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Items: 1 to 50 of 90

1.

Novel Antiviral Activities of Obatoclax, Emetine, Niclosamide, Brequinar, and Homoharringtonine.

Andersen PI, Krpina K, Ianevski A, Shtaida N, Jo E, Yang J, Koit S, Tenson T, Hukkanen V, Anthonsen MW, Bjoras M, Evander M, Windisch MP, Zusinaite E, Kainov DE.

Viruses. 2019 Oct 18;11(10). pii: E964. doi: 10.3390/v11100964.

2.

Comparison of Herpes Simplex Virus 1 Strains Circulating in Finland Demonstrates the Uncoupling of Whole-Genome Relatedness and Phenotypic Outcomes of Viral Infection.

Bowen CD, Paavilainen H, Renner DW, Palomäki J, Lehtinen J, Vuorinen T, Norberg P, Hukkanen V, Szpara ML.

J Virol. 2019 Apr 3;93(8). pii: e01824-18. doi: 10.1128/JVI.01824-18. Print 2019 Apr 15.

3.

Personalized Cancer Vaccine Platform for Clinically Relevant Oncolytic Enveloped Viruses.

Ylösmäki E, Malorzo C, Capasso C, Honkasalo O, Fusciello M, Martins B, Ylösmäki L, Louna A, Feola S, Paavilainen H, Peltonen K, Hukkanen V, Viitala T, Cerullo V.

Mol Ther. 2018 Sep 5;26(9):2315-2325. doi: 10.1016/j.ymthe.2018.06.008. Epub 2018 Jun 19.

4.

Novel activities of safe-in-human broad-spectrum antiviral agents.

Ianevski A, Zusinaite E, Kuivanen S, Strand M, Lysvand H, Teppor M, Kakkola L, Paavilainen H, Laajala M, Kallio-Kokko H, Valkonen M, Kantele A, Telling K, Lutsar I, Letjuka P, Metelitsa N, Oksenych V, Bjørås M, Nordbø SA, Dumpis U, Vitkauskiene A, Öhrmalm C, Bondeson K, Bergqvist A, Aittokallio T, Cox RJ, Evander M, Hukkanen V, Marjomaki V, Julkunen I, Vapalahti O, Tenson T, Merits A, Kainov D.

Antiviral Res. 2018 Jun;154:174-182. doi: 10.1016/j.antiviral.2018.04.016. Epub 2018 Apr 23. Review.

PMID:
29698664
5.

Herpes simplex and human papilloma virus coinfections in oral mucosa of men-A 6-year follow-up study.

Mäki J, Paavilainen H, Kero K, Hukkanen V, Syrjänen S.

J Med Virol. 2018 Mar;90(3):564-570. doi: 10.1002/jmv.24965. Epub 2017 Oct 20.

PMID:
28975630
6.

Antiviral Properties of Chemical Inhibitors of Cellular Anti-Apoptotic Bcl-2 Proteins.

Bulanova D, Ianevski A, Bugai A, Akimov Y, Kuivanen S, Paavilainen H, Kakkola L, Nandania J, Turunen L, Ohman T, Ala-Hongisto H, Pesonen HM, Kuisma MS, Honkimaa A, Walton EL, Oksenych V, Lorey MB, Guschin D, Shim J, Kim J, Than TT, Chang SY, Hukkanen V, Kulesskiy E, Marjomaki VS, Julkunen I, Nyman TA, Matikainen S, Saarela JS, Sane F, Hober D, Gabriel G, De Brabander JK, Martikainen M, Windisch MP, Min JY, Bruzzone R, Aittokallio T, Vähä-Koskela M, Vapalahti O, Pulk A, Velagapudi V, Kainov DE.

Viruses. 2017 Sep 25;9(10). pii: E271. doi: 10.3390/v9100271.

7.

The ERK-1 function is required for HSV-1-mediated G1/S progression in HEP-2 cells and contributes to virus growth.

Colao I, Pennisi R, Venuti A, Nygårdas M, Heikkilä O, Hukkanen V, Sciortino MT.

Sci Rep. 2017 Aug 23;7(1):9176. doi: 10.1038/s41598-017-09529-y.

8.

Chromatin organization regulates viral egress dynamics.

Aho V, Myllys M, Ruokolainen V, Hakanen S, Mäntylä E, Virtanen J, Hukkanen V, Kühn T, Timonen J, Mattila K, Larabell CA, Vihinen-Ranta M.

Sci Rep. 2017 Jun 16;7(1):3692. doi: 10.1038/s41598-017-03630-y.

9.

Topical treatment of herpes simplex virus infection with enzymatically created siRNA swarm.

Paavilainen H, Lehtinen J, Romanovskaya A, Nygårdas M, Bamford DH, Poranen MM, Hukkanen V.

Antivir Ther. 2017;22(7):631-637. doi: 10.3851/IMP3153. Epub 2017 Mar 13.

PMID:
28287396
10.

Regulation of kynurenine biosynthesis during influenza virus infection.

Gaelings L, Söderholm S, Bugai A, Fu Y, Nandania J, Schepens B, Lorey MB, Tynell J, Vande Ginste L, Le Goffic R, Miller MS, Kuisma M, Marjomäki V, De Brabander J, Matikainen S, Nyman TA, Bamford DH, Saelens X, Julkunen I, Paavilainen H, Hukkanen V, Velagapudi V, Kainov DE.

FEBS J. 2017 Jan;284(2):222-236. doi: 10.1111/febs.13966. Epub 2016 Dec 14.

11.

Interleukin-27 Inhibits Herpes Simplex Virus Type 1 Infection by Activating STAT1 and 3, Interleukin-6, and Chemokines IP-10 and MIG.

Heikkilä O, Nygårdas M, Paavilainen H, Ryödi E, Hukkanen V.

J Interferon Cytokine Res. 2016 Nov;36(11):617-629. Epub 2016 Sep 12.

PMID:
27617644
12.

The γ134.5 Neurovirulence Gene of Herpes Simplex Virus 1 Modifies the Exosome Secretion Profile in Epithelial Cells.

Heikkilä O, Ryödi E, Hukkanen V.

J Virol. 2016 Nov 14;90(23):10981-10984. doi: 10.1128/JVI.01157-16. Print 2016 Dec 1. No abstract available.

13.

Herpes simplex virus 1 induces egress channels through marginalized host chromatin.

Myllys M, Ruokolainen V, Aho V, Smith EA, Hakanen S, Peri P, Salvetti A, Timonen J, Hukkanen V, Larabell CA, Vihinen-Ranta M.

Sci Rep. 2016 Jun 28;6:28844. doi: 10.1038/srep28844.

14.

Inhibition of clinical pathogenic herpes simplex virus 1 strains with enzymatically created siRNA pools.

Paavilainen H, Lehtinen J, Romanovskaya A, Nygårdas M, Bamford DH, Poranen MM, Hukkanen V.

J Med Virol. 2016 Dec;88(12):2196-2205. doi: 10.1002/jmv.24578. Epub 2016 May 30.

PMID:
27191509
15.

HSV-1 Infection Modulates the Radioresponse of a HPV16-positive Head and Neck Cancer Cell Line.

Turunen A, Hukkanen V, Kulmala J, Syrjanen S.

Anticancer Res. 2016 Feb;36(2):565-74.

PMID:
26851010
16.

Carriage of herpes simplex virus and human papillomavirus in oral mucosa is rare in young women: A long-term prospective follow-up.

Mäki J, Paavilainen H, Grénman S, Syrjänen S, Hukkanen V.

J Clin Virol. 2015 Sep;70:58-62. doi: 10.1016/j.jcv.2015.07.006. Epub 2015 Jul 8.

PMID:
26305821
17.

An investigation of herpes simplex virus type 1 latency in a novel mouse dorsal root ganglion model suggests a role for ICP34.5 in reactivation.

Mattila RK, Harila K, Kangas SM, Paavilainen H, Heape AM, Mohr IJ, Hukkanen V.

J Gen Virol. 2015 Aug;96(8):2304-13. doi: 10.1099/vir.0.000138. Epub 2015 Apr 8.

PMID:
25854552
18.

The combined effects of irradiation and herpes simplex virus type 1 infection on an immortal gingival cell line.

Turunen A, Hukkanen V, Nygårdas M, Kulmala J, Syrjänen S.

Virol J. 2014 Jul 8;11:125. doi: 10.1186/1743-422X-11-125.

19.

Innate responses to small interfering RNA pools inhibiting herpes simplex virus infection in astrocytoid and epithelial cells.

Paavilainen H, Romanovskaya A, Nygårdas M, Bamford DH, Poranen MM, Hukkanen V.

Innate Immun. 2015 May;21(4):349-57. doi: 10.1177/1753425914537921. Epub 2014 Jul 3.

PMID:
24996409
20.

Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth.

Karttunen H, Savas JN, McKinney C, Chen YH, Yates JR 3rd, Hukkanen V, Huang TT, Mohr I.

Mol Cell. 2014 Jul 3;55(1):111-22. doi: 10.1016/j.molcel.2014.05.020. Epub 2014 Jun 19.

21.

Herpes simplex virus type 1 genital herpes in young women: current trend in Northern Finland.

Tuokko H, Bloigu R, Hukkanen V.

Sex Transm Infect. 2014 Mar;90(2):160. doi: 10.1136/sextrans-2013-051453. Epub 2014 Jan 15. No abstract available.

PMID:
24431184
22.

The virtues and vices of harnessing HSV vectors for CNS autoimmunity modulation.

Hukkanen V, Nygårdas M.

Immunotherapy. 2013 Sep;5(9):911-3. doi: 10.2217/imt.13.100. Review. No abstract available.

PMID:
23998724
23.

Anticancer compound ABT-263 accelerates apoptosis in virus-infected cells and imbalances cytokine production and lowers survival rates of infected mice.

Kakkola L, Denisova OV, Tynell J, Viiliäinen J, Ysenbaert T, Matos RC, Nagaraj A, Ohman T, Kuivanen S, Paavilainen H, Feng L, Yadav B, Julkunen I, Vapalahti O, Hukkanen V, Stenman J, Aittokallio T, Verschuren EW, Ojala PM, Nyman T, Saelens X, Dzeyk K, Kainov DE.

Cell Death Dis. 2013 Jul 25;4:e742. doi: 10.1038/cddis.2013.267.

24.

A herpes simplex virus-derived replicative vector expressing LIF limits experimental demyelinating disease and modulates autoimmunity.

Nygårdas M, Paavilainen H, Müther N, Nagel CH, Röyttä M, Sodeik B, Hukkanen V.

PLoS One. 2013 May 20;8(5):e64200. doi: 10.1371/journal.pone.0064200. Print 2013.

25.

[Herpes simplex].

Välimaa H, Seppänen M, Hukkanen V.

Duodecim. 2013;129(1):31-40. Review. Finnish.

PMID:
23431880
26.

Enzymatically produced pools of canonical and Dicer-substrate siRNA molecules display comparable gene silencing and antiviral activities against herpes simplex virus.

Romanovskaya A, Paavilainen H, Nygårdas M, Bamford DH, Hukkanen V, Poranen MM.

PLoS One. 2012;7(11):e51019. doi: 10.1371/journal.pone.0051019. Epub 2012 Nov 30.

27.

Obatoclax, saliphenylhalamide, and gemcitabine inhibit influenza a virus infection.

Denisova OV, Kakkola L, Feng L, Stenman J, Nagaraj A, Lampe J, Yadav B, Aittokallio T, Kaukinen P, Ahola T, Kuivanen S, Vapalahti O, Kantele A, Tynell J, Julkunen I, Kallio-Kokko H, Paavilainen H, Hukkanen V, Elliott RM, De Brabander JK, Saelens X, Kainov DE.

J Biol Chem. 2012 Oct 12;287(42):35324-32. doi: 10.1074/jbc.M112.392142. Epub 2012 Aug 21.

28.

Treatment of experimental autoimmune encephalomyelitis in SJL/J mice with a replicative HSV-1 vector expressing interleukin-5.

Nygårdas M, Aspelin C, Paavilainen H, Röyttä M, Waris M, Hukkanen V.

Gene Ther. 2011 Jul;18(7):646-55. doi: 10.1038/gt.2011.4. Epub 2011 Feb 17.

PMID:
21326329
29.

Cathepsins are involved in virus-induced cell death in ICP4 and Us3 deletion mutant herpes simplex virus type 1-infected monocytic cells.

Peri P, Nuutila K, Vuorinen T, Saukko P, Hukkanen V.

J Gen Virol. 2011 Jan;92(Pt 1):173-80. doi: 10.1099/vir.0.025080-0. Epub 2010 Sep 29.

PMID:
20881085
30.

Herpesvirus vectors in gene therapy.

Hukkanen V.

Open Virol J. 2010 Jun 18;4:94-5. doi: 10.2174/1874357901004030094. No abstract available.

31.

Expression of LIF and LIF receptor beta in Alzheimer's and Parkinson's diseases.

Soilu-Hänninen M, Broberg E, Röyttä M, Mattila P, Rinne J, Hukkanen V.

Acta Neurol Scand. 2010 Jan;121(1):44-50. doi: 10.1111/j.1600-0404.2009.01179.x.

PMID:
20074285
32.

Inhibition of coxsackievirus B3 and related enteroviruses by antiviral short interfering RNA pools produced using phi6 RNA-dependent RNA polymerase.

Nygårdas M, Vuorinen T, Aalto AP, Bamford DH, Hukkanen V.

J Gen Virol. 2009 Oct;90(Pt 10):2468-73. doi: 10.1099/vir.0.011338-0. Epub 2009 Jun 24.

PMID:
19553393
33.

Human lactoferrin but not lysozyme neutralizes HSV-1 and inhibits HSV-1 replication and cell-to-cell spread.

Välimaa H, Tenovuo J, Waris M, Hukkanen V.

Virol J. 2009 May 12;6:53. doi: 10.1186/1743-422X-6-53.

34.

Herpes simplex virus type 1 Us3 gene deletion influences toll-like receptor responses in cultured monocytic cells.

Peri P, Mattila RK, Kantola H, Broberg E, Karttunen HS, Waris M, Vuorinen T, Hukkanen V.

Virol J. 2008 Nov 21;5:140. doi: 10.1186/1743-422X-5-140.

35.

Serum level of CNTF is elevated in patients with amyotrophic lateral sclerosis and correlates with site of disease onset.

Laaksovirta H, Soinila S, Hukkanen V, Röyttä M, Soilu-Hänninen M.

Eur J Neurol. 2008 Apr;15(4):355-9. doi: 10.1111/j.1468-1331.2008.02080.x.

PMID:
18353124
36.

The cysteine protease inhibitors cystatins inhibit herpes simplex virus type 1-induced apoptosis and virus yield in HEp-2 cells.

Peri P, Hukkanen V, Nuutila K, Saukko P, Abrahamson M, Vuorinen T.

J Gen Virol. 2007 Aug;88(Pt 8):2101-5.

PMID:
17622610
38.

Enhancement of Th2 responses to replicative herpes simplex virus type 1 vectors by immunomodulative chemotherapy.

Peltoniemi J, Broberg EK, Nygårdas M, Erälinna JP, Waris M, Hukkanen V.

Int Immunopharmacol. 2006 May;6(5):817-29. Epub 2006 Jan 4.

PMID:
16546713
39.

Etiology of aseptic meningitis and encephalitis in an adult population.

Kupila L, Vuorinen T, Vainionpää R, Hukkanen V, Marttila RJ, Kotilainen P.

Neurology. 2006 Jan 10;66(1):75-80.

PMID:
16401850
40.

Immune response to herpes simplex virus and gamma134.5 deleted HSV vectors.

Broberg EK, Hukkanen V.

Curr Gene Ther. 2005 Oct;5(5):523-30. Review.

PMID:
16250892
41.

Spread and replication of and immune response to gamma134.5-negative herpes simplex virus type 1 vectors in BALB/c mice.

Broberg EK, Peltoniemi J, Nygårdas M, Vahlberg T, Röyttä M, Hukkanen V.

J Virol. 2004 Dec;78(23):13139-52.

42.

Immunomodulation by roquinimex decreases the expression of IL-23 (p19) mRNA in the brains of herpes simplex virus type 1 infected BALB/c mice.

Peltoniemi J, Broberg EK, Halenius A, Setala N, Eralinna JP, Salmi AA, Roytta M, Hukkanen V.

Clin Exp Immunol. 2004 Aug;137(2):305-12.

43.
44.
45.

Herpesviruses in brains in Alzheimer's and Parkinson's diseases.

Hemling N, Röyttä M, Rinne J, Pöllänen P, Broberg E, Tapio V, Vahlberg T, Hukkanen V.

Ann Neurol. 2003 Aug;54(2):267-71.

PMID:
12891684
46.

Cytokines in experimental herpes simplex virus infection.

Hukkanen V, Broberg E, Salmi A, Erälinna JP.

Int Rev Immunol. 2002 Jul-Oct;21(4-5):355-71. Review.

PMID:
12486819
47.

Semliki Forest virus infection is enhanced in Th1-prone SJL mice but not in Th2-prone BALB/c mice during Linomide-induced immunomodulation.

Peltoniemi J, Setälä N, Broberg E, Röyttä M, Hukkanen V, Salmi AA, Erälinna JP.

J Neuroimmunol. 2002 Nov;132(1-2):83-92.

PMID:
12417437
49.

Herpes simplex virus type 1 infection induces upregulation of interleukin-23 (p19) mRNA expression in trigeminal ganglia of BALB/c mice.

Broberg EK, Setälä N, Erälinna JP, Salmi AA, Röyttä M, Hukkanen V.

J Interferon Cytokine Res. 2002 Jun;22(6):641-51.

PMID:
12162874
50.

[Viruses as helpful instruments in medicine].

Hukkanen V, Kähäri VM, Hyypiä T.

Duodecim. 2001;117(10):1059-65. Finnish. No abstract available.

PMID:
12116465

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