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Items: 1 to 50 of 77

1.

Targeting Multidrug-Resistant Acinetobacter spp.: Sulbactam and the Diazabicyclooctenone β-Lactamase Inhibitor ETX2514 as a Novel Therapeutic Agent.

Barnes MD, Kumar V, Bethel CR, Moussa SH, O'Donnell J, Rutter JD, Good CE, Hujer KM, Hujer AM, Marshall SH, Kreiswirth BN, Richter SS, Rather PN, Jacobs MR, Papp-Wallace KM, van den Akker F, Bonomo RA.

MBio. 2019 Mar 12;10(2). pii: e00159-19. doi: 10.1128/mBio.00159-19.

2.

The Role of Trimethoprim/Sulfamethoxazole in the Treatment of Infections Caused by Carbapenem-Resistant Enterobacteriaceae.

Luterbach CL, Boshe A, Henderson HI, Cober E, Richter SS, Salata RA, Kalayjian RC, Watkins RR, Hujer AM, Hujer KM, Rudin SD, Domitrovic TN, Doi Y, Kaye KS, Evans S, Fowler VG Jr, Bonomo RA, van Duin D.

Open Forum Infect Dis. 2018 Dec 14;6(1):ofy351. doi: 10.1093/ofid/ofy351. eCollection 2019 Jan.

3.

ARGONAUT-I: Activity of Cefiderocol (S-649266), a Siderophore Cephalosporin, against Gram-Negative Bacteria, Including Carbapenem-Resistant Nonfermenters and Enterobacteriaceae with Defined Extended-Spectrum β-Lactamases and Carbapenemases.

Jacobs MR, Abdelhamed AM, Good CE, Rhoads DD, Hujer KM, Hujer AM, Domitrovic TN, Rudin SD, Richter SS, van Duin D, Kreiswirth BN, Greco C, Fouts DE, Bonomo RA.

Antimicrob Agents Chemother. 2018 Dec 21;63(1). pii: e01801-18. doi: 10.1128/AAC.01801-18. Print 2019 Jan.

4.

Rapid Molecular Diagnostics to Inform Empiric Use of Ceftazidime/Avibactam and Ceftolozane/Tazobactam Against Pseudomonas aeruginosa: PRIMERS IV.

Evans SR, Tran TTT, Hujer AM, Hill CB, Hujer KM, Mediavilla JR, Manca C, Domitrovic TN, Perez F, Farmer M, Pitzer KM, Wilson BM, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Fowler VG, Chambers HF, Bonomo RA; Antibacterial Resistance Leadership Group (ARLG).

Clin Infect Dis. 2019 May 17;68(11):1823-1830. doi: 10.1093/cid/ciy801.

PMID:
30239599
5.

Evaluation of Sensititre Broth Microdilution Plate for determining the susceptibility of carbapenem-resistant Klebsiella pneumoniae to polymyxins.

Richter SS, Karichu J, Otiso J, Van Heule H, Keller G, Cober E, Rojas LJ, Hujer AM, Hujer KM, Marshall S, Perez F, Rudin SD, Domitrovic TN, Kaye KS, Salata R, van Duin D, Bonomo RA.

Diagn Microbiol Infect Dis. 2018 May;91(1):89-92. doi: 10.1016/j.diagmicrobio.2018.01.005. Epub 2018 Jan 9.

6.

Multidrug Resistant Pseudomonas aeruginosa Causing Prosthetic Valve Endocarditis: A Genetic-Based Chronicle of Evolving Antibiotic Resistance.

Domitrovic TN, Hujer AM, Perez F, Marshall SH, Hujer KM, Woc-Colburn LE, Parta M, Bonomo RA.

Open Forum Infect Dis. 2016 Oct 21;3(4):ofw188. doi: 10.1093/ofid/ofw188. eCollection 2016 Oct.

7.

An Analysis of the Epidemic of Klebsiella pneumoniae Carbapenemase-Producing K. pneumoniae: Convergence of Two Evolutionary Mechanisms Creates the "Perfect Storm".

Rojas LJ, Weinstock GM, De La Cadena E, Diaz L, Rios R, Hanson BM, Brown JS, Vats P, Phillips DS, Nguyen H, Hujer KM, Correa A, Adams MD, Perez F, Sodergren E, Narechania A, Planet PJ, Villegas MV, Bonomo RA, Arias CA.

J Infect Dis. 2017 Dec 27;217(1):82-92. doi: 10.1093/infdis/jix524.

8.

A Prospective Observational Study of the Epidemiology, Management, and Outcomes of Skin and Soft Tissue Infections Due to Carbapenem-Resistant Enterobacteriaceae.

Henig O, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC, Watkins RR, Marshall S, Rudin SD, Domitrovic TN, Hujer AM, Hujer KM, Doi Y, Evans S, Fowler VG Jr, Bonomo RA, van Duin D, Kaye KS; Antibacterial Resistance Leadership Group.

Open Forum Infect Dis. 2017 Jul 27;4(3):ofx157. doi: 10.1093/ofid/ofx157. eCollection 2017 Summer.

9.

Monoclonal Antibody Protects Against Acinetobacter baumannii Infection by Enhancing Bacterial Clearance and Evading Sepsis.

Nielsen TB, Pantapalangkoor P, Luna BM, Bruhn KW, Yan J, Dekitani K, Hsieh S, Yeshoua B, Pascual B, Vinogradov E, Hujer KM, Domitrovic TN, Bonomo RA, Russo TA, Lesczcyniecka M, Schneider T, Spellberg B.

J Infect Dis. 2017 Aug 15;216(4):489-501. doi: 10.1093/infdis/jix315.

10.

Correction for Evans et al., "Informing Antibiotic Treatment Decisions: Evaluating Rapid Molecular Diagnostics To Identify Susceptibility and Resistance to Carbapenems against Acinetobacter spp. in PRIMERS III".

Evans SR, Hujer AM, Jiang H, Hill CB, Hujer KM, Mediavilla JR, Manca C, Tran TTT, Domitrovic TN, Higgins PG, Seifert H, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Sampath R, Hall T, Marzan C, Fowler VG Jr, Chambers HF, Bonomo RA.

J Clin Microbiol. 2017 Jun;55(6):1970. doi: 10.1128/JCM.00525-17. No abstract available.

11.

NDM-5 and OXA-181 Beta-Lactamases, a Significant Threat Continues To Spread in the Americas.

Rojas LJ, Hujer AM, Rudin SD, Wright MS, Domitrovic TN, Marshall SH, Hujer KM, Richter SS, Cober E, Perez F, Adams MD, van Duin D, Bonomo RA.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00454-17. doi: 10.1128/AAC.00454-17. Print 2017 Jul.

12.

Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae?

Marshall S, Hujer AM, Rojas LJ, Papp-Wallace KM, Humphries RM, Spellberg B, Hujer KM, Marshall EK, Rudin SD, Perez F, Wilson BM, Wasserman RB, Chikowski L, Paterson DL, Vila AJ, van Duin D, Kreiswirth BN, Chambers HF, Fowler VG Jr, Jacobs MR, Pulse ME, Weiss WJ, Bonomo RA.

Antimicrob Agents Chemother. 2017 Mar 24;61(4). pii: e02243-16. doi: 10.1128/AAC.02243-16. Print 2017 Apr.

13.

Colistin Resistance in Carbapenem-Resistant Klebsiella pneumoniae: Laboratory Detection and Impact on Mortality.

Rojas LJ, Salim M, Cober E, Richter SS, Perez F, Salata RA, Kalayjian RC, Watkins RR, Marshall S, Rudin SD, Domitrovic TN, Hujer AM, Hujer KM, Doi Y, Kaye KS, Evans S, Fowler VG Jr, Bonomo RA, van Duin D; Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2017 Mar 15;64(6):711-718. doi: 10.1093/cid/ciw805.

14.

Informing Antibiotic Treatment Decisions: Evaluating Rapid Molecular Diagnostics To Identify Susceptibility and Resistance to Carbapenems against Acinetobacter spp. in PRIMERS III.

Evans SR, Hujer AM, Jiang H, Hill CB, Hujer KM, Mediavilla JR, Manca C, Tran TT, Domitrovic TN, Higgins PG, Seifert H, Kreiswirth BN, Patel R, Jacobs MR, Chen L, Sampath R, Hall T, Marzan C, Fowler VG Jr, Chambers HF, Bonomo RA.

J Clin Microbiol. 2016 Dec 28;55(1):134-144. doi: 10.1128/JCM.01524-16. Print 2017 Jan. Erratum in: J Clin Microbiol. 2017 Jun;55(6):1970.

15.

Benefit-risk Evaluation for Diagnostics: A Framework (BED-FRAME).

Evans SR, Pennello G, Pantoja-Galicia N, Jiang H, Hujer AM, Hujer KM, Manca C, Hill C, Jacobs MR, Chen L, Patel R, Kreiswirth BN, Bonomo RA; Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2016 Sep 15;63(6):812-7. doi: 10.1093/cid/ciw329. Epub 2016 May 18.

16.

Initial Assessment of the Molecular Epidemiology of blaNDM-1 in Colombia.

Rojas LJ, Wright MS, De La Cadena E, Motoa G, Hujer KM, Villegas MV, Adams MD, Bonomo RA.

Antimicrob Agents Chemother. 2016 Jun 20;60(7):4346-50. doi: 10.1128/AAC.03072-15. Print 2016 Jul.

17.

Are Staphylococcus intermedius Infections in Humans Cases of Mistaken Identity? A Case Series and Literature Review.

Viau R, Hujer AM, Hujer KM, Bonomo RA, Jump RL.

Open Forum Infect Dis. 2015 Jul 17;2(3):ofv110. doi: 10.1093/ofid/ofv110. eCollection 2015 Sep.

18.

Rapid Molecular Diagnostics, Antibiotic Treatment Decisions, and Developing Approaches to Inform Empiric Therapy: PRIMERS I and II.

Evans SR, Hujer AM, Jiang H, Hujer KM, Hall T, Marzan C, Jacobs MR, Sampath R, Ecker DJ, Manca C, Chavda K, Zhang P, Fernandez H, Chen L, Mediavilla JR, Hill CB, Perez F, Caliendo AM, Fowler VG Jr, Chambers HF, Kreiswirth BN, Bonomo RA; Antibacterial Resistance Leadership Group.

Clin Infect Dis. 2016 Jan 15;62(2):181-9. doi: 10.1093/cid/civ837. Epub 2015 Sep 25.

19.

Erratum for "New Insights into Dissemination and Variation of the Health Care-Associated Pathogen Acinetobacter baumannii from Genomic Analysis".

Wright MS, Haft DH, Harkins DM, Perez F, Hujer KM, Bajaksouzian S, Benard MF, Jacobs MR, Bonomo RA, Adams MD.

MBio. 2015 Jun 4;6(3):e00585. doi: 10.1128/mBio.00585-15. No abstract available.

20.

Unexpected challenges in treating multidrug-resistant Gram-negative bacteria: resistance to ceftazidime-avibactam in archived isolates of Pseudomonas aeruginosa.

Winkler ML, Papp-Wallace KM, Hujer AM, Domitrovic TN, Hujer KM, Hurless KN, Tuohy M, Hall G, Bonomo RA.

Antimicrob Agents Chemother. 2015 Feb;59(2):1020-9. doi: 10.1128/AAC.04238-14. Epub 2014 Dec 1.

21.

Host fate is rapidly determined by innate effector-microbial interactions during Acinetobacter baumannii bacteremia.

Bruhn KW, Pantapalangkoor P, Nielsen T, Tan B, Junus J, Hujer KM, Wright MS, Bonomo RA, Adams MD, Chen W, Spellberg B.

J Infect Dis. 2015 Apr 15;211(8):1296-305. doi: 10.1093/infdis/jiu593. Epub 2014 Nov 5.

22.

Infections caused by fluoroquinolone-resistant Escherichia coli following transrectal ultrasound-guided biopsy of the prostate.

Suwantarat N, Rudin SD, Marshall SH, Hujer AM, Perez F, Hujer KM, Domitrovic TN, Dumford DM 3rd, Donskey CJ, Bonomo RA.

J Glob Antimicrob Resist. 2014 Jun 1;2(2):71-76.

23.

Population structure of KPC-producing Klebsiella pneumoniae isolates from midwestern U.S. hospitals.

Wright MS, Perez F, Brinkac L, Jacobs MR, Kaye K, Cober E, van Duin D, Marshall SH, Hujer AM, Rudin SD, Hujer KM, Bonomo RA, Adams MD.

Antimicrob Agents Chemother. 2014 Aug;58(8):4961-5. doi: 10.1128/AAC.00125-14. Epub 2014 Jun 9.

24.

New insights into dissemination and variation of the health care-associated pathogen Acinetobacter baumannii from genomic analysis.

Wright MS, Haft DH, Harkins DM, Perez F, Hujer KM, Bajaksouzian S, Benard MF, Jacobs MR, Bonomo RA, Adams MD.

MBio. 2014 Jan 21;5(1):e00963-13. doi: 10.1128/mBio.00963-13. Erratum in: MBio. 2015;6(3):e00585.

25.

Draft Genome Sequence of the Clinical Isolate Acinetobacter nosocomialis Strain M2.

Carruthers MD, Harding CM, Baker BD, Bonomo RA, Hujer KM, Rather PN, Munson RS Jr.

Genome Announc. 2013 Nov 7;1(6). pii: e00906-13. doi: 10.1128/genomeA.00906-13.

26.

Genome Sequences of Two Klebsiella pneumoniae Isolates from Different Geographical Regions, Argentina (Strain JHCK1) and the United States (Strain VA360).

Xie G, Ramirez MS, Marshall SH, Hujer KM, Lo CC, Johnson S, Li PE, Davenport K, Endimiani A, Bonomo RA, Tolmasky ME, Chain PS.

Genome Announc. 2013 May 2;1(2). pii: e00168-13. doi: 10.1128/genomeA.00168-13.

27.

Multidrug-resistant (MDR) Klebsiella pneumoniae clinical isolates: a zone of high heterogeneity (HHZ) as a tool for epidemiological studies.

Ramirez MS, Xie G, Marshall SH, Hujer KM, Chain PS, Bonomo RA, Tolmasky ME.

Clin Microbiol Infect. 2012 Jul;18(7):E254-8. doi: 10.1111/j.1469-0691.2012.03886.x. Epub 2012 May 2.

28.

Longitudinal analysis of the temporal evolution of Acinetobacter baumannii strains in Ohio, USA, by using rapid automated typing methods.

Decker BK, Perez F, Hujer AM, Hujer KM, Hall GS, Jacobs MR, Gebreyes WA, Zoll ST, Massire C, Eshoo MW, Ecker DJ, Rather PN, Bonomo RA.

PLoS One. 2012;7(4):e33443. doi: 10.1371/journal.pone.0033443. Epub 2012 Apr 12.

29.

"Silent" dissemination of Klebsiella pneumoniae isolates bearing K. pneumoniae carbapenemase in a long-term care facility for children and young adults in Northeast Ohio.

Viau RA, Hujer AM, Marshall SH, Perez F, Hujer KM, Briceño DF, Dul M, Jacobs MR, Grossberg R, Toltzis P, Bonomo RA.

Clin Infect Dis. 2012 May;54(9):1314-21. doi: 10.1093/cid/cis036.

30.

In vitro activity of antibiotic combinations against multidrug-resistant strains of Acinetobacter baumannii and the effects of their antibiotic resistance determinants.

Miyasaki Y, Morgan MA, Chan RC, Nichols WS, Hujer KM, Bonomo RA, Murthy AR.

FEMS Microbiol Lett. 2012 Mar;328(1):26-31. doi: 10.1111/j.1574-6968.2011.02480.x. Epub 2012 Jan 6.

31.

Interlaboratory reproducibility of DiversiLab rep-PCR typing and clustering of Acinetobacter baumannii isolates.

Higgins PG, Hujer AM, Hujer KM, Bonomo RA, Seifert H.

J Med Microbiol. 2012 Jan;61(Pt 1):137-41. doi: 10.1099/jmm.0.036046-0. Epub 2011 Sep 8.

32.

Acinetobacter baumannii isolates from pets and horses in Switzerland: molecular characterization and clinical data.

Endimiani A, Hujer KM, Hujer AM, Bertschy I, Rossano A, Koch C, Gerber V, Francey T, Bonomo RA, Perreten V.

J Antimicrob Chemother. 2011 Oct;66(10):2248-54. doi: 10.1093/jac/dkr289. Epub 2011 Jul 6.

33.

Exploring the inhibition of CTX-M-9 by beta-lactamase inhibitors and carbapenems.

Bethel CR, Taracila M, Shyr T, Thomson JM, Distler AM, Hujer KM, Hujer AM, Endimiani A, Papp-Wallace K, Bonnet R, Bonomo RA.

Antimicrob Agents Chemother. 2011 Jul;55(7):3465-75. doi: 10.1128/AAC.00089-11. Epub 2011 May 9.

34.

Are we ready for novel detection methods to treat respiratory pathogens in hospital-acquired pneumonia?

Endimiani A, Hujer KM, Hujer AM, Kurz S, Jacobs MR, Perlin DS, Bonomo RA.

Clin Infect Dis. 2011 May;52 Suppl 4:S373-83. doi: 10.1093/cid/cir054. Review.

35.

In vivo and in vitro activity of the siderophore monosulfactam BAL30072 against Acinetobacter baumannii.

Russo TA, Page MG, Beanan JM, Olson R, Hujer AM, Hujer KM, Jacobs M, Bajaksouzian S, Endimiani A, Bonomo RA.

J Antimicrob Chemother. 2011 Apr;66(4):867-73. doi: 10.1093/jac/dkr013. Epub 2011 Feb 13.

36.

Emergence of linezolid-resistant Staphylococcus aureus after prolonged treatment of cystic fibrosis patients in Cleveland, Ohio.

Endimiani A, Blackford M, Dasenbrook EC, Reed MD, Bajaksouszian S, Hujer AM, Rudin SD, Hujer KM, Perreten V, Rice LB, Jacobs MR, Konstan MW, Bonomo RA.

Antimicrob Agents Chemother. 2011 Apr;55(4):1684-92. doi: 10.1128/AAC.01308-10. Epub 2011 Jan 24.

37.

Evaluation of ceftazidime and NXL104 in two murine models of infection due to KPC-producing Klebsiella pneumoniae.

Endimiani A, Hujer KM, Hujer AM, Pulse ME, Weiss WJ, Bonomo RA.

Antimicrob Agents Chemother. 2011 Jan;55(1):82-5. doi: 10.1128/AAC.01198-10. Epub 2010 Nov 1.

38.

Elucidating the role of Trp105 in the KPC-2 β-lactamase.

Papp-Wallace KM, Taracila M, Wallace CJ, Hujer KM, Bethel CR, Hornick JM, Bonomo RA.

Protein Sci. 2010 Sep;19(9):1714-27. doi: 10.1002/pro.454.

39.

Rapid identification of bla KPC-possessing Enterobacteriaceae by PCR/electrospray ionization-mass spectrometry.

Endimiani A, Hujer KM, Hujer AM, Sampath R, Ecker DJ, Bonomo RA.

J Antimicrob Chemother. 2010 Aug;65(8):1833-4. doi: 10.1093/jac/dkq207. Epub 2010 Jun 10. No abstract available.

40.

Carbapenem-resistant Acinetobacter baumannii and Klebsiella pneumoniae across a hospital system: impact of post-acute care facilities on dissemination.

Perez F, Endimiani A, Ray AJ, Decker BK, Wallace CJ, Hujer KM, Ecker DJ, Adams MD, Toltzis P, Dul MJ, Windau A, Bajaksouzian S, Jacobs MR, Salata RA, Bonomo RA.

J Antimicrob Chemother. 2010 Aug;65(8):1807-18. doi: 10.1093/jac/dkq191. Epub 2010 May 31.

41.

Evaluation of a commercial microarray system for detection of SHV-, TEM-, CTX-M-, and KPC-type beta-lactamase genes in Gram-negative isolates.

Endimiani A, Hujer AM, Hujer KM, Gatta JA, Schriver AC, Jacobs MR, Rice LB, Bonomo RA.

J Clin Microbiol. 2010 Jul;48(7):2618-22. doi: 10.1128/JCM.00568-10. Epub 2010 May 26.

42.

Substrate selectivity and a novel role in inhibitor discrimination by residue 237 in the KPC-2 beta-lactamase.

Papp-Wallace KM, Taracila M, Hornick JM, Hujer AM, Hujer KM, Distler AM, Endimiani A, Bonomo RA.

Antimicrob Agents Chemother. 2010 Jul;54(7):2867-77. doi: 10.1128/AAC.00197-10. Epub 2010 Apr 26.

43.

In vitro activity of fosfomycin against blaKPC-containing Klebsiella pneumoniae isolates, including those nonsusceptible to tigecycline and/or colistin.

Endimiani A, Patel G, Hujer KM, Swaminathan M, Perez F, Rice LB, Jacobs MR, Bonomo RA.

Antimicrob Agents Chemother. 2010 Jan;54(1):526-9. doi: 10.1128/AAC.01235-09. Epub 2009 Nov 9.

44.

Antibiotic resistance determinants in Acinetobacter spp and clinical outcomes in patients from a major military treatment facility.

Perez F, Hujer AM, Hulten EA, Fishbain J, Hujer KM, Aron D, Thweatt K, Donskey CJ, Bonomo RA.

Am J Infect Control. 2010 Feb;38(1):63-5. doi: 10.1016/j.ajic.2009.05.007. Epub 2009 Sep 24.

45.

ACHN-490, a neoglycoside with potent in vitro activity against multidrug-resistant Klebsiella pneumoniae isolates.

Endimiani A, Hujer KM, Hujer AM, Armstrong ES, Choudhary Y, Aggen JB, Bonomo RA.

Antimicrob Agents Chemother. 2009 Oct;53(10):4504-7. doi: 10.1128/AAC.00556-09.

46.

Performance of the Phoenix bacterial identification system compared with disc diffusion methods for identifying extended-spectrum beta-lactamase, AmpC and KPC producers.

Fisher MA, Stamper PD, Hujer KM, Love Z, Croft A, Cohen S, Bonomo RA, Carroll KC, Petti CA.

J Med Microbiol. 2009 Jun;58(Pt 6):774-8. doi: 10.1099/jmm.0.006171-0.

47.

The role of a second-shell residue in modifying substrate and inhibitor interactions in the SHV beta-lactamase: a study of ambler position Asn276.

Drawz SM, Bethel CR, Hujer KM, Hurless KN, Distler AM, Caselli E, Prati F, Bonomo RA.

Biochemistry. 2009 Jun 2;48(21):4557-66. doi: 10.1021/bi9003292.

48.

Rapid determination of quinolone resistance in Acinetobacter spp.

Hujer KM, Hujer AM, Endimiani A, Thomson JM, Adams MD, Goglin K, Rather PN, Pennella TT, Massire C, Eshoo MW, Sampath R, Blyn LB, Ecker DJ, Bonomo RA.

J Clin Microbiol. 2009 May;47(5):1436-42. doi: 10.1128/JCM.02380-08. Epub 2009 Mar 18.

49.

Characterization of blaKPC-containing Klebsiella pneumoniae isolates detected in different institutions in the Eastern USA.

Endimiani A, Hujer AM, Perez F, Bethel CR, Hujer KM, Kroeger J, Oethinger M, Paterson DL, Adams MD, Jacobs MR, Diekema DJ, Hall GS, Jenkins SG, Rice LB, Tenover FC, Bonomo RA.

J Antimicrob Chemother. 2009 Mar;63(3):427-37. doi: 10.1093/jac/dkn547. Epub 2009 Jan 20.

50.

Strategic design of an effective beta-lactamase inhibitor: LN-1-255, a 6-alkylidene-2'-substituted penicillin sulfone.

Pattanaik P, Bethel CR, Hujer AM, Hujer KM, Distler AM, Taracila M, Anderson VE, Fritsche TR, Jones RN, Pagadala SR, van den Akker F, Buynak JD, Bonomo RA.

J Biol Chem. 2009 Jan 9;284(2):945-53. doi: 10.1074/jbc.M806833200. Epub 2008 Oct 27.

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