Humbert PO[au] - PubMed

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Select item 303259181.

A genome-wide Drosophila epithelial tumorigenesis screen identifies Tetraspanin 29Fb as an evolutionarily conserved suppressor of Ras-driven cancer.

Zoranovic T, Manent J, Willoughby L, Matos de Simoes R, La Marca JE, Golenkina S, Cuiping X, Gruber S, Angjeli B, Kanitz EE, Cronin SJF, Neely GG, Wernitznig A, Humbert PO, Simpson KJ, Mitsiades CS, Richardson HE, Penninger JM.

PLoS Genet. 2018 Oct 16;14(10):e1007688. doi: 10.1371/journal.pgen.1007688. eCollection 2018 Oct.

PMID:: 30325918

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Select item 300318942.

Cell Polarity Regulation-From Atomic to Macroscopic Scale.

Kvansakul M, Humbert PO.

J Mol Biol. 2018 Sep 28;430(19):3455-3456. doi: 10.1016/j.jmb.2018.07.021. Epub 2018 Jul 20. No abstract available.

PMID:: 30031894

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Select item 297130573.

Intermittent hypoxia induces a metastatic phenotype in breast cancer.

Chen A, Sceneay J, Gödde N, Kinwel T, Ham S, Thompson EW, Humbert PO, Möller A.

Oncogene. 2018 Aug;37(31):4214-4225. doi: 10.1038/s41388-018-0259-3. Epub 2018 May 1.

PMID:: 29713057

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Select item 295811764.

Identification of Pik3ca Mutation as a Genetic Driver of Prostate Cancer That Cooperates with Pten Loss to Accelerate Progression and Castration-Resistant Growth.

Pearson HB, Li J, Meniel VS, Fennell CM, Waring P, Montgomery KG, Rebello RJ, Macpherson AA, Koushyar S, Furic L, Cullinane C, Clarkson RW, Smalley MJ, Simpson KJ, Phesse TJ, Shepherd PR, Humbert PO, Sansom OJ, Phillips WA.

Cancer Discov. 2018 Jun;8(6):764-779. doi: 10.1158/2159-8290.CD-17-0867. Epub 2018 Mar 26.

PMID:: 29581176

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Select item 294099955.

The Scribble Cell Polarity Module in the Regulation of Cell Signaling in Tissue Development and Tumorigenesis.

Stephens R, Lim K, Portela M, Kvansakul M, Humbert PO, Richardson HE.

J Mol Biol. 2018 Sep 28;430(19):3585-3612. doi: 10.1016/j.jmb.2018.01.011. Epub 2018 Feb 8. Review.

PMID:: 29409995

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Select item 293788496.

Drosophila melanogaster Guk-holder interacts with the Scribbled PDZ1 domain and regulates epithelial development with Scribbled and Discs Large.

Caria S, Magtoto CM, Samiei T, Portela M, Lim KYB, How JY, Stewart BZ, Humbert PO, Richardson HE, Kvansakul M.

J Biol Chem. 2018 Mar 23;293(12):4519-4531. doi: 10.1074/jbc.M117.817528. Epub 2018 Jan 29.

PMID:: 29378849

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Select item 291548237.

Regulation of cellular and PCP signalling by the Scribble polarity module.

Milgrom-Hoffman M, Humbert PO.

Semin Cell Dev Biol. 2018 Sep;81:33-45. doi: 10.1016/j.semcdb.2017.11.021. Epub 2017 Nov 23. Review.

PMID:: 29154823

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Select item 290618528.

Structural basis for the differential interaction of Scribble PDZ domains with the guanine nucleotide exchange factor β-PIX.

Lim KYB, Gödde NJ, Humbert PO, Kvansakul M.

J Biol Chem. 2017 Dec 15;292(50):20425-20436. doi: 10.1074/jbc.M117.799452. Epub 2017 Oct 23.

PMID:: 29061852

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Select item 289806259.

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5658-5660. doi: 10.1038/onc.2017.239.

PMID:: 28980625

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Select item 2858151910.

Autophagy suppresses Ras-driven epithelial tumourigenesis by limiting the accumulation of reactive oxygen species.

Manent J, Banerjee S, de Matos Simoes R, Zoranovic T, Mitsiades C, Penninger JM, Simpson KJ, Humbert PO, Richardson HE.

Oncogene. 2017 Oct 5;36(40):5576-5592. doi: 10.1038/onc.2017.175. Epub 2017 Jun 5. Erratum in: Oncogene. 2017 Oct 5;36(40):5658-5660.

PMID:: 28581519

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Select item 2810274911.

How to expel a bad tenant: Linking cyclin A2, enucleation and cell size.

Wölwer CB, Humbert PO.

Cell Cycle. 2017 Mar 4;16(5):397-398. doi: 10.1080/15384101.2016.1274586. Epub 2017 Jan 19. No abstract available.

PMID:: 28102749

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Select item 2809547312.

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation.

Wölwer CB, Gödde N, Pase LB, Elsum IA, Lim KY, Sacirbegovic F, Walkley CR, Ellis S, Ohno S, Matsuzaki F, Russell SM, Humbert PO.

PLoS One. 2017 Jan 17;12(1):e0170295. doi: 10.1371/journal.pone.0170295. eCollection 2017.

PMID:: 28095473

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Select item 2766129013.

A Phenotypic High-Content Screening Assay to Identify Regulators of Membrane Protein Localization.

Smith LK, Thomas DW, Simpson KJ, Humbert PO.

Assay Drug Dev Technol. 2016 Oct;14(8):478-488. Epub 2016 Sep 23.

PMID:: 27661290

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Select item 2673110814.

Calcium Signaling Is Required for Erythroid Enucleation.

Wölwer CB, Pase LB, Russell SM, Humbert PO.

PLoS One. 2016 Jan 5;11(1):e0146201. doi: 10.1371/journal.pone.0146201. eCollection 2016.

PMID:: 26731108

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Select item 2656910215.

A Chemical Screening Approach to Identify Novel Key Mediators of Erythroid Enucleation.

Wölwer CB, Pase LB, Pearson HB, Gödde NJ, Lackovic K, Huang DC, Russell SM, Humbert PO.

PLoS One. 2015 Nov 16;10(11):e0142655. doi: 10.1371/journal.pone.0142655. eCollection 2015.

PMID:: 26569102

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Select item 2639181016.

Lethal giant larvae-1 deficiency enhances the CD8(+) effector T-cell response to antigen challenge in vivo.

Ramsbottom KM, Sacirbegovic F, Hawkins ED, Kallies A, Belz GT, Van Ham V, Haynes NM, Durrant MJ, Humbert PO, Russell SM, Oliaro J.

Immunol Cell Biol. 2016 Mar;94(3):306-11. doi: 10.1038/icb.2015.82. Epub 2015 Sep 22.

PMID:: 26391810

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Select item 2637050017.

Asymmetric cell division during T cell development controls downstream fate.

Pham K, Shimoni R, Charnley M, Ludford-Menting MJ, Hawkins ED, Ramsbottom K, Oliaro J, Izon D, Ting SB, Reynolds J, Lythe G, Molina-Paris C, Melichar H, Robey E, Humbert PO, Gu M, Russell SM.

J Cell Biol. 2015 Sep 14;210(6):933-50. doi: 10.1083/jcb.201502053.

PMID:: 26370500

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Select item 2620596118.

Polarity Protein Scrib Facilitates Endothelial Inflammatory Signaling.

Kruse C, Kurz AR, Pálfi K, Humbert PO, Sperandio M, Brandes RP, Fork C, Michaelis UR.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1954-62. doi: 10.1161/ATVBAHA.115.305678. Epub 2015 Jul 23.

PMID:: 26205961

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Select item 2598228019.

Scribble acts as an oncogene in Eμ-myc-driven lymphoma.

Hawkins ED, Oliaro J, Ramsbottom KM, Newbold A, Humbert PO, Johnstone RW, Russell SM.

Oncogene. 2016 Mar 3;35(9):1193-7. doi: 10.1038/onc.2015.167. Epub 2015 May 18.

PMID:: 25982280

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Select item 2594262020.

Mitotic spindle orientation: semaphorin-plexin signaling flags the way.

Humbert PO, Gödde NJ.

Dev Cell. 2015 May 4;33(3):243-4. doi: 10.1016/j.devcel.2015.04.012.

PMID:: 25942620

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Select item 2580706221.

The polarity protein Scribble regulates myelination and remyelination in the central nervous system.

Jarjour AA, Boyd A, Dow LE, Holloway RK, Goebbels S, Humbert PO, Williams A, ffrench-Constant C.

PLoS Biol. 2015 Mar 25;13(3):e1002107. doi: 10.1371/journal.pbio.1002107. eCollection 2015 Mar.

PMID:: 25807062

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Select item 2570481622.

Muscle stem cell fate is controlled by the cell-polarity protein Scrib.

Ono Y, Urata Y, Goto S, Nakagawa S, Humbert PO, Li TS, Zammit PS.

Cell Rep. 2015 Feb 24;10(7):1135-48. doi: 10.1016/j.celrep.2015.01.045. Epub 2015 Feb 19.

PMID:: 25704816

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Select item 2534034523.

Keratin 76 is required for tight junction function and maintenance of the skin barrier.

DiTommaso T, Cottle DL, Pearson HB, Schlüter H, Kaur P, Humbert PO, Smyth IM.

PLoS Genet. 2014 Oct 23;10(10):e1004706. doi: 10.1371/journal.pgen.1004706. eCollection 2014 Oct.

PMID:: 25340345

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Select item 2517975924.

Dissecting the role of polarity regulators in cancer through the use of mouse models.

Gödde NJ, Pearson HB, Smith LK, Humbert PO.

Exp Cell Res. 2014 Nov 1;328(2):249-57. doi: 10.1016/j.yexcr.2014.08.036. Epub 2014 Aug 30. Review.

PMID:: 25179759

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Select item 2485202225.

Scribble modulates the MAPK/Fra1 pathway to disrupt luminal and ductal integrity and suppress tumour formation in the mammary gland.

Godde NJ, Sheridan JM, Smith LK, Pearson HB, Britt KL, Galea RC, Yates LL, Visvader JE, Humbert PO.

PLoS Genet. 2014 May 22;10(5):e1004323. doi: 10.1371/journal.pgen.1004323. eCollection 2014 May.

PMID:: 24852022

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Select item 2447528126.

Lethal giant larvae 1 tumour suppressor activity is not conserved in models of mammalian T and B cell leukaemia.

Hawkins ED, Oliaro J, Ramsbottom KM, Ting SB, Sacirbegovic F, Harvey M, Kinwell T, Ghysdael J, Johnstone RW, Humbert PO, Russell SM.

PLoS One. 2014 Jan 27;9(1):e87376. doi: 10.1371/journal.pone.0087376. eCollection 2014.

PMID:: 24475281

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Select item 2427623827.

Scrib heterozygosity predisposes to lung cancer and cooperates with KRas hyperactivation to accelerate lung cancer progression in vivo.

Elsum IA, Yates LL, Pearson HB, Phesse TJ, Long F, O'Donoghue R, Ernst M, Cullinane C, Humbert PO.

Oncogene. 2014 Nov 27;33(48):5523-33. doi: 10.1038/onc.2013.498. Epub 2013 Nov 25.

PMID:: 24276238

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Select item 2381395628.

Scribble regulates an EMT polarity pathway through modulation of MAPK-ERK signaling to mediate junction formation.

Elsum IA, Martin C, Humbert PO.

J Cell Sci. 2013 Sep 1;126(Pt 17):3990-9. doi: 10.1242/jcs.129387. Epub 2013 Jun 26.

PMID:: 23813956

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Select item 2377480829.

Localization, not important in all tumor-suppressing properties: a lesson learnt from scribble.

Elsum IA, Humbert PO.

Cells Tissues Organs. 2013;198(1):1-11. doi: 10.1159/000348423. Epub 2013 Jun 15.

PMID:: 23774808

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Select item 2365685930.

Increasing intracellular bioavailable copper selectively targets prostate cancer cells.

Cater MA, Pearson HB, Wolyniec K, Klaver P, Bilandzic M, Paterson BM, Bush AI, Humbert PO, La Fontaine S, Donnelly PS, Haupt Y.

ACS Chem Biol. 2013 Jul 19;8(7):1621-31. doi: 10.1021/cb400198p. Epub 2013 May 24.

PMID:: 23656859

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Select item 2365321331.

Regulation of asymmetric cell division and polarity by Scribble is not required for humoral immunity.

Hawkins ED, Oliaro J, Kallies A, Belz GT, Filby A, Hogan T, Haynes N, Ramsbottom KM, Van Ham V, Kinwell T, Seddon B, Davies D, Tarlinton D, Lew AM, Humbert PO, Russell SM.

Nat Commun. 2013;4:1801. doi: 10.1038/ncomms2796.

PMID:: 23653213

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Select item 2302890232.

Characterization of in vivo Dlg1 deletion on T cell development and function.

Humphries LA, Shaffer MH, Sacirbegovic F, Tomassian T, McMahon KA, Humbert PO, Silva O, Round JL, Takamiya K, Huganir RL, Burkhardt JK, Russell SM, Miceli MC.

PLoS One. 2012;7(9):e45276. doi: 10.1371/journal.pone.0045276. Epub 2012 Sep 18.

PMID:: 23028902

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Select item 2299664533.

An in vivo large-scale chemical screening platform using Drosophila for anti-cancer drug discovery.

Willoughby LF, Schlosser T, Manning SA, Parisot JP, Street IP, Richardson HE, Humbert PO, Brumby AM.

Dis Model Mech. 2013 Mar;6(2):521-9. doi: 10.1242/dmm.009985. Epub 2012 Sep 20.

PMID:: 22996645

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Select item 2292851434.

The Scribble-Dlg-Lgl polarity module in development and cancer: from flies to man.

Elsum I, Yates L, Humbert PO, Richardson HE.

Essays Biochem. 2012;53:141-68. doi: 10.1042/bse0530141. Review.

PMID:: 22928514

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Select item 2196532935.

SCRIB expression is deregulated in human prostate cancer, and its deficiency in mice promotes prostate neoplasia.

Pearson HB, Perez-Mancera PA, Dow LE, Ryan A, Tennstedt P, Bogani D, Elsum I, Greenfield A, Tuveson DA, Simon R, Humbert PO.

J Clin Invest. 2011 Nov;121(11):4257-67. doi: 10.1172/JCI58509. Epub 2011 Oct 3.

PMID:: 21965329

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Select item 2154962136.

Loss of APKC expression independently predicts tumor recurrence in superficial bladder cancers.

Namdarian B, Wong E, Galea R, Pedersen J, Chin X, Speirs R, Humbert PO, Costello AJ, Corcoran NM, Hovens CM.

Urol Oncol. 2013 Jul;31(5):649-55. doi: 10.1016/j.urolonc.2011.03.012. Epub 2011 May 5.

PMID:: 21549621

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Select item 2136827437.

Identification of novel Ras-cooperating oncogenes in Drosophila melanogaster: a RhoGEF/Rho-family/JNK pathway is a central driver of tumorigenesis.

Brumby AM, Goulding KR, Schlosser T, Loi S, Galea R, Khoo P, Bolden JE, Aigaki T, Humbert PO, Richardson HE.

Genetics. 2011 May;188(1):105-25. doi: 10.1534/genetics.111.127910. Epub 2011 Mar 2.

PMID:: 21368274

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Select item 2134739638.

RNAi-mediated knock-down of arylamine N-acetyltransferase-1 expression induces E-cadherin up-regulation and cell-cell contact growth inhibition.

Tiang JM, Butcher NJ, Cullinane C, Humbert PO, Minchin RF.

PLoS One. 2011 Feb 9;6(2):e17031. doi: 10.1371/journal.pone.0017031.

PMID:: 21347396

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Select item 2064335639.

Epidermal wound repair is regulated by the planar cell polarity signaling pathway.

Caddy J, Wilanowski T, Darido C, Dworkin S, Ting SB, Zhao Q, Rank G, Auden A, Srivastava S, Papenfuss TA, Murdoch JN, Humbert PO, Parekh V, Boulos N, Weber T, Zuo J, Cunningham JM, Jane SM.

Dev Cell. 2010 Jul 20;19(1):138-47. doi: 10.1016/j.devcel.2010.06.008. Erratum in: Dev Cell. 2010 Aug 17;19(2):353. Parekh, Vishwas [added].

PMID:: 20643356

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Select item 2053026640.

Asymmetric cell division of T cells upon antigen presentation uses multiple conserved mechanisms.

Oliaro J, Van Ham V, Sacirbegovic F, Pasam A, Bomzon Z, Pham K, Ludford-Menting MJ, Waterhouse NJ, Bots M, Hawkins ED, Watt SV, Cluse LA, Clarke CJ, Izon DJ, Chang JT, Thompson N, Gu M, Johnstone RW, Smyth MJ, Humbert PO, Reiner SL, Russell SM.

J Immunol. 2010 Jul 1;185(1):367-75. doi: 10.4049/jimmunol.0903627. Epub 2010 Jun 7.