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ApoER2 (Apolipoprotein E Receptor-2) Deficiency Accelerates Smooth Muscle Cell Senescence via Cytokinesis Impairment and Promotes Fibrotic Neointima After Vascular Injury.

Komaravolu RK, Waltmann MD, Konaniah E, Jaeschke A, Hui DY.

Arterioscler Thromb Vasc Biol. 2019 Aug 15:ATVBAHA119313194. doi: 10.1161/ATVBAHA.119.313194. [Epub ahead of print]


Enhancer of zeste homolog 2 (EZH2) regulates adipocyte lipid metabolism independent of adipogenic differentiation: Role of apolipoprotein E.

Yiew NKH, Greenway C, Zarzour A, Ahmadieh S, Goo B, Kim D, Benson TW, Ogbi M, Tang YL, Chen W, Stepp D, Patel V, Hilton R, Lu XY, Hui DY, Kim HW, Weintraub NL.

J Biol Chem. 2019 May 24;294(21):8577-8591. doi: 10.1074/jbc.RA118.006871. Epub 2019 Apr 10.


Therapeutic reduction of lysophospholipids in the digestive tract recapitulates the metabolic benefits of bariatric surgery and promotes diabetes remission.

Cash JG, Konaniah E, Hegde N, Kuhel DG, Watanabe M, Romick-Rosendale L, Hui DY.

Mol Metab. 2018 Oct;16:55-64. doi: 10.1016/j.molmet.2018.07.009. Epub 2018 Jul 26.


Group 1B phospholipase A2 in metabolic and inflammatory disease modulation.

Hui DY.

Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jun;1864(6):784-788. doi: 10.1016/j.bbalip.2018.07.001. Epub 2018 Jul 9. Review.


Naturally Occurring Variants in LRP1 (Low-Density Lipoprotein Receptor-Related Protein 1) Affect HDL (High-Density Lipoprotein) Metabolism Through ABCA1 (ATP-Binding Cassette A1) and SR-B1 (Scavenger Receptor Class B Type 1) in Humans.

Oldoni F, van Capelleveen JC, Dalila N, Wolters JC, Heeren J, Sinke RJ, Hui DY, Dallinga-Thie GM, Frikke-Schmidt R, Hovingh KG, van de Sluis B, Tybjærg-Hansen A, Kuivenhoven JA.

Arterioscler Thromb Vasc Biol. 2018 Jul;38(7):1440-1453. doi: 10.1161/ATVBAHA.117.310309. Epub 2018 May 31.


Low-density lipoprotein receptor-related protein-1 dysfunction synergizes with dietary cholesterol to accelerate steatohepatitis progression.

Hamlin AN, Chinnarasu S, Ding Y, Xian X, Herz J, Jaeschke A, Hui DY.

J Biol Chem. 2018 Jun 22;293(25):9674-9684. doi: 10.1074/jbc.RA118.001952. Epub 2018 May 11.


Antiphospholipid antibodies induce thrombosis by PP2A activation via apoER2-Dab2-SHC1 complex formation in endothelium.

Sacharidou A, Chambliss KL, Ulrich V, Salmon JE, Shen YM, Herz J, Hui DY, Terada LS, Shaul PW, Mineo C.

Blood. 2018 May 10;131(19):2097-2110. doi: 10.1182/blood-2017-11-814681. Epub 2018 Mar 2.


Epithelial-Cell-Derived Phospholipase A2 Group 1B Is an Endogenous Anthelmintic.

Entwistle LJ, Pelly VS, Coomes SM, Kannan Y, Perez-Lloret J, Czieso S, Silva Dos Santos M, MacRae JI, Collinson L, Sesay A, Nikolov N, Metidji A, Helmby H, Hui DY, Wilson MS.

Cell Host Microbe. 2017 Oct 11;22(4):484-493.e5. doi: 10.1016/j.chom.2017.09.006.


The good side of cholesterol: a requirement for maintenance of intestinal integrity.

Hui DY.

J Lipid Res. 2017 Oct;58(10):1935-1936. doi: 10.1194/jlr.C079715. Epub 2017 Aug 2. No abstract available.


Deficiency of LRP1 in Mature Adipocytes Promotes Diet-Induced Inflammation and Atherosclerosis-Brief Report.

Konaniah ES, Kuhel DG, Basford JE, Weintraub NL, Hui DY.

Arterioscler Thromb Vasc Biol. 2017 Jun;37(6):1046-1049. doi: 10.1161/ATVBAHA.117.309414. Epub 2017 May 4.


A novel role for the Wnt inhibitor APCDD1 in adipocyte differentiation: Implications for diet-induced obesity.

Yiew NKH, Chatterjee TK, Tang YL, Pellenberg R, Stansfield BK, Bagi Z, Fulton DJ, Stepp DW, Chen W, Patel V, Kamath VM, Litwin SE, Hui DY, Rudich SM, Kim HW, Weintraub NL.

J Biol Chem. 2017 Apr 14;292(15):6312-6324. doi: 10.1074/jbc.M116.758078. Epub 2017 Feb 27.


Weight loss surgery in adolescents corrects high-density lipoprotein subspecies and their function.

Davidson WS, Inge TH, Sexmith H, Heink A, Elder D, Hui DY, Melchior JT, Kelesidis T, Shah AS.

Int J Obes (Lond). 2017 Jan;41(1):83-89. doi: 10.1038/ijo.2016.190. Epub 2016 Oct 26.


Intestinal phospholipid and lysophospholipid metabolism in cardiometabolic disease.

Hui DY.

Curr Opin Lipidol. 2016 Oct;27(5):507-12. doi: 10.1097/MOL.0000000000000334. Review.


LRP1 Protein Deficiency Exacerbates Palmitate-induced Steatosis and Toxicity in Hepatocytes.

Hamlin AN, Basford JE, Jaeschke A, Hui DY.

J Biol Chem. 2016 Aug 5;291(32):16610-9. doi: 10.1074/jbc.M116.717744. Epub 2016 Jun 17.


Chronic stress and Rosiglitazone increase indices of vascular stiffness in male rats.

Goodson ML, Packard AEB, Buesing DR, Maney M, Myers B, Fang Y, Basford JE, Hui DY, Ulrich-Lai YM, Herman JP, Ryan KK.

Physiol Behav. 2017 Apr 1;172:16-23. doi: 10.1016/j.physbeh.2016.03.031. Epub 2016 Mar 31.


Red Blood Cell Dysfunction Induced by High-Fat Diet: Potential Implications for Obesity-Related Atherosclerosis.

Unruh D, Srinivasan R, Benson T, Haigh S, Coyle D, Batra N, Keil R, Sturm R, Blanco V, Palascak M, Franco RS, Tong W, Chatterjee T, Hui DY, Davidson WS, Aronow BJ, Kalfa T, Manka D, Peairs A, Blomkalns A, Fulton DJ, Brittain JE, Weintraub NL, Bogdanov VY.

Circulation. 2015 Nov 17;132(20):1898-908. doi: 10.1161/CIRCULATIONAHA.115.017313. Epub 2015 Oct 14.


Role of histone deacetylase 9 in regulating adipogenic differentiation and high fat diet-induced metabolic disease.

Chatterjee TK, Basford JE, Yiew KH, Stepp DW, Hui DY, Weintraub NL.

Adipocyte. 2014 Dec 10;3(4):333-8. doi: 10.4161/adip.28814. eCollection 2014 Oct-Dec.


Histone Deacetylases and Cardiometabolic Diseases.

Yiew KH, Chatterjee TK, Hui DY, Weintraub NL.

Arterioscler Thromb Vasc Biol. 2015 Sep;35(9):1914-9. doi: 10.1161/ATVBAHA.115.305046. Epub 2015 Jul 16. Review.


PDZK1 prevents neointima formation via suppression of breakpoint cluster region kinase in vascular smooth muscle.

Lee WR, Sacharidou A, Behling-Kelly E, Oltmann SC, Zhu W, Ahmed M, Gerard RD, Hui DY, Abe J, Shaul PW, Mineo C.

PLoS One. 2015 Apr 17;10(4):e0124494. doi: 10.1371/journal.pone.0124494. eCollection 2015.


A flexible transparent gas barrier film employing the method of mixing ALD/MLD-grown Al2O3 and alucone layers.

Xiao W, Hui DY, Zheng C, Yu D, Qiang YY, Ping C, Xiang CL, Yi Z.

Nanoscale Res Lett. 2015 Mar 14;10:130. doi: 10.1186/s11671-015-0838-y. eCollection 2015.


Antiphospholipid antibodies attenuate endothelial repair and promote neointima formation in mice.

Ulrich V, Konaniah ES, Lee WR, Khadka S, Shen YM, Herz J, Salmon JE, Hui DY, Shaul PW, Mineo C.

J Am Heart Assoc. 2014 Oct 14;3(5):e001369. doi: 10.1161/JAHA.114.001369.


Reduced levels of microRNAs miR-124a and miR-150 are associated with increased proinflammatory mediator expression in Krüppel-like factor 2 (KLF2)-deficient macrophages.

Manoharan P, Basford JE, Pilcher-Roberts R, Neumann J, Hui DY, Lingrel JB.

J Biol Chem. 2014 Nov 7;289(45):31638-46. doi: 10.1074/jbc.M114.579763. Epub 2014 Sep 23.


Genetic variants of ApoE and ApoER2 differentially modulate endothelial function.

Ulrich V, Konaniah ES, Herz J, Gerard RD, Jung E, Yuhanna IS, Ahmed M, Hui DY, Mineo C, Shaul PW.

Proc Natl Acad Sci U S A. 2014 Sep 16;111(37):13493-8. doi: 10.1073/pnas.1402106111. Epub 2014 Sep 2.


Transplanted perivascular adipose tissue accelerates injury-induced neointimal hyperplasia: role of monocyte chemoattractant protein-1.

Manka D, Chatterjee TK, Stoll LL, Basford JE, Konaniah ES, Srinivasan R, Bogdanov VY, Tang Y, Blomkalns AL, Hui DY, Weintraub NL.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1723-30. doi: 10.1161/ATVBAHA.114.303983. Epub 2014 Jun 19.


Proinflammatory phenotype of perivascular adipocytes.

Omar A, Chatterjee TK, Tang Y, Hui DY, Weintraub NL.

Arterioscler Thromb Vasc Biol. 2014 Aug;34(8):1631-6. doi: 10.1161/ATVBAHA.114.303030. Epub 2014 Jun 12. Review.


Apolipoprotein E receptor-2 deficiency enhances macrophage susceptibility to lipid accumulation and cell death to augment atherosclerotic plaque progression and necrosis.

Waltmann MD, Basford JE, Konaniah ES, Weintraub NL, Hui DY.

Biochim Biophys Acta. 2014 Sep;1842(9):1395-405. doi: 10.1016/j.bbadis.2014.05.009. Epub 2014 May 16.


Mixed-lineage kinase 3 deficiency promotes neointima formation through increased activation of the RhoA pathway in vascular smooth muscle cells.

Gadang V, Konaniah E, Hui DY, Jaeschke A.

Arterioscler Thromb Vasc Biol. 2014 Jul;34(7):1429-36. doi: 10.1161/ATVBAHA.114.303439. Epub 2014 May 1.


Is gastric lymphoepithelioma-like carcinoma a special subtype of EBV-associated gastric carcinoma? New insight based on clinicopathological features and EBV genome polymorphisms.

Cheng N, Hui DY, Liu Y, Zhang NN, Jiang Y, Han J, Li HG, Ding YG, Du H, Chen JN, Shao CK.

Gastric Cancer. 2015 Apr;18(2):246-55. doi: 10.1007/s10120-014-0376-9. Epub 2014 Apr 27.


Overexpression of apolipoprotein C-III decreases secretion of dietary triglyceride into lymph.

Wang F, Kohan AB, Dong HH, Yang Q, Xu M, Huesman S, Lou D, Hui DY, Tso P.

Physiol Rep. 2014 Mar 20;2(3):e00247. doi: 10.1002/phy2.247. Print 2014.


Group 1B phospholipase A₂ inactivation suppresses atherosclerosis and metabolic diseases in LDL receptor-deficient mice.

Hollie NI, Konaniah ES, Goodin C, Hui DY.

Atherosclerosis. 2014 Jun;234(2):377-80. doi: 10.1016/j.atherosclerosis.2014.03.027. Epub 2014 Apr 1.


Molecular cloning and characterization of a novel chicken gene named grni.

Hua Y, Hui DY, Rong ZH, Cheng T.

Genet Mol Res. 2014 Jan 21;13(1):386-95. doi: 10.4238/2014.January.21.6.


Micromolar changes in lysophosphatidylcholine concentration cause minor effects on mitochondrial permeability but major alterations in function.

Hollie NI, Cash JG, Matlib MA, Wortman M, Basford JE, Abplanalp W, Hui DY.

Biochim Biophys Acta. 2014 Jun;1841(6):888-95. doi: 10.1016/j.bbalip.2013.11.013. Epub 2013 Dec 5.


Smooth muscle LDL receptor-related protein-1 deletion induces aortic insufficiency and promotes vascular cardiomyopathy in mice.

Basford JE, Koch S, Anjak A, Singh VP, Krause EG, Robbins N, Weintraub NL, Hui DY, Rubinstein J.

PLoS One. 2013 Nov 29;8(11):e82026. doi: 10.1371/journal.pone.0082026. eCollection 2013.


HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding.

Chatterjee TK, Basford JE, Knoll E, Tong WS, Blanco V, Blomkalns AL, Rudich S, Lentsch AB, Hui DY, Weintraub NL.

Diabetes. 2014 Jan;63(1):176-87. doi: 10.2337/db13-1148. Epub 2013 Oct 7.


MLK3 promotes metabolic dysfunction induced by saturated fatty acid-enriched diet.

Gadang V, Kohli R, Myronovych A, Hui DY, Perez-Tilve D, Jaeschke A.

Am J Physiol Endocrinol Metab. 2013 Aug 15;305(4):E549-56. doi: 10.1152/ajpendo.00197.2013. Epub 2013 Jul 16.


Human coronary artery perivascular adipocytes overexpress genes responsible for regulating vascular morphology, inflammation, and hemostasis.

Chatterjee TK, Aronow BJ, Tong WS, Manka D, Tang Y, Bogdanov VY, Unruh D, Blomkalns AL, Piegore MG Jr, Weintraub DS, Rudich SM, Kuhel DG, Hui DY, Weintraub NL.

Physiol Genomics. 2013 Aug 15;45(16):697-709. doi: 10.1152/physiolgenomics.00042.2013. Epub 2013 Jun 4.


Ginsenoside Rb1 reduces fatty liver by activating AMP-activated protein kinase in obese rats.

Shen L, Xiong Y, Wang DQ, Howles P, Basford JE, Wang J, Xiong YQ, Hui DY, Woods SC, Liu M.

J Lipid Res. 2013 May;54(5):1430-8. doi: 10.1194/jlr.M035907. Epub 2013 Feb 22.


Engineering a lysosomal enzyme with a derivative of receptor-binding domain of apoE enables delivery across the blood-brain barrier.

Wang D, El-Amouri SS, Dai M, Kuan CY, Hui DY, Brady RO, Pan D.

Proc Natl Acad Sci U S A. 2013 Feb 19;110(8):2999-3004. doi: 10.1073/pnas.1222742110. Epub 2013 Feb 4.


Variations of Epstein-Barr virus nuclear antigen 1 in Epstein-Barr virus-associated gastric carcinomas from Guangzhou, southern China.

Chen JN, Zhang NN, Jiang Y, Hui DY, Wen ZJ, Li HG, Ding YG, Du H, Shao CK.

PLoS One. 2012;7(11):e50084. doi: 10.1371/journal.pone.0050084. Epub 2012 Nov 26.


Apolipoprotein E2 accentuates postprandial inflammation and diet-induced obesity to promote hyperinsulinemia in mice.

Kuhel DG, Konaniah ES, Basford JE, McVey C, Goodin CT, Chatterjee TK, Weintraub NL, Hui DY.

Diabetes. 2013 Feb;62(2):382-91. doi: 10.2337/db12-0390. Epub 2012 Sep 6.


Physiological role of hepatic NPC1L1 in human cholesterol and lipoprotein metabolism: new perspectives and open questions.

Howles PN, Hui DY; Editorial Board.

J Lipid Res. 2012 Nov;53(11):2253-5. doi: 10.1194/jlr.E031823. Epub 2012 Aug 31. No abstract available.


Apolipoprotein E does not cross the blood-cerebrospinal fluid barrier, as revealed by an improved technique for sampling CSF from mice.

Liu M, Kuhel DG, Shen L, Hui DY, Woods SC.

Am J Physiol Regul Integr Comp Physiol. 2012 Nov 1;303(9):R903-8. doi: 10.1152/ajpregu.00219.2012. Epub 2012 Aug 29.


Apolipoprotein E4 impairs macrophage efferocytosis and potentiates apoptosis by accelerating endoplasmic reticulum stress.

Cash JG, Kuhel DG, Basford JE, Jaeschke A, Chatterjee TK, Weintraub NL, Hui DY.

J Biol Chem. 2012 Aug 10;287(33):27876-84. doi: 10.1074/jbc.M112.377549. Epub 2012 Jun 23.


Nonproteolytic properties of murine alternatively spliced tissue factor: implications for integrin-mediated signaling in murine models.

Godby RC, Van Den Berg YW, Srinivasan R, Sturm R, Hui DY, Konieczny SF, Aronow BJ, Ozhegov E, Ruf W, Versteeg HH, Bogdanov VY.

Mol Med. 2012 Jul 18;18:771-9. doi: 10.2119/molmed.2011.00416.


Myeloid-specific Krüppel-like factor 2 inactivation increases macrophage and neutrophil adhesion and promotes atherosclerosis.

Lingrel JB, Pilcher-Roberts R, Basford JE, Manoharan P, Neumann J, Konaniah ES, Srinivasan R, Bogdanov VY, Hui DY.

Circ Res. 2012 May 11;110(10):1294-302. doi: 10.1161/CIRCRESAHA.112.267310. Epub 2012 Apr 3.


Metabolic control by S6 kinases depends on dietary lipids.

Castañeda TR, Abplanalp W, Um SH, Pfluger PT, Schrott B, Brown K, Grant E, Carnevalli L, Benoit SC, Morgan DA, Gilham D, Hui DY, Rahmouni K, Thomas G, Kozma SC, Clegg DJ, Tschöp MH.

PLoS One. 2012;7(3):e32631. doi: 10.1371/journal.pone.0032631. Epub 2012 Mar 7.


Phospholipase A(2) enzymes in metabolic and cardiovascular diseases.

Hui DY.

Curr Opin Lipidol. 2012 Jun;23(3):235-40. doi: 10.1097/MOL.0b013e328351b439. Review.


Group 1B phospholipase A₂ deficiency protects against diet-induced hyperlipidemia in mice.

Hollie NI, Hui DY.

J Lipid Res. 2011 Nov;52(11):2005-11. doi: 10.1194/jlr.M019463. Epub 2011 Sep 9.


Histone deacetylase 9 is a negative regulator of adipogenic differentiation.

Chatterjee TK, Idelman G, Blanco V, Blomkalns AL, Piegore MG Jr, Weintraub DS, Kumar S, Rajsheker S, Manka D, Rudich SM, Tang Y, Hui DY, Bassel-Duby R, Olson EN, Lingrel JB, Ho SM, Weintraub NL.

J Biol Chem. 2011 Aug 5;286(31):27836-47. doi: 10.1074/jbc.M111.262964. Epub 2011 Jun 16.

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