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Potent Vasodilator and Cellular Antioxidant Activity of Endemic Patagonian Calafate Berries (Berberis microphylla) with Nutraceutical Potential.

Calfío C, Huidobro-Toro JP.

Molecules. 2019 Jul 25;24(15). pii: E2700. doi: 10.3390/molecules24152700.


ATP-loaded biomimetic nanoparticles as controlled release system for extracellular drugs in cancer applications.

Díaz-Saldívar P, Huidobro-Toro JP.

Int J Nanomedicine. 2019 Apr 5;14:2433-2447. doi: 10.2147/IJN.S192925. eCollection 2019.


Copper-induced increased expression of genes involved in photosynthesis, carotenoid synthesis and C assimilation in the marine alga Ulva compressa.

Rodríguez FE, Laporte D, González A, Mendez KN, Castro-Nallar E, Meneses C, Huidobro-Toro JP, Moenne A.

BMC Genomics. 2018 Nov 20;19(1):829. doi: 10.1186/s12864-018-5226-4.


Increased ATP and ADO Overflow From Sympathetic Nerve Endings and Mesentery Endothelial Cells Plus Reduced Nitric Oxide Are Involved in Diabetic Neurovascular Dysfunction.

Donoso MV, Mascayano MJ, Poblete IM, Huidobro-Toro JP.

Front Pharmacol. 2018 May 29;9:546. doi: 10.3389/fphar.2018.00546. eCollection 2018.


Subcellular Localization and Activity of TRPM4 in Medial Prefrontal Cortex Layer 2/3.

Riquelme D, Silva I, Philp AM, Huidobro-Toro JP, Cerda O, Trimmer JS, Leiva-Salcedo E.

Front Cell Neurosci. 2018 Jan 30;12:12. doi: 10.3389/fncel.2018.00012. eCollection 2018.


P2X4 Receptor in Silico and Electrophysiological Approaches Reveal Insights of Ivermectin and Zinc Allosteric Modulation.

Latapiat V, Rodríguez FE, Godoy F, Montenegro FA, Barrera NP, Huidobro-Toro JP.

Front Pharmacol. 2017 Dec 15;8:918. doi: 10.3389/fphar.2017.00918. eCollection 2017.


Zinc as Allosteric Ion Channel Modulator: Ionotropic Receptors as Metalloproteins.

Peralta FA, Huidobro-Toro JP.

Int J Mol Sci. 2016 Jul 2;17(7). pii: E1059. doi: 10.3390/ijms17071059. Review.


ATP and related purines stimulate motility, spatial congregation, and coalescence in red algal spores.

Huidobro-Toro JP, Donoso V, Flores V, Santelices B.

J Phycol. 2015 Apr;51(2):247-54. doi: 10.1111/jpy.12278. Epub 2015 Mar 3.


Vas deferens neuro-effector junction: from kymographic tracings to structural biology principles.

Navarrete LC, Barrera NP, Huidobro-Toro JP.

Auton Neurosci. 2014 Oct;185:8-28. doi: 10.1016/j.autneu.2014.05.010. Epub 2014 Jun 2. Review.


The 5' untranslated region of the human T-cell lymphotropic virus type 1 mRNA enables cap-independent translation initiation.

Olivares E, Landry DM, Cáceres CJ, Pino K, Rossi F, Navarrete C, Huidobro-Toro JP, Thompson SR, López-Lastra M.

J Virol. 2014 Jun;88(11):5936-55. doi: 10.1128/JVI.00279-14. Epub 2014 Mar 12.


Wnt-5a increases NO and modulates NMDA receptor in rat hippocampal neurons.

Muñoz FJ, Godoy JA, Cerpa W, Poblete IM, Huidobro-Toro JP, Inestrosa NC.

Biochem Biophys Res Commun. 2014 Feb 7;444(2):189-94. doi: 10.1016/j.bbrc.2014.01.031. Epub 2014 Jan 16.


P2X1 receptors localized in lipid rafts mediate ATP motor responses in the human vas deferens longitudinal muscles.

Donoso MV, Norambuena A, Navarrete C, Poblete I, Velasco A, Huidobro-Toro JP.

Biol Reprod. 2014 Feb 6;90(2):23. doi: 10.1095/biolreprod.113.109660. Print 2014 Feb.


ATP induces NO production in hippocampal neurons by P2X(7) receptor activation independent of glutamate signaling.

Codocedo JF, Godoy JA, Poblete MI, Inestrosa NC, Huidobro-Toro JP.

PLoS One. 2013;8(3):e57626. doi: 10.1371/journal.pone.0057626. Epub 2013 Mar 5.


A cis-acting element present within the Gag open reading frame negatively impacts on the activity of the HIV-1 IRES.

Valiente-Echeverría F, Vallejos M, Monette A, Pino K, Letelier A, Huidobro-Toro JP, Mouland AJ, López-Lastra M.

PLoS One. 2013;8(2):e56962. doi: 10.1371/journal.pone.0056962. Epub 2013 Feb 25.


Functional and structural analysis of the internal ribosome entry site present in the mRNA of natural variants of the HIV-1.

Vallejos M, Carvajal F, Pino K, Navarrete C, Ferres M, Huidobro-Toro JP, Sargueil B, López-Lastra M.

PLoS One. 2012;7(4):e35031. doi: 10.1371/journal.pone.0035031. Epub 2012 Apr 4.


Reciprocal sympatho-sensory control: functional role of nucleotides and calcitonin gene-related peptide in a peripheral neuroeffector junction.

Donoso MV, Hermosilla D, Navarrete C, Álvarez P, Lillo JG, Huidobro-Toro JP.

Neuroscience. 2012 Feb 17;203:216-29. doi: 10.1016/j.neuroscience.2011.11.067. Epub 2011 Dec 9.


The Cellular Prion Protein Prevents Copper-Induced Inhibition of P2X(4) Receptors.

Lorca RA, Varela-Nallar L, Inestrosa NC, Huidobro-Toro JP.

Int J Alzheimers Dis. 2011;2011:706576. doi: 10.4061/2011/706576. Epub 2011 Oct 19.


Lipopolysaccharide inhibits the channel activity of the P2X7 receptor.

Leiva-Salcedo E, Coddou C, Rodríguez FE, Penna A, Lopez X, Neira T, Fernández R, Imarai M, Rios M, Escobar J, Montoya M, Huidobro-Toro JP, Escobar A, Acuña-Castillo C.

Mediators Inflamm. 2011;2011:152625. doi: 10.1155/2011/152625. Epub 2011 Sep 14.


Activation and regulation of purinergic P2X receptor channels.

Coddou C, Yan Z, Obsil T, Huidobro-Toro JP, Stojilkovic SS.

Pharmacol Rev. 2011 Sep;63(3):641-83. doi: 10.1124/pr.110.003129. Epub 2011 Jul 7. Review.


Chronic intermittent hypoxia augments sympatho-excitatory response to ATP but not to L-glutamate in the RVLM of rats.

Zoccal DB, Huidobro-Toro JP, Machado BH.

Auton Neurosci. 2011 Dec 7;165(2):156-62. doi: 10.1016/j.autneu.2011.06.001. Epub 2011 Jun 17.


Allosteric modulation of ATP-gated P2X receptor channels.

Coddou C, Stojilkovic SS, Huidobro-Toro JP.

Rev Neurosci. 2011;22(3):335-54. doi: 10.1515/RNS.2011.014. Epub 2011 Mar 16. Review.


Zinc enhances long-term potentiation through P2X receptor modulation in the hippocampal CA1 region.

Lorca RA, Rozas C, Loyola S, Moreira-Ramos S, Zeise ML, Kirkwood A, Huidobro-Toro JP, Morales B.

Eur J Neurosci. 2011 Apr;33(7):1175-1185. doi: 10.1111/j.1460-9568.2010.07589.x. Epub 2011 Feb 17.


IFPA Meeting 2010 Workshop Report I: Immunology; ion transport; epigenetics; vascular reactivity; epitheliochorial placentation; proteomics.

Abad C, Antczak DF, Carvalho J, Chamley LW, Chen Q, Daher S, Damiano AE, Dantzer V, Díaz P, Dunk CE, Daly E, Escudero C, Falcón B, Guillomot M, Han YW, Harris LK, Huidobro-Toro JP, Illsley N, Jammes H, Jansson T, Johnson GA, Kfoury JR Jr, Marín R, Murthi P, Novakovic B, Myatt L, Petroff MG, Pereira FT, Pfarrer C, Redman CW, Rice G, Saffery R, Tolosa JM, Vaillancourt C, Wareing M, Yuen R, Lash GE.

Placenta. 2011 Mar;32 Suppl 2:S81-9. doi: 10.1016/j.placenta.2010.12.019. Epub 2011 Jan 12.


UTP controls cell surface distribution and vasomotor activity of the human P2Y2 receptor through an epidermal growth factor receptor-transregulated mechanism.

Norambuena A, Palma F, Poblete MI, Donoso MV, Pardo E, González A, Huidobro-Toro JP.

J Biol Chem. 2010 Jan 29;285(5):2940-50. doi: 10.1074/jbc.M109.081166. Epub 2009 Dec 7.


The 5'-untranslated region of the mouse mammary tumor virus mRNA exhibits cap-independent translation initiation.

Vallejos M, Ramdohr P, Valiente-Echeverría F, Tapia K, Rodriguez FE, Lowy F, Huidobro-Toro JP, Dangerfield JA, López-Lastra M.

Nucleic Acids Res. 2010 Jan;38(2):618-32. doi: 10.1093/nar/gkp890. Epub 2009 Nov 4.


ATP released by electrical stimuli elicits calcium transients and gene expression in skeletal muscle.

Buvinic S, Almarza G, Bustamante M, Casas M, López J, Riquelme M, Sáez JC, Huidobro-Toro JP, Jaimovich E.

J Biol Chem. 2009 Dec 11;284(50):34490-505. doi: 10.1074/jbc.M109.057315. Epub 2009 Oct 12.


Reactive oxygen species potentiate the P2X2 receptor activity through intracellular Cys430.

Coddou C, Codocedo JF, Li S, Lillo JG, Acuña-Castillo C, Bull P, Stojilkovic SS, Huidobro-Toro JP.

J Neurosci. 2009 Sep 30;29(39):12284-91. doi: 10.1523/JNEUROSCI.2096-09.2009.


The Elav-like protein HuR exerts translational control of viral internal ribosome entry sites.

Rivas-Aravena A, Ramdohr P, Vallejos M, Valiente-Echeverría F, Dormoy-Raclet V, Rodríguez F, Pino K, Holzmann C, Huidobro-Toro JP, Gallouzi IE, López-Lastra M.

Virology. 2009 Sep 30;392(2):178-85. doi: 10.1016/j.virol.2009.06.050. Epub 2009 Aug 3.


Neurosteroids differentially modulate P2X ATP-gated channels through non-genomic interactions.

Codocedo JF, Rodríguez FE, Huidobro-Toro JP.

J Neurochem. 2009 Jul;110(2):734-44. doi: 10.1111/j.1471-4159.2009.06166.x. Epub 2009 May 13.


NO production and eNOS phosphorylation induced by epinephrine through the activation of beta-adrenoceptors.

Figueroa XF, Poblete I, Fernández R, Pedemonte C, Cortés V, Huidobro-Toro JP.

Am J Physiol Heart Circ Physiol. 2009 Jul;297(1):H134-43. doi: 10.1152/ajpheart.00023.2009. Epub 2009 May 8.


The release of sympathetic neurotransmitters is impaired in aged rats after an inflammatory stimulus: a possible link between cytokine production and sympathetic transmission.

Donoso V, Gomez CR, Orriantia MA, Pérez V, Torres C, Coddou C, Nelson P, Maisey K, Morales B, Fernandez R, Imarai M, Huidobro-Toro JP, Sierra F, Acuña-Castillo C.

Mech Ageing Dev. 2008 Dec;129(12):728-34. doi: 10.1016/j.mad.2008.09.018. Epub 2008 Oct 10.


P2Y1 receptor activation elicits its partition out of membrane rafts and its rapid internalization from human blood vessels: implications for receptor signaling.

Norambuena A, Poblete MI, Donoso MV, Espinoza CS, González A, Huidobro-Toro JP.

Mol Pharmacol. 2008 Dec;74(6):1666-77. doi: 10.1124/mol.108.048496. Epub 2008 Sep 17.


Nucleotide P2Y1 receptor regulates EGF receptor mitogenic signaling and expression in epithelial cells.

Buvinic S, Bravo-Zehnder M, Boyer JL, Huidobro-Toro JP, González A.

J Cell Sci. 2007 Dec 15;120(Pt 24):4289-301.


Trace metals in the brain: allosteric modulators of ligand-gated receptor channels, the case of ATP-gated P2X receptors.

Huidobro-Toro JP, Lorca RA, Coddou C.

Eur Biophys J. 2008 Mar;37(3):301-14. Epub 2007 Oct 31. Review.


Differential role of extracellular histidines in copper, zinc, magnesium and proton modulation of the P2X7 purinergic receptor.

Acuña-Castillo C, Coddou C, Bull P, Brito J, Huidobro-Toro JP.

J Neurochem. 2007 Apr;101(1):17-26.


Stoichiometry and conditional stability constants of Cu(II) or Zn(II) clioquinol complexes; implications for Alzheimer's and Huntington's disease therapy.

Ferrada E, Arancibia V, Loeb B, Norambuena E, Olea-Azar C, Huidobro-Toro JP.

Neurotoxicology. 2007 May;28(3):445-9. Epub 2007 Feb 11.


Vasomotion in human umbilical and placental veins: role of gap junctions and intracellular calcium reservoirs in their synchronous propagation.

García-Huidobro DN, García-Huidobro MT, Huidobro-Toro JP.

Placenta. 2007 Apr;28(4):328-38. Epub 2006 Jun 22.


P2Y1 and P2Y2 receptor distribution varies along the human placental vascular tree: role of nucleotides in vascular tone regulation.

Buvinic S, Poblete MI, Donoso MV, Delpiano AM, Briones R, Miranda R, Huidobro-Toro JP.

J Physiol. 2006 Jun 1;573(Pt 2):427-43. Epub 2006 Mar 16.


Modulator role of neuropeptide Y in human vascular sympathetic neuroeffector junctions.

Donoso MV, Delpiano AM, Huidobro-Toro JP.

EXS. 2006;(95):65-76. Review.


Extracellular histidine residues identify common structural determinants in the copper/zinc P2X2 receptor modulation.

Lorca RA, Coddou C, Gazitúa MC, Bull P, Arredondo C, Huidobro-Toro JP.

J Neurochem. 2005 Oct;95(2):499-512.


Anandamide elicits an acute release of nitric oxide through endothelial TRPV1 receptor activation in the rat arterial mesenteric bed.

Poblete IM, Orliac ML, Briones R, Adler-Graschinsky E, Huidobro-Toro JP.

J Physiol. 2005 Oct 15;568(Pt 2):539-51. Epub 2005 Aug 4.


A2B adenosine receptor mediates human chorionic vasoconstriction and signals through arachidonic acid cascade.

Donoso MV, López R, Miranda R, Briones R, Huidobro-Toro JP.

Am J Physiol Heart Circ Physiol. 2005 May;288(5):H2439-49. Epub 2005 Jan 6.


Heavy metals modulate the activity of the purinergic P2X4 receptor.

Coddou C, Lorca RA, Acuña-Castillo C, Grauso M, Rassendren F, Huidobro-Toro JP.

Toxicol Appl Pharmacol. 2005 Jan 15;202(2):121-31.


Neuropeptide Y is released from human mammary and radial vascular biopsies and is a functional modulator of sympathetic cotransmission.

Donoso MV, Miranda R, Irarrázaval MJ, Huidobro-Toro JP.

J Vasc Res. 2004 Sep-Oct;41(5):387-99. Epub 2004 Sep 20.


Sex-linked differences in the vasorelaxant effects of anandamide in vascular mesenteric beds: role of oestrogens.

Peroni RN, Orliac ML, Becu-Villalobos D, Huidobro-Toro JP, Adler-Graschinsky E, Celuch SM.

Eur J Pharmacol. 2004 Jun 16;493(1-3):151-60.


4-Bromo-2,5-dimethoxyphenethylamine (2C-B) and structurally related phenylethylamines are potent 5-HT2A receptor antagonists in Xenopus laevis oocytes.

Villalobos CA, Bull P, Sáez P, Cassels BK, Huidobro-Toro JP.

Br J Pharmacol. 2004 Apr;141(7):1167-74. Epub 2004 Mar 8.


Release and functional role of neuropeptide Y as a sympathetic modulator in human saphenous vein biopsies.

Donoso MV, Miranda R, Briones R, Irarrázaval MJ, Huidobro-Toro JP.

Peptides. 2004 Jan;25(1):53-64.


A human prion protein peptide (PrP(59-91)) protects against copper neurotoxicity.

Chacón MA, Barría MI, Lorca R, Huidobro-Toro JP, Inestrosa NC.

Mol Psychiatry. 2003 Oct;8(10):853-62, 835.


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