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Items: 43

1.

Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells.

Andersson CK, Shikhagaie M, Mori M, Al-Garawi A, Reed JL, Humbles AA, Welliver R, Mauad T, Bjermer L, Jordana M, Erjefält JS.

ERJ Open Res. 2018 Nov 23;4(4). pii: 00038-2018. doi: 10.1183/23120541.00038-2018. eCollection 2018 Oct.

2.

NK cells join the plasticity party.

Silver JS, Humbles AA.

Nat Immunol. 2017 Aug 22;18(9):959-960. doi: 10.1038/ni.3817. No abstract available.

PMID:
28829441
3.

Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.

Magnen M, Gueugnon F, Guillon A, Baranek T, Thibault VC, Petit-Courty A, de Veer SJ, Harris J, Humbles AA, Si-Tahar M, Courty Y.

J Virol. 2017 Jul 27;91(16). pii: e00421-17. doi: 10.1128/JVI.00421-17. Print 2017 Aug 15.

4.

Role of BAFF in pulmonary autoantibody responses induced by chronic cigarette smoke exposure in mice.

Morissette MC, Gao Y, Shen P, Thayaparan D, Bérubé JC, Paré PD, Brandsma CA, Hao K, Bossé Y, Ettinger R, Herbst R, Humbles AA, Kolbeck R, Zhong N, Chen R, Stämpfli MR.

Physiol Rep. 2016 Dec;4(24). pii: e13057. doi: 10.14814/phy2.13057.

5.

Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.

Nat Immunol. 2016 Jul 19;17(8):1005. doi: 10.1038/ni0816-1005c. No abstract available.

PMID:
27434015
6.

Erratum: IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.

Ohne Y, Silver JS, Thompson-Snipes L, Collet MA, Blanck JP, Cantarel BL, Copenhaver AM, Humbles AA, Liu YJ.

Nat Immunol. 2016 Jul 19;17(8):1005. doi: 10.1038/ni0816-1005a. No abstract available.

PMID:
27434012
7.

Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.

Nat Immunol. 2016 Jun;17(6):626-35. doi: 10.1038/ni.3443. Epub 2016 Apr 25. Erratum in: Nat Immunol. 2016 Jul 19;17 (8):1005.

8.

IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.

Ohne Y, Silver JS, Thompson-Snipes L, Collet MA, Blanck JP, Cantarel BL, Copenhaver AM, Humbles AA, Liu YJ.

Nat Immunol. 2016 Jun;17(6):646-55. doi: 10.1038/ni.3447. Epub 2016 Apr 25. Erratum in: Nat Immunol. 2016 Jul 19;17(8):1005.

PMID:
27111142
9.

Altered expression of the CCN genes in the lungs of mice in response to cigarette smoke exposure and viral and bacterial infections.

Gueugnon F, Thibault VC, Kearley J, Petit-Courty A, Vallet A, Guillon A, Si-Tahar M, Humbles AA, Courty Y.

Gene. 2016 Jul 15;586(1):176-83. doi: 10.1016/j.gene.2016.04.022. Epub 2016 Apr 11.

PMID:
27080955
10.

Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.

Kearley J, Silver JS, Sanden C, Liu Z, Berlin AA, White N, Mori M, Pham TH, Ward CK, Criner GJ, Marchetti N, Mustelin T, Erjefalt JS, Kolbeck R, Humbles AA.

Immunity. 2015 Mar 17;42(3):566-79. doi: 10.1016/j.immuni.2015.02.011.

11.

S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo.

Chen B, Miller AL, Rebelatto M, Brewah Y, Rowe DC, Clarke L, Czapiga M, Rosenthal K, Imamichi T, Chen Y, Chang CS, Chowdhury PS, Naiman B, Wang Y, Yang D, Humbles AA, Herbst R, Sims GP.

PLoS One. 2015 Feb 23;10(2):e0115828. doi: 10.1371/journal.pone.0115828. eCollection 2015.

12.

Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.

Sutherland TE, Logan N, Rückerl D, Humbles AA, Allan SM, Papayannopoulos V, Stockinger B, Maizels RM, Allen JE.

Nat Immunol. 2014 Dec;15(12):1116-25. doi: 10.1038/ni.3023. Epub 2014 Oct 19.

13.

Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice.

Nikota JK, Shen P, Morissette MC, Fernandes K, Roos A, Chu DK, Barra NG, Iwakura Y, Kolbeck R, Humbles AA, Stampfli MR.

J Immunol. 2014 Sep 15;193(6):3134-45. doi: 10.4049/jimmunol.1302412. Epub 2014 Aug 4.

14.

Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M.

J Exp Med. 2014 Jul 28;211(8):1657-72. doi: 10.1084/jem.20131800.

15.

T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J, Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL, Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Nov;7(6):1395-404. doi: 10.1038/mi.2014.29. Epub 2014 Apr 30.

PMID:
24781052
16.

Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure.

Morissette MC, Jobse BN, Thayaparan D, Nikota JK, Shen P, Labiris NR, Kolbeck R, Nair P, Humbles AA, Stämpfli MR.

Respir Res. 2014 Apr 22;15:49. doi: 10.1186/1465-9921-15-49.

17.

A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

Llop-Guevara A, Chu DK, Walker TD, Goncharova S, Fattouh R, Silver JS, Moore CL, Xie JL, O'Byrne PM, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Jordana M.

PLoS One. 2014 Feb 14;9(2):e88714. doi: 10.1371/journal.pone.0088714. eCollection 2014.

18.

RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E.

J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30. Erratum in: J Exp Med. 2014 May 5;211(5):1001.

19.

IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.

Chu DK, Llop-Guevara A, Walker TD, Flader K, Goncharova S, Boudreau JE, Moore CL, Seunghyun In T, Waserman S, Coyle AJ, Kolbeck R, Humbles AA, Jordana M.

J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8. doi: 10.1016/j.jaci.2012.08.002. Epub 2012 Sep 21.

PMID:
23006545
20.

Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice.

Botelho FM, Nikota JK, Bauer CM, Morissette MC, Iwakura Y, Kolbeck R, Finch D, Humbles AA, Stämpfli MR.

Respir Res. 2012 Sep 19;13:81. doi: 10.1186/1465-9921-13-81.

21.

Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection.

Miller AL, Sims GP, Brewah YA, Rebelatto MC, Kearley J, Benjamin E, Keller AE, Brohawn P, Herbst R, Coyle AJ, Humbles AA, Kolbeck R.

J Infect Dis. 2012 Apr 15;205(8):1311-20. doi: 10.1093/infdis/jir826. Epub 2012 Jan 18.

22.

Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insights.

Al-Garawi A, Husain M, Ilieva D, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

J Immunol. 2012 Jan 15;188(2):832-43. doi: 10.4049/jimmunol.1102349. Epub 2011 Dec 14.

23.

IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

Botelho FM, Bauer CM, Finch D, Nikota JK, Zavitz CC, Kelly A, Lambert KN, Piper S, Foster ML, Goldring JJ, Wedzicha JA, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle AJ, Humbles AA, Stämpfli MR.

PLoS One. 2011;6(12):e28457. doi: 10.1371/journal.pone.0028457. Epub 2011 Dec 6.

24.

Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood.

Al-Garawi A, Fattouh R, Botelho F, Walker TD, Goncharova S, Moore CL, Mori M, Erjefalt JS, Chu DK, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

Mucosal Immunol. 2011 Nov;4(6):682-94. doi: 10.1038/mi.2011.35. Epub 2011 Aug 31.

PMID:
21881572
25.

Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.

Arias K, Chu DK, Flader K, Botelho F, Walker T, Arias N, Humbles AA, Coyle AJ, Oettgen HC, Chang HD, Van Rooijen N, Waserman S, Jordana M.

J Allergy Clin Immunol. 2011 Jun;127(6):1552-61.e1. doi: 10.1016/j.jaci.2011.03.044.

PMID:
21624619
26.

Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation.

Nikota JK, Botelho FM, Bauer CM, Jordana M, Coyle AJ, Humbles AA, Stampfli MR.

Respir Res. 2011 Apr 7;12:39. doi: 10.1186/1465-9921-12-39.

27.

A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke.

Botelho FM, Nikota JK, Bauer C, Davis NH, Cohen ES, Anderson IK, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Sleeman MA.

Eur Respir J. 2011 Aug;38(2):285-94. doi: 10.1183/09031936.00076210. Epub 2011 Mar 24.

28.

IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.

Kearley J, Erjefalt JS, Andersson C, Benjamin E, Jones CP, Robichaud A, Pegorier S, Brewah Y, Burwell TJ, Bjermer L, Kiener PA, Kolbeck R, Lloyd CM, Coyle AJ, Humbles AA.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):865-75. doi: 10.1164/rccm.200909-1462OC. Epub 2010 Oct 22.

29.

Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease.

Fattouh R, Al-Garawi A, Fattouh M, Arias K, Walker TD, Goncharova S, Coyle AJ, Humbles AA, Jordana M.

Am J Respir Crit Care Med. 2011 Jan 15;183(2):179-88. doi: 10.1164/rccm.200905-0736OC. Epub 2010 Aug 23.

PMID:
20732990
30.

MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

Kolbeck R, Kozhich A, Koike M, Peng L, Andersson CK, Damschroder MM, Reed JL, Woods R, Dall'acqua WW, Stephens GL, Erjefalt JS, Bjermer L, Humbles AA, Gossage D, Wu H, Kiener PA, Spitalny GL, Mackay CR, Molfino NA, Coyle AJ.

J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2. doi: 10.1016/j.jaci.2010.04.004.

PMID:
20513525
31.

CCR3 is a target for age-related macular degeneration diagnosis and therapy.

Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J.

Nature. 2009 Jul 9;460(7252):225-30. doi: 10.1038/nature08151. Epub 2009 Jun 14.

32.

Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection.

Miller AL, Gerard C, Schaller M, Gruber AD, Humbles AA, Lukacs NW.

J Immunol. 2006 Feb 15;176(4):2562-7.

33.

Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses.

John AE, Gerard CJ, Schaller M, Miller AL, Berlin AA, Humbles AA, Lukacs NW.

Eur J Immunol. 2005 Jan;35(1):108-16. Erratum in: Eur J Immunol. 2005 Oct;35(10):3083.

34.

A critical role for eosinophils in allergic airways remodeling.

Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C.

Science. 2004 Sep 17;305(5691):1776-9.

35.

The anaphylatoxin C3a downregulates the Th2 response to epicutaneously introduced antigen.

Kawamoto S, Yalcindag A, Laouini D, Brodeur S, Bryce P, Lu B, Humbles AA, Oettgen H, Gerard C, Geha RS.

J Clin Invest. 2004 Aug;114(3):399-407.

36.

Essential role for the C5a receptor in regulating the effector phase of synovial infiltration and joint destruction in experimental arthritis.

Grant EP, Picarella D, Burwell T, Delaney T, Croci A, Avitahl N, Humbles AA, Gutierrez-Ramos JC, Briskin M, Gerard C, Coyle AJ.

J Exp Med. 2002 Dec 2;196(11):1461-71.

37.

CCR3 is essential for skin eosinophilia and airway hyperresponsiveness in a murine model of allergic skin inflammation.

Ma W, Bryce PJ, Humbles AA, Laouini D, Yalcindag A, Alenius H, Friend DS, Oettgen HC, Gerard C, Geha RS.

J Clin Invest. 2002 Mar;109(5):621-8.

38.

The murine CCR3 receptor regulates both the role of eosinophils and mast cells in allergen-induced airway inflammation and hyperresponsiveness.

Humbles AA, Lu B, Friend DS, Okinaga S, Lora J, Al-Garawi A, Martin TR, Gerard NP, Gerard C.

Proc Natl Acad Sci U S A. 2002 Feb 5;99(3):1479-84.

39.

A role for the C3a anaphylatoxin receptor in the effector phase of asthma.

Humbles AA, Lu B, Nilsson CA, Lilly C, Israel E, Fujiwara Y, Gerard NP, Gerard C.

Nature. 2000 Aug 31;406(6799):998-1001.

PMID:
10984054
40.

Targeted disruption of migration inhibitory factor gene reveals its critical role in sepsis.

Bozza M, Satoskar AR, Lin G, Lu B, Humbles AA, Gerard C, David JR.

J Exp Med. 1999 Jan 18;189(2):341-6.

41.

Kinetics of eotaxin generation and its relationship to eosinophil accumulation in allergic airways disease: analysis in a guinea pig model in vivo.

Humbles AA, Conroy DM, Marleau S, Rankin SM, Palframan RT, Proudfoot AE, Wells TN, Li D, Jeffery PK, Griffiths-Johnson DA, Williams TJ, Jose PJ.

J Exp Med. 1997 Aug 18;186(4):601-12.

42.

The role of the eosinophil-selective chemokine, eotaxin, in allergic and non-allergic airways inflammation.

Conroy DM, Humbles AA, Rankin SM, Palframan RT, Collins PD, Griffiths-Johnson DA, Jose PJ, Williams TJ.

Mem Inst Oswaldo Cruz. 1997;92 Suppl 2:183-91. Review.

43.

Formoterol on airway smooth muscle and human lung mast cells: a comparison with salbutamol and salmeterol.

Nials AT, Ball DI, Butchers PR, Coleman RA, Humbles AA, Johnson M, Vardey CJ.

Eur J Pharmacol. 1994 Jan 14;251(2-3):127-35.

PMID:
8149969

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