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c-Kit-positive ILC2s exhibit an ILC3-like signature that may contribute to IL-17-mediated pathologies.

Bernink JH, Ohne Y, Teunissen MBM, Wang J, Wu J, Krabbendam L, Guntermann C, Volckmann R, Koster J, van Tol S, Ramirez I, Shrestha Y, de Rie MA, Spits H, Romero Ros X, Humbles AA.

Nat Immunol. 2019 Aug;20(8):992-1003. doi: 10.1038/s41590-019-0423-0. Epub 2019 Jul 1.


Tissue kallikrein regulates alveolar macrophage apoptosis early in influenza virus infection.

Magnen M, Gueugnon F, Petit-Courty A, Baranek T, Sizaret D, Brewah YA, Humbles AA, Si-Tahar M, Courty Y.

Am J Physiol Lung Cell Mol Physiol. 2019 Jun 1;316(6):L1127-L1140. doi: 10.1152/ajplung.00379.2018. Epub 2019 Mar 25.


Distal respiratory tract viral infections in young children trigger a marked increase in alveolar mast cells.

Andersson CK, Shikhagaie M, Mori M, Al-Garawi A, Reed JL, Humbles AA, Welliver R, Mauad T, Bjermer L, Jordana M, Erjefält JS.

ERJ Open Res. 2018 Nov 23;4(4). pii: 00038-2018. doi: 10.1183/23120541.00038-2018. eCollection 2018 Oct.


A Paradigm Shift in Leadership Education: Integrating Critical Perspectives Into Leadership Development.

Dugan JP, Humbles AD.

New Dir Stud Leadersh. 2018 Sep;2018(159):9-26. doi: 10.1002/yd.20294.


NK cells join the plasticity party.

Silver JS, Humbles AA.

Nat Immunol. 2017 Aug 22;18(9):959-960. doi: 10.1038/ni.3817. No abstract available.


Kallikrein-Related Peptidase 5 Contributes to H3N2 Influenza Virus Infection in Human Lungs.

Magnen M, Gueugnon F, Guillon A, Baranek T, Thibault VC, Petit-Courty A, de Veer SJ, Harris J, Humbles AA, Si-Tahar M, Courty Y.

J Virol. 2017 Jul 27;91(16). pii: e00421-17. doi: 10.1128/JVI.00421-17. Print 2017 Aug 15.


Role of BAFF in pulmonary autoantibody responses induced by chronic cigarette smoke exposure in mice.

Morissette MC, Gao Y, Shen P, Thayaparan D, Bérubé JC, Paré PD, Brandsma CA, Hao K, Bossé Y, Ettinger R, Herbst R, Humbles AA, Kolbeck R, Zhong N, Chen R, Stämpfli MR.

Physiol Rep. 2016 Dec;4(24). pii: e13057. doi: 10.14814/phy2.13057.


Erratum: Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.

Nat Immunol. 2016 Jul 19;17(8):1005. doi: 10.1038/ni0816-1005c. No abstract available.


Erratum: IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.

Ohne Y, Silver JS, Thompson-Snipes L, Collet MA, Blanck JP, Cantarel BL, Copenhaver AM, Humbles AA, Liu YJ.

Nat Immunol. 2016 Jul 19;17(8):1005. doi: 10.1038/ni0816-1005a. No abstract available.


Inflammatory triggers associated with exacerbations of COPD orchestrate plasticity of group 2 innate lymphoid cells in the lungs.

Silver JS, Kearley J, Copenhaver AM, Sanden C, Mori M, Yu L, Pritchard GH, Berlin AA, Hunter CA, Bowler R, Erjefalt JS, Kolbeck R, Humbles AA.

Nat Immunol. 2016 Jun;17(6):626-35. doi: 10.1038/ni.3443. Epub 2016 Apr 25. Erratum in: Nat Immunol. 2016 Jul 19;17 (8):1005.


IL-1 is a critical regulator of group 2 innate lymphoid cell function and plasticity.

Ohne Y, Silver JS, Thompson-Snipes L, Collet MA, Blanck JP, Cantarel BL, Copenhaver AM, Humbles AA, Liu YJ.

Nat Immunol. 2016 Jun;17(6):646-55. doi: 10.1038/ni.3447. Epub 2016 Apr 25. Erratum in: Nat Immunol. 2016 Jul 19;17(8):1005.


Altered expression of the CCN genes in the lungs of mice in response to cigarette smoke exposure and viral and bacterial infections.

Gueugnon F, Thibault VC, Kearley J, Petit-Courty A, Vallet A, Guillon A, Si-Tahar M, Humbles AA, Courty Y.

Gene. 2016 Jul 15;586(1):176-83. doi: 10.1016/j.gene.2016.04.022. Epub 2016 Apr 11.


Cigarette smoke silences innate lymphoid cell function and facilitates an exacerbated type I interleukin-33-dependent response to infection.

Kearley J, Silver JS, Sanden C, Liu Z, Berlin AA, White N, Mori M, Pham TH, Ward CK, Criner GJ, Marchetti N, Mustelin T, Erjefalt JS, Kolbeck R, Humbles AA.

Immunity. 2015 Mar 17;42(3):566-79. doi: 10.1016/j.immuni.2015.02.011.


Allergen induced pulmonary inflammation enhances mammary tumor growth and metastasis: Role of CHI3L1.

Libreros S, Garcia-Areas R, Keating P, Gazaniga N, Robinson P, Humbles A, Iragavarapu-Charyulu VL.

J Leukoc Biol. 2015 May;97(5):929-940. doi: 10.1189/jlb.3A0214-114RR. Epub 2015 Mar 12.


S100A9 induced inflammatory responses are mediated by distinct damage associated molecular patterns (DAMP) receptors in vitro and in vivo.

Chen B, Miller AL, Rebelatto M, Brewah Y, Rowe DC, Clarke L, Czapiga M, Rosenthal K, Imamichi T, Chen Y, Chang CS, Chowdhury PS, Naiman B, Wang Y, Yang D, Humbles AA, Herbst R, Sims GP.

PLoS One. 2015 Feb 23;10(2):e0115828. doi: 10.1371/journal.pone.0115828. eCollection 2015.


IL-33 drives airway hyper-responsiveness through IL-13-mediated mast cell: airway smooth muscle crosstalk.

Kaur D, Gomez E, Doe C, Berair R, Woodman L, Saunders R, Hollins F, Rose FR, Amrani Y, May R, Kearley J, Humbles A, Cohen ES, Brightling CE.

Allergy. 2015 May;70(5):556-67. doi: 10.1111/all.12593. Epub 2015 Mar 16.


Chitinase-like proteins promote IL-17-mediated neutrophilia in a tradeoff between nematode killing and host damage.

Sutherland TE, Logan N, Rückerl D, Humbles AA, Allan SM, Papayannopoulos V, Stockinger B, Maizels RM, Allen JE.

Nat Immunol. 2014 Dec;15(12):1116-25. doi: 10.1038/ni.3023. Epub 2014 Oct 19.


Cigarette smoke primes the pulmonary environment to IL-1α/CXCR-2-dependent nontypeable Haemophilus influenzae-exacerbated neutrophilia in mice.

Nikota JK, Shen P, Morissette MC, Fernandes K, Roos A, Chu DK, Barra NG, Iwakura Y, Kolbeck R, Humbles AA, Stampfli MR.

J Immunol. 2014 Sep 15;193(6):3134-45. doi: 10.4049/jimmunol.1302412. Epub 2014 Aug 4.


Indigenous enteric eosinophils control DCs to initiate a primary Th2 immune response in vivo.

Chu DK, Jimenez-Saiz R, Verschoor CP, Walker TD, Goncharova S, Llop-Guevara A, Shen P, Gordon ME, Barra NG, Bassett JD, Kong J, Fattouh R, McCoy KD, Bowdish DM, Erjefält JS, Pabst O, Humbles AA, Kolbeck R, Waserman S, Jordana M.

J Exp Med. 2014 Jul 28;211(8):1657-72. doi: 10.1084/jem.20131800.


T helper cell IL-4 drives intestinal Th2 priming to oral peanut antigen, under the control of OX40L and independent of innate-like lymphocytes.

Chu DK, Mohammed-Ali Z, Jiménez-Saiz R, Walker TD, Goncharova S, Llop-Guevara A, Kong J, Gordon ME, Barra NG, Gillgrass AE, Van Seggelen H, Khan WI, Ashkar AA, Bramson JL, Humbles AA, Kolbeck R, Waserman S, Jordana M.

Mucosal Immunol. 2014 Nov;7(6):1395-404. doi: 10.1038/mi.2014.29. Epub 2014 Apr 30.


Persistence of pulmonary tertiary lymphoid tissues and anti-nuclear antibodies following cessation of cigarette smoke exposure.

Morissette MC, Jobse BN, Thayaparan D, Nikota JK, Shen P, Labiris NR, Kolbeck R, Nair P, Humbles AA, Stämpfli MR.

Respir Res. 2014 Apr 22;15:49. doi: 10.1186/1465-9921-15-49.


A GM-CSF/IL-33 pathway facilitates allergic airway responses to sub-threshold house dust mite exposure.

Llop-Guevara A, Chu DK, Walker TD, Goncharova S, Fattouh R, Silver JS, Moore CL, Xie JL, O'Byrne PM, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Jordana M.

PLoS One. 2014 Feb 14;9(2):e88714. doi: 10.1371/journal.pone.0088714. eCollection 2014.


RAGE is a nucleic acid receptor that promotes inflammatory responses to DNA.

Sirois CM, Jin T, Miller AL, Bertheloot D, Nakamura H, Horvath GL, Mian A, Jiang J, Schrum J, Bossaller L, Pelka K, Garbi N, Brewah Y, Tian J, Chang C, Chowdhury PS, Sims GP, Kolbeck R, Coyle AJ, Humbles AA, Xiao TS, Latz E.

J Exp Med. 2013 Oct 21;210(11):2447-63. doi: 10.1084/jem.20120201. Epub 2013 Sep 30. Erratum in: J Exp Med. 2014 May 5;211(5):1001.


An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation.

Traub S, Nikonova A, Carruthers A, Dunmore R, Vousden KA, Gogsadze L, Hao W, Zhu Q, Bernard K, Zhu J, Dymond M, McLean GR, Walton RP, Glanville N, Humbles A, Khaitov M, Wells T, Kolbeck R, Leishman AJ, Sleeman MA, Bartlett NW, Johnston SL.

PLoS Pathog. 2013;9(8):e1003520. doi: 10.1371/journal.ppat.1003520. Epub 2013 Aug 1.


IL-33, but not thymic stromal lymphopoietin or IL-25, is central to mite and peanut allergic sensitization.

Chu DK, Llop-Guevara A, Walker TD, Flader K, Goncharova S, Boudreau JE, Moore CL, Seunghyun In T, Waserman S, Coyle AJ, Kolbeck R, Humbles AA, Jordana M.

J Allergy Clin Immunol. 2013 Jan;131(1):187-200.e1-8. doi: 10.1016/j.jaci.2012.08.002. Epub 2012 Sep 21.


Cigarette smoke-induced accumulation of lung dendritic cells is interleukin-1α-dependent in mice.

Botelho FM, Nikota JK, Bauer CM, Morissette MC, Iwakura Y, Kolbeck R, Finch D, Humbles AA, Stämpfli MR.

Respir Res. 2012 Sep 19;13:81. doi: 10.1186/1465-9921-13-81.


Opposing roles of membrane and soluble forms of the receptor for advanced glycation end products in primary respiratory syncytial virus infection.

Miller AL, Sims GP, Brewah YA, Rebelatto MC, Kearley J, Benjamin E, Keller AE, Brohawn P, Herbst R, Coyle AJ, Humbles AA, Kolbeck R.

J Infect Dis. 2012 Apr 15;205(8):1311-20. doi: 10.1093/infdis/jir826. Epub 2012 Jan 18.


Shifting of immune responsiveness to house dust mite by influenza A infection: genomic insights.

Al-Garawi A, Husain M, Ilieva D, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

J Immunol. 2012 Jan 15;188(2):832-43. doi: 10.4049/jimmunol.1102349. Epub 2011 Dec 14.


IL-1α/IL-1R1 expression in chronic obstructive pulmonary disease and mechanistic relevance to smoke-induced neutrophilia in mice.

Botelho FM, Bauer CM, Finch D, Nikota JK, Zavitz CC, Kelly A, Lambert KN, Piper S, Foster ML, Goldring JJ, Wedzicha JA, Bassett J, Bramson J, Iwakura Y, Sleeman M, Kolbeck R, Coyle AJ, Humbles AA, Stämpfli MR.

PLoS One. 2011;6(12):e28457. doi: 10.1371/journal.pone.0028457. Epub 2011 Dec 6.


Influenza A facilitates sensitization to house dust mite in infant mice leading to an asthma phenotype in adulthood.

Al-Garawi A, Fattouh R, Botelho F, Walker TD, Goncharova S, Moore CL, Mori M, Erjefalt JS, Chu DK, Humbles AA, Kolbeck R, Stampfli MR, O'Byrne PM, Coyle AJ, Jordana M.

Mucosal Immunol. 2011 Nov;4(6):682-94. doi: 10.1038/mi.2011.35. Epub 2011 Aug 31.


Distinct immune effector pathways contribute to the full expression of peanut-induced anaphylactic reactions in mice.

Arias K, Chu DK, Flader K, Botelho F, Walker T, Arias N, Humbles AA, Coyle AJ, Oettgen HC, Chang HD, Van Rooijen N, Waserman S, Jordana M.

J Allergy Clin Immunol. 2011 Jun;127(6):1552-61.e1. doi: 10.1016/j.jaci.2011.03.044.


Differential expression and function of breast regression protein 39 (BRP-39) in murine models of subacute cigarette smoke exposure and allergic airway inflammation.

Nikota JK, Botelho FM, Bauer CM, Jordana M, Coyle AJ, Humbles AA, Stampfli MR.

Respir Res. 2011 Apr 7;12:39. doi: 10.1186/1465-9921-12-39.


A mouse GM-CSF receptor antibody attenuates neutrophilia in mice exposed to cigarette smoke.

Botelho FM, Nikota JK, Bauer C, Davis NH, Cohen ES, Anderson IK, Coyle AJ, Kolbeck R, Humbles AA, Stämpfli MR, Sleeman MA.

Eur Respir J. 2011 Aug;38(2):285-94. doi: 10.1183/09031936.00076210. Epub 2011 Mar 24.


IL-9 is a Th17-derived cytokine that limits pathogenic activity in organ-specific autoimmune disease.

Stephens GL, Swerdlow B, Benjamin E, Coyle AJ, Humbles A, Kolbeck R, Fung M.

Eur J Immunol. 2011 Apr;41(4):952-62. doi: 10.1002/eji.201040879. Epub 2011 Feb 24.


IL-9 governs allergen-induced mast cell numbers in the lung and chronic remodeling of the airways.

Kearley J, Erjefalt JS, Andersson C, Benjamin E, Jones CP, Robichaud A, Pegorier S, Brewah Y, Burwell TJ, Bjermer L, Kiener PA, Kolbeck R, Lloyd CM, Coyle AJ, Humbles AA.

Am J Respir Crit Care Med. 2011 Apr 1;183(7):865-75. doi: 10.1164/rccm.200909-1462OC. Epub 2010 Oct 22.


Eosinophils are dispensable for allergic remodeling and immunity in a model of house dust mite-induced airway disease.

Fattouh R, Al-Garawi A, Fattouh M, Arias K, Walker TD, Goncharova S, Coyle AJ, Humbles AA, Jordana M.

Am J Respir Crit Care Med. 2011 Jan 15;183(2):179-88. doi: 10.1164/rccm.200905-0736OC. Epub 2010 Aug 23.


MEDI-563, a humanized anti-IL-5 receptor alpha mAb with enhanced antibody-dependent cell-mediated cytotoxicity function.

Kolbeck R, Kozhich A, Koike M, Peng L, Andersson CK, Damschroder MM, Reed JL, Woods R, Dall'acqua WW, Stephens GL, Erjefalt JS, Bjermer L, Humbles AA, Gossage D, Wu H, Kiener PA, Spitalny GL, Mackay CR, Molfino NA, Coyle AJ.

J Allergy Clin Immunol. 2010 Jun;125(6):1344-1353.e2. doi: 10.1016/j.jaci.2010.04.004.


Lung chitinolytic activity and chitotriosidase are elevated in chronic obstructive pulmonary disease and contribute to lung inflammation.

Létuvé S, Kozhich A, Humbles A, Brewah Y, Dombret MC, Grandsaigne M, Adle H, Kolbeck R, Aubier M, Coyle AJ, Pretolani M.

Am J Pathol. 2010 Feb;176(2):638-49. doi: 10.2353/ajpath.2010.090455. Epub 2009 Dec 30.


Antigen-induced increases in pulmonary mast cell progenitor numbers depend on IL-9 and CD1d-restricted NKT cells.

Jones TG, Hallgren J, Humbles A, Burwell T, Finkelman FD, Alcaide P, Austen KF, Gurish MF.

J Immunol. 2009 Oct 15;183(8):5251-60. doi: 10.4049/jimmunol.0901471. Epub 2009 Sep 25.


CCR3 is a target for age-related macular degeneration diagnosis and therapy.

Takeda A, Baffi JZ, Kleinman ME, Cho WG, Nozaki M, Yamada K, Kaneko H, Albuquerque RJ, Dridi S, Saito K, Raisler BJ, Budd SJ, Geisen P, Munitz A, Ambati BK, Green MG, Ishibashi T, Wright JD, Humbles AA, Gerard CJ, Ogura Y, Pan Y, Smith JR, Grisanti S, Hartnett ME, Rothenberg ME, Ambati J.

Nature. 2009 Jul 9;460(7252):225-30. doi: 10.1038/nature08151. Epub 2009 Jun 14.


Capillary defects and exaggerated inflammatory response in the airways of EphA2-deficient mice.

Okazaki T, Ni A, Baluk P, Ayeni OA, Kearley J, Coyle AJ, Humbles A, McDonald DM.

Am J Pathol. 2009 Jun;174(6):2388-99. doi: 10.2353/ajpath.2009.080949. Epub 2009 May 14.


Role of breast regression protein 39 (BRP-39)/chitinase 3-like-1 in Th2 and IL-13-induced tissue responses and apoptosis.

Lee CG, Hartl D, Lee GR, Koller B, Matsuura H, Da Silva CA, Sohn MH, Cohn L, Homer RJ, Kozhich AA, Humbles A, Kearley J, Coyle A, Chupp G, Reed J, Flavell RA, Elias JA.

J Exp Med. 2009 May 11;206(5):1149-66. doi: 10.1084/jem.20081271. Epub 2009 May 4.


Macrophage impairment underlies airway occlusion in primary respiratory syncytial virus bronchiolitis.

Reed JL, Brewah YA, Delaney T, Welliver T, Burwell T, Benjamin E, Kuta E, Kozhich A, McKinney L, Suzich J, Kiener PA, Avendano L, Velozo L, Humbles A, Welliver RC Sr, Coyle AJ.

J Infect Dis. 2008 Dec 15;198(12):1783-93. doi: 10.1086/593173.


Strain-specific requirement for eosinophils in the recruitment of T cells to the lung during the development of allergic asthma.

Walsh ER, Sahu N, Kearley J, Benjamin E, Kang BH, Humbles A, August A.

J Exp Med. 2008 Jun 9;205(6):1285-92. doi: 10.1084/jem.20071836. Epub 2008 May 19.


Pulmonary CXCR2 regulates VCAM-1 and antigen-induced recruitment of mast cell progenitors.

Hallgren J, Jones TG, Abonia JP, Xing W, Humbles A, Austen KF, Gurish MF.

Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20478-83. Epub 2007 Dec 10.


C5 modulates airway hyperreactivity and pulmonary eosinophilia during enhanced respiratory syncytial virus disease by decreasing C3a receptor expression.

Melendi GA, Hoffman SJ, Karron RA, Irusta PM, Laham FR, Humbles A, Schofield B, Pan CH, Rabold R, Thumar B, Thumar A, Gerard NP, Mitzner W, Barnum SR, Gerard C, Kleeberger SR, Polack FP.

J Virol. 2007 Jan;81(2):991-9. Epub 2006 Nov 1.


Deletion of CCR1 attenuates pathophysiologic responses during respiratory syncytial virus infection.

Miller AL, Gerard C, Schaller M, Gruber AD, Humbles AA, Lukacs NW.

J Immunol. 2006 Feb 15;176(4):2562-7.


Mast cell protease 5 mediates ischemia-reperfusion injury of mouse skeletal muscle.

Abonia JP, Friend DS, Austen WG Jr, Moore FD Jr, Carroll MC, Chan R, Afnan J, Humbles A, Gerard C, Knight P, Kanaoka Y, Yasuda S, Morokawa N, Austen KF, Stevens RL, Gurish MF.

J Immunol. 2005 Jun 1;174(11):7285-91.


Respiratory syncytial virus-induced exaggeration of allergic airway disease is dependent upon CCR1-associated immune responses.

John AE, Gerard CJ, Schaller M, Miller AL, Berlin AA, Humbles AA, Lukacs NW.

Eur J Immunol. 2005 Jan;35(1):108-16. Erratum in: Eur J Immunol. 2005 Oct;35(10):3083.


A critical role for eosinophils in allergic airways remodeling.

Humbles AA, Lloyd CM, McMillan SJ, Friend DS, Xanthou G, McKenna EE, Ghiran S, Gerard NP, Yu C, Orkin SH, Gerard C.

Science. 2004 Sep 17;305(5691):1776-9.

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