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Items: 20

1.

Origins of stereoselectivity in evolved ketoreductases.

Noey EL, Tibrewal N, Jiménez-Osés G, Osuna S, Park J, Bond CM, Cascio D, Liang J, Zhang X, Huisman GW, Tang Y, Houk KN.

Proc Natl Acad Sci U S A. 2015 Dec 22;112(51):E7065-72. doi: 10.1073/pnas.1507910112. Epub 2015 Dec 7.

2.

The role of distant mutations and allosteric regulation on LovD active site dynamics.

Jiménez-Osés G, Osuna S, Gao X, Sawaya MR, Gilson L, Collier SJ, Huisman GW, Yeates TO, Tang Y, Houk KN.

Nat Chem Biol. 2014 Jun;10(6):431-6. doi: 10.1038/nchembio.1503. Epub 2014 Apr 13.

3.

On the development of new biocatalytic processes for practical pharmaceutical synthesis.

Huisman GW, Collier SJ.

Curr Opin Chem Biol. 2013 Apr;17(2):284-92. doi: 10.1016/j.cbpa.2013.01.017. Epub 2013 Feb 22. Review.

PMID:
23462589
4.

Engineering the third wave of biocatalysis.

Bornscheuer UT, Huisman GW, Kazlauskas RJ, Lutz S, Moore JC, Robins K.

Nature. 2012 May 9;485(7397):185-94. doi: 10.1038/nature11117. Review.

PMID:
22575958
5.

Biocatalytic asymmetric synthesis of chiral amines from ketones applied to sitagliptin manufacture.

Savile CK, Janey JM, Mundorff EC, Moore JC, Tam S, Jarvis WR, Colbeck JC, Krebber A, Fleitz FJ, Brands J, Devine PN, Huisman GW, Hughes GJ.

Science. 2010 Jul 16;329(5989):305-9. doi: 10.1126/science.1188934. Epub 2010 Jun 17.

6.

Practical chiral alcohol manufacture using ketoreductases.

Huisman GW, Liang J, Krebber A.

Curr Opin Chem Biol. 2010 Apr;14(2):122-9. doi: 10.1016/j.cbpa.2009.12.003. Epub 2010 Jan 12. Review.

PMID:
20071211
7.

Enzyme optimization: moving from blind evolution to statistical exploration of sequence-function space.

Fox RJ, Huisman GW.

Trends Biotechnol. 2008 Mar;26(3):132-8. doi: 10.1016/j.tibtech.2007.12.001. Epub 2008 Jan 28. Review.

PMID:
18222559
8.

Improving catalytic function by ProSAR-driven enzyme evolution.

Fox RJ, Davis SC, Mundorff EC, Newman LM, Gavrilovic V, Ma SK, Chung LM, Ching C, Tam S, Muley S, Grate J, Gruber J, Whitman JC, Sheldon RA, Huisman GW.

Nat Biotechnol. 2007 Mar;25(3):338-44. Epub 2007 Feb 18.

PMID:
17322872
9.

Directed Evolution and Biocatalysis.

Powell KA, Ramer SW, Del Cardayré SB, Stemmer WP, Tobin MB, Longchamp PF, Huisman GW.

Angew Chem Int Ed Engl. 2001 Nov 5;40(21):3948-3959.

PMID:
12404465
10.

Towards novel processes for the fine-chemical and pharmaceutical industries.

Huisman GW, Gray D.

Curr Opin Biotechnol. 2002 Aug;13(4):352-8. Review.

PMID:
12323358
11.

Directed evolution: the 'rational' basis for 'irrational' design.

Tobin MB, Gustafsson C, Huisman GW.

Curr Opin Struct Biol. 2000 Aug;10(4):421-7. Review.

PMID:
10981629
12.

Reduction of cell lysate viscosity during processing of poly(3-hydroxyalkanoates) by chromosomal integration of the staphylococcal nuclease gene in Pseudomonas putida.

Boynton ZL, Koon JJ, Brennan EM, Clouart JD, Horowitz DM, Gerngross TU, Huisman GW.

Appl Environ Microbiol. 1999 Apr;65(4):1524-9.

13.

Metabolic engineering of poly(3-hydroxyalkanoates): from DNA to plastic.

Madison LL, Huisman GW.

Microbiol Mol Biol Rev. 1999 Mar;63(1):21-53. Review.

15.

A functionally diverse enzyme superfamily that abstracts the alpha protons of carboxylic acids.

Babbitt PC, Mrachko GT, Hasson MS, Huisman GW, Kolter R, Ringe D, Petsko GA, Kenyon GL, Gerlt JA.

Science. 1995 Feb 24;267(5201):1159-61.

PMID:
7855594
16.

Sensing starvation: a homoserine lactone--dependent signaling pathway in Escherichia coli.

Huisman GW, Kolter R.

Science. 1994 Jul 22;265(5171):537-9.

PMID:
7545940
17.

Pseudomonas putida KT2442 cultivated on glucose accumulates poly(3-hydroxyalkanoates) consisting of saturated and unsaturated monomers.

Huijberts GN, Eggink G, de Waard P, Huisman GW, Witholt B.

Appl Environ Microbiol. 1992 Feb;58(2):536-44.

19.

Synthesis of poly-3-hydroxyalkanoates is a common feature of fluorescent pseudomonads.

Huisman GW, de Leeuw O, Eggink G, Witholt B.

Appl Environ Microbiol. 1989 Aug;55(8):1949-54.

20.

Formation of Polyesters by Pseudomonas oleovorans: Effect of Substrates on Formation and Composition of Poly-(R)-3-Hydroxyalkanoates and Poly-(R)-3-Hydroxyalkenoates.

Lageveen RG, Huisman GW, Preusting H, Ketelaar P, Eggink G, Witholt B.

Appl Environ Microbiol. 1988 Dec;54(12):2924-32.

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