Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 73


Approaches for investigating the extracellular signaling function of ISG15.

Swaim CD, Canadeo LA, Huibregtse JM.

Methods Enzymol. 2019;618:211-227. doi: 10.1016/bs.mie.2018.12.027. Epub 2019 Feb 1.


A proteasomal partner goes missing in Angelman syndrome.

Huibregtse JM.

J Biol Chem. 2018 Nov 23;293(47):18400-18401. doi: 10.1074/jbc.H118.006328.


Ubiquitin-Activated Interaction Traps (UBAITs): Tools for Capturing Protein-Protein Interactions.

O'Connor HF, Swaim CD, Canadeo LA, Huibregtse JM.

Methods Mol Biol. 2018;1844:85-100. doi: 10.1007/978-1-4939-8706-1_7.


Extracellular ISG15 Signals Cytokine Secretion through the LFA-1 Integrin Receptor.

Swaim CD, Scott AF, Canadeo LA, Huibregtse JM.

Mol Cell. 2017 Nov 2;68(3):581-590.e5. doi: 10.1016/j.molcel.2017.10.003.


Enzyme-substrate relationships in the ubiquitin system: approaches for identifying substrates of ubiquitin ligases.

O'Connor HF, Huibregtse JM.

Cell Mol Life Sci. 2017 Sep;74(18):3363-3375. doi: 10.1007/s00018-017-2529-6. Epub 2017 Apr 28. Review.


A Billion Ubiquitin Variants to Probe and Modulate the UPS.

Canadeo LA, Huibregtse JM.

Mol Cell. 2016 Apr 7;62(1):2-4. doi: 10.1016/j.molcel.2016.03.023.


Ramping up degradation for proliferation.

Huibregtse JM, Matouschek A.

Nat Cell Biol. 2016 Feb;18(2):141-2. doi: 10.1038/ncb3306.


Ubiquitin-Activated Interaction Traps (UBAITs) identify E3 ligase binding partners.

O'Connor HF, Lyon N, Leung JW, Agarwal P, Swaim CD, Miller KM, Huibregtse JM.

EMBO Rep. 2015 Dec;16(12):1699-712. doi: 10.15252/embr.201540620. Epub 2015 Oct 27.


Ubiquitination of newly synthesized proteins at the ribosome.

Wang F, Canadeo LA, Huibregtse JM.

Biochimie. 2015 Jul;114:127-33. doi: 10.1016/j.biochi.2015.02.006. Epub 2015 Feb 17. Review.


A cotranslational ubiquitination pathway for quality control of misfolded proteins.

Wang F, Durfee LA, Huibregtse JM.

Mol Cell. 2013 May 9;50(3):368-78. doi: 10.1016/j.molcel.2013.03.009. Epub 2013 Apr 11.


Mycobacterial disease and impaired IFN-γ immunity in humans with inherited ISG15 deficiency.

Bogunovic D, Byun M, Durfee LA, Abhyankar A, Sanal O, Mansouri D, Salem S, Radovanovic I, Grant AV, Adimi P, Mansouri N, Okada S, Bryant VL, Kong XF, Kreins A, Velez MM, Boisson B, Khalilzadeh S, Ozcelik U, Darazam IA, Schoggins JW, Rice CM, Al-Muhsen S, Behr M, Vogt G, Puel A, Bustamante J, Gros P, Huibregtse JM, Abel L, Boisson-Dupuis S, Casanova JL.

Science. 2012 Sep 28;337(6102):1684-8. Epub 2012 Aug 2.


The ISG15 conjugation system.

Durfee LA, Huibregtse JM.

Methods Mol Biol. 2012;832:141-9. doi: 10.1007/978-1-61779-474-2_9.


Structure and function of a HECT domain ubiquitin-binding site.

Kim HC, Steffen AM, Oldham ML, Chen J, Huibregtse JM.

EMBO Rep. 2011 Apr;12(4):334-41. doi: 10.1038/embor.2011.23. Epub 2011 Mar 11.


Identification and Validation of ISG15 Target Proteins.

Durfee LA, Huibregtse JM.

Subcell Biochem. 2010;54:228-37. doi: 10.1007/978-1-4419-6676-6_18. Review.


Rescue of HIV-1 release by targeting widely divergent NEDD4-type ubiquitin ligases and isolated catalytic HECT domains to Gag.

Weiss ER, Popova E, Yamanaka H, Kim HC, Huibregtse JM, Göttlinger H.

PLoS Pathog. 2010 Sep 16;6(9):e1001107. doi: 10.1371/journal.ppat.1001107.


The ISG15 conjugation system broadly targets newly synthesized proteins: implications for the antiviral function of ISG15.

Durfee LA, Lyon N, Seo K, Huibregtse JM.

Mol Cell. 2010 Jun 11;38(5):722-32. doi: 10.1016/j.molcel.2010.05.002.


Polyubiquitination by HECT E3s and the determinants of chain type specificity.

Kim HC, Huibregtse JM.

Mol Cell Biol. 2009 Jun;29(12):3307-18. doi: 10.1128/MCB.00240-09. Epub 2009 Apr 13.


HPV E6, E6AP and cervical cancer.

Beaudenon S, Huibregtse JM.

BMC Biochem. 2008 Oct 21;9 Suppl 1:S4. doi: 10.1186/1471-2091-9-S1-S4. Review.


The basis for selective E1-E2 interactions in the ISG15 conjugation system.

Durfee LA, Kelley ML, Huibregtse JM.

J Biol Chem. 2008 Aug 29;283(35):23895-902. doi: 10.1074/jbc.M804069200. Epub 2008 Jun 26.


Crystal structure of SopA, a Salmonella effector protein mimicking a eukaryotic ubiquitin ligase.

Diao J, Zhang Y, Huibregtse JM, Zhou D, Chen J.

Nat Struct Mol Biol. 2008 Jan;15(1):65-70. Epub 2007 Dec 9.


Regulation of catalytic activities of HECT ubiquitin ligases.

Kee Y, Huibregtse JM.

Biochem Biophys Res Commun. 2007 Mar 9;354(2):329-33. Epub 2007 Jan 16. Review.


The deubiquitinating enzyme Ubp2 modulates Rsp5-dependent Lys63-linked polyubiquitin conjugates in Saccharomyces cerevisiae.

Kee Y, Muñoz W, Lyon N, Huibregtse JM.

J Biol Chem. 2006 Dec 1;281(48):36724-31. Epub 2006 Oct 6.


Human scribble, a novel tumor suppressor identified as a target of high-risk HPV E6 for ubiquitin-mediated degradation, interacts with adenomatous polyposis coli.

Takizawa S, Nagasaka K, Nakagawa S, Yano T, Nakagawa K, Yasugi T, Takeuchi T, Kanda T, Huibregtse JM, Akiyama T, Taketani Y.

Genes Cells. 2006 Apr;11(4):453-64.


Involvement of a cellular ubiquitin-protein ligase E6AP in the ubiquitin-mediated degradation of extensive substrates of high-risk human papillomavirus E6.

Matsumoto Y, Nakagawa S, Yano T, Takizawa S, Nagasaka K, Nakagawa K, Minaguchi T, Wada O, Ooishi H, Matsumoto K, Yasugi T, Kanda T, Huibregtse JM, Taketani Y.

J Med Virol. 2006 Apr;78(4):501-7.


Herc5, an interferon-induced HECT E3 enzyme, is required for conjugation of ISG15 in human cells.

Dastur A, Beaudenon S, Kelley M, Krug RM, Huibregtse JM.

J Biol Chem. 2006 Feb 17;281(7):4334-8. Epub 2005 Dec 28.


Expression and assay of HECT domain ligases.

Beaudenon S, Dastur A, Huibregtse JM.

Methods Enzymol. 2005;398:112-25.


High-level expression and purification of recombinant E1 enzyme.

Beaudenon S, Huibregtse JM.

Methods Enzymol. 2005;398:3-8. Review.


Human ISG15 conjugation targets both IFN-induced and constitutively expressed proteins functioning in diverse cellular pathways.

Zhao C, Denison C, Huibregtse JM, Gygi S, Krug RM.

Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10200-5. Epub 2005 Jul 11.


The Rsp5 ubiquitin ligase is coupled to and antagonized by the Ubp2 deubiquitinating enzyme.

Kee Y, Lyon N, Huibregtse JM.

EMBO J. 2005 Jul 6;24(13):2414-24. Epub 2005 Jun 2.


UPS shipping and handling.

Huibregtse JM.

Cell. 2005 Jan 14;120(1):2-4. Review.


A single PXY motif located within the carboxyl terminus of Spt23p and Mga2p mediates a physical and functional interaction with ubiquitin ligase Rsp5p.

Shcherbik N, Kee Y, Lyon N, Huibregtse JM, Haines DS.

J Biol Chem. 2004 Dec 17;279(51):53892-8. Epub 2004 Oct 5.


The UbcH8 ubiquitin E2 enzyme is also the E2 enzyme for ISG15, an IFN-alpha/beta-induced ubiquitin-like protein.

Zhao C, Beaudenon SL, Kelley ML, Waddell MB, Yuan W, Schulman BA, Huibregtse JM, Krug RM.

Proc Natl Acad Sci U S A. 2004 May 18;101(20):7578-82. Epub 2004 May 6.


The -4 phenylalanine is required for substrate ubiquitination catalyzed by HECT ubiquitin ligases.

Salvat C, Wang G, Dastur A, Lyon N, Huibregtse JM.

J Biol Chem. 2004 Apr 30;279(18):18935-43. Epub 2004 Feb 13.


Analysis of the expression and localisation of a LAP protein, human scribble, in the normal and neoplastic epithelium of uterine cervix.

Nakagawa S, Yano T, Nakagawa K, Takizawa S, Suzuki Y, Yasugi T, Huibregtse JM, Taketani Y.

Br J Cancer. 2004 Jan 12;90(1):194-9.


Human papillomavirus E6-induced degradation of E6TP1 is mediated by E6AP ubiquitin ligase.

Gao Q, Kumar A, Singh L, Huibregtse JM, Beaudenon S, Srinivasan S, Wazer DE, Band H, Band V.

Cancer Res. 2002 Jun 1;62(11):3315-21.


Rhabdoviruses and the cellular ubiquitin-proteasome system: a budding interaction.

Harty RN, Brown ME, McGettigan JP, Wang G, Jayakar HR, Huibregtse JM, Whitt MA, Schnell MJ.

J Virol. 2001 Nov;75(22):10623-9.


Nuclear import/export of hRPF1/Nedd4 regulates the ubiquitin-dependent degradation of its nuclear substrates.

Hamilton MH, Tcherepanova I, Huibregtse JM, McDonnell DP.

J Biol Chem. 2001 Jul 13;276(28):26324-31. Epub 2001 May 7.


Localization of the Rsp5p ubiquitin-protein ligase at multiple sites within the endocytic pathway.

Wang G, McCaffery JM, Wendland B, Dupré S, Haguenauer-Tsapis R, Huibregtse JM.

Mol Cell Biol. 2001 May;21(10):3564-75.


Human papillomavirus type 16 E6 induces self-ubiquitination of the E6AP ubiquitin-protein ligase.

Kao WH, Beaudenon SL, Talis AL, Huibregtse JM, Howley PM.

J Virol. 2000 Jul;74(14):6408-17.


Structure of an E6AP-UbcH7 complex: insights into ubiquitination by the E2-E3 enzyme cascade.

Huang L, Kinnucan E, Wang G, Beaudenon S, Howley PM, Huibregtse JM, Pavletich NP.

Science. 1999 Nov 12;286(5443):1321-6.


Rsp5 ubiquitin-protein ligase mediates DNA damage-induced degradation of the large subunit of RNA polymerase II in Saccharomyces cerevisiae.

Beaudenon SL, Huacani MR, Wang G, McDonnell DP, Huibregtse JM.

Mol Cell Biol. 1999 Oct;19(10):6972-9.


Functional domains of the Rsp5 ubiquitin-protein ligase.

Wang G, Yang J, Huibregtse JM.

Mol Cell Biol. 1999 Jan;19(1):342-52.


The human E6-AP gene (UBE3A) encodes three potential protein isoforms generated by differential splicing.

Yamamoto Y, Huibregtse JM, Howley PM.

Genomics. 1997 Apr 15;41(2):263-6.


The large subunit of RNA polymerase II is a substrate of the Rsp5 ubiquitin-protein ligase.

Huibregtse JM, Yang JC, Beaudenon SL.

Proc Natl Acad Sci U S A. 1997 Apr 15;94(8):3656-61.


Mechanism of HPV E6 proteins in cellular transformation.

Huibregtse JM, Beaudenon SL.

Semin Cancer Biol. 1996 Dec;7(6):317-26. Review.


In vivo ubiquitination and proteasome-mediated degradation of p53(1).

Maki CG, Huibregtse JM, Howley PM.

Cancer Res. 1996 Jun 1;56(11):2649-54.

Supplemental Content

Loading ...
Support Center