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Items: 15


Ezh2 inhibition in Kras-driven lung cancer amplifies inflammation and associated vulnerabilities.

Serresi M, Siteur B, Hulsman D, Company C, Schmitt MJ, Lieftink C, Morris B, Cesaroni M, Proost N, Beijersbergen RL, van Lohuizen M, Gargiulo G.

J Exp Med. 2018 Dec 3;215(12):3115-3135. doi: 10.1084/jem.20180801. Epub 2018 Nov 28.


TRIM28 is an Epigenetic Barrier to Induced Pluripotent Stem Cell Reprogramming.

Miles DC, de Vries NA, Gisler S, Lieftink C, Akhtar W, Gogola E, Pawlitzky I, Hulsman D, Tanger E, Koppens M, Beijersbergen RL, van Lohuizen M.

Stem Cells. 2017 Jan;35(1):147-157. doi: 10.1002/stem.2453. Epub 2016 Jul 6.


Polycomb Repressive Complex 2 Is a Barrier to KRAS-Driven Inflammation and Epithelial-Mesenchymal Transition in Non-Small-Cell Lung Cancer.

Serresi M, Gargiulo G, Proost N, Siteur B, Cesaroni M, Koppens M, Xie H, Sutherland KD, Hulsman D, Citterio E, Orkin S, Berns A, van Lohuizen M.

Cancer Cell. 2016 Jan 11;29(1):17-31. doi: 10.1016/j.ccell.2015.12.006. Erratum in: Cancer Cell. 2016 Feb 8;29(2):241.


Prolonged Ezh2 Depletion in Glioblastoma Causes a Robust Switch in Cell Fate Resulting in Tumor Progression.

de Vries NA, Hulsman D, Akhtar W, de Jong J, Miles DC, Blom M, van Tellingen O, Jonkers J, van Lohuizen M.

Cell Rep. 2015 Jan 14. pii: S2211-1247(14)01057-2. doi: 10.1016/j.celrep.2014.12.028. [Epub ahead of print]


In vivo shRNA screens in solid tumors.

Gargiulo G, Serresi M, Cesaroni M, Hulsman D, van Lohuizen M.

Nat Protoc. 2014 Dec;9(12):2880-902. doi: 10.1038/nprot.2014.185. Epub 2014 Nov 20.


Tight regulation of ubiquitin-mediated DNA damage response by USP3 preserves the functional integrity of hematopoietic stem cells.

Lancini C, van den Berk PC, Vissers JH, Gargiulo G, Song JY, Hulsman D, Serresi M, Tanger E, Blom M, Vens C, van Lohuizen M, Jacobs H, Citterio E.

J Exp Med. 2014 Aug 25;211(9):1759-77. doi: 10.1084/jem.20131436. Epub 2014 Aug 11.


In vivo RNAi screen for BMI1 targets identifies TGF-β/BMP-ER stress pathways as key regulators of neural- and malignant glioma-stem cell homeostasis.

Gargiulo G, Cesaroni M, Serresi M, de Vries N, Hulsman D, Bruggeman SW, Lancini C, van Lohuizen M.

Cancer Cell. 2013 May 13;23(5):660-76. doi: 10.1016/j.ccr.2013.03.030.


The chromodomain helicase Chd4 is required for Polycomb-mediated inhibition of astroglial differentiation.

Sparmann A, Xie Y, Verhoeven E, Vermeulen M, Lancini C, Gargiulo G, Hulsman D, Mann M, Knoblich JA, van Lohuizen M.

EMBO J. 2013 May 29;32(11):1598-612. doi: 10.1038/emboj.2013.93. Epub 2013 Apr 26.


Rapid and robust transgenic high-grade glioma mouse models for therapy intervention studies.

de Vries NA, Bruggeman SW, Hulsman D, de Vries HI, Zevenhoven J, Buckle T, Hamans BC, Leenders WP, Beijnen JH, van Lohuizen M, Berns AJ, van Tellingen O.

Clin Cancer Res. 2010 Jul 1;16(13):3431-41. doi: 10.1158/1078-0432.CCR-09-3414. Epub 2010 May 14.


Bmi1 deficient neural stem cells have increased integrin dependent adhesion to self-secreted matrix.

Bruggeman SW, Hulsman D, van Lohuizen M.

Biochim Biophys Acta. 2009 May;1790(5):351-60. doi: 10.1016/j.bbagen.2009.03.009. Epub 2009 Mar 16.


Ubiquitin E3 ligase Ring1b/Rnf2 of polycomb repressive complex 1 contributes to stable maintenance of mouse embryonic stem cells.

van der Stoop P, Boutsma EA, Hulsman D, Noback S, Heimerikx M, Kerkhoven RM, Voncken JW, Wessels LF, van Lohuizen M.

PLoS One. 2008 May 21;3(5):e2235. doi: 10.1371/journal.pone.0002235.


Bmi1 controls tumor development in an Ink4a/Arf-independent manner in a mouse model for glioma.

Bruggeman SW, Hulsman D, Tanger E, Buckle T, Blom M, Zevenhoven J, van Tellingen O, van Lohuizen M.

Cancer Cell. 2007 Oct;12(4):328-41.


Emerging roles of Polycomb silencing in X-inactivation and stem cell maintenance.

Muyrers-Chen I, Hernández-Muñoz I, Lund AH, Valk-Lingbeek ME, van der Stoop P, Boutsma E, Tolhuis B, Bruggeman SW, Taghavi P, Verhoeven E, Hulsman D, Noback S, Tanger E, Theunissen H, van Lohuizen M.

Cold Spring Harb Symp Quant Biol. 2004;69:319-26. Review. No abstract available.


Ink4a and Arf differentially affect cell proliferation and neural stem cell self-renewal in Bmi1-deficient mice.

Bruggeman SW, Valk-Lingbeek ME, van der Stoop PP, Jacobs JJ, Kieboom K, Tanger E, Hulsman D, Leung C, Arsenijevic Y, Marino S, van Lohuizen M.

Genes Dev. 2005 Jun 15;19(12):1438-43.


Genome-wide retroviral insertional tagging of genes involved in cancer in Cdkn2a-deficient mice.

Lund AH, Turner G, Trubetskoy A, Verhoeven E, Wientjens E, Hulsman D, Russell R, DePinho RA, Lenz J, van Lohuizen M.

Nat Genet. 2002 Sep;32(1):160-5. Epub 2002 Aug 19.


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