Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 274

1.

Establishment and Characterization of Bacterial Infection of Breast Implants in a Murine Model.

Walker JN, Poppler L, Pinkner CL, Hultgren SJ, Myckatyn T.

Aesthet Surg J. 2019 Jul 1. pii: sjz190. doi: 10.1093/asj/sjz190. [Epub ahead of print]

PMID:
31259380
2.

Urinary tract colonization is enhanced by a plasmid that regulates uropathogenic Acinetobacter baumannii chromosomal genes.

Di Venanzio G, Flores-Mireles AL, Calix JJ, Haurat MF, Scott NE, Palmer LD, Potter RF, Hibbing ME, Friedman L, Wang B, Dantas G, Skaar EP, Hultgren SJ, Feldman MF.

Nat Commun. 2019 Jun 24;10(1):2763. doi: 10.1038/s41467-019-10706-y.

3.

Fimbriae reprogram host gene expression - Divergent effects of P and type 1 fimbriae.

Ambite I, Butler DSC, Stork C, Grönberg-Hernández J, Köves B, Zdziarski J, Pinkner J, Hultgren SJ, Dobrindt U, Wullt B, Svanborg C.

PLoS Pathog. 2019 Jun 10;15(6):e1007671. doi: 10.1371/journal.ppat.1007671. eCollection 2019 Jun.

4.

Reaching the End of the Line: Urinary Tract Infections.

Tamadonfar KO, Omattage NS, Spaulding CN, Hultgren SJ.

Microbiol Spectr. 2019 May;7(3). doi: 10.1128/microbiolspec.BAI-0014-2019.

PMID:
31172909
5.

Chemical disarming of isoniazid resistance in Mycobacterium tuberculosis.

Flentie K, Harrison GA, Tükenmez H, Livny J, Good JAD, Sarkar S, Zhu DX, Kinsella RL, Weiss LA, Solomon SD, Schene ME, Hansen MR, Cairns AG, Kulén M, Wixe T, Lindgren AEG, Chorell E, Bengtsson C, Krishnan KS, Hultgren SJ, Larsson C, Almqvist F, Stallings CL.

Proc Natl Acad Sci U S A. 2019 May 21;116(21):10510-10517. doi: 10.1073/pnas.1818009116. Epub 2019 May 6.

PMID:
31061116
6.

Deposition of Host Matrix Proteins on Breast Implant Surfaces Facilitates Staphylococcus Epidermidis Biofilm Formation: In Vitro Analysis.

Walker JN, Pinkner CL, Lynch AJL, Ortbal S, Pinkner JS, Hultgren SJ, Myckatyn TM.

Aesthet Surg J. 2019 Apr 6. pii: sjz099. doi: 10.1093/asj/sjz099. [Epub ahead of print]

PMID:
30953053
7.

The Detection of Bacteria and Matrix Proteins on Clinically Benign and Pathologic Implants.

Walker JN, Pinkner CL, Pinkner JS, Hultgren SJ, Myckatyn TM.

Plast Reconstr Surg Glob Open. 2019 Feb 8;7(2):e2037. doi: 10.1097/GOX.0000000000002037. eCollection 2019 Feb.

8.

Host restriction of Escherichia coli recurrent urinary tract infection occurs in a bacterial strain-specific manner.

O'Brien VP, Dorsey DA, Hannan TJ, Hultgren SJ.

PLoS Pathog. 2018 Dec 13;14(12):e1007457. doi: 10.1371/journal.ppat.1007457. eCollection 2018 Dec.

9.

Biphenyl Gal and GalNAc FmlH Lectin Antagonists of Uropathogenic E. coli (UPEC): Optimization through Iterative Rational Drug Design.

Maddirala AR, Klein R, Pinkner JS, Kalas V, Hultgren SJ, Janetka JW.

J Med Chem. 2019 Jan 24;62(2):467-479. doi: 10.1021/acs.jmedchem.8b01561. Epub 2019 Jan 2.

PMID:
30540910
10.

Structural basis for usher activation and intramolecular subunit transfer in P pilus biogenesis in Escherichia coli.

Omattage NS, Deng Z, Pinkner JS, Dodson KW, Almqvist F, Yuan P, Hultgren SJ.

Nat Microbiol. 2018 Dec;3(12):1362-1368. doi: 10.1038/s41564-018-0255-y. Epub 2018 Oct 1.

11.

Manganese acquisition is essential for virulence of Enterococcus faecalis.

Colomer-Winter C, Flores-Mireles AL, Baker SP, Frank KL, Lynch AJL, Hultgren SJ, Kitten T, Lemos JA.

PLoS Pathog. 2018 Sep 20;14(9):e1007102. doi: 10.1371/journal.ppat.1007102. eCollection 2018 Sep.

12.

Structure-Function Analysis of the Curli Accessory Protein CsgE Defines Surfaces Essential for Coordinating Amyloid Fiber Formation.

Klein RD, Shu Q, Cusumano ZT, Nagamatsu K, Gualberto NC, Lynch AJL, Wu C, Wang W, Jain N, Pinkner JS, Amarasinghe GK, Hultgren SJ, Frieden C, Chapman MR.

MBio. 2018 Jul 17;9(4). pii: e01349-18. doi: 10.1128/mBio.01349-18.

13.

Differential Regulation of Escherichia coli fim Genes following Binding to Mannose Receptors.

Schwan WR, Beck MT, Hung CS, Hultgren SJ.

J Pathog. 2018 May 22;2018:2897581. doi: 10.1155/2018/2897581. eCollection 2018.

14.

Hydrogen Sulfide Sensing through Reactive Sulfur Species (RSS) and Nitroxyl (HNO) in Enterococcus faecalis.

Shen J, Walsh BJC, Flores-Mireles AL, Peng H, Zhang Y, Zhang Y, Trinidad JC, Hultgren SJ, Giedroc DP.

ACS Chem Biol. 2018 Jun 15;13(6):1610-1620. doi: 10.1021/acschembio.8b00230. Epub 2018 May 17.

15.

Precision antimicrobial therapeutics: the path of least resistance?

Spaulding CN, Klein RD, Schreiber HL 4th, Janetka JW, Hultgren SJ.

NPJ Biofilms Microbiomes. 2018 Feb 27;4:4. doi: 10.1038/s41522-018-0048-3. eCollection 2018. Review.

16.

Structure-based discovery of glycomimetic FmlH ligands as inhibitors of bacterial adhesion during urinary tract infection.

Kalas V, Hibbing ME, Maddirala AR, Chugani R, Pinkner JS, Mydock-McGrane LK, Conover MS, Janetka JW, Hultgren SJ.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2819-E2828. doi: 10.1073/pnas.1720140115. Epub 2018 Mar 5.

17.

Narrowing the spectrum: the new frontier of precision antimicrobials.

Paharik AE, Schreiber HL 4th, Spaulding CN, Dodson KW, Hultgren SJ.

Genome Med. 2017 Dec 14;9(1):110. doi: 10.1186/s13073-017-0504-3. Review.

18.

Host and bacterial proteases influence biofilm formation and virulence in a murine model of enterococcal catheter-associated urinary tract infection.

Xu W, Flores-Mireles AL, Cusumano ZT, Takagi E, Hultgren SJ, Caparon MG.

NPJ Biofilms Microbiomes. 2017 Nov 6;3:28. doi: 10.1038/s41522-017-0036-z. eCollection 2017.

19.

Catheterization alters bladder ecology to potentiate Staphylococcus aureus infection of the urinary tract.

Walker JN, Flores-Mireles AL, Pinkner CL, Schreiber HL 4th, Joens MS, Park AM, Potretzke AM, Bauman TM, Pinkner JS, Fitzpatrick JAJ, Desai A, Caparon MG, Hultgren SJ.

Proc Natl Acad Sci U S A. 2017 Oct 10;114(41):E8721-E8730. doi: 10.1073/pnas.1707572114. Epub 2017 Sep 25.

20.

Selective depletion of uropathogenic E. coli from the gut by a FimH antagonist.

Spaulding CN, Klein RD, Ruer S, Kau AL, Schreiber HL, Cusumano ZT, Dodson KW, Pinkner JS, Fremont DH, Janetka JW, Remaut H, Gordon JI, Hultgren SJ.

Nature. 2017 Jun 22;546(7659):528-532. doi: 10.1038/nature22972. Epub 2017 Jun 14.

21.

Highly conserved type 1 pili promote enterotoxigenic E. coli pathogen-host interactions.

Sheikh A, Rashu R, Begum YA, Kuhlman FM, Ciorba MA, Hultgren SJ, Qadri F, Fleckenstein JM.

PLoS Negl Trop Dis. 2017 May 22;11(5):e0005586. doi: 10.1371/journal.pntd.0005586. eCollection 2017 May.

22.

Bacterial virulence phenotypes of Escherichia coli and host susceptibility determine risk for urinary tract infections.

Schreiber HL 4th, Conover MS, Chou WC, Hibbing ME, Manson AL, Dodson KW, Hannan TJ, Roberts PL, Stapleton AE, Hooton TM, Livny J, Earl AM, Hultgren SJ.

Sci Transl Med. 2017 Mar 22;9(382). pii: eaaf1283. doi: 10.1126/scitranslmed.aaf1283.

23.

Evolutionary fine-tuning of conformational ensembles in FimH during host-pathogen interactions.

Kalas V, Pinkner JS, Hannan TJ, Hibbing ME, Dodson KW, Holehouse AS, Zhang H, Tolia NH, Gross ML, Pappu RV, Janetka J, Hultgren SJ.

Sci Adv. 2017 Feb 10;3(2):e1601944. doi: 10.1126/sciadv.1601944. eCollection 2017 Feb.

24.

One size doesn't fit all: unraveling the diversity of factors and interactions that drive E. coli urovirulence.

Schreiber HL 4th, Spaulding CN, Dodson KW, Livny J, Hultgren SJ.

Ann Transl Med. 2017 Jan;5(2):28. doi: 10.21037/atm.2016.12.73. No abstract available.

25.

A mucosal imprint left by prior Escherichia coli bladder infection sensitizes to recurrent disease.

O'Brien VP, Hannan TJ, Yu L, Livny J, Roberson ED, Schwartz DJ, Souza S, Mendelsohn CL, Colonna M, Lewis AL, Hultgren SJ.

Nat Microbiol. 2016 Oct 31;2:16196. doi: 10.1038/nmicrobiol.2016.196.

26.

Antibody-Based Therapy for Enterococcal Catheter-Associated Urinary Tract Infections.

Flores-Mireles AL, Walker JN, Potretzke A, Schreiber HL 4th, Pinkner JS, Bauman TM, Park AM, Desai A, Hultgren SJ, Caparon MG.

MBio. 2016 Oct 25;7(5). pii: e01653-16. doi: 10.1128/mBio.01653-16.

27.

The Catabolite Repressor Protein-Cyclic AMP Complex Regulates csgD and Biofilm Formation in Uropathogenic Escherichia coli.

Hufnagel DA, Evans ML, Greene SE, Pinkner JS, Hultgren SJ, Chapman MR.

J Bacteriol. 2016 Nov 18;198(24):3329-3334. Print 2016 Dec 15.

28.

Antivirulence C-Mannosides as Antibiotic-Sparing, Oral Therapeutics for Urinary Tract Infections.

Mydock-McGrane L, Cusumano Z, Han Z, Binkley J, Kostakioti M, Hannan T, Pinkner JS, Klein R, Kalas V, Crowley J, Rath NP, Hultgren SJ, Janetka JW.

J Med Chem. 2016 Oct 27;59(20):9390-9408. Epub 2016 Oct 14.

29.

Inflammation-Induced Adhesin-Receptor Interaction Provides a Fitness Advantage to Uropathogenic E. coli during Chronic Infection.

Conover MS, Ruer S, Taganna J, Kalas V, De Greve H, Pinkner JS, Dodson KW, Remaut H, Hultgren SJ.

Cell Host Microbe. 2016 Oct 12;20(4):482-492. doi: 10.1016/j.chom.2016.08.013. Epub 2016 Sep 22.

30.

Solution NMR structure of CsgE: Structural insights into a chaperone and regulator protein important for functional amyloid formation.

Shu Q, Krezel AM, Cusumano ZT, Pinkner JS, Klein R, Hultgren SJ, Frieden C.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7130-5. doi: 10.1073/pnas.1607222113. Epub 2016 Jun 13.

31.

Innovative Solutions to Sticky Situations: Antiadhesive Strategies for Treating Bacterial Infections.

Cusumano ZT, Klein RD, Hultgren SJ.

Microbiol Spectr. 2016 Apr;4(2). doi: 10.1128/microbiolspec.VMBF-0023-2015. Review.

PMID:
27227305
32.

The UbiI (VisC) Aerobic Ubiquinone Synthase Is Required for Expression of Type 1 Pili, Biofilm Formation, and Pathogenesis in Uropathogenic Escherichia coli.

Floyd KA, Mitchell CA, Eberly AR, Colling SJ, Zhang EW, DePas W, Chapman MR, Conover M, Rogers BR, Hultgren SJ, Hadjifrangiskou M.

J Bacteriol. 2016 Sep 9;198(19):2662-72. doi: 10.1128/JB.00030-16. Print 2016 Oct 1.

33.

Metabolic Requirements of Escherichia coli in Intracellular Bacterial Communities during Urinary Tract Infection Pathogenesis.

Conover MS, Hadjifrangiskou M, Palermo JJ, Hibbing ME, Dodson KW, Hultgren SJ.

MBio. 2016 Apr 12;7(2):e00104-16. doi: 10.1128/mBio.00104-16.

34.

Drug and Vaccine Development for the Treatment and Prevention of Urinary Tract Infections.

O'Brien VP, Hannan TJ, Nielsen HV, Hultgren SJ.

Microbiol Spectr. 2016 Feb;4(1). doi: 10.1128/microbiolspec.UTI-0013-2012. Review.

35.

Adhesive Pili in UTI Pathogenesis and Drug Development.

Spaulding CN, Hultgren SJ.

Pathogens. 2016 Mar 15;5(1). pii: E30. doi: 10.3390/pathogens5010030. Review.

36.

Fibrinogen Release and Deposition on Urinary Catheters Placed during Urological Procedures.

Flores-Mireles AL, Walker JN, Bauman TM, Potretzke AM, Schreiber HL 4th, Park AM, Pinkner JS, Caparon MG, Hultgren SJ, Desai A.

J Urol. 2016 Aug;196(2):416-421. doi: 10.1016/j.juro.2016.01.100. Epub 2016 Jan 28.

37.

Antivirulence Isoquinolone Mannosides: Optimization of the Biaryl Aglycone for FimH Lectin Binding Affinity and Efficacy in the Treatment of Chronic UTI.

Jarvis C, Han Z, Kalas V, Klein R, Pinkner JS, Ford B, Binkley J, Cusumano CK, Cusumano Z, Mydock-McGrane L, Hultgren SJ, Janetka JW.

ChemMedChem. 2016 Feb 17;11(4):367-73. doi: 10.1002/cmdc.201600006. Epub 2016 Jan 26.

38.

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling.

Hospenthal MK, Redzej A, Dodson K, Ukleja M, Frenz B, Rodrigues C, Hultgren SJ, DiMaio F, Egelman EH, Waksman G.

Cell. 2016 Jan 14;164(1-2):269-278. doi: 10.1016/j.cell.2015.11.049. Epub 2015 Dec 24.

39.

Bacterial amyloid formation: structural insights into curli biogensis.

Van Gerven N, Klein RD, Hultgren SJ, Remaut H.

Trends Microbiol. 2015 Nov;23(11):693-706. doi: 10.1016/j.tim.2015.07.010. Epub 2015 Oct 1. Review.

40.

Fueling the Fire with Fibers: Bacterial Amyloids Promote Inflammatory Disorders.

Spaulding CN, Dodson KW, Chapman MR, Hultgren SJ.

Cell Host Microbe. 2015 Jul 8;18(1):1-2. doi: 10.1016/j.chom.2015.06.013.

41.

Establishment and Characterization of UTI and CAUTI in a Mouse Model.

Conover MS, Flores-Mireles AL, Hibbing ME, Dodson K, Hultgren SJ.

J Vis Exp. 2015 Jun 23;(100):e52892. doi: 10.3791/52892.

42.

Human Urine Decreases Function and Expression of Type 1 Pili in Uropathogenic Escherichia coli.

Greene SE, Hibbing ME, Janetka J, Chen SL, Hultgren SJ.

MBio. 2015 Jun 30;6(4):e00820. doi: 10.1128/mBio.00820-15.

43.

Inhibition of Cyclooxygenase-2 Prevents Chronic and Recurrent Cystitis.

Hannan TJ, Roberts PL, Riehl TE, van der Post S, Binkley JM, Schwartz DJ, Miyoshi H, Mack M, Schwendener RA, Hooton TM, Stappenbeck TS, Hansson GC, Stenson WF, Colonna M, Stapleton AE, Hultgren SJ.

EBioMedicine. 2014 Oct 24;1(1):46-57. doi: 10.1016/j.ebiom.2014.10.011. eCollection 2014 Nov.

44.

The unexplored relationship between urinary tract infections and the autonomic nervous system.

Hibbing ME, Conover MS, Hultgren SJ.

Auton Neurosci. 2016 Oct;200:29-34. doi: 10.1016/j.autneu.2015.06.002. Epub 2015 Jun 6. Review.

45.

The pilus usher controls protein interactions via domain masking and is functional as an oligomer.

Werneburg GT, Henderson NS, Portnoy EB, Sarowar S, Hultgren SJ, Li H, Thanassi DG.

Nat Struct Mol Biol. 2015 Jul;22(7):540-6. doi: 10.1038/nsmb.3044. Epub 2015 Jun 8.

46.

Advanced glycation end products facilitate bacterial adherence in urinary tract infection in diabetic mice.

Ozer A, Altuntas CZ, Izgi K, Bicer F, Hultgren SJ, Liu G, Daneshgari F.

Pathog Dis. 2015 Jul;73(5). pii: ftu004. doi: 10.1093/femspd/ftu004. Epub 2014 Dec 4.

47.

Role of Hypoxia Inducible Factor-1α (HIF-1α) in Innate Defense against Uropathogenic Escherichia coli Infection.

Lin AE, Beasley FC, Olson J, Keller N, Shalwitz RA, Hannan TJ, Hultgren SJ, Nizet V.

PLoS Pathog. 2015 Apr 30;11(4):e1004818. doi: 10.1371/journal.ppat.1004818. eCollection 2015 Apr.

48.

Urinary tract infections: epidemiology, mechanisms of infection and treatment options.

Flores-Mireles AL, Walker JN, Caparon M, Hultgren SJ.

Nat Rev Microbiol. 2015 May;13(5):269-84. doi: 10.1038/nrmicro3432. Epub 2015 Apr 8. Review.

49.

Subinhibitory antibiotic therapy alters recurrent urinary tract infection pathogenesis through modulation of bacterial virulence and host immunity.

Goneau LW, Hannan TJ, MacPhee RA, Schwartz DJ, Macklaim JM, Gloor GB, Razvi H, Reid G, Hultgren SJ, Burton JP.

MBio. 2015 Mar 31;6(2). pii: e00356-15. doi: 10.1128/mBio.00356-15.

50.

Dysregulation of Escherichia coli α-hemolysin expression alters the course of acute and persistent urinary tract infection.

Nagamatsu K, Hannan TJ, Guest RL, Kostakioti M, Hadjifrangiskou M, Binkley J, Dodson K, Raivio TL, Hultgren SJ.

Proc Natl Acad Sci U S A. 2015 Feb 24;112(8):E871-80. doi: 10.1073/pnas.1500374112. Epub 2015 Feb 9.

Supplemental Content

Loading ...
Support Center