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Macroautophagy in Dendritic Cells Controls the Homeostasis and Stability of Regulatory T Cells.

Niven J, Madelon N, Page N, Caruso A, Harlé G, Lemeille S, Seemayer CA, Hugues S, Gannagé M.

Cell Rep. 2019 Jul 2;28(1):21-29.e6. doi: 10.1016/j.celrep.2019.05.110.


Tumor-Associated Lymphatic Vessel Features and Immunomodulatory Functions.

Garnier L, Gkountidi AO, Hugues S.

Front Immunol. 2019 Apr 9;10:720. doi: 10.3389/fimmu.2019.00720. eCollection 2019. Review.


Absence of MHC-II expression by lymph node stromal cells results in autoimmunity.

Dubrot J, Duraes FV, Harlé G, Schlaeppi A, Brighouse D, Madelon N, Göpfert C, Stokar-Regenscheit N, Acha-Orbea H, Reith W, Gannagé M, Hugues S.

Life Sci Alliance. 2018 Dec 17;1(6):e201800164. doi: 10.26508/lsa.201800164. eCollection 2018 Dec.


Extended Freeze-Dried BCG Instructed pDCs Induce Suppressive Tregs and Dampen EAE.

Lippens C, Garnier L, Guyonvarc'h PM, Santiago-Raber ML, Hugues S.

Front Immunol. 2018 Nov 29;9:2777. doi: 10.3389/fimmu.2018.02777. eCollection 2018.


Warming up the tumor microenvironment in order to enhance immunogenicity.

Humbert M, Hugues S.

Oncoimmunology. 2018 Oct 1;8(1):e1510710. doi: 10.1080/2162402X.2018.1510710. eCollection 2019.


The Timing of Sensory-Guided Behavioral Response is Represented in the Mouse Primary Somatosensory Cortex.

Camon J, Hugues S, Erlandson MA, Robbe D, Lagoun S, Marouane E, Bureau I.

Cereb Cortex. 2019 Jul 5;29(7):3034-3047. doi: 10.1093/cercor/bhy169.


Altered Humoral Immune Responses and IgG Subtypes in NOX2-Deficient Mice and Patients: A Key Role for NOX2 in Antigen-Presenting Cells.

Cachat J, Deffert C, Alessandrini M, Roux-Lombard P, Le Gouellec A, Stasia MJ, Hugues S, Krause KH.

Front Immunol. 2018 Jul 11;9:1555. doi: 10.3389/fimmu.2018.01555. eCollection 2018.


Dendritic Cell Migration Toward CCL21 Gradient Requires Functional Cx43.

Ruez R, Dubrot J, Zoso A, Bacchetta M, Molica F, Hugues S, Kwak BR, Chanson M.

Front Physiol. 2018 Mar 27;9:288. doi: 10.3389/fphys.2018.00288. eCollection 2018.


Intratumoral CpG-B Promotes Antitumoral Neutrophil, cDC, and T-cell Cooperation without Reprograming Tolerogenic pDC.

Humbert M, Guery L, Brighouse D, Lemeille S, Hugues S.

Cancer Res. 2018 Jun 15;78(12):3280-3292. doi: 10.1158/0008-5472.CAN-17-2549. Epub 2018 Mar 27.


STIM1 promotes migration, phagosomal maturation and antigen cross-presentation in dendritic cells.

Nunes-Hasler P, Maschalidi S, Lippens C, Castelbou C, Bouvet S, Guido D, Bermont F, Bassoy EY, Page N, Merkler D, Hugues S, Martinvalet D, Manoury B, Demaurex N.

Nat Commun. 2017 Nov 24;8(1):1852. doi: 10.1038/s41467-017-01600-6.


Pannexin1 links lymphatic function to lipid metabolism and atherosclerosis.

Molica F, Meens MJ, Dubrot J, Ehrlich A, Roth CL, Morel S, Pelli G, Vinet L, Braunersreuther V, Ratib O, Chanson M, Hugues S, Scemes E, Kwak BR.

Sci Rep. 2017 Oct 20;7(1):13706. doi: 10.1038/s41598-017-14130-4.


Cx47 fine-tunes the handling of serum lipids but is dispensable for lymphatic vascular function.

Meens MJ, Kutkut I, Rochemont V, Dubrot J, Kaladji FR, Sabine A, Lyons O, Hendrikx S, Bernier-Latmani J, Kiefer F, Smith A, Hugues S, Petrova TV, Kwak BR.

PLoS One. 2017 Jul 21;12(7):e0181476. doi: 10.1371/journal.pone.0181476. eCollection 2017.


Shaping of Peripheral T Cell Responses by Lymphatic Endothelial Cells.

Humbert M, Hugues S, Dubrot J.

Front Immunol. 2017 Jan 12;7:684. doi: 10.3389/fimmu.2016.00684. eCollection 2016. Review.


The Heterogeneity of Ly6Chi Monocytes Controls Their Differentiation into iNOS+ Macrophages or Monocyte-Derived Dendritic Cells.

Menezes S, Melandri D, Anselmi G, Perchet T, Loschko J, Dubrot J, Patel R, Gautier EL, Hugues S, Longhi MP, Henry JY, Quezada SA, Lauvau G, Lennon-Duménil AM, Gutiérrez-Martínez E, Bessis A, Gomez-Perdiguero E, Jacome-Galarza CE, Garner H, Geissmann F, Golub R, Nussenzweig MC, Guermonprez P.

Immunity. 2016 Dec 20;45(6):1205-1218. doi: 10.1016/j.immuni.2016.12.001.


IDO-orchestrated crosstalk between pDCs and Tregs inhibits autoimmunity.

Lippens C, Duraes FV, Dubrot J, Brighouse D, Lacroix M, Irla M, Aubry-Lachainaye JP, Reith W, Mandl JN, Hugues S.

J Autoimmun. 2016 Dec;75:39-49. doi: 10.1016/j.jaut.2016.07.004. Epub 2016 Jul 26.


Btn2a2, a T cell immunomodulatory molecule coregulated with MHC class II genes.

Sarter K, Leimgruber E, Gobet F, Agrawal V, Dunand-Sauthier I, Barras E, Mastelic-Gavillet B, Kamath A, Fontannaz P, Guéry L, Duraes Fdo V, Lippens C, Ravn U, Santiago-Raber ML, Magistrelli G, Fischer N, Siegrist CA, Hugues S, Reith W.

J Exp Med. 2016 Feb 8;213(2):177-87. doi: 10.1084/jem.20150435. Epub 2016 Jan 25.


Th17 Cell Plasticity and Functions in Cancer Immunity.

Guéry L, Hugues S.

Biomed Res Int. 2015;2015:314620. doi: 10.1155/2015/314620. Epub 2015 Oct 25. Review.


IL-22 capacitates dermal fibroblast responses to TNF in scleroderma.

Brembilla NC, Dufour AM, Alvarez M, Hugues S, Montanari E, Truchetet ME, Lonati P, Fontao L, Gabrielli A, Vettori S, Valentini G, Boehncke WH, Meroni P, Chizzolini C.

Ann Rheum Dis. 2016 Sep;75(9):1697-705. doi: 10.1136/annrheumdis-2015-207477. Epub 2015 Oct 9.


Macroautophagy in Endogenous Processing of Self- and Pathogen-Derived Antigens for MHC Class II Presentation.

Duraes FV, Niven J, Dubrot J, Hugues S, Gannagé M.

Front Immunol. 2015 Sep 22;6:459. doi: 10.3389/fimmu.2015.00459. eCollection 2015. Review.


pDC therapy induces recovery from EAE by recruiting endogenous pDC to sites of CNS inflammation.

Duraes FV, Lippens C, Steinbach K, Dubrot J, Brighouse D, Bendriss-Vermare N, Issazadeh-Navikas S, Merkler D, Hugues S.

J Autoimmun. 2016 Feb;67:8-18. doi: 10.1016/j.jaut.2015.08.014. Epub 2015 Sep 1.


New role for antigen-presenting activated pDCs in promoting Th17 cells and impacting antitumor immunity.

Guéry L, Hugues S.

Oncoimmunology. 2015 May 8;4(5):e988476. eCollection 2015 May.


Immune tolerance. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4⁺ T cells.

Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonnenberg GF.

Science. 2015 May 29;348(6238):1031-5. doi: 10.1126/science.aaa4812. Epub 2015 Apr 23.


Phagocyte NADPH oxidase and specific immunity.

Cachat J, Deffert C, Hugues S, Krause KH.

Clin Sci (Lond). 2015 May 1;128(10):635-48. doi: 10.1042/CS20140635. Review.


Oxysterols regulate encephalitogenic CD4(+) T cell trafficking during central nervous system autoimmunity.

Chalmin F, Rochemont V, Lippens C, Clottu A, Sailer AW, Merkler D, Hugues S, Pot C.

J Autoimmun. 2015 Jan;56:45-55. doi: 10.1016/j.jaut.2014.10.001. Epub 2014 Nov 10.


Ag-presenting CpG-activated pDCs prime Th17 cells that induce tumor regression.

Guéry L, Dubrot J, Lippens C, Brighouse D, Malinge P, Irla M, Pot C, Reith W, Waldburger JM, Hugues S.

Cancer Res. 2014 Nov 15;74(22):6430-40. doi: 10.1158/0008-5472.CAN-14-1149. Epub 2014 Sep 24.


MHC Class II-restricted antigen presentation by plasmacytoid dendritic cells drives proatherogenic T cell immunity.

Sage AP, Murphy D, Maffia P, Masters LM, Sabir SR, Baker LL, Cambrook H, Finigan AJ, Ait-Oufella H, Grassia G, Harrison JE, Ludewig B, Reith W, Hansson GK, Reizis B, Hugues S, Mallat Z.

Circulation. 2014 Oct 14;130(16):1363-73. doi: 10.1161/CIRCULATIONAHA.114.011090. Epub 2014 Sep 15.


Lymph node stromal cells acquire peptide-MHCII complexes from dendritic cells and induce antigen-specific CD4⁺ T cell tolerance.

Dubrot J, Duraes FV, Potin L, Capotosti F, Brighouse D, Suter T, LeibundGut-Landmann S, Garbi N, Reith W, Swartz MA, Hugues S.

J Exp Med. 2014 Jun 2;211(6):1153-66. doi: 10.1084/jem.20132000. Epub 2014 May 19.


Steady-state antigen scavenging, cross-presentation, and CD8+ T cell priming: a new role for lymphatic endothelial cells.

Hirosue S, Vokali E, Raghavan VR, Rincon-Restrepo M, Lund AW, Corthésy-Henrioud P, Capotosti F, Halin Winter C, Hugues S, Swartz MA.

J Immunol. 2014 Jun 1;192(11):5002-11. doi: 10.4049/jimmunol.1302492. Epub 2014 May 2.


Role of major histocompatibility complex class II expression by non-hematopoietic cells in autoimmune and inflammatory disorders: facts and fiction.

Duraes FV, Thelemann C, Sarter K, Acha-Orbea H, Hugues S, Reith W.

Tissue Antigens. 2013 Jul;82(1):1-15. doi: 10.1111/tan.12136. Review.


Tolerogenic and activatory plasmacytoid dendritic cells in autoimmunity.

Guéry L, Hugues S.

Front Immunol. 2013 Mar 6;4:59. doi: 10.3389/fimmu.2013.00059. eCollection 2013.


VEGF-C promotes immune tolerance in B16 melanomas and cross-presentation of tumor antigen by lymph node lymphatics.

Lund AW, Duraes FV, Hirosue S, Raghavan VR, Nembrini C, Thomas SN, Issa A, Hugues S, Swartz MA.

Cell Rep. 2012 Mar 29;1(3):191-9. doi: 10.1016/j.celrep.2012.01.005. Epub 2012 Feb 23.


Plasmacytoid dendritic cells control T-cell response to chronic viral infection.

Cervantes-Barragan L, Lewis KL, Firner S, Thiel V, Hugues S, Reith W, Ludewig B, Reizis B.

Proc Natl Acad Sci U S A. 2012 Feb 21;109(8):3012-7. doi: 10.1073/pnas.1117359109. Epub 2012 Feb 6.


Associative learning changes the organization of functional excitatory circuits targeting the supragranular layers of mouse barrel cortex.

Rosselet C, Fieschi M, Hugues S, Bureau I.

Front Neural Circuits. 2011 Jan 14;4:126. doi: 10.3389/fncir.2010.00126. eCollection 2011.


Saccadic foveation of a moving visual target in the rhesus monkey.

Fleuriet J, Hugues S, Perrinet L, Goffart L.

J Neurophysiol. 2011 Feb;105(2):883-95. doi: 10.1152/jn.00622.2010. Epub 2010 Dec 15.


MHC class II-restricted antigen presentation by plasmacytoid dendritic cells inhibits T cell-mediated autoimmunity.

Irla M, Küpfer N, Suter T, Lissilaa R, Benkhoucha M, Skupsky J, Lalive PH, Fontana A, Reith W, Hugues S.

J Exp Med. 2010 Aug 30;207(9):1891-905. doi: 10.1084/jem.20092627. Epub 2010 Aug 9.


Dynamics of dendritic cell-T cell interactions: a role in T cell outcome.

Hugues S.

Semin Immunopathol. 2010 Sep;32(3):227-38. doi: 10.1007/s00281-010-0211-2. Epub 2010 Jul 6. Review.


A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells.

Bougnères L, Helft J, Tiwari S, Vargas P, Chang BH, Chan L, Campisi L, Lauvau G, Hugues S, Kumar P, Kamphorst AO, Dumenil AM, Nussenzweig M, MacMicking JD, Amigorena S, Guermonprez P.

Immunity. 2009 Aug 21;31(2):232-44. doi: 10.1016/j.immuni.2009.06.022.


Regulation of dendritic cell migration by CD74, the MHC class II-associated invariant chain.

Faure-André G, Vargas P, Yuseff MI, Heuzé M, Diaz J, Lankar D, Steri V, Manry J, Hugues S, Vascotto F, Boulanger J, Raposo G, Bono MR, Rosemblatt M, Piel M, Lennon-Duménil AM.

Science. 2008 Dec 12;322(5908):1705-10. doi: 10.1126/science.1159894.


Direct presentation of a melanocyte-associated antigen in peripheral lymph nodes induces cytotoxic CD8+ T cells.

Schuler P, Contassot E, Irla M, Hugues S, Preynat-Seauve O, Beermann F, Donda A, French LE, Huard B.

Cancer Res. 2008 Oct 15;68(20):8410-8. doi: 10.1158/0008-5472.CAN-08-0809.


Imaging of plasmacytoid dendritic cell interactions with T cells.

Mittelbrunn M, Martínez del Hoyo G, López-Bravo M, Martín-Cofreces NB, Scholer A, Hugues S, Fetler L, Amigorena S, Ardavín C, Sánchez-Madrid F.

Blood. 2009 Jan 1;113(1):75-84. doi: 10.1182/blood-2008-02-139865. Epub 2008 Sep 25.


Autoantigen-specific interactions with CD4+ thymocytes control mature medullary thymic epithelial cell cellularity.

Irla M, Hugues S, Gill J, Nitta T, Hikosaka Y, Williams IR, Hubert FX, Scott HS, Takahama Y, Holländer GA, Reith W.

Immunity. 2008 Sep 19;29(3):451-63. doi: 10.1016/j.immuni.2008.08.007.


Intercellular adhesion molecule-1-dependent stable interactions between T cells and dendritic cells determine CD8+ T cell memory.

Scholer A, Hugues S, Boissonnas A, Fetler L, Amigorena S.

Immunity. 2008 Feb;28(2):258-70. doi: 10.1016/j.immuni.2007.12.016.


TLR4/MD-2 monoclonal antibody therapy affords protection in experimental models of septic shock.

Daubeuf B, Mathison J, Spiller S, Hugues S, Herren S, Ferlin W, Kosco-Vilbois M, Wagner H, Kirschning CJ, Ulevitch R, Elson G.

J Immunol. 2007 Nov 1;179(9):6107-14.


Dynamic imaging of chemokine-dependent CD8+ T cell help for CD8+ T cell responses.

Hugues S, Scholer A, Boissonnas A, Nussbaum A, Combadière C, Amigorena S, Fetler L.

Nat Immunol. 2007 Sep;8(9):921-30. Epub 2007 Jul 29.


In vivo imaging of cytotoxic T cell infiltration and elimination of a solid tumor.

Boissonnas A, Fetler L, Zeelenberg IS, Hugues S, Amigorena S.

J Exp Med. 2007 Feb 19;204(2):345-56. Epub 2007 Jan 29.


NOX2 controls phagosomal pH to regulate antigen processing during crosspresentation by dendritic cells.

Savina A, Jancic C, Hugues S, Guermonprez P, Vargas P, Moura IC, Lennon-Duménil AM, Seabra MC, Raposo G, Amigorena S.

Cell. 2006 Jul 14;126(1):205-18.


The dynamics of dendritic cell-T cell interactions in priming and tolerance.

Hugues S, Boissonnas A, Amigorena S, Fetler L.

Curr Opin Immunol. 2006 Aug;18(4):491-5. Epub 2006 Jun 12. Review.


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