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Items: 29

1.

A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.

van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB), Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L, Maier W, Dols-Icardo O, Kawalia A, Dalmasso MC, Boada M, Zettl UK, van Schoor NM, Beekman M, Allen M, Masliah E, de Munain AL, Pantelyat A, Wszolek ZK, Ross OA, Dickson DW, Graff-Radford NR, Knopman D, Rademakers R, Lemstra AW, Pijnenburg YAL, Scheltens P, Gasser T, Chinnery PF, Hemmer B, Huisman MA, Troncoso J, Moreno F, Nohr EA, Sørensen TIA, Heutink P, Sánchez-Juan P, Posthuma D; GIFT (Genetic Investigation in Frontotemporal Dementia and Alzheimer’s Disease) Study Group, Clarimón J, Christensen K, Ertekin-Taner N, Scholz SW, Ramirez A, Ruiz A, Slagboom E, van der Flier WM, Holstege H.

Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27.

2.

Neuropsychological Test Performance of Cognitively Healthy Centenarians: Normative Data From the Dutch 100-Plus Study.

Beker N, Sikkes SAM, Hulsman M, Schmand B, Scheltens P, Holstege H.

J Am Geriatr Soc. 2019 Apr;67(4):759-767. doi: 10.1111/jgs.15729. Epub 2018 Dec 27.

PMID:
30592018
3.

The 100-plus Study of cognitively healthy centenarians: rationale, design and cohort description.

Holstege H, Beker N, Dijkstra T, Pieterse K, Wemmenhove E, Schouten K, Thiessens L, Horsten D, Rechtuijt S, Sikkes S, van Poppel FWA, Meijers-Heijboer H, Hulsman M, Scheltens P.

Eur J Epidemiol. 2018 Dec;33(12):1229-1249. doi: 10.1007/s10654-018-0451-3. Epub 2018 Oct 25.

4.

EIF2AK3 variants in Dutch patients with Alzheimer's disease.

Wong TH, van der Lee SJ, van Rooij JGJ, Meeter LHH, Frick P, Melhem S, Seelaar H, Ikram MA, Rozemuller AJ, Holstege H, Hulsman M, Uitterlinden A, Neumann M, Hoozemans JJM, van Duijn CM, Rademakers R, van Swieten JC.

Neurobiol Aging. 2019 Jan;73:229.e11-229.e18. doi: 10.1016/j.neurobiolaging.2018.08.016. Epub 2018 Aug 24.

5.

Centenarian controls increase variant effect sizes by an average twofold in an extreme case-extreme control analysis of Alzheimer's disease.

Tesi N, van der Lee SJ, Hulsman M, Jansen IE, Stringa N, van Schoor N, Meijers-Heijboer H, Huisman M, Scheltens P, Reinders MJT, van der Flier WM, Holstege H.

Eur J Hum Genet. 2019 Feb;27(2):244-253. doi: 10.1038/s41431-018-0273-5. Epub 2018 Sep 26.

6.

Neuropathology and cognitive performance in self-reported cognitively healthy centenarians.

Ganz AB, Beker N, Hulsman M, Sikkes S, Netherlands Brain Bank, Scheltens P, Smit AB, Rozemuller AJM, Hoozemans JJM, Holstege H.

Acta Neuropathol Commun. 2018 Jul 23;6(1):64. doi: 10.1186/s40478-018-0558-5.

7.

Characterization of pathogenic SORL1 genetic variants for association with Alzheimer's disease: a clinical interpretation strategy.

Holstege H, van der Lee SJ, Hulsman M, Wong TH, van Rooij JG, Weiss M, Louwersheimer E, Wolters FJ, Amin N, Uitterlinden AG, Hofman A, Ikram MA, van Swieten JC, Meijers-Heijboer H, van der Flier WM, Reinders MJ, van Duijn CM, Scheltens P.

Eur J Hum Genet. 2017 Aug;25(8):973-981. doi: 10.1038/ejhg.2017.87. Epub 2017 May 24.

8.

Mining for osteogenic surface topographies: In silico design to in vivo osseo-integration.

Hulshof FFB, Papenburg B, Vasilevich A, Hulsman M, Zhao Y, Levers M, Fekete N, de Boer M, Yuan H, Singh S, Beijer N, Bray MA, Logan DJ, Reinders M, Carpenter AE, van Blitterswijk C, Stamatialis D, de Boer J.

Biomaterials. 2017 Aug;137:49-60. doi: 10.1016/j.biomaterials.2017.05.020. Epub 2017 May 12.

PMID:
28535442
9.

Rare Genetic Variant in SORL1 May Increase Penetrance of Alzheimer's Disease in a Family with Several Generations of APOE-ɛ4 Homozygosity.

Louwersheimer E, Cohn-Hokke PE, Pijnenburg YA, Weiss MM, Sistermans EA, Rozemuller AJ, Hulsman M, van Swieten JC, van Duijn CM, Barkhof F, Koene T, Scheltens P, Van der Flier WM, Holstege H.

J Alzheimers Dis. 2017;56(1):63-74. doi: 10.3233/JAD-160091.

10.

Transcriptomic and molecular genetic analysis of the cell wall salvage response of Aspergillus niger to the absence of galactofuranose synthesis.

Park J, Hulsman M, Arentshorst M, Breeman M, Alazi E, Lagendijk EL, Rocha MC, Malavazi I, Nitsche BM, van den Hondel CA, Meyer V, Ram AF.

Cell Microbiol. 2016 Sep;18(9):1268-84. doi: 10.1111/cmi.12624. Epub 2016 Jul 29.

11.

Improved intra-array and interarray normalization of peptide microarray phosphorylation for phosphorylome and kinome profiling by rational selection of relevant spots.

Scholma J, Fuhler GM, Joore J, Hulsman M, Schivo S, List AF, Reinders MJ, Peppelenbosch MP, Post JN.

Sci Rep. 2016 May 26;6:26695. doi: 10.1038/srep26695.

12.

Unbiased Quantitative Models of Protein Translation Derived from Ribosome Profiling Data.

Gritsenko AA, Hulsman M, Reinders MJ, de Ridder D.

PLoS Comput Biol. 2015 Aug 14;11(8):e1004336. doi: 10.1371/journal.pcbi.1004336. eCollection 2015 Aug.

13.

Hi-C Chromatin Interaction Networks Predict Co-expression in the Mouse Cortex.

Babaei S, Mahfouz A, Hulsman M, Lelieveldt BP, de Ridder J, Reinders M.

PLoS Comput Biol. 2015 May 12;11(5):e1004221. doi: 10.1371/journal.pcbi.1004221. eCollection 2015 May.

14.

Switching from a unicellular to multicellular organization in an Aspergillus niger hypha.

Bleichrodt RJ, Hulsman M, Wösten HA, Reinders MJ.

MBio. 2015 Mar 3;6(2):e00111. doi: 10.1128/mBio.00111-15.

15.

Analysis of high-throughput screening reveals the effect of surface topographies on cellular morphology.

Hulsman M, Hulshof F, Unadkat H, Papenburg BJ, Stamatialis DF, Truckenmüller R, van Blitterswijk C, de Boer J, Reinders MJ.

Acta Biomater. 2015 Mar;15:29-38. doi: 10.1016/j.actbio.2014.12.019. Epub 2014 Dec 30.

PMID:
25554402
16.

FluG affects secretion in colonies of Aspergillus niger.

Wang F, Krijgsheld P, Hulsman M, de Bekker C, Müller WH, Reinders M, de Vries RP, Wösten HA.

Antonie Van Leeuwenhoek. 2015 Jan;107(1):225-40. doi: 10.1007/s10482-014-0321-2. Epub 2014 Nov 5.

PMID:
25370014
17.

Scale-space measures for graph topology link protein network architecture to function.

Hulsman M, Dimitrakopoulos C, de Ridder J.

Bioinformatics. 2014 Jun 15;30(12):i237-45. doi: 10.1093/bioinformatics/btu283.

18.

Somatic mutations found in the healthy blood compartment of a 115-yr-old woman demonstrate oligoclonal hematopoiesis.

Holstege H, Pfeiffer W, Sie D, Hulsman M, Nicholas TJ, Lee CC, Ross T, Lin J, Miller MA, Ylstra B, Meijers-Heijboer H, Brugman MH, Staal FJ, Holstege G, Reinders MJ, Harkins TT, Levy S, Sistermans EA.

Genome Res. 2014 May;24(5):733-42. doi: 10.1101/gr.162131.113. Epub 2014 Apr 23.

19.

Meta-analysis on blood transcriptomic studies identifies consistently coexpressed protein-protein interaction modules as robust markers of human aging.

van den Akker EB, Passtoors WM, Jansen R, van Zwet EW, Goeman JJ, Hulsman M, Emilsson V, Perola M, Willemsen G, Penninx BW, Heijmans BT, Maier AB, Boomsma DI, Kok JN, Slagboom PE, Reinders MJ, Beekman M.

Aging Cell. 2014 Apr;13(2):216-25. doi: 10.1111/acel.12160. Epub 2013 Nov 19.

20.

Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells.

Barradas AM, Monticone V, Hulsman M, Danoux C, Fernandes H, Tahmasebi Birgani Z, Barrère-de Groot F, Yuan H, Reinders M, Habibovic P, van Blitterswijk C, de Boer J.

Integr Biol (Camb). 2013 Jul 24;5(7):920-31. doi: 10.1039/c3ib40027a. Epub 2013 Jun 11.

PMID:
23752904
21.

Predicting the therapeutic efficacy of MSC in bone tissue engineering using the molecular marker CADM1.

Mentink A, Hulsman M, Groen N, Licht R, Dechering KJ, van der Stok J, Alves HA, Dhert WJ, van Someren EP, Reinders MJ, van Blitterswijk CA, de Boer J.

Biomaterials. 2013 Jun;34(19):4592-601. doi: 10.1016/j.biomaterials.2013.03.001. Epub 2013 Mar 26.

PMID:
23541110
22.

Detecting recurrent gene mutation in interaction network context using multi-scale graph diffusion.

Babaei S, Hulsman M, Reinders M, de Ridder J.

BMC Bioinformatics. 2013 Jan 23;14:29. doi: 10.1186/1471-2105-14-29.

23.

High content imaging in the screening of biomaterial-induced MSC behavior.

Unadkat HV, Groen N, Doorn J, Fischer B, Barradas AM, Hulsman M, van de Peppel J, Moroni L, van Leeuwen JP, Reinders MJ, van Blitterswijk CA, de Boer J.

Biomaterials. 2013 Feb;34(5):1498-505. doi: 10.1016/j.biomaterials.2012.10.035. Epub 2012 Nov 23.

PMID:
23182347
24.

A modular versatile chip carrier for high-throughput screening of cell-biomaterial interactions.

Unadkat HV, Rewagad RR, Hulsman M, Hulshof GF, Truckenmüller RK, Stamatialis DF, Reinders MJ, Eijkel JC, van den Berg A, van Blitterswijk CA, de Boer J.

J R Soc Interface. 2013 Jan 6;10(78):20120753. doi: 10.1098/rsif.2012.0753.

25.

Exploring sequence characteristics related to high-level production of secreted proteins in Aspergillus niger.

van den Berg BA, Reinders MJ, Hulsman M, Wu L, Pel HJ, Roubos JA, de Ridder D.

PLoS One. 2012;7(10):e45869. doi: 10.1371/journal.pone.0045869. Epub 2012 Oct 1.

26.

A mesenchymal stromal cell gene signature for donor age.

Alves H, van Ginkel J, Groen N, Hulsman M, Mentink A, Reinders M, van Blitterswijk C, de Boer J.

PLoS One. 2012;7(8):e42908. doi: 10.1371/journal.pone.0042908. Epub 2012 Aug 23.

27.

An algorithm-based topographical biomaterials library to instruct cell fate.

Unadkat HV, Hulsman M, Cornelissen K, Papenburg BJ, Truckenmüller RK, Carpenter AE, Wessling M, Post GF, Uetz M, Reinders MJ, Stamatialis D, van Blitterswijk CA, de Boer J.

Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16565-70. doi: 10.1073/pnas.1109861108. Epub 2011 Sep 26. Erratum in: Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5905. Carpenter, Anne E [added]; Wessling, Matthias [added]. Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5731.

28.

Delineation of amplification, hybridization and location effects in microarray data yields better-quality normalization.

Hulsman M, Mentink A, van Someren EP, Dechering KJ, de Boer J, Reinders MJ.

BMC Bioinformatics. 2010 Mar 26;11:156. doi: 10.1186/1471-2105-11-156.

29.

Evolutionary optimization of kernel weights improves protein complex comembership prediction.

Hulsman M, Reinders MJ, de Ridder D.

IEEE/ACM Trans Comput Biol Bioinform. 2009 Jul-Sep;6(3):427-37. doi: 10.1109/TCBB.2008.137.

PMID:
19644171

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