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Tryptophan Fluorescence Quenching in β-Lactam-Interacting Proteins Is Modulated by the Structure of Intermediates and Final Products of the Acylation Reaction.

Triboulet S, Edoo Z, Compain F, Ourghanlian C, Dupuis A, Dubée V, Sutterlin L, Atze H, Etheve-Quelquejeu M, Hugonnet JE, Arthur M.

ACS Infect Dis. 2019 Jul 12;5(7):1169-1176. doi: 10.1021/acsinfecdis.9b00023. Epub 2019 May 14.


Structural insight into YcbB-mediated beta-lactam resistance in Escherichia coli.

Caveney NA, Caballero G, Voedts H, Niciforovic A, Worrall LJ, Vuckovic M, Fonvielle M, Hugonnet JE, Arthur M, Strynadka NCJ.

Nat Commun. 2019 Apr 23;10(1):1849. doi: 10.1038/s41467-019-09507-0.


Negative Impact of Carbapenem Methylation on the Reactivity of β-Lactams for Cysteine Acylation as Revealed by Quantum Calculations and Kinetic Analyses.

Bhattacharjee N, Triboulet S, Dubée V, Fonvielle M, Edoo Z, Hugonnet JE, Ethève-Quelquejeu M, Simorre JP, Field MJ, Arthur M, Bougault CM.

Antimicrob Agents Chemother. 2019 Mar 27;63(4). pii: e02039-18. doi: 10.1128/AAC.02039-18. Print 2019 Apr.


Copper inhibits peptidoglycan LD-transpeptidases suppressing β-lactam resistance due to bypass of penicillin-binding proteins.

Peters K, Pazos M, Edoo Z, Hugonnet JE, Martorana AM, Polissi A, VanNieuwenhze MS, Arthur M, Vollmer W.

Proc Natl Acad Sci U S A. 2018 Oct 16;115(42):10786-10791. doi: 10.1073/pnas.1809285115. Epub 2018 Oct 1.


Synthesis of Avibactam Derivatives and Activity on β-Lactamases and Peptidoglycan Biosynthesis Enzymes of Mycobacteria.

Edoo Z, Iannazzo L, Compain F, Li de la Sierra Gallay I, van Tilbeurgh H, Fonvielle M, Bouchet F, Le Run E, Mainardi JL, Arthur M, Ethève-Quelquejeu M, Hugonnet JE.

Chemistry. 2018 Jun 7;24(32):8081-8086. doi: 10.1002/chem.201800923. Epub 2018 May 14.


Critical Impact of Peptidoglycan Precursor Amidation on the Activity of l,d-Transpeptidases from Enterococcus faecium and Mycobacterium tuberculosis.

Ngadjeua F, Braud E, Saidjalolov S, Iannazzo L, Schnappinger D, Ehrt S, Hugonnet JE, Mengin-Lecreulx D, Patin D, Ethève-Quelquejeu M, Fonvielle M, Arthur M.

Chemistry. 2018 Apr 17;24(22):5743-5747. doi: 10.1002/chem.201706082. Epub 2018 Feb 21.


Peptidoglycan Cross-Linking Activity of l,d-Transpeptidases from Clostridium difficile and Inactivation of These Enzymes by β-Lactams.

Sütterlin L, Edoo Z, Hugonnet JE, Mainardi JL, Arthur M.

Antimicrob Agents Chemother. 2017 Dec 21;62(1). pii: e01607-17. doi: 10.1128/AAC.01607-17. Print 2018 Jan.


Inhibition of β-lactamases of mycobacteria by avibactam and clavulanate.

Soroka D, Ourghanlian C, Compain F, Fichini M, Dubée V, Mainardi JL, Hugonnet JE, Arthur M.

J Antimicrob Chemother. 2017 Apr 1;72(4):1081-1088. doi: 10.1093/jac/dkw546.


Factors essential for L,D-transpeptidase-mediated peptidoglycan cross-linking and β-lactam resistance in Escherichia coli.

Hugonnet JE, Mengin-Lecreulx D, Monton A, den Blaauwen T, Carbonnelle E, Veckerlé C, Brun YV, van Nieuwenhze M, Bouchier C, Tu K, Rice LB, Arthur M.

Elife. 2016 Oct 21;5. pii: e19469. doi: 10.7554/eLife.19469.


Routes of Synthesis of Carbapenems for Optimizing Both the Inactivation of L,D-Transpeptidase LdtMt1 of Mycobacterium tuberculosis and the Stability toward Hydrolysis by β-Lactamase BlaC.

Iannazzo L, Soroka D, Triboulet S, Fonvielle M, Compain F, Dubée V, Mainardi JL, Hugonnet JE, Braud E, Arthur M, Etheve-Quelquejeu M.

J Med Chem. 2016 Apr 14;59(7):3427-38. doi: 10.1021/acs.jmedchem.6b00096. Epub 2016 Mar 18.


Methicillin-Susceptible, Vancomycin-Resistant Staphylococcus aureus, Brazil.

Panesso D, Planet PJ, Diaz L, Hugonnet JE, Tran TT, Narechania A, Munita JM, Rincon S, Carvajal LP, Reyes J, Londoño A, Smith H, Sebra R, Deikus G, Weinstock GM, Murray BE, Rossi F, Arthur M, Arias CA.

Emerg Infect Dis. 2015 Oct;21(10):1844-8. doi: 10.3201/eid2110.141914.


Hydrolysis of clavulanate by Mycobacterium tuberculosis β-lactamase BlaC harboring a canonical SDN motif.

Soroka D, Li de la Sierra-Gallay I, Dubée V, Triboulet S, van Tilbeurgh H, Compain F, Ballell L, Barros D, Mainardi JL, Hugonnet JE, Arthur M.

Antimicrob Agents Chemother. 2015 Sep;59(9):5714-20. doi: 10.1128/AAC.00598-15. Epub 2015 Jul 6.


Acyl acceptor recognition by Enterococcus faecium L,D-transpeptidase Ldtfm.

Triboulet S, Bougault CM, Laguri C, Hugonnet JE, Arthur M, Simorre JP.

Mol Microbiol. 2015 Oct;98(1):90-100. doi: 10.1111/mmi.13104. Epub 2015 Jul 17.


Mutation landscape of acquired cross-resistance to glycopeptide and β-lactam antibiotics in Enterococcus faecium.

Sacco E, Cortes M, Josseaume N, Bouchier C, Dubée V, Hugonnet JE, Mainardi JL, Rice LB, Arthur M.

Antimicrob Agents Chemother. 2015 Sep;59(9):5306-15. doi: 10.1128/AAC.00634-15. Epub 2015 Jun 15.


Combinations of β-Lactam Antibiotics Currently in Clinical Trials Are Efficacious in a DHP-I-Deficient Mouse Model of Tuberculosis Infection.

Rullas J, Dhar N, McKinney JD, García-Pérez A, Lelievre J, Diacon AH, Hugonnet JE, Arthur M, Angulo-Barturen I, Barros-Aguirre D, Ballell L.

Antimicrob Agents Chemother. 2015 Aug;59(8):4997-9. doi: 10.1128/AAC.01063-15. Epub 2015 May 18.


Impact of β-lactamase inhibition on the activity of ceftaroline against Mycobacterium tuberculosis and Mycobacterium abscessus.

Dubée V, Soroka D, Cortes M, Lefebvre AL, Gutmann L, Hugonnet JE, Arthur M, Mainardi JL.

Antimicrob Agents Chemother. 2015 May;59(5):2938-41. doi: 10.1128/AAC.05080-14. Epub 2015 Mar 2.


β-Lactamase inhibition by avibactam in Mycobacterium abscessus.

Dubée V, Bernut A, Cortes M, Lesne T, Dorchene D, Lefebvre AL, Hugonnet JE, Gutmann L, Mainardi JL, Herrmann JL, Gaillard JL, Kremer L, Arthur M.

J Antimicrob Chemother. 2015 Apr;70(4):1051-8. doi: 10.1093/jac/dku510. Epub 2014 Dec 18.


Rapid cytolysis of Mycobacterium tuberculosis by faropenem, an orally bioavailable β-lactam antibiotic.

Dhar N, Dubée V, Ballell L, Cuinet G, Hugonnet JE, Signorino-Gelo F, Barros D, Arthur M, McKinney JD.

Antimicrob Agents Chemother. 2015 Feb;59(2):1308-19. doi: 10.1128/AAC.03461-14. Epub 2014 Nov 24.


Peptidoglycan cross-linking in glycopeptide-resistant Actinomycetales.

Hugonnet JE, Haddache N, Veckerlé C, Dubost L, Marie A, Shikura N, Mainardi JL, Rice LB, Arthur M.

Antimicrob Agents Chemother. 2014;58(3):1749-56. doi: 10.1128/AAC.02329-13. Epub 2014 Jan 6.


Characterization of broad-spectrum Mycobacterium abscessus class A β-lactamase.

Soroka D, Dubée V, Soulier-Escrihuela O, Cuinet G, Hugonnet JE, Gutmann L, Mainardi JL, Arthur M.

J Antimicrob Chemother. 2014 Mar;69(3):691-6. doi: 10.1093/jac/dkt410. Epub 2013 Oct 16.


In vitro cross-linking of Mycobacterium tuberculosis peptidoglycan by L,D-transpeptidases and inactivation of these enzymes by carbapenems.

Cordillot M, Dubée V, Triboulet S, Dubost L, Marie A, Hugonnet JE, Arthur M, Mainardi JL.

Antimicrob Agents Chemother. 2013 Dec;57(12):5940-5. doi: 10.1128/AAC.01663-13. Epub 2013 Sep 16.


Chemical shift perturbations induced by the acylation of Enterococcus faecium L,D-transpeptidase catalytic cysteine with ertapenem.

Lecoq L, Bougault C, Triboulet S, Dubée V, Hugonnet JE, Arthur M, Simorre JP.

Biomol NMR Assign. 2014 Oct;8(2):339-43. doi: 10.1007/s12104-013-9513-3. Epub 2013 Aug 2.


Discovery of the first inhibitors of bacterial enzyme D-aspartate ligase from Enterococcus faecium (Aslfm).

Škedelj V, Perdih A, Brvar M, Kroflič A, Dubbée V, Savage V, O'Neill AJ, Solmajer T, Bešter-Rogač M, Blanot D, Hugonnet JE, Magnet S, Arthur M, Mainardi JL, Stojan J, Zega A.

Eur J Med Chem. 2013 Sep;67:208-20. doi: 10.1016/j.ejmech.2013.06.017. Epub 2013 Jun 28.


Kinetic features of L,D-transpeptidase inactivation critical for β-lactam antibacterial activity.

Triboulet S, Dubée V, Lecoq L, Bougault C, Mainardi JL, Rice LB, Ethève-Quelquejeu M, Gutmann L, Marie A, Dubost L, Hugonnet JE, Simorre JP, Arthur M.

PLoS One. 2013 Jul 4;8(7):e67831. doi: 10.1371/journal.pone.0067831. Print 2013.


Structure of Enterococcus faeciuml,d-transpeptidase acylated by ertapenem provides insight into the inactivation mechanism.

Lecoq L, Dubée V, Triboulet S, Bougault C, Hugonnet JE, Arthur M, Simorre JP.

ACS Chem Biol. 2013;8(6):1140-6. doi: 10.1021/cb4001603. Epub 2013 Apr 12.


Inactivation of Mycobacterium tuberculosis l,d-transpeptidase LdtMt₁ by carbapenems and cephalosporins.

Dubée V, Triboulet S, Mainardi JL, Ethève-Quelquejeu M, Gutmann L, Marie A, Dubost L, Hugonnet JE, Arthur M.

Antimicrob Agents Chemother. 2012 Aug;56(8):4189-95. doi: 10.1128/AAC.00665-12. Epub 2012 May 21.


Dynamics induced by β-lactam antibiotics in the active site of Bacillus subtilis L,D-transpeptidase.

Lecoq L, Bougault C, Hugonnet JE, Veckerlé C, Pessey O, Arthur M, Simorre JP.

Structure. 2012 May 9;20(5):850-61. doi: 10.1016/j.str.2012.03.015.


Kinetic analysis of Enterococcus faecium L,D-transpeptidase inactivation by carbapenems.

Dubée V, Arthur M, Fief H, Triboulet S, Mainardi JL, Gutmann L, Sollogoub M, Rice LB, Ethève-Quelquejeu M, Hugonnet JE.

Antimicrob Agents Chemother. 2012 Jun;56(6):3409-12. doi: 10.1128/AAC.06398-11. Epub 2012 Mar 26.


Backbone and side-chain 1H, 15N and 13C assignment of apo- and imipenem-acylated L,D-transpeptidase from Bacillus subtilis.

Lecoq L, Bougault C, Kern T, Hugonnet JE, Veckerlé C, Pessey O, Arthur M, Simorre JP.

Biomol NMR Assign. 2012 Oct;6(2):205-8. doi: 10.1007/s12104-012-9358-1. Epub 2012 Jan 26.


Fighting resistant tuberculosis with old compounds: the carbapenem paradigm.

Mainardi JL, Hugonnet JE, Gutmann L, Arthur M.

Clin Microbiol Infect. 2011 Dec;17(12):1755-6. doi: 10.1111/j.1469-0691.2011.03699.x. Epub 2011 Nov 1. No abstract available.


Inactivation kinetics of a new target of beta-lactam antibiotics.

Triboulet S, Arthur M, Mainardi JL, Veckerlé C, Dubée V, Nguekam-Moumi A, Gutmann L, Rice LB, Hugonnet JE.

J Biol Chem. 2011 Jul 1;286(26):22777-84. doi: 10.1074/jbc.M111.239988. Epub 2011 May 4.


Characterization of CrgA, a new partner of the Mycobacterium tuberculosis peptidoglycan polymerization complexes.

Plocinski P, Ziolkiewicz M, Kiran M, Vadrevu SI, Nguyen HB, Hugonnet J, Veckerle C, Arthur M, Dziadek J, Cross TA, Madiraju M, Rajagopalan M.

J Bacteriol. 2011 Jul;193(13):3246-56. doi: 10.1128/JB.00188-11. Epub 2011 Apr 29.


Activation of the L,D-transpeptidation peptidoglycan cross-linking pathway by a metallo-D,D-carboxypeptidase in Enterococcus faecium.

Sacco E, Hugonnet JE, Josseaume N, Cremniter J, Dubost L, Marie A, Patin D, Blanot D, Rice LB, Mainardi JL, Arthur M.

Mol Microbiol. 2010 Feb;75(4):874-85. doi: 10.1111/j.1365-2958.2009.07014.x. Epub 2009 Dec 16.


[Efficient combination of clavulanate and beta-lactam antibiotics against extensively drug-resistant M. tuberculosis].

Hugonnet JE.

Med Sci (Paris). 2009 Aug-Sep;25(8-9):661-3. doi: 10.1051/medsci/2009258-9661. French. No abstract available.


Meropenem-clavulanate is effective against extensively drug-resistant Mycobacterium tuberculosis.

Hugonnet JE, Tremblay LW, Boshoff HI, Barry CE 3rd, Blanchard JS.

Science. 2009 Feb 27;323(5918):1215-8. doi: 10.1126/science.1167498.


Structure of the covalent adduct formed between Mycobacterium tuberculosis beta-lactamase and clavulanate.

Tremblay LW, Hugonnet JE, Blanchard JS.

Biochemistry. 2008 May 13;47(19):5312-6. doi: 10.1021/bi8001055. Epub 2008 Apr 19.


Idiosyncratic features in tRNAs participating in bacterial cell wall synthesis.

Villet R, Fonvielle M, Busca P, Chemama M, Maillard AP, Hugonnet JE, Dubost L, Marie A, Josseaume N, Mesnage S, Mayer C, Valéry JM, Ethève-Quelquejeu M, Arthur M.

Nucleic Acids Res. 2007;35(20):6870-83. Epub 2007 Oct 11.


Irreversible inhibition of the Mycobacterium tuberculosis beta-lactamase by clavulanate.

Hugonnet JE, Blanchard JS.

Biochemistry. 2007 Oct 30;46(43):11998-2004. Epub 2007 Oct 4.


Unexpected inhibition of peptidoglycan LD-transpeptidase from Enterococcus faecium by the beta-lactam imipenem.

Mainardi JL, Hugonnet JE, Rusconi F, Fourgeaud M, Dubost L, Moumi AN, Delfosse V, Mayer C, Gutmann L, Rice LB, Arthur M.

J Biol Chem. 2007 Oct 19;282(42):30414-22. Epub 2007 Jul 23.


Specificity of L,D-transpeptidases from gram-positive bacteria producing different peptidoglycan chemotypes.

Magnet S, Arbeloa A, Mainardi JL, Hugonnet JE, Fourgeaud M, Dubost L, Marie A, Delfosse V, Mayer C, Rice LB, Arthur M.

J Biol Chem. 2007 May 4;282(18):13151-9. Epub 2007 Feb 20.


Novel mechanism of resistance to glycopeptide antibiotics in Enterococcus faecium.

Cremniter J, Mainardi JL, Josseaume N, Quincampoix JC, Dubost L, Hugonnet JE, Marie A, Gutmann L, Rice LB, Arthur M.

J Biol Chem. 2006 Oct 27;281(43):32254-62. Epub 2006 Aug 29.


Crystal structure of a novel beta-lactam-insensitive peptidoglycan transpeptidase.

Biarrotte-Sorin S, Hugonnet JE, Delfosse V, Mainardi JL, Gutmann L, Arthur M, Mayer C.

J Mol Biol. 2006 Jun 9;359(3):533-8. Epub 2006 Mar 23.


Cloning, purification, crystallization and preliminary crystallographic analysis of a penicillin-binding protein homologue from Pyrococcus abyssi.

Delfosse V, Hugonnet JE, Sougakoff W, Mayer C.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Nov 1;61(Pt 11):1006-8. Epub 2005 Oct 25.


Aslfm, the D-aspartate ligase responsible for the addition of D-aspartic acid onto the peptidoglycan precursor of Enterococcus faecium.

Bellais S, Arthur M, Dubost L, Hugonnet JE, Gutmann L, van Heijenoort J, Legrand R, Brouard JP, Rice L, Mainardi JL.

J Biol Chem. 2006 Apr 28;281(17):11586-94. Epub 2006 Feb 28.


A novel peptidoglycan cross-linking enzyme for a beta-lactam-resistant transpeptidation pathway.

Mainardi JL, Fourgeaud M, Hugonnet JE, Dubost L, Brouard JP, Ouazzani J, Rice LB, Gutmann L, Arthur M.

J Biol Chem. 2005 Nov 18;280(46):38146-52. Epub 2005 Sep 6.


Synthesis of mosaic peptidoglycan cross-bridges by hybrid peptidoglycan assembly pathways in gram-positive bacteria.

Arbeloa A, Hugonnet JE, Sentilhes AC, Josseaume N, Dubost L, Monsempes C, Blanot D, Brouard JP, Arthur M.

J Biol Chem. 2004 Oct 1;279(40):41546-56. Epub 2004 Jul 26.


Role of class A penicillin-binding proteins in PBP5-mediated beta-lactam resistance in Enterococcus faecalis.

Arbeloa A, Segal H, Hugonnet JE, Josseaume N, Dubost L, Brouard JP, Gutmann L, Mengin-Lecreulx D, Arthur M.

J Bacteriol. 2004 Mar;186(5):1221-8.


The CroRS two-component regulatory system is required for intrinsic beta-lactam resistance in Enterococcus faecalis.

Comenge Y, Quintiliani R Jr, Li L, Dubost L, Brouard JP, Hugonnet JE, Arthur M.

J Bacteriol. 2003 Dec;185(24):7184-92.


Crystallization and preliminary X-ray analysis of Weissella viridescens FemX UDP-MurNAc-pentapeptide:l-alanine ligase.

Biarrotte-Sorin S, Maillard AP, Delettré J, Sougakoff W, Blanot D, Blondeau K, Hugonnet JE, Mayer C, Arthur M.

Acta Crystallogr D Biol Crystallogr. 2003 Jun;59(Pt 6):1055-7. Epub 2003 May 23.


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