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Items: 41


Experimental lupus is aggravated in mouse strains with impaired induction of neutrophil extracellular traps.

Kienhöfer D, Hahn J, Stoof J, Csepregi JZ, Reinwald C, Urbonaviciute V, Johnsson C, Maueröder C, Podolska MJ, Biermann MH, Leppkes M, Harrer T, Hultqvist M, Olofsson P, Munoz LE, Mocsai A, Herrmann M, Schett G, Holmdahl R, Hoffmann MH.

JCI Insight. 2017 May 18;2(10). pii: 92920. doi: 10.1172/jci.insight.92920. eCollection 2017 May 18.


Animal Models of Rheumatoid Arthritis (I): Pristane-Induced Arthritis in the Rat.

Tuncel J, Haag S, Hoffmann MH, Yau AC, Hultqvist M, Olofsson P, Bäcklund J, Nandakumar KS, Weidner D, Fischer A, Leichsenring A, Lange F, Haase C, Lu S, Gulko PS, Steiner G, Holmdahl R.

PLoS One. 2016 May 26;11(5):e0155936. doi: 10.1371/journal.pone.0155936. eCollection 2016.


The SKG Mutation in ZAP-70 also Confers Arthritis Susceptibility in C57 Black Mouse Strains.

Guerard S, Boieri M, Hultqvist M, Holmdahl R, Wing K.

Scand J Immunol. 2016 Jul;84(1):3-11. doi: 10.1111/sji.12438.


Nanodosimetry and RBE values in radiotherapy.

Lindborg L, Hultqvist M, Carlsson Tedgren Å, Nikjoo H.

Radiat Prot Dosimetry. 2015 Sep;166(1-4):339-42. doi: 10.1093/rpd/ncv196. Epub 2015 May 6.


Microdosimetry of proton and carbon ions.

Liamsuwan T, Hultqvist M, Lindborg L, Uehara S, Nikjoo H.

Med Phys. 2014 Aug;41(8):081721. doi: 10.1118/1.4888338.


Reactive oxygen species deficiency induces autoimmunity with type 1 interferon signature.

Kelkka T, Kienhöfer D, Hoffmann M, Linja M, Wing K, Sareila O, Hultqvist M, Laajala E, Chen Z, Vasconcelos J, Neves E, Guedes M, Marques L, Krönke G, Helminen M, Kainulainen L, Olofsson P, Jalkanen S, Lahesmaa R, Souto-Carneiro MM, Holmdahl R.

Antioxid Redox Signal. 2014 Dec 1;21(16):2231-45. doi: 10.1089/ars.2013.5828. Epub 2014 Jul 29.


Pharmacological Potential of NOX2 Agonists in Inflammatory Conditions.

Hultqvist M, Olofsson P, Wallner FK, Holmdahl R.

Antioxid Redox Signal. 2015 Aug 10;23(5):446-59. doi: 10.1089/ars.2013.5788. Epub 2014 Feb 26. Review.


Lineal energy and radiation quality in radiation therapy: model calculations and comparison with experiment.

Lindborg L, Hultqvist M, Carlsson Tedgren Å, Nikjoo H.

Phys Med Biol. 2013 May 21;58(10):3089-105. doi: 10.1088/0031-9155/58/10/3089. Epub 2013 Apr 18.


Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice.

Förster M, Raposo B, Ekman D, Klaczkowska D, Popovic M, Nandakumar KS, Lindvall T, Hultqvist M, Teneva I, Johannesson M, Ahlqvist E, Holmdahl R.

Arthritis Rheum. 2012 Nov;64(11):3594-603. doi: 10.1002/art.34658.


NADPH oxidase elevations in pyramidal neurons drive psychosocial stress-induced neuropathology.

Schiavone S, Jaquet V, Sorce S, Dubois-Dauphin M, Hultqvist M, Bäckdahl L, Holmdahl R, Colaianna M, Cuomo V, Trabace L, Krause KH.

Transl Psychiatry. 2012 May 8;2:e111. doi: 10.1038/tp.2012.36.


Evaluation of nuclear reaction cross-sections and fragment yields in carbon beams using the SHIELD-HIT Monte Carlo code. Comparison with experiments.

Hultqvist M, Lazzeroni M, Botvina A, Gudowska I, Sobolevsky N, Brahme A.

Phys Med Biol. 2012 Jul 7;57(13):4369-85. doi: 10.1088/0031-9155/57/13/4369. Epub 2012 Jun 15.


Enhancement of antibody-induced arthritis via Toll-like receptor 2 stimulation is regulated by granulocyte reactive oxygen species.

Kelkka T, Hultqvist M, Nandakumar KS, Holmdahl R.

Am J Pathol. 2012 Jul;181(1):141-50. doi: 10.1016/j.ajpath.2012.03.031. Epub 2012 May 27.


Reactive oxygen species produced by the NADPH oxidase 2 complex in monocytes protect mice from bacterial infections.

Pizzolla A, Hultqvist M, Nilson B, Grimm MJ, Eneljung T, Jonsson IM, Verdrengh M, Kelkka T, Gjertsson I, Segal BH, Holmdahl R.

J Immunol. 2012 May 15;188(10):5003-11. doi: 10.4049/jimmunol.1103430. Epub 2012 Apr 9.


Collagen type II and a thermo-responsive polymer of N-isopropylacrylamide induce arthritis independent of Toll-like receptors: a strong influence by major histocompatibility complex class II and Ncf1 genes.

Shakya AK, Kumar A, Klaczkowska D, Hultqvist M, Hagenow K, Holmdahl R, Nandakumar KS.

Am J Pathol. 2011 Nov;179(5):2490-500. doi: 10.1016/j.ajpath.2011.07.034. Epub 2011 Sep 18.


A Monte Carlo evaluation of carbon and lithium ions dose distributions in water.

Taleei R, Hultqvist M, Gudowska I, Nikjoo H.

Int J Radiat Biol. 2012 Jan;88(1-2):189-94. doi: 10.3109/09553002.2011.624572.


High-resolution mapping of a complex disease, a model for rheumatoid arthritis, using heterogeneous stock mice.

Ahlqvist E, Ekman D, Lindvall T, Popovic M, Förster M, Hultqvist M, Klaczkowska D, Teneva I, Johannesson M, Flint J, Valdar W, Nandakumar KS, Holmdahl R.

Hum Mol Genet. 2011 Aug 1;20(15):3031-41. doi: 10.1093/hmg/ddr206. Epub 2011 May 12.


Positioning of a polymorphic quantitative trait nucleotide in the Ncf1 gene controlling oxidative burst response and arthritis severity in rats.

Hultqvist M, Sareila O, Vilhardt F, Norin U, Olsson LM, Olofsson P, Hellman U, Holmdahl R.

Antioxid Redox Signal. 2011 Jun 15;14(12):2373-83. doi: 10.1089/ars.2010.3440. Epub 2011 Mar 31.


CD68-expressing cells can prime T cells and initiate autoimmune arthritis in the absence of reactive oxygen species.

Pizzolla A, Gelderman KA, Hultqvist M, Vestberg M, Gustafsson K, Mattsson R, Holmdahl R.

Eur J Immunol. 2011 Feb;41(2):403-12. doi: 10.1002/eji.201040598. Epub 2010 Dec 23.


Secondary absorbed doses from light ion irradiation in anthropomorphic phantoms representing an adult male and a 10 year old child.

Hultqvist M, Gudowska I.

Phys Med Biol. 2010 Nov 21;55(22):6633-53. doi: 10.1088/0031-9155/55/22/004. Epub 2010 Oct 20.


NOX2 complex-derived ROS as immune regulators.

Sareila O, Kelkka T, Pizzolla A, Hultqvist M, Holmdahl R.

Antioxid Redox Signal. 2011 Oct 15;15(8):2197-208. doi: 10.1089/ars.2010.3635. Epub 2011 Apr 11. Review.


Rabeximod reduces arthritis severity in mice by decreasing activation of inflammatory cells.

Hultqvist M, Nandakumar KS, Björklund U, Holmdahl R.

Ann Rheum Dis. 2010 Aug;69(8):1527-32. doi: 10.1136/ard.2009.121178. Epub 2010 Jun 11.


Monte Carlo simulation of correction factors for IAEA TLD holders.

Hultqvist M, Fernández-Varea JM, Izewska J.

Phys Med Biol. 2010 Mar 21;55(6):N161-6. doi: 10.1088/0031-9155/55/6/N03. Epub 2010 Mar 2.


Ncf1-associated reduced oxidative burst promotes IL-33R+ T cell-mediated adjuvant-free arthritis in mice.

Hagenow K, Gelderman KA, Hultqvist M, Merky P, Bäcklund J, Frey O, Kamradt T, Holmdahl R.

J Immunol. 2009 Jul 15;183(2):874-81. doi: 10.4049/jimmunol.0900966. Epub 2009 Jun 24.


The value of animal models in predicting genetic susceptibility to complex diseases such as rheumatoid arthritis.

Ahlqvist E, Hultqvist M, Holmdahl R.

Arthritis Res Ther. 2009;11(3):226. doi: 10.1186/ar2600. Epub 2009 May 19. Review.


The protective role of ROS in autoimmune disease.

Hultqvist M, Olsson LM, Gelderman KA, Holmdahl R.

Trends Immunol. 2009 May;30(5):201-8. doi: 10.1016/ Epub 2009 Apr 6. Review.


Advanced intercross line mapping suggests that ncf1 (ean6) regulates severity in an animal model of guillain-barre syndrome.

Huberle A, Beyeen AD, Ockinger J, Ayturan M, Jagodic M, de Graaf KL, Fissolo N, Marta M, Olofsson P, Hultqvist M, Holmdahl R, Olsson T, Weissert R.

J Immunol. 2009 Apr 1;182(7):4432-8. doi: 10.4049/jimmunol.0803847.


Ncf1 provides a reactive oxygen species-independent negative feedback regulation of TLR9-induced IL-12p70 in murine dendritic cells.

Richter C, Juan MH, Will J, Brandes RP, Kalinke U, Akira S, Pfeilschifter JM, Hultqvist M, Holmdahl R, Radeke HH.

J Immunol. 2009 Apr 1;182(7):4183-91. doi: 10.4049/jimmunol.0800795.


Cartilage oligomeric matrix protein induction of chronic arthritis in mice.

Carlsen S, Nandakumar KS, Bäcklund J, Holmberg J, Hultqvist M, Vestberg M, Holmdahl R.

Arthritis Rheum. 2008 Jul;58(7):2000-11. doi: 10.1002/art.23554.


Identification of oxidative stress and Toll-like receptor 4 signaling as a key pathway of acute lung injury.

Imai Y, Kuba K, Neely GG, Yaghubian-Malhami R, Perkmann T, van Loo G, Ermolaeva M, Veldhuizen R, Leung YH, Wang H, Liu H, Sun Y, Pasparakis M, Kopf M, Mech C, Bavari S, Peiris JS, Slutsky AS, Akira S, Hultqvist M, Holmdahl R, Nicholls J, Jiang C, Binder CJ, Penninger JM.

Cell. 2008 Apr 18;133(2):235-49. doi: 10.1016/j.cell.2008.02.043.


The novel small molecule drug Rabeximod is effective in reducing disease severity of mouse models of autoimmune disorders.

Hultqvist M, Nandakumar KS, Björklund U, Holmdahl R.

Ann Rheum Dis. 2009 Jan;68(1):130-5. doi: 10.1136/ard.2007.085241. Epub 2008 Mar 17.


Macrophages suppress T cell responses and arthritis development in mice by producing reactive oxygen species.

Gelderman KA, Hultqvist M, Pizzolla A, Zhao M, Nandakumar KS, Mattsson R, Holmdahl R.

J Clin Invest. 2007 Oct;117(10):3020-8.


Rheumatoid arthritis: the role of reactive oxygen species in disease development and therapeutic strategies.

Gelderman KA, Hultqvist M, Olsson LM, Bauer K, Pizzolla A, Olofsson P, Holmdahl R.

Antioxid Redox Signal. 2007 Oct;9(10):1541-67. Review.


Lack of reactive oxygen species breaks T cell tolerance to collagen type II and allows development of arthritis in mice.

Hultqvist M, Bäcklund J, Bauer K, Gelderman KA, Holmdahl R.

J Immunol. 2007 Aug 1;179(3):1431-7.


Arthritis suppression by NADPH activation operates through an interferon-beta pathway.

Olofsson P, Nerstedt A, Hultqvist M, Nilsson EC, Andersson S, Bergelin A, Holmdahl R.

BMC Biol. 2007 May 9;5:19.


A new arthritis therapy with oxidative burst inducers.

Hultqvist M, Olofsson P, Gelderman KA, Holmberg J, Holmdahl R.

PLoS Med. 2006 Sep;3(9):e348.


T cell surface redox levels determine T cell reactivity and arthritis susceptibility.

Gelderman KA, Hultqvist M, Holmberg J, Olofsson P, Holmdahl R.

Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12831-6. Epub 2006 Aug 14.


Genetics of autoimmune diseases: a multistep process.

Johannesson M, Hultqvist M, Holmdahl R.

Curr Top Microbiol Immunol. 2006;305:259-76. Review.


Ncf1 (p47phox) polymorphism determines oxidative burst and the severity of arthritis in rats and mice.

Hultqvist M, Holmdahl R.

Cell Immunol. 2005 Feb;233(2):97-101. Review.


Enhanced autoimmunity, arthritis, and encephalomyelitis in mice with a reduced oxidative burst due to a mutation in the Ncf1 gene.

Hultqvist M, Olofsson P, Holmberg J, Bäckström BT, Tordsson J, Holmdahl R.

Proc Natl Acad Sci U S A. 2004 Aug 24;101(34):12646-51. Epub 2004 Aug 13.


Plasma concentrations of vitamin C, vitamin E and/or malondialdehyde as markers of oxygen free radical production during hemodialysis.

Hultqvist M, Hegbrant J, Nilsson-Thorell C, Lindholm T, Nilsson P, Lindén T, Hultqvist-Bengtsson U.

Clin Nephrol. 1997 Jan;47(1):37-46.


Toxicity of effluent peritoneal dialysis fluid.

Wieslander AP, Andrén A, Martinson E, Kjellstrand P, Hultqvist M.

Adv Perit Dial. 1993;9:31-5.


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