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Items: 1 to 50 of 58

1.

A Protective Monoclonal Antibody Targets a Site of Vulnerability on the Surface of Rift Valley Fever Virus.

Allen ER, Krumm SA, Raghwani J, Halldorsson S, Elliott A, Graham VA, Koudriakova E, Harlos K, Wright D, Warimwe GM, Brennan B, Huiskonen JT, Dowall SD, Elliott RM, Pybus OG, Burton DR, Hewson R, Doores KJ, Bowden TA.

Cell Rep. 2018 Dec 26;25(13):3750-3758.e4. doi: 10.1016/j.celrep.2018.12.001.

2.

Characterization of a potent and highly unusual minimally enhancing antibody directed against dengue virus.

Renner M, Flanagan A, Dejnirattisai W, Puttikhunt C, Kasinrerk W, Supasa P, Wongwiwat W, Chawansuntati K, Duangchinda T, Cowper A, Midgley CM, Malasit P, Huiskonen JT, Mongkolsapaya J, Screaton GR, Grimes JM.

Nat Immunol. 2018 Nov;19(11):1248-1256. doi: 10.1038/s41590-018-0227-7. Epub 2018 Oct 15.

PMID:
30323338
3.

Dual Role of a Viral Polymerase in Viral Genome Replication and Particle Self-Assembly.

Sun X, Ilca SL, Huiskonen JT, Poranen MM.

MBio. 2018 Oct 2;9(5). pii: e01242-18. doi: 10.1128/mBio.01242-18.

4.

Beyond structures of highly symmetric purified viral capsids by cryo-EM.

Stass R, Ilca SL, Huiskonen JT.

Curr Opin Struct Biol. 2018 Oct;52:25-31. doi: 10.1016/j.sbi.2018.07.011. Epub 2018 Aug 7. Review.

PMID:
30096461
5.

Mycobacterium tuberculosis CarD, an essential global transcriptional regulator forms amyloid-like fibrils.

Kaur G, Kaundal S, Kapoor S, Grimes JM, Huiskonen JT, Thakur KG.

Sci Rep. 2018 Jul 4;8(1):10124. doi: 10.1038/s41598-018-28290-4.

6.

Structure of the Lassa virus glycan shield provides a model for immunological resistance.

Watanabe Y, Raghwani J, Allen JD, Seabright GE, Li S, Moser F, Huiskonen JT, Strecker T, Bowden TA, Crispin M.

Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):7320-7325. doi: 10.1073/pnas.1803990115. Epub 2018 Jun 25.

7.

Towards in cellulo virus crystallography.

Duyvesteyn HME, Ginn HM, Pietilä MK, Wagner A, Hattne J, Grimes JM, Hirvonen E, Evans G, Parsy ML, Sauter NK, Brewster AS, Huiskonen JT, Stuart DI, Sutton G, Bamford DH.

Sci Rep. 2018 Feb 28;8(1):3771. doi: 10.1038/s41598-018-21693-3.

8.

Image processing for cryogenic transmission electron microscopy of symmetry-mismatched complexes.

Huiskonen JT.

Biosci Rep. 2018 Feb 8. pii: BSR20170203. doi: 10.1042/BSR20170203. [Epub ahead of print]

9.

Shielding and activation of a viral membrane fusion protein.

Halldorsson S, Li S, Li M, Harlos K, Bowden TA, Huiskonen JT.

Nat Commun. 2018 Jan 24;9(1):349. doi: 10.1038/s41467-017-02789-2.

10.

Unique architecture of thermophilic archaeal virus APBV1 and its genome packaging.

Ptchelkine D, Gillum A, Mochizuki T, Lucas-Staat S, Liu Y, Krupovic M, Phillips SEV, Prangishvili D, Huiskonen JT.

Nat Commun. 2017 Nov 10;8(1):1436. doi: 10.1038/s41467-017-01668-0.

11.

Structures of foot and mouth disease virus pentamers: Insight into capsid dissociation and unexpected pentamer reassociation.

Malik N, Kotecha A, Gold S, Asfor A, Ren J, Huiskonen JT, Tuthill TJ, Fry EE, Stuart DI.

PLoS Pathog. 2017 Sep 22;13(9):e1006607. doi: 10.1371/journal.ppat.1006607. eCollection 2017 Sep.

12.

Structural Transitions of the Conserved and Metastable Hantaviral Glycoprotein Envelope.

Rissanen I, Stass R, Zeltina A, Li S, Hepojoki J, Harlos K, Gilbert RJC, Huiskonen JT, Bowden TA.

J Virol. 2017 Oct 13;91(21). pii: e00378-17. doi: 10.1128/JVI.00378-17. Print 2017 Nov 1.

13.

Virus found in a boreal lake links ssDNA and dsDNA viruses.

Laanto E, Mäntynen S, De Colibus L, Marjakangas J, Gillum A, Stuart DI, Ravantti JJ, Huiskonen JT, Sundberg LR.

Proc Natl Acad Sci U S A. 2017 Aug 1;114(31):8378-8383. doi: 10.1073/pnas.1703834114. Epub 2017 Jul 17.

14.

Building bridges between cellular and molecular structural biology.

Patwardhan A, Brandt R, Butcher SJ, Collinson L, Gault D, Grünewald K, Hecksel C, Huiskonen JT, Iudin A, Jones ML, Korir PK, Koster AJ, Lagerstedt I, Lawson CL, Mastronarde D, McCormick M, Parkinson H, Rosenthal PB, Saalfeld S, Saibil HR, Sarntivijai S, Solanes Valero I, Subramaniam S, Swedlow JR, Tudose I, Winn M, Kleywegt GJ.

Elife. 2017 Jul 6;6. pii: e25835. doi: 10.7554/eLife.25835.

15.

Rules of engagement between αvβ6 integrin and foot-and-mouth disease virus.

Kotecha A, Wang Q, Dong X, Ilca SL, Ondiviela M, Zihe R, Seago J, Charleston B, Fry EE, Abrescia NGA, Springer TA, Huiskonen JT, Stuart DI.

Nat Commun. 2017 May 23;8:15408. doi: 10.1038/ncomms15408.

16.

Near-atomic structure of Japanese encephalitis virus reveals critical determinants of virulence and stability.

Wang X, Li SH, Zhu L, Nian QG, Yuan S, Gao Q, Hu Z, Ye Q, Li XF, Xie DY, Shaw N, Wang J, Walter TS, Huiskonen JT, Fry EE, Qin CF, Stuart DI, Rao Z.

Nat Commun. 2017 Apr 26;8(1):14. doi: 10.1038/s41467-017-00024-6.

17.

Double-stranded RNA virus outer shell assembly by bona fide domain-swapping.

Sun Z, El Omari K, Sun X, Ilca SL, Kotecha A, Stuart DI, Poranen MM, Huiskonen JT.

Nat Commun. 2017 Mar 13;8:14814. doi: 10.1038/ncomms14814.

18.

Molecular insights into lipid-assisted Ca2+ regulation of the TRP channel Polycystin-2.

Wilkes M, Madej MG, Kreuter L, Rhinow D, Heinz V, De Sanctis S, Ruppel S, Richter RM, Joos F, Grieben M, Pike AC, Huiskonen JT, Carpenter EP, Kühlbrandt W, Witzgall R, Ziegler C.

Nat Struct Mol Biol. 2017 Feb;24(2):123-130. doi: 10.1038/nsmb.3357. Epub 2017 Jan 16.

PMID:
28092368
19.

Structure of the polycystic kidney disease TRP channel Polycystin-2 (PC2).

Grieben M, Pike AC, Shintre CA, Venturi E, El-Ajouz S, Tessitore A, Shrestha L, Mukhopadhyay S, Mahajan P, Chalk R, Burgess-Brown NA, Sitsapesan R, Huiskonen JT, Carpenter EP.

Nat Struct Mol Biol. 2017 Feb;24(2):114-122. doi: 10.1038/nsmb.3343. Epub 2016 Dec 19.

PMID:
27991905
20.

Editorial overview: Virus structure and assembly: Virions - from structure and physics to design principles.

Zlotnick A, Huiskonen JT.

Curr Opin Virol. 2016 Jun;18:vii-viii. doi: 10.1016/j.coviro.2016.07.001. No abstract available.

PMID:
27521688
21.

A Molecular-Level Account of the Antigenic Hantaviral Surface.

Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA.

Cell Rep. 2016 Jun 28;16(1):278. doi: 10.1016/j.celrep.2016.06.039. Epub 2016 Jun 28. No abstract available.

22.

Structure of a phleboviral envelope glycoprotein reveals a consolidated model of membrane fusion.

Halldorsson S, Behrens AJ, Harlos K, Huiskonen JT, Elliott RM, Crispin M, Brennan B, Bowden TA.

Proc Natl Acad Sci U S A. 2016 Jun 28;113(26):7154-9. doi: 10.1073/pnas.1603827113. Epub 2016 Jun 20.

23.

A Molecular-Level Account of the Antigenic Hantaviral Surface.

Li S, Rissanen I, Zeltina A, Hepojoki J, Raghwani J, Harlos K, Pybus OG, Huiskonen JT, Bowden TA.

Cell Rep. 2016 May 3;15(5):959-967. doi: 10.1016/j.celrep.2016.03.082. Epub 2016 Apr 21. Erratum in: Cell Rep. 2016 Jun 28;16(1):278.

24.

Nucleocapsid assembly in pneumoviruses is regulated by conformational switching of the N protein.

Renner M, Bertinelli M, Leyrat C, Paesen GC, Saraiva de Oliveira LF, Huiskonen JT, Grimes JM.

Elife. 2016 Feb 15;5:e12627. doi: 10.7554/eLife.12627.

25.

Acidic pH-Induced Conformations and LAMP1 Binding of the Lassa Virus Glycoprotein Spike.

Li S, Sun Z, Pryce R, Parsy ML, Fehling SK, Schlie K, Siebert CA, Garten W, Bowden TA, Strecker T, Huiskonen JT.

PLoS Pathog. 2016 Feb 5;12(2):e1005418. doi: 10.1371/journal.ppat.1005418. eCollection 2016 Feb.

26.

Low pH and Anionic Lipid-dependent Fusion of Uukuniemi Phlebovirus to Liposomes.

Bitto D, Halldorsson S, Caputo A, Huiskonen JT.

J Biol Chem. 2016 Mar 18;291(12):6412-22. doi: 10.1074/jbc.M115.691113. Epub 2016 Jan 25.

27.

Localized reconstruction of subunits from electron cryomicroscopy images of macromolecular complexes.

Ilca SL, Kotecha A, Sun X, Poranen MM, Stuart DI, Huiskonen JT.

Nat Commun. 2015 Nov 4;6:8843. doi: 10.1038/ncomms9843.

28.

Structure-based energetics of protein interfaces guides foot-and-mouth disease virus vaccine design.

Kotecha A, Seago J, Scott K, Burman A, Loureiro S, Ren J, Porta C, Ginn HM, Jackson T, Perez-Martin E, Siebert CA, Paul G, Huiskonen JT, Jones IM, Esnouf RM, Fry EE, Maree FF, Charleston B, Stuart DI.

Nat Struct Mol Biol. 2015 Oct;22(10):788-94. doi: 10.1038/nsmb.3096. Epub 2015 Sep 21.

29.

Determination of N-linked Glycosylation in Viral Glycoproteins by Negative Ion Mass Spectrometry and Ion Mobility.

Bitto D, Harvey DJ, Halldorsson S, Doores KJ, Pritchard LK, Huiskonen JT, Bowden TA, Crispin M.

Methods Mol Biol. 2015;1331:93-121. doi: 10.1007/978-1-4939-2874-3_7.

30.

Averaging of viral envelope glycoprotein spikes from electron cryotomography reconstructions using Jsubtomo.

Huiskonen JT, Parsy ML, Li S, Bitto D, Renner M, Bowden TA.

J Vis Exp. 2014 Oct 21;(92):e51714. doi: 10.3791/51714.

31.

Uukuniemi Phlebovirus assembly and secretion leave a functional imprint on the virion glycome.

Crispin M, Harvey DJ, Bitto D, Halldorsson S, Bonomelli C, Edgeworth M, Scrivens JH, Huiskonen JT, Bowden TA.

J Virol. 2014 Sep 1;88(17):10244-51. doi: 10.1128/JVI.01662-14. Epub 2014 Jun 18.

32.

Drastic changes in conformational dynamics of the antiterminator M2-1 regulate transcription efficiency in Pneumovirinae.

Leyrat C, Renner M, Harlos K, Huiskonen JT, Grimes JM.

Elife. 2014 May 19;3:e02674. doi: 10.7554/eLife.02674.

33.

Structural plasticity of the Semliki Forest virus glycome upon interspecies transmission.

Crispin M, Harvey DJ, Bitto D, Bonomelli C, Edgeworth M, Scrivens JH, Huiskonen JT, Bowden TA.

J Proteome Res. 2014 Mar 7;13(3):1702-12. doi: 10.1021/pr401162k. Epub 2014 Feb 10.

34.

Structure and self-assembly of the calcium binding matrix protein of human metapneumovirus.

Leyrat C, Renner M, Harlos K, Huiskonen JT, Grimes JM.

Structure. 2014 Jan 7;22(1):136-48. doi: 10.1016/j.str.2013.10.013. Epub 2013 Dec 5.

35.

Isolation and characterization of the positive-sense replicative intermediate of a negative-strand RNA virus.

York A, Hengrung N, Vreede FT, Huiskonen JT, Fodor E.

Proc Natl Acad Sci U S A. 2013 Nov 5;110(45):E4238-45. doi: 10.1073/pnas.1315068110. Epub 2013 Oct 21.

36.

Crystal structure of Venezuelan hemorrhagic fever virus fusion glycoprotein reveals a class 1 postfusion architecture with extensive glycosylation.

Parsy ML, Harlos K, Huiskonen JT, Bowden TA.

J Virol. 2013 Dec;87(23):13070-5. doi: 10.1128/JVI.02298-13. Epub 2013 Sep 18.

37.

The structure of herpesvirus fusion glycoprotein B-bilayer complex reveals the protein-membrane and lateral protein-protein interaction.

Maurer UE, Zeev-Ben-Mordehai T, Pandurangan AP, Cairns TM, Hannah BP, Whitbeck JC, Eisenberg RJ, Cohen GH, Topf M, Huiskonen JT, Grünewald K.

Structure. 2013 Aug 6;21(8):1396-405. doi: 10.1016/j.str.2013.05.018. Epub 2013 Jul 11.

38.

Orthobunyavirus ultrastructure and the curious tripodal glycoprotein spike.

Bowden TA, Bitto D, McLees A, Yeromonahos C, Elliott RM, Huiskonen JT.

PLoS Pathog. 2013;9(5):e1003374. doi: 10.1371/journal.ppat.1003374. Epub 2013 May 16.

39.

Snapshot of virus evolution in hypersaline environments from the characterization of a membrane-containing Salisaeta icosahedral phage 1.

Aalto AP, Bitto D, Ravantti JJ, Bamford DH, Huiskonen JT, Oksanen HM.

Proc Natl Acad Sci U S A. 2012 May 1;109(18):7079-84. doi: 10.1073/pnas.1120174109. Epub 2012 Apr 16.

40.

Cryo electron tomography of herpes simplex virus during axonal transport and secondary envelopment in primary neurons.

Ibiricu I, Huiskonen JT, Döhner K, Bradke F, Sodeik B, Grünewald K.

PLoS Pathog. 2011 Dec;7(12):e1002406. doi: 10.1371/journal.ppat.1002406. Epub 2011 Dec 15.

41.

Eisosome proteins assemble into a membrane scaffold.

Karotki L, Huiskonen JT, Stefan CJ, Ziółkowska NE, Roth R, Surma MA, Krogan NJ, Emr SD, Heuser J, Grünewald K, Walther TC.

J Cell Biol. 2011 Nov 28;195(5):889-902. doi: 10.1083/jcb.201104040.

42.

Electron cryotomography of measles virus reveals how matrix protein coats the ribonucleocapsid within intact virions.

Liljeroos L, Huiskonen JT, Ora A, Susi P, Butcher SJ.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18085-90. doi: 10.1073/pnas.1105770108. Epub 2011 Oct 24.

43.

Eisosome-driven plasma membrane organization is mediated by BAR domains.

Ziółkowska NE, Karotki L, Rehman M, Huiskonen JT, Walther TC.

Nat Struct Mol Biol. 2011 Jun 19;18(7):854-6. doi: 10.1038/nsmb.2080.

PMID:
21685922
44.

Electron cryotomography of Tula hantavirus suggests a unique assembly paradigm for enveloped viruses.

Huiskonen JT, Hepojoki J, Laurinmäki P, Vaheri A, Lankinen H, Butcher SJ, Grünewald K.

J Virol. 2010 May;84(10):4889-97. doi: 10.1128/JVI.00057-10. Epub 2010 Mar 10.

45.

Electron cryo-microscopy and single-particle averaging of Rift Valley fever virus: evidence for GN-GC glycoprotein heterodimers.

Huiskonen JT, Overby AK, Weber F, Grünewald K.

J Virol. 2009 Apr;83(8):3762-9. doi: 10.1128/JVI.02483-08. Epub 2009 Feb 4.

46.

Efficient production of Rift Valley fever virus-like particles: The antiviral protein MxA can inhibit primary transcription of bunyaviruses.

Habjan M, Penski N, Wagner V, Spiegel M, Overby AK, Kochs G, Huiskonen JT, Weber F.

Virology. 2009 Mar 15;385(2):400-8. doi: 10.1016/j.virol.2008.12.011. Epub 2009 Jan 19.

47.

Insights into bunyavirus architecture from electron cryotomography of Uukuniemi virus.

Overby AK, Pettersson RF, Grünewald K, Huiskonen JT.

Proc Natl Acad Sci U S A. 2008 Feb 19;105(7):2375-9. doi: 10.1073/pnas.0708738105. Epub 2008 Feb 12.

48.

Tale of two spikes in bacteriophage PRD1.

Huiskonen JT, Manole V, Butcher SJ.

Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6666-71. Epub 2007 Apr 6.

49.

Membrane-containing viruses with icosahedrally symmetric capsids.

Huiskonen JT, Butcher SJ.

Curr Opin Struct Biol. 2007 Apr;17(2):229-36. Epub 2007 Mar 26. Review.

PMID:
17387010
50.

Electron cryomicroscopy comparison of the architectures of the enveloped bacteriophages phi6 and phi8.

Jäälinoja HT, Huiskonen JT, Butcher SJ.

Structure. 2007 Feb;15(2):157-67.

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