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Items: 28

1.

A Functional Homologous Recombination Assay Predicts Primary Chemotherapy Response and Long-Term Survival in Ovarian Cancer Patients.

Tumiati M, Hietanen S, Hynninen J, Pietilä E, Färkkilä A, Kaipio K, Roering P, Huhtinen K, Alkodsi A, Li Y, Lehtonen R, Erkan EP, Tuominen MM, Lehti K, Hautaniemi SK, Vähärautio A, Grénman S, Carpén O, Kauppi L.

Clin Cancer Res. 2018 Sep 15;24(18):4482-4493. doi: 10.1158/1078-0432.CCR-17-3770. Epub 2018 Jun 1.

2.

Secreted frizzled-related protein 2 (SFRP2) expression promotes lesion proliferation via canonical WNT signaling and indicates lesion borders in extraovarian endometriosis.

Heinosalo T, Gabriel M, Kallio L, Adhikari P, Huhtinen K, Laajala TD, Kaikkonen E, Mehmood A, Suvitie P, Kujari H, Aittokallio T, Perheentupa A, Poutanen M.

Hum Reprod. 2018 May 1;33(5):817-831. doi: 10.1093/humrep/dey026.

PMID:
29462326
3.

The Expression of HSD17B12 Is Associated with COX-2 Expression and Is Increased in High-Grade Epithelial Ovarian Cancer.

Kemiläinen H, Huhtinen K, Auranen A, Carpén O, Strauss L, Poutanen M.

Oncology. 2018;94(4):233-242. doi: 10.1159/000485624. Epub 2018 Jan 12.

PMID:
29324448
4.

DNA methylation and Transcriptome Changes Associated with Cisplatin Resistance in Ovarian Cancer.

Lund RJ, Huhtinen K, Salmi J, Rantala J, Nguyen EV, Moulder R, Goodlett DR, Lahesmaa R, Carpén O.

Sci Rep. 2017 May 4;7(1):1469. doi: 10.1038/s41598-017-01624-4.

5.

Hyper-phosphorylation of Sequestosome-1 Distinguishes Resistance to Cisplatin in Patient Derived High Grade Serous Ovarian Cancer Cells.

Nguyen EV, Huhtinen K, Goo YA, Kaipio K, Andersson N, Rantanen V, Hynninen J, Lahesmaa R, Carpen O, Goodlett DR.

Mol Cell Proteomics. 2017 Jul;16(7):1377-1392. doi: 10.1074/mcp.M116.058321. Epub 2017 Apr 28.

6.

A Nanoparticle-Lectin Immunoassay Improves Discrimination of Serum CA125 from Malignant and Benign Sources.

Gidwani K, Huhtinen K, Kekki H, van Vliet S, Hynninen J, Koivuviita N, Perheentupa A, Poutanen M, Auranen A, Grenman S, Lamminmäki U, Carpen O, van Kooyk Y, Pettersson K.

Clin Chem. 2016 Oct;62(10):1390-400. doi: 10.1373/clinchem.2016.257691. Epub 2016 Aug 18.

7.

Novel Mad2-targeting miR-493-3p controls mitotic fidelity and cancer cells' sensitivity to paclitaxel.

Tambe M, Pruikkonen S, Mäki-Jouppila J, Chen P, Elgaaen BV, Straume AH, Huhtinen K, Cárpen O, Lønning PE, Davidson B, Hautaniemi S, Kallio MJ.

Oncotarget. 2016 Mar 15;7(11):12267-85. doi: 10.18632/oncotarget.7860.

8.

Identification of Prognostic Groups in High-Grade Serous Ovarian Cancer Treated with Platinum-Taxane Chemotherapy.

Chen P, Huhtinen K, Kaipio K, Mikkonen P, Aittomäki V, Lindell R, Hynninen J, Auranen A, Grénman S, Lehtonen R, Carpén O, Hautaniemi S.

Cancer Res. 2015 Aug 1;75(15):2987-98. doi: 10.1158/0008-5472.CAN-14-3242. Epub 2015 Jun 29.

9.

Intra-tissue steroid profiling indicates differential progesterone and testosterone metabolism in the endometrium and endometriosis lesions.

Huhtinen K, Saloniemi-Heinonen T, Keski-Rahkonen P, Desai R, Laajala D, Ståhle M, Häkkinen MR, Awosanya M, Suvitie P, Kujari H, Aittokallio T, Handelsman DJ, Auriola S, Perheentupa A, Poutanen M.

J Clin Endocrinol Metab. 2014 Nov;99(11):E2188-97. doi: 10.1210/jc.2014-1913. Epub 2014 Aug 19.

PMID:
25137424
10.

Ovarian endometriosis signatures established through discovery and directed mass spectrometry analysis.

Vehmas AP, Muth-Pawlak D, Huhtinen K, Saloniemi-Heinonen T, Jaakkola K, Laajala TD, Kaprio H, Suvitie PA, Aittokallio T, Siitari H, Perheentupa A, Poutanen M, Corthals GL.

J Proteome Res. 2014 Nov 7;13(11):4983-94. doi: 10.1021/pr500384n. Epub 2014 Aug 20.

PMID:
25099244
11.

Serum concentrations of HE4 change little during in vitro fertilization.

Hallamaa M, Huhtinen K, Suvitie P, Perheentupa A.

Acta Obstet Gynecol Scand. 2014 Jul;93(7):640-6. doi: 10.1111/aogs.12393. Epub 2014 May 12.

PMID:
24734893
12.

LC-MS analysis of estradiol in human serum and endometrial tissue: Comparison of electrospray ionization, atmospheric pressure chemical ionization and atmospheric pressure photoionization.

Keski-Rahkonen P, Huhtinen K, Desai R, Harwood DT, Handelsman DJ, Poutanen M, Auriola S.

J Mass Spectrom. 2013 Sep;48(9):1050-8. doi: 10.1002/jms.3252.

PMID:
24078246
13.

Endometrial and endometriotic concentrations of estrone and estradiol are determined by local metabolism rather than circulating levels.

Huhtinen K, Desai R, Ståhle M, Salminen A, Handelsman DJ, Perheentupa A, Poutanen M.

J Clin Endocrinol Metab. 2012 Nov;97(11):4228-35. doi: 10.1210/jc.2012-1154. Epub 2012 Sep 11.

14.

Interactions between inflammatory signals and the progesterone receptor in regulating gene expression in pregnant human uterine myocytes.

Lee Y, Sooranna SR, Terzidou V, Christian M, Brosens J, Huhtinen K, Poutanen M, Barton G, Johnson MR, Bennett PR.

J Cell Mol Med. 2012 Oct;16(10):2487-503. doi: 10.1111/j.1582-4934.2012.01567.x.

15.

Serum HE4 concentration is not dependent on menstrual cycle or hormonal treatment among endometriosis patients and healthy premenopausal women.

Hallamaa M, Suvitie P, Huhtinen K, Matomäki J, Poutanen M, Perheentupa A.

Gynecol Oncol. 2012 Jun;125(3):667-72. doi: 10.1016/j.ygyno.2012.03.011. Epub 2012 Mar 14.

PMID:
22426487
16.

[Pathogenesis of endometriosis].

Huhtinen K, Perheentupa A, Poutanen M, Heikinheimo O.

Duodecim. 2011;127(17):1827-35. Finnish.

PMID:
21995119
17.

Estrogen biosynthesis and signaling in endometriosis.

Huhtinen K, Ståhle M, Perheentupa A, Poutanen M.

Mol Cell Endocrinol. 2012 Jul 25;358(2):146-54. doi: 10.1016/j.mce.2011.08.022. Epub 2011 Aug 22. Review.

PMID:
21875644
18.

Fast and sensitive liquid chromatography-mass spectrometry assay for seven androgenic and progestagenic steroids in human serum.

Keski-Rahkonen P, Huhtinen K, Poutanen M, Auriola S.

J Steroid Biochem Mol Biol. 2011 Nov;127(3-5):396-404. doi: 10.1016/j.jsbmb.2011.06.006. Epub 2011 Jun 12.

PMID:
21684334
19.

Synthesis and biological evaluation of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) inhibitors based on a thieno[2,3-d]pyrimidin-4(3H)-one core.

Lilienkampf A, Karkola S, Alho-Richmond S, Koskimies P, Johansson N, Huhtinen K, Vihko K, Wähälä K.

J Med Chem. 2009 Nov 12;52(21):6660-71. doi: 10.1021/jm900928k.

PMID:
19824648
20.

Resampling reveals sample-level differential expression in clinical genome-wide studies.

Hiissa J, Elo LL, Huhtinen K, Perheentupa A, Poutanen M, Aittokallio T.

OMICS. 2009 Oct;13(5):381-96. doi: 10.1089/omi.2009.0027.

PMID:
19663710
21.

Induction of PUMA-alpha and down-regulation of PUMA-beta expression is associated with benzo(a)pyrene-induced apoptosis in MCF-7 cells.

Tampio M, Markkanen P, Puttonen KA, Hagelberg E, Heikkinen H, Huhtinen K, Loikkanen J, Hirvonen MR, Vähäkangas KH.

Toxicol Lett. 2009 Aug 10;188(3):214-22. doi: 10.1016/j.toxlet.2009.04.016. Epub 2009 May 3.

PMID:
19397966
22.

Serum HE4 concentration differentiates malignant ovarian tumours from ovarian endometriotic cysts.

Huhtinen K, Suvitie P, Hiissa J, Junnila J, Huvila J, Kujari H, Setälä M, Härkki P, Jalkanen J, Fraser J, Mäkinen J, Auranen A, Poutanen M, Perheentupa A.

Br J Cancer. 2009 Apr 21;100(8):1315-9. doi: 10.1038/sj.bjc.6605011. Epub 2009 Mar 31.

23.

In vivo mouse model for analysis of hydroxysteroid (17beta) dehydrogenase 1 inhibitors.

Lamminen T, Saloniemi T, Huhtinen K, Koskimies P, Messinger J, Husen B, Thole H, Poutanen M.

Mol Cell Endocrinol. 2009 Mar 25;301(1-2):158-62. doi: 10.1016/j.mce.2008.10.034. Epub 2008 Nov 5.

PMID:
19026716
24.

The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium.

Cloke B, Huhtinen K, Fusi L, Kajihara T, Yliheikkilä M, Ho KK, Teklenburg G, Lavery S, Jones MC, Trew G, Kim JJ, Lam EW, Cartwright JE, Poutanen M, Brosens JJ.

Endocrinology. 2008 Sep;149(9):4462-74. doi: 10.1210/en.2008-0356. Epub 2008 May 29.

25.

Activation of androgens by hydroxysteroid (17beta) dehydrogenase 1 in vivo as a cause of prenatal masculinization and ovarian benign serous cystadenomas.

Saloniemi T, Lamminen T, Huhtinen K, Welsh M, Saunders P, Kujari H, Poutanen M.

Mol Endocrinol. 2007 Nov;21(11):2627-36. Epub 2007 Jul 31.

PMID:
17666583
26.

Human hydroxysteroid (17-beta) dehydrogenase 1 expression enhances estrogen sensitivity of MCF-7 breast cancer cell xenografts.

Husen B, Huhtinen K, Saloniemi T, Messinger J, Thole HH, Poutanen M.

Endocrinology. 2006 Nov;147(11):5333-9. Epub 2006 Aug 17.

PMID:
16916945
27.

Evaluation of inhibitors for 17beta-hydroxysteroid dehydrogenase type 1 in vivo in immunodeficient mice inoculated with MCF-7 cells stably expressing the recombinant human enzyme.

Husen B, Huhtinen K, Poutanen M, Kangas L, Messinger J, Thole H.

Mol Cell Endocrinol. 2006 Mar 27;248(1-2):109-13. Epub 2006 Jan 10.

PMID:
16406284
28.

The peroxisome proliferator-induced cytosolic type I acyl-CoA thioesterase (CTE-I) is a serine-histidine-aspartic acid alpha /beta hydrolase.

Huhtinen K, O'Byrne J, Lindquist PJ, Contreras JA, Alexson SE.

J Biol Chem. 2002 Feb 1;277(5):3424-32. Epub 2001 Nov 2.

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