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Items: 7


Antitumor activity of a novel bispecific antibody that targets the ErbB2/ErbB3 oncogenic unit and inhibits heregulin-induced activation of ErbB3.

McDonagh CF, Huhalov A, Harms BD, Adams S, Paragas V, Oyama S, Zhang B, Luus L, Overland R, Nguyen S, Gu J, Kohli N, Wallace M, Feldhaus MJ, Kudla AJ, Schoeberl B, Nielsen UB.

Mol Cancer Ther. 2012 Mar;11(3):582-93. doi: 10.1158/1535-7163.MCT-11-0820. Epub 2012 Jan 16.


Characterisation and radioimmunotherapy of L19-SIP, an anti-angiogenic antibody against the extra domain B of fibronectin, in colorectal tumour models.

El-Emir E, Dearling JL, Huhalov A, Robson MP, Boxer G, Neri D, van Dongen GA, Trachsel E, Begent RH, Pedley RB.

Br J Cancer. 2007 Jun 18;96(12):1862-70. Epub 2007 May 22.


Deglycosylation to obtain stable and homogeneous Pichia pastoris-expressed N-A1 domains of carcinoembryonic antigen.

Sainz-Pastor N, Tolner B, Huhalov A, Kogelberg H, Lee YC, Zhu D, Begent RH, Chester KA.

Int J Biol Macromol. 2006 Aug 15;39(1-3):141-50. Epub 2006 Mar 28.


Engineered single chain antibody fragments for radioimmunotherapy.

Huhalov A, Chester KA.

Q J Nucl Med Mol Imaging. 2004 Dec;48(4):279-88.


Mapping antibody:antigen interactions by mass spectrometry and bioinformatics.

Huhalov A, Spencer DI, Chester KA.

Methods Mol Biol. 2004;248:465-80. No abstract available.


Clinical applications of phage-derived sFvs and sFv fusion proteins.

Chester KA, Bhatia J, Boxer G, Cooke SP, Flynn AA, Huhalov A, Mayer A, Pedley RB, Robson L, Sharma SK, Spencer DI, Begent RH.

Dis Markers. 2000;16(1-2):53-62. Review.


Extended half-life and elevated steady-state level of a single-chain Fv intrabody are critical for specific intracellular retargeting of its antigen, caspase-7.

Zhu Q, Zeng C, Huhalov A, Yao J, Turi TG, Danley D, Hynes T, Cong Y, DiMattia D, Kennedy S, Daumy G, Schaeffer E, Marasco WA, Huston JS.

J Immunol Methods. 1999 Dec 10;231(1-2):207-22.


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