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Structural analysis of phosphorylation-associated interactions of human MCC with Scribble PDZ domains.

Caria S, Stewart BZ, Jin R, Smith BJ, Humbert PO, Kvansakul M.

FEBS J. 2019 Dec;286(24):4910-4925. doi: 10.1111/febs.15002. Epub 2019 Jul 30.


VANGL2 regulates luminal epithelial organization and cell turnover in the mammary gland.

Smith P, Godde N, Rubio S, Tekeste M, Vladar EK, Axelrod JD, Henderson DJ, Milgrom-Hoffman M, Humbert PO, Hinck L.

Sci Rep. 2019 May 8;9(1):7079. doi: 10.1038/s41598-019-43444-8.


The polarity protein Scrib limits atherosclerosis development in mice.

Schürmann C, Dienst FL, Pálfi K, Vasconez AE, Oo JA, Wang S, Buchmann GK, Offermanns S, van de Sluis B, Leisegang MS, Günther S, Humbert PO, Lee E, Zhu J, Weigert A, Mathoor P, Wittig I, Kruse C, Brandes RP.

Cardiovasc Res. 2019 Dec 1;115(14):1963-1974. doi: 10.1093/cvr/cvz093.


Crystal structure of the human Scribble PDZ1 domain bound to the PDZ-binding motif of APC.

How JY, Caria S, Humbert PO, Kvansakul M.

FEBS Lett. 2019 Mar;593(5):533-542. doi: 10.1002/1873-3468.13329. Epub 2019 Feb 2.


A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.

Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca JE, Golenkina S, Cuiping X, Gruber S, Angjeli B, Kanitz EE, Cronin SJF, Neely GG, Wernitznig A, Humbert PO, Simpson KJ, Mitsiades CS, Richardson HE, Penninger JM.

PLoS Genet. 2018 Oct 16;14(10):e1007688. doi: 10.1371/journal.pgen.1007688. eCollection 2018 Oct.


Cell Polarity Regulation-From Atomic to Macroscopic Scale.

Kvansakul M, Humbert PO.

J Mol Biol. 2018 Sep 28;430(19):3455-3456. doi: 10.1016/j.jmb.2018.07.021. Epub 2018 Jul 20. No abstract available.


Intermittent hypoxia induces a metastatic phenotype in breast cancer.

Chen A, Sceneay J, Gödde N, Kinwel T, Ham S, Thompson EW, Humbert PO, Möller A.

Oncogene. 2018 Aug;37(31):4214-4225. doi: 10.1038/s41388-018-0259-3. Epub 2018 May 1.


Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.


The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis.

Stephens R, Lim K, Portela M, Kvansakul M, Humbert PO, Richardson HE.

J Mol Biol. 2018 Sep 28;430(19):3585-3612. doi: 10.1016/j.jmb.2018.01.011. Epub 2018 Feb 8. Review.


Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

Caria S, Magtoto CM, Samiei T, Portela M, Lim KYB, How JY, Stewart BZ, Humbert PO, Richardson HE, Kvansakul M.

J Biol Chem. 2018 Mar 23;293(12):4519-4531. doi: 10.1074/jbc.M117.817528. Epub 2018 Jan 29.


Regulation of cellular and PCP signalling by the Scribble polarity module.

Milgrom-Hoffman M, Humbert PO.

Semin Cell Dev Biol. 2018 Sep;81:33-45. doi: 10.1016/j.semcdb.2017.11.021. Epub 2017 Nov 23. Review.


Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.

Lim KYB, Gödde NJ, Humbert PO, Kvansakul M.

J Biol Chem. 2017 Dec 15;292(50):20425-20436. doi: 10.1074/jbc.M117.799452. Epub 2017 Oct 23.


Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5658-5660. doi: 10.1038/onc.2017.239.


Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5576-5592. doi: 10.1038/onc.2017.175. Epub 2017 Jun 5. Erratum in: Oncogene. 2017 Oct 5;36(40):5658-5660.


How to expel a bad tenant: Linking cyclin A2, enucleation and cell size.

Wölwer CB, Humbert PO.

Cell Cycle. 2017 Mar 4;16(5):397-398. doi: 10.1080/15384101.2016.1274586. Epub 2017 Jan 19. No abstract available.


The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation.

Wölwer CB, Gödde N, Pase LB, Elsum IA, Lim KY, Sacirbegovic F, Walkley CR, Ellis S, Ohno S, Matsuzaki F, Russell SM, Humbert PO.

PLoS One. 2017 Jan 17;12(1):e0170295. doi: 10.1371/journal.pone.0170295. eCollection 2017.


A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization.

Smith LK, Thomas DW, Simpson KJ, Humbert PO.

Assay Drug Dev Technol. 2016 Oct;14(8):478-488. Epub 2016 Sep 23.


Calcium Signaling Is Required for Erythroid Enucleation.

Wölwer CB, Pase LB, Russell SM, Humbert PO.

PLoS One. 2016 Jan 5;11(1):e0146201. doi: 10.1371/journal.pone.0146201. eCollection 2016.


A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.

Wölwer CB, Pase LB, Pearson HB, Gödde NJ, Lackovic K, Huang DC, Russell SM, Humbert PO.

PLoS One. 2015 Nov 16;10(11):e0142655. doi: 10.1371/journal.pone.0142655. eCollection 2015.


Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Ramsbottom KM, Sacirbegovic F, Hawkins ED, Kallies A, Belz GT, Van Ham V, Haynes NM, Durrant MJ, Humbert PO, Russell SM, Oliaro J.

Immunol Cell Biol. 2016 Mar;94(3):306-11. doi: 10.1038/icb.2015.82. Epub 2015 Sep 22.


Asymmetric cell division during T cell development controls downstream fate.

Pham K, Shimoni R, Charnley M, Ludford-Menting MJ, Hawkins ED, Ramsbottom K, Oliaro J, Izon D, Ting SB, Reynolds J, Lythe G, Molina-Paris C, Melichar H, Robey E, Humbert PO, Gu M, Russell SM.

J Cell Biol. 2015 Sep 14;210(6):933-50. doi: 10.1083/jcb.201502053.


Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

Kruse C, Kurz AR, Pálfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23.


Scribble acts as an oncogene in Eμ-myc-driven lymphoma.

Hawkins ED, Oliaro J, Ramsbottom KM, Newbold A, Humbert PO, Johnstone RW, Russell SM.

Oncogene. 2016 Mar 3;35(9):1193-7. doi: 10.1038/onc.2015.167. Epub 2015 May 18.


Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

Humbert PO, Gödde NJ.

Dev Cell. 2015 May 4;33(3):243-4. doi: 10.1016/j.devcel.2015.04.012.


The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A, ffrench-Constant C.

PLoS Biol. 2015 Mar 25;13(3):e1002107. doi: 10.1371/journal.pbio.1002107. eCollection 2015 Mar.


Muscle stem cell fate is controlled by the cell-polarity protein Scrib.

Ono Y, Urata Y, Goto S, Nakagawa S, Humbert PO, Li TS, Zammit PS.

Cell Rep. 2015 Feb 24;10(7):1135-48. doi: 10.1016/j.celrep.2015.01.045. Epub 2015 Feb 19.


Keratin 76 is required for tight junction function and maintenance of the skin barrier.

DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO, Smyth IM.

PLoS Genet. 2014 Oct 23;10(10):e1004706. doi: 10.1371/journal.pgen.1004706. eCollection 2014 Oct.


Dissecting the role of polarity regulators in cancer through the use of mouse models.

Gödde NJ, Pearson HB, Smith LK, Humbert PO.

Exp Cell Res. 2014 Nov 1;328(2):249-57. doi: 10.1016/j.yexcr.2014.08.036. Epub 2014 Aug 30. Review.


Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.

Godde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE, Humbert PO.

PLoS Genet. 2014 May 22;10(5):e1004323. doi: 10.1371/journal.pgen.1004323. eCollection 2014 May.


Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO, Russell SM.

PLoS One. 2014 Jan 27;9(1):e87376. doi: 10.1371/journal.pone.0087376. eCollection 2014.


Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

Elsum IA, Yates LL, Pearson HB, Phesse TJ, Long F, O'Donoghue R, Ernst M, Cullinane C, Humbert PO.

Oncogene. 2014 Nov 27;33(48):5523-33. doi: 10.1038/onc.2013.498. Epub 2013 Nov 25.


Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.

Elsum IA, Martin C, Humbert PO.

J Cell Sci. 2013 Sep 1;126(Pt 17):3990-9. doi: 10.1242/jcs.129387. Epub 2013 Jun 26.


Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble.

Elsum IA, Humbert PO.

Cells Tissues Organs. 2013;198(1):1-11. doi: 10.1159/000348423. Epub 2013 Jun 15.


Increasing intracellular bioavailable copper selectively targets prostate cancer cells.

Cater MA, Pearson HB, Wolyniec K, Klaver P, Bilandzic M, Paterson BM, Bush AI, Humbert PO, La Fontaine S, Donnelly PS, Haupt Y.

ACS Chem Biol. 2013 Jul 19;8(7):1621-31. doi: 10.1021/cb400198p. Epub 2013 May 24.


Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM.

Nat Commun. 2013;4:1801. doi: 10.1038/ncomms2796.


Characterization of in vivo Dlg1 deletion on T cell development and function.

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.

PLoS One. 2012;7(9):e45276. doi: 10.1371/journal.pone.0045276. Epub 2012 Sep 18.


An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

Willoughby LF, Schlosser T, Manning SA, Parisot JP, Street IP, Richardson HE, Humbert PO, Brumby AM.

Dis Model Mech. 2013 Mar;6(2):521-9. doi: 10.1242/dmm.009985. Epub 2012 Sep 20.


The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

Elsum I, Yates L, Humbert PO, Richardson HE.

Essays Biochem. 2012;53:141-68. doi: 10.1042/bse0530141. Review.


SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

Pearson HB, Perez-Mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R, Humbert PO.

J Clin Invest. 2011 Nov;121(11):4257-67. doi: 10.1172/JCI58509. Epub 2011 Oct 3.


Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers.

Namdarian B, Wong E, Galea R, Pedersen J, Chin X, Speirs R, Humbert PO, Costello AJ, Corcoran NM, Hovens CM.

Urol Oncol. 2013 Jul;31(5):649-55. doi: 10.1016/j.urolonc.2011.03.012. Epub 2011 May 5.


Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.

Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert PO, Richardson HE.

Genetics. 2011 May;188(1):105-25. doi: 10.1534/genetics.111.127910. Epub 2011 Mar 2.


RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition.

Tiang JM, Butcher NJ, Cullinane C, Humbert PO, Minchin RF.

PLoS One. 2011 Feb 9;6(2):e17031. doi: 10.1371/journal.pone.0017031.


Epidermal wound repair is regulated by the planar cell polarity signaling pathway.

Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Parekh V, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM.

Dev Cell. 2010 Jul 20;19(1):138-47. doi: 10.1016/j.devcel.2010.06.008. Erratum in: Dev Cell. 2010 Aug 17;19(2):353. Parekh, Vishwas [added].


Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.

Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM.

J Immunol. 2010 Jul 1;185(1):367-75. doi: 10.4049/jimmunol.0903627. Epub 2010 Jun 7.


Cell polarity in motion: redefining mammary tissue organization through EMT and cell polarity transitions.

Godde NJ, Galea RC, Elsum IA, Humbert PO.

J Mammary Gland Biol Neoplasia. 2010 Jun;15(2):149-68. doi: 10.1007/s10911-010-9180-2. Epub 2010 May 12. Review.


Tumor suppressor scribble regulates assembly of tight junctions in the intestinal epithelium.

Ivanov AI, Young C, Den Beste K, Capaldo CT, Humbert PO, Brennwald P, Parkos CA, Nusrat A.

Am J Pathol. 2010 Jan;176(1):134-45. doi: 10.2353/ajpath.2010.090220. Epub 2009 Dec 3.


Transcriptional output of the Salvador/warts/hippo pathway is controlled in distinct fashions in Drosophila melanogaster and mammalian cell lines.

Zhang X, Milton CC, Humbert PO, Harvey KF.

Cancer Res. 2009 Aug 1;69(15):6033-41. doi: 10.1158/0008-5472.CAN-08-4592. Epub 2009 Jul 7.


Scribble interacts with beta-catenin to localize synaptic vesicles to synapses.

Sun Y, Aiga M, Yoshida E, Humbert PO, Bamji SX.

Mol Biol Cell. 2009 Jul;20(14):3390-400. doi: 10.1091/mbc.E08-12-1172. Epub 2009 May 20.


EKLF/KLF1 controls cell cycle entry via direct regulation of E2f2.

Tallack MR, Keys JR, Humbert PO, Perkins AC.

J Biol Chem. 2009 Jul 31;284(31):20966-74. doi: 10.1074/jbc.M109.006346. Epub 2009 May 20.


Vimentin regulates scribble activity by protecting it from proteasomal degradation.

Phua DC, Humbert PO, Hunziker W.

Mol Biol Cell. 2009 Jun;20(12):2841-55. doi: 10.1091/mbc.E08-02-0199. Epub 2009 Apr 22.

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