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[IL6R is the key therapeutical target in pulmonary arterial hypertension].

Tu L, Phan C, Humbert M, Guignabert C.

Med Sci (Paris). 2018 Oct;34(10):765-768. doi: 10.1051/medsci/2018201. Epub 2018 Nov 19. French. No abstract available.


[Staying at home : which dimensions to assess in older persons ?]

Büla C, Humbert M, Nguyen S, Major K, Joly Schwartz C.

Rev Med Suisse. 2018 Nov 7;14(626):1993-1997. French.


Loss-of-Function ABCC8 Mutations in Pulmonary Arterial Hypertension.

Bohnen MS, Ma L, Zhu N, Qi H, McClenaghan C, Gonzaga-Jauregui C, Dewey FE, Overton JD, Reid JG, Shuldiner AR, Baras A, Sampson KJ, Bleda M, Hadinnapola C, Haimel M, Bogaard HJ, Church C, Coghlan G, Corris PA, Eyries M, Gibbs JSR, Girerd B, Houweling AC, Humbert M, Guignabert C, Kiely DG, Lawrie A, MacKenzie Ross RV, Martin JM, Montani D, Peacock AJ, Pepke-Zaba J, Soubrier F, Suntharalingam J, Toshner M, Treacy CM, Trembath RC, Vonk Noordegraaf A, Wharton J, Wilkins MR, Wort SJ, Yates K, Gräf S, Morrell NW, Krishnan U, Rosenzweig EB, Shen Y, Nichols CG, Kass RS, Chung WK.

Circ Genom Precis Med. 2018 Oct;11(10):e002087. doi: 10.1161/CIRCGEN.118.002087.


Ion Channels in Pulmonary Hypertension: A Therapeutic Interest?

Lambert M, Capuano V, Olschewski A, Sabourin J, Nagaraj C, Girerd B, Weatherald J, Humbert M, Antigny F.

Int J Mol Sci. 2018 Oct 14;19(10). pii: E3162. doi: 10.3390/ijms19103162. Review.


Chronic blood exchange transfusions in the management of pre-capillary pulmonary hypertension complicating sickle cell disease.

Turpin M, Chantalat-Auger C, Parent F, Driss F, Lionnet F, Habibi A, Maître B, Huertas A, Jaïs X, Weatherald J, Montani D, Sitbon O, Simonneau G, Galactéros F, Humbert M, Bartolucci P, Savale L.

Eur Respir J. 2018 Oct 10;52(4). pii: 1800272. doi: 10.1183/13993003.00272-2018. Print 2018 Oct.


Structure of the Recombinant Neisseria gonorrhoeae Adhesin Complex Protein (rNg-ACP) and Generation of Murine Antibodies with Bactericidal Activity against Gonococci.

Almonacid-Mendoza HL, Humbert MV, Dijokaite A, Cleary DW, Soo Y, Hung MC, Orr CM, Machelett MM, Tews I, Christodoulides M.

mSphere. 2018 Oct 10;3(5). pii: e00331-18. doi: 10.1128/mSphere.00331-18.


Haemodynamics and serial risk assessment in systemic sclerosis associated pulmonary arterial hypertension.

Weatherald J, Boucly A, Launay D, Cottin V, Prévot G, Bourlier D, Dauphin C, Chaouat A, Savale L, Jaïs X, Jevnikar M, Traclet J, De Groote P, Simonneau G, Hachulla E, Mouthon L, Montani D, Humbert M, Sitbon O.

Eur Respir J. 2018 Oct 18;52(4). pii: 1800678. doi: 10.1183/13993003.00678-2018. Print 2018 Oct.


[Liver diseases and pulmonary vascular disorders].

Riou M, Jutant EM, Mignard X, Canuet M, Humbert M, Sitbon O, Savale L, Montani D.

Rev Med Interne. 2018 Aug 30. pii: S0248-8663(18)30667-2. doi: 10.1016/j.revmed.2018.07.015. [Epub ahead of print] French.


Pulmonary hypertension associated with neurofibromatosis type 1.

Jutant EM, Girerd B, Jaïs X, Savale L, O'Connell C, Perros F, Sitbon O, Humbert M, Montani D.

Eur Respir Rev. 2018 Aug 29;27(149). pii: 180053. doi: 10.1183/16000617.0053-2018. Print 2018 Sep 30.


Lessons from pulmonary hypertension registries.

Humbert M.

Rev Port Cardiol. 2018 Sep;37(9):759-761. doi: 10.1016/j.repc.2018.08.003. Epub 2018 Aug 22. English, Portuguese. No abstract available.


Pharmacovigilance in a rare disease: example of the VIGIAPATH program in pulmonary arterial hypertension.

Chaumais MC, O'Connell C, Savale L, Guignabert C, Perros F, Jaïs X, Sitbon O, Humbert M, Montani D.

Int J Clin Pharm. 2018 Aug;40(4):790-794. doi: 10.1007/s11096-018-0712-y. Epub 2018 Aug 13.


Cisplatin sensitivity in breast cancer cells is associated with particular DMTF1 splice variant expression.

Niklaus NJ, Humbert M, Tschan MP.

Biochem Biophys Res Commun. 2018 Sep 18;503(4):2800-2806. doi: 10.1016/j.bbrc.2018.08.042. Epub 2018 Aug 9.


Efficacy and safety of once-daily fluticasone furoate/vilanterol (FF/VI) versus twice-daily inhaled corticosteroids/long-acting β2-agonists (ICS/LABA) in patients with uncontrolled asthma: An open-label, randomized, controlled trial.

Devillier P, Humbert M, Boye A, Zachgo W, Jacques L, Nunn C, West S, Nicholls A, Antoun Z, Spinu L, Grouin JM.

Respir Med. 2018 Aug;141:111-120. doi: 10.1016/j.rmed.2018.06.009. Epub 2018 Jun 9.


Simulating the Large-Scale Erosion of Genomic Privacy Over Time.

Backes M, Berrang P, Humbert M, Xiaoyu Shen, Wolf V.

IEEE/ACM Trans Comput Biol Bioinform. 2018 Sep-Oct;15(5):1405-1412. doi: 10.1109/TCBB.2018.2859380. Epub 2018 Jul 24.


Impact of the initiation of balloon pulmonary angioplasty program on referral of patients with chronic thromboembolic pulmonary hypertension to surgery.

Amsallem M, Guihaire J, Arthur Ataam J, Lamrani L, Boulate D, Mussot S, Fabre D, Taniguchi Y, Haddad F, Sitbon O, Jais X, Humbert M, Simonneau G, Mercier O, Brenot P, Fadel E.

J Heart Lung Transplant. 2018 Sep;37(9):1102-1110. doi: 10.1016/j.healun.2018.05.004. Epub 2018 May 24.


Neisseria gonorrhoeae employs two protein inhibitors to evade killing by human lysozyme.

Ragland SA, Humbert MV, Christodoulides M, Criss AK.

PLoS Pathog. 2018 Jul 5;14(7):e1007080. doi: 10.1371/journal.ppat.1007080. eCollection 2018 Jul.


Right heart catheterisation is still a fundamental part of the follow-up assessment of pulmonary arterial hypertension.

Humbert M, Weatherald J.

Eur Respir J. 2018 Jul 4;52(1). pii: 1800738. doi: 10.1183/13993003.00738-2018. Print 2018 Jul. No abstract available.


Reply to Voelkel and Newman: The Light at the End of the Long Pulmonary Hypertension Tunnel Brightens.

Elinoff JM, Humbert M, Solomon MA.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):820-821. doi: 10.1164/rccm.201804-0792LE. No abstract available.


Clinical and Hemodynamic Correlates of Pulmonary Arterial Stiffness in Incident, Untreated Patients With Idiopathic Pulmonary Arterial Hypertension.

Chemla D, Weatherald J, Lau EMT, Savale L, Boucly A, Attal P, Jaïs X, Parent F, Girerd B, Simonneau G, Montani D, Humbert M, Sitbon O, Hervé P.

Chest. 2018 Oct;154(4):882-892. doi: 10.1016/j.chest.2018.06.015. Epub 2018 Jun 27.


How to perform microscopic/endoscopic resection of large petrous apex lesions.

Patron V, Humbert M, Micault E, Emery E, Hitier M.

Eur Ann Otorhinolaryngol Head Neck Dis. 2018 Dec;135(6):443-447. doi: 10.1016/j.anorl.2018.06.002. Epub 2018 Jun 20.


Factors predicting outcome after pulmonary endarterectomy.

Tromeur C, Jaïs X, Mercier O, Couturaud F, Montani D, Savale L, Jevnikar M, Weatherald J, Sitbon O, Parent F, Fabre D, Mussot S, Dartevelle P, Humbert M, Simonneau G, Fadel E.

PLoS One. 2018 Jun 21;13(6):e0198198. doi: 10.1371/journal.pone.0198198. eCollection 2018.


A specific expression profile of LC3B and p62 is associated with nonresponse to neoadjuvant chemotherapy in esophageal adenocarcinomas.

Adams O, Janser FA, Dislich B, Berezowska S, Humbert M, Seiler CA, Kroell D, Slotta-Huspenina J, Feith M, Ott K, Tschan MP, Langer R.

PLoS One. 2018 Jun 13;13(6):e0197610. doi: 10.1371/journal.pone.0197610. eCollection 2018.


Association Between BMI and Obesity With Survival in Pulmonary Arterial Hypertension.

Weatherald J, Huertas A, Boucly A, Guignabert C, Taniguchi Y, Adir Y, Jevnikar M, Savale L, Jaïs X, Peng M, Simonneau G, Montani D, Humbert M, Sitbon O.

Chest. 2018 Oct;154(4):872-881. doi: 10.1016/j.chest.2018.05.006. Epub 2018 May 22.


PKD1 is a potential biomarker and therapeutic target in triple-negative breast cancer.

Spasojevic C, Marangoni E, Vacher S, Assayag F, Meseure D, Château-Joubert S, Humbert M, Karam M, Ricort JM, Auclair C, Regairaz M, Bièche I.

Oncotarget. 2018 May 1;9(33):23208-23219. doi: 10.18632/oncotarget.25292. eCollection 2018 May 1.


Clinical phenotypes and survival of pre-capillary pulmonary hypertension in systemic sclerosis.

Launay D, Montani D, Hassoun PM, Cottin V, Le Pavec J, Clerson P, Sitbon O, Jaïs X, Savale L, Weatherald J, Sobanski V, Mathai SC, Shafiq M, Cordier JF, Hachulla E, Simonneau G, Humbert M.

PLoS One. 2018 May 15;13(5):e0197112. doi: 10.1371/journal.pone.0197112. eCollection 2018.


Pulmonary Vascular Involvement in Chronic Obstructive Pulmonary Disease. Is There a Pulmonary Vascular Phenotype?

Kovacs G, Agusti A, Barberà JA, Celli B, Criner G, Humbert M, Sin DD, Voelkel N, Olschewski H.

Am J Respir Crit Care Med. 2018 Oct 15;198(8):1000-1011. doi: 10.1164/rccm.201801-0095PP. No abstract available.


Low Autophagy (ATG) Gene Expression Is Associated with an Immature AML Blast Cell Phenotype and Can Be Restored during AML Differentiation Therapy.

Jin J, Britschgi A, Schläfli AM, Humbert M, Shan-Krauer D, Batliner J, Federzoni EA, Ernst M, Torbett BE, Yousefi S, Simon HU, Tschan MP.

Oxid Med Cell Longev. 2018 Mar 18;2018:1482795. doi: 10.1155/2018/1482795. eCollection 2018.


Poor Subpleural Perfusion Predicts Failure After Balloon Pulmonary Angioplasty for Nonoperable Chronic Thromboembolic Pulmonary Hypertension.

Taniguchi Y, Brenot P, Jais X, Garcia C, Weatherald J, Planche O, Fadel E, Humbert M, Simonneau G.

Chest. 2018 Sep;154(3):521-531. doi: 10.1016/j.chest.2018.03.059. Epub 2018 May 3.


Natural History over 8 Years of Pulmonary Vascular Disease in a Patient Carrying Biallelic EIF2AK4 Mutations.

Montani D, Dorfmüller P, Girerd B, Le Pavec J, Fadel E, Simonneau G, Sitbon O, Humbert M.

Am J Respir Crit Care Med. 2018 Aug 15;198(4):537-541. doi: 10.1164/rccm.201802-0317LE. No abstract available.


Precision medicine and personalising therapy in pulmonary hypertension: seeing the light from the dawn of a new era.

Savale L, Guignabert C, Weatherald J, Humbert M.

Eur Respir Rev. 2018 Apr 13;27(148). pii: 180004. doi: 10.1183/16000617.0004-2018. Print 2018 Jun 30. Review.


Identification of rare sequence variation underlying heritable pulmonary arterial hypertension.

Gräf S, Haimel M, Bleda M, Hadinnapola C, Southgate L, Li W, Hodgson J, Liu B, Salmon RM, Southwood M, Machado RD, Martin JM, Treacy CM, Yates K, Daugherty LC, Shamardina O, Whitehorn D, Holden S, Aldred M, Bogaard HJ, Church C, Coghlan G, Condliffe R, Corris PA, Danesino C, Eyries M, Gall H, Ghio S, Ghofrani HA, Gibbs JSR, Girerd B, Houweling AC, Howard L, Humbert M, Kiely DG, Kovacs G, MacKenzie Ross RV, Moledina S, Montani D, Newnham M, Olschewski A, Olschewski H, Peacock AJ, Pepke-Zaba J, Prokopenko I, Rhodes CJ, Scelsi L, Seeger W, Soubrier F, Stein DF, Suntharalingam J, Swietlik EM, Toshner MR, van Heel DA, Vonk Noordegraaf A, Waisfisz Q, Wharton J, Wort SJ, Ouwehand WH, Soranzo N, Lawrie A, Upton PD, Wilkins MR, Trembath RC, Morrell NW.

Nat Commun. 2018 Apr 12;9(1):1416. doi: 10.1038/s41467-018-03672-4.


Ca2+ handling remodeling and STIM1L/Orai1/TRPC1/TRPC4 upregulation in monocrotaline-induced right ventricular hypertrophy.

Sabourin J, Boet A, Rucker-Martin C, Lambert M, Gomez AM, Benitah JP, Perros F, Humbert M, Antigny F.

J Mol Cell Cardiol. 2018 May;118:208-224. doi: 10.1016/j.yjmcc.2018.04.003. Epub 2018 Apr 7.


Ectopic upregulation of membrane-bound IL6R drives vascular remodeling in pulmonary arterial hypertension.

Tamura Y, Phan C, Tu L, Le Hiress M, Thuillet R, Jutant EM, Fadel E, Savale L, Huertas A, Humbert M, Guignabert C.

J Clin Invest. 2018 May 1;128(5):1956-1970. doi: 10.1172/JCI96462. Epub 2018 Apr 9.


Rapid Contour-based Segmentation for 18F-FDG PET Imaging of Lung Tumors by Using ITK-SNAP: Comparison to Expert-based Segmentation.

Besson FL, Henry T, Meyer C, Chevance V, Roblot V, Blanchet E, Arnould V, Grimon G, Chekroun M, Mabille L, Parent F, Seferian A, Bulifon S, Montani D, Humbert M, Chaumet-Riffaud P, Lebon V, Durand E.

Radiology. 2018 Jul;288(1):277-284. doi: 10.1148/radiol.2018171756. Epub 2018 Apr 3.


Risk assessment in pulmonary arterial hypertension.

Boucly A, Weatherald J, Humbert M, Sitbon O.

Eur Respir J. 2018 Mar 29;51(3). pii: 1800279. doi: 10.1183/13993003.00279-2018. Print 2018 Mar. No abstract available.


Intratumoral CpG-B Promotes Antitumoral Neutrophil, cDC, and T-cell Cooperation without Reprograming Tolerogenic pDC.

Humbert M, Guery L, Brighouse D, Lemeille S, Hugues S.

Cancer Res. 2018 Jun 15;78(12):3280-3292. doi: 10.1158/0008-5472.CAN-17-2549. Epub 2018 Mar 27.


Riociguat treatment for portopulmonary hypertension: a subgroup analysis from the PATENT-1/-2 studies.

Cartin-Ceba R, Halank M, Ghofrani HA, Humbert M, Mattson J, Fritsch A, Krowka M.

Pulm Circ. 2018 Apr-Jun;8(2):2045894018769305. doi: 10.1177/2045894018769305. Epub 2018 Mar 22.


Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study.

Humbert M, Taillé C, Mala L, Le Gros V, Just J, Molimard M; STELLAIR investigators.

Eur Respir J. 2018 May 10;51(5). pii: 1702523. doi: 10.1183/13993003.02523-2017. Print 2018 May.


Pulmonary vascular endothelium: the orchestra conductor in respiratory diseases: Highlights from basic research to therapy.

Huertas A, Guignabert C, Barberà JA, Bärtsch P, Bhattacharya J, Bhattacharya S, Bonsignore MR, Dewachter L, Dinh-Xuan AT, Dorfmüller P, Gladwin MT, Humbert M, Kotsimbos T, Vassilakopoulos T, Sanchez O, Savale L, Testa U, Wilkins MR.

Eur Respir J. 2018 Apr 4;51(4). pii: 1700745. doi: 10.1183/13993003.00745-2017. Print 2018 Apr. Review.


Design, Synthesis, and Biological Activity of New N-(Phenylmethyl)-benzoxazol-2-thiones as Macrophage Migration Inhibitory Factor (MIF) Antagonists: Efficacies in Experimental Pulmonary Hypertension.

Le Hiress M, Akagah B, Bernadat G, Tu L, Thuillet R, Huertas A, Phan C, Fadel E, Simonneau G, Humbert M, Jalce G, Guignabert C.

J Med Chem. 2018 Apr 12;61(7):2725-2736. doi: 10.1021/acs.jmedchem.7b01312. Epub 2018 Mar 19.


Promoting physical activity, healthy eating and gross motor skills development among preschoolers attending childcare centers: Process evaluation of the Healthy Start-Départ Santé intervention using the RE-AIM framework.

Ward S, Chow AF, Humbert ML, Bélanger M, Muhajarine N, Vatanparast H, Leis A.

Eval Program Plann. 2018 Jun;68:90-98. doi: 10.1016/j.evalprogplan.2018.02.005. Epub 2018 Feb 14.


[Pulmonary veno-occlusive disease].

Boucly A, Girerd B, Bourlier D, Nemlaghi S, Caliez J, Savale L, Jaïs X, Dorfmüller P, Simonneau G, Sitbon O, Humbert M, Montani D.

Rev Mal Respir. 2018 Feb;35(2):160-170. doi: 10.1016/j.rmr.2017.11.005. Epub 2018 Mar 1. Review. French.


Association between Rheumatoid Arthritis and Pulmonary Hypertension: Data from the French Pulmonary Hypertension Registry.

Montani D, Henry J, O'Connell C, Jaïs X, Cottin V, Launay D, Habib G, Bourdin A, Jevnikar M, Savale L, Rottat L, Simonneau G, Sitbon O, Humbert M, Allanore Y.

Respiration. 2018;95(4):244-250. doi: 10.1159/000485631. Epub 2018 Feb 28.


NMDA-Type Glutamate Receptor Activation Promotes Vascular Remodeling and Pulmonary Arterial Hypertension.

Dumas SJ, Bru-Mercier G, Courboulin A, Quatredeniers M, Rücker-Martin C, Antigny F, Nakhleh MK, Ranchoux B, Gouadon E, Vinhas MC, Vocelle M, Raymond N, Dorfmüller P, Fadel E, Perros F, Humbert M, Cohen-Kaminsky S.

Circulation. 2018 May 29;137(22):2371-2389. doi: 10.1161/CIRCULATIONAHA.117.029930. Epub 2018 Feb 14.


RV Fractional Area Change and TAPSE as Predictors of Severe Right Ventricular Dysfunction in Pulmonary Hypertension: A CMR Study.

Hoette S, Creuzé N, Günther S, Montani D, Savale L, Jaïs X, Parent F, Sitbon O, Rochitte CE, Simonneau G, Humbert M, Souza R, Chemla D.

Lung. 2018 Apr;196(2):157-164. doi: 10.1007/s00408-018-0089-7. Epub 2018 Feb 12.


Challenges in Pulmonary Hypertension: Controversies in Treating the Tip of the Iceberg. A Joint National Institutes of Health Clinical Center and Pulmonary Hypertension Association Symposium Report.

Elinoff JM, Agarwal R, Barnett CF, Benza RL, Cuttica MJ, Gharib AM, Gray MP, Hassoun PM, Hemnes AR, Humbert M, Kolb TM, Lahm T, Leopold JA, Mathai SC, McLaughlin VV, Preston IR, Rosenzweig EB, Shlobin OA, Steen VD, Zamanian RT, Solomon MA.

Am J Respir Crit Care Med. 2018 Jul 15;198(2):166-174. doi: 10.1164/rccm.201710-2093PP. No abstract available.


Respiratory effects of trichloroethylene.

Dumas O, Despreaux T, Perros F, Lau E, Andujar P, Humbert M, Montani D, Descatha A.

Respir Med. 2018 Jan;134:47-53. doi: 10.1016/j.rmed.2017.11.021. Epub 2017 Dec 1. Review.


Sirtuin 1 regulates pulmonary artery smooth muscle cell proliferation: role in pulmonary arterial hypertension.

Zurlo G, Piquereau J, Moulin M, Pires Da Silva J, Gressette M, Ranchoux B, Garnier A, Ventura-Clapier R, Fadel E, Humbert M, Lemaire C, Perros F, Veksler V.

J Hypertens. 2018 May;36(5):1164-1177. doi: 10.1097/HJH.0000000000001676.


Loss of KCNK3 is a hallmark of RV hypertrophy/dysfunction associated with pulmonary hypertension.

Lambert M, Boet A, Rucker-Martin C, Mendes-Ferreira P, Capuano V, Hatem S, Adão R, Brás-Silva C, Hautefort A, Michel JB, Dorfmuller P, Fadel E, Kotsimbos T, Price L, Jourdon P, Montani D, Humbert M, Perros F, Antigny F.

Cardiovasc Res. 2018 May 1;114(6):880-893. doi: 10.1093/cvr/cvy016.


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