;121(Pt 24):3995-9. doi: 10.1242/jcs.040667. No abstract available.


Defective cellular trafficking of missense NPR-B mutants is the major mechanism underlying acromesomelic dysplasia-type Maroteaux.

Hume AN, Buttgereit J, Al-Awadhi AM, Al-Suwaidi SS, John A, Bader M, Seabra MC, Al-Gazali L, Ali BR.

Hum Mol Genet. 2009 Jan 15;18(2):267-77. doi: 10.1093/hmg/ddn354. Epub 2008 Oct 22.


Rab27a and MyoVa are the primary Mlph interactors regulating melanosome transport in melanocytes.

Hume AN, Ushakov DS, Tarafder AK, Ferenczi MA, Seabra MC.

J Cell Sci. 2007 Sep 1;120(Pt 17):3111-22. Epub 2007 Aug 14.


Structurally distinct membrane nanotubes between human macrophages support long-distance vesicular traffic or surfing of bacteria.

Onfelt B, Nedvetzki S, Benninger RK, Purbhoo MA, Sowinski S, Hume AN, Seabra MC, Neil MA, French PM, Davis DM.

J Immunol. 2006 Dec 15;177(12):8476-83.


A coiled-coil domain of melanophilin is essential for Myosin Va recruitment and melanosome transport in melanocytes.

Hume AN, Tarafder AK, Ramalho JS, Sviderskaya EV, Seabra MC.

Mol Biol Cell. 2006 Nov;17(11):4720-35. Epub 2006 Aug 16.


Multiple factors contribute to inefficient prenylation of Rab27a in Rab prenylation diseases.

Larijani B, Hume AN, Tarafder AK, Seabra MC.

J Biol Chem. 2003 Nov 21;278(47):46798-804. Epub 2003 Aug 25.


Weibel-Palade bodies recruit Rab27 by a content-driven, maturation-dependent mechanism that is independent of cell type.

Hannah MJ, Hume AN, Arribas M, Williams R, Hewlett LJ, Seabra MC, Cutler DF.

J Cell Sci. 2003 Oct 1;116(Pt 19):3939-48. Epub 2003 Aug 19.


Membrane targeting of Rab GTPases is influenced by the prenylation motif.

Gomes AQ, Ali BR, Ramalho JS, Godfrey RF, Barral DC, Hume AN, Seabra MC.

Mol Biol Cell. 2003 May;14(5):1882-99. Epub 2003 Feb 6.


Functional redundancy of Rab27 proteins and the pathogenesis of Griscelli syndrome.

Barral DC, Ramalho JS, Anders R, Hume AN, Knapton HJ, Tolmachova T, Collinson LM, Goulding D, Authi KS, Seabra MC.

J Clin Invest. 2002 Jul;110(2):247-57. Erratum in: J Clin Invest 2002 Oct;110(8):1213.


A family of Rab27-binding proteins. Melanophilin links Rab27a and myosin Va function in melanosome transport.

Strom M, Hume AN, Tarafder AK, Barkagianni E, Seabra MC.

J Biol Chem. 2002 Jul 12;277(28):25423-30. Epub 2002 Apr 29.


The leaden gene product is required with Rab27a to recruit myosin Va to melanosomes in melanocytes.

Hume AN, Collinson LM, Hopkins CR, Strom M, Barral DC, Bossi G, Griffiths GM, Seabra MC.

Traffic. 2002 Mar;3(3):193-202.


Rab GTPases, intracellular traffic and disease.

Seabra MC, Mules EH, Hume AN.

Trends Mol Med. 2002 Jan;8(1):23-30. Review.


Prenylation of Rab GTPases: molecular mechanisms and involvement in genetic disease.

Pereira-Leal JB, Hume AN, Seabra MC.

FEBS Lett. 2001 Jun 8;498(2-3):197-200. Review.


Rab27a is required for regulated secretion in cytotoxic T lymphocytes.

Stinchcombe JC, Barral DC, Mules EH, Booth S, Hume AN, Machesky LM, Seabra MC, Griffiths GM.

J Cell Biol. 2001 Feb 19;152(4):825-34.


Rab27a regulates the peripheral distribution of melanosomes in melanocytes.

Hume AN, Collinson LM, Rapak A, Gomes AQ, Hopkins CR, Seabra MC.

J Cell Biol. 2001 Feb 19;152(4):795-808.


Chromosomal mapping, gene structure and characterization of the human and murine RAB27B gene.

Ramalho JS, Tolmachova T, Hume AN, McGuigan A, Gregory-Evans CY, Huxley C, Seabra MC.

BMC Genet. 2001;2:2. Epub 2001 Feb 2.



Hume AN.

Science. 1915 Apr 16;41(1059):575-7. No abstract available.



Hume AN.

Science. 1913 Sep 5;38(975):331-4. No abstract available.



Hume AN.

Science. 1913 Aug 1;38(970):158-9. No abstract available.


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