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Items: 8


The scaffolding protein Cnk binds to the receptor tyrosine kinase Alk to promote visceral founder cell specification in Drosophila.

Wolfstetter G, Pfeifer K, van Dijk JR, Hugosson F, Lu X, Palmer RH.

Sci Signal. 2017 Oct 24;10(502). pii: eaan0804. doi: 10.1126/scisignal.aan0804.


The Zic family homologue Odd-paired regulates Alk expression in Drosophila.

Mendoza-García P, Hugosson F, Fallah M, Higgins ML, Iwasaki Y, Pfeifer K, Wolfstetter G, Varshney G, Popichenko D, Gergen JP, Hens K, Deplancke B, Palmer RH.

PLoS Genet. 2017 Apr 3;13(4):e1006617. doi: 10.1371/journal.pgen.1006617. eCollection 2017 Apr.


Anaplastic lymphoma kinase L1198F and G1201E mutations identified in anaplastic thyroid cancer patients are not ligand-independent.

Guan J, Wolfstetter G, Siaw J, Chand D, Hugosson F, Palmer RH, Hallberg B.

Oncotarget. 2017 Feb 14;8(7):11566-11578. doi: 10.18632/oncotarget.14141.


FAM150A and FAM150B are activating ligands for anaplastic lymphoma kinase.

Guan J, Umapathy G, Yamazaki Y, Wolfstetter G, Mendoza P, Pfeifer K, Mohammed A, Hugosson F, Zhang H, Hsu AW, Halenbeck R, Hallberg B, Palmer RH.

Elife. 2015 Sep 29;4:e09811. doi: 10.7554/eLife.09811.


The Drosophila midkine/pleiotrophin homologues Miple1 and Miple2 affect adult lifespan but are dispensable for alk signaling during embryonic gut formation.

Hugosson F, Sjögren C, Birve A, Hedlund L, Eriksson T, Palmer RH.

PLoS One. 2014 Nov 7;9(11):e112250. doi: 10.1371/journal.pone.0112250. eCollection 2014.


Phosphoproteomic analysis of anaplastic lymphoma kinase (ALK) downstream signaling pathways identifies signal transducer and activator of transcription 3 as a functional target of activated ALK in neuroblastoma cells.

Sattu K, Hochgräfe F, Wu J, Umapathy G, Schönherr C, Ruuth K, Chand D, Witek B, Fuchs J, Li PK, Hugosson F, Daly RJ, Palmer RH, Hallberg B.

FEBS J. 2013 Nov;280(21):5269-82. doi: 10.1111/febs.12453. Epub 2013 Aug 22.


Jeb/Alk signalling regulates the Lame duck GLI family transcription factor in the Drosophila visceral mesoderm.

Popichenko D, Hugosson F, Sjögren C, Dogru M, Yamazaki Y, Wolfstetter G, Schönherr C, Fallah M, Hallberg B, Nguyen H, Palmer RH.

Development. 2013 Aug;140(15):3156-66. doi: 10.1242/dev.094466. Epub 2013 Jul 3.


The Rap1 guanine nucleotide exchange factor C3G is required for preservation of larval muscle integrity in Drosophila melanogaster.

Shirinian M, Popovic M, Grabbe C, Varshney G, Hugosson F, Bos H, Rehmann H, Palmer RH.

PLoS One. 2010 Mar 3;5(3):e9403. doi: 10.1371/journal.pone.0009403. Erratum in: PLoS One. 2010;5(3). doi: 10.1371/annotation/c3ebafa0-1531-4e9f-ab3a-660db7b8dcd2.

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