Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 38

1.

Inactivation of chronic wasting disease prions using sodium hypochlorite.

Williams K, Hughson AG, Chesebro B, Race B.

PLoS One. 2019 Oct 4;14(10):e0223659. doi: 10.1371/journal.pone.0223659. eCollection 2019.

2.

Ultrasensitive RT-QuIC Seed Amplification Assays for Disease-Associated Tau, α-Synuclein, and Prion Aggregates.

Saijo E, Groveman BR, Kraus A, Metrick M, Orrù CD, Hughson AG, Caughey B.

Methods Mol Biol. 2019;1873:19-37. doi: 10.1007/978-1-4939-8820-4_2.

PMID:
30341601
3.

Lack of Transmission of Chronic Wasting Disease to Cynomolgus Macaques.

Race B, Williams K, Orrú CD, Hughson AG, Lubke L, Chesebro B.

J Virol. 2018 Jun 29;92(14). pii: e00550-18. doi: 10.1128/JVI.00550-18. Print 2018 Jul 15.

4.

Familial human prion diseases associated with prion protein mutations Y226X and G131V are transmissible to transgenic mice expressing human prion protein.

Race B, Williams K, Hughson AG, Jansen C, Parchi P, Rozemuller AJM, Chesebro B.

Acta Neuropathol Commun. 2018 Feb 20;6(1):13. doi: 10.1186/s40478-018-0516-2.

5.

Rapid and ultra-sensitive quantitation of disease-associated α-synuclein seeds in brain and cerebrospinal fluid by αSyn RT-QuIC.

Groveman BR, Orrù CD, Hughson AG, Raymond LD, Zanusso G, Ghetti B, Campbell KJ, Safar J, Galasko D, Caughey B.

Acta Neuropathol Commun. 2018 Feb 9;6(1):7. doi: 10.1186/s40478-018-0508-2.

6.

A Promising Antiprion Trimethoxychalcone Binds to the Globular Domain of the Cellular Prion Protein and Changes Its Cellular Location.

Ferreira NC, Ascari LM, Hughson AG, Cavalheiro GR, Góes CF, Fernandes PN, Hollister JR, da Conceição RA, Silva DS, Souza AMT, Barbosa MLC, Lara FA, Martins RAP, Caughey B, Cordeiro Y.

Antimicrob Agents Chemother. 2018 Jan 25;62(2). pii: e01441-17. doi: 10.1128/AAC.01441-17. Print 2018 Feb.

7.

Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregates.

Groveman BR, Raymond GJ, Campbell KJ, Race B, Raymond LD, Hughson AG, Orrú CD, Kraus A, Phillips K, Caughey B.

PLoS Pathog. 2017 Sep 14;13(9):e1006623. doi: 10.1371/journal.ppat.1006623. eCollection 2017 Sep.

8.

High diagnostic value of second generation CSF RT-QuIC across the wide spectrum of CJD prions.

Franceschini A, Baiardi S, Hughson AG, McKenzie N, Moda F, Rossi M, Capellari S, Green A, Giaccone G, Caughey B, Parchi P.

Sci Rep. 2017 Sep 6;7(1):10655. doi: 10.1038/s41598-017-10922-w.

9.

RT-QuIC Assays for Prion Disease Detection and Diagnostics.

Orrù CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Campbell KJ, Anson KJ, Kraus A, Caughey B.

Methods Mol Biol. 2017;1658:185-203. doi: 10.1007/978-1-4939-7244-9_14.

PMID:
28861791
10.

Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants.

Caughey B, Orru CD, Groveman BR, Hughson AG, Manca M, Raymond LD, Raymond GJ, Race B, Saijo E, Kraus A.

Prog Mol Biol Transl Sci. 2017;150:375-388. doi: 10.1016/bs.pmbts.2017.06.003. Epub 2017 Jul 27. Review.

PMID:
28838670
11.

PrP P102L and Nearby Lysine Mutations Promote Spontaneous In Vitro Formation of Transmissible Prions.

Kraus A, Raymond GJ, Race B, Campbell KJ, Hughson AG, Anson KJ, Raymond LD, Caughey B.

J Virol. 2017 Oct 13;91(21). pii: e01276-17. doi: 10.1128/JVI.01276-17. Print 2017 Nov 1.

12.

Extended and direct evaluation of RT-QuIC assays for Creutzfeldt-Jakob disease diagnosis.

Groveman BR, Orrú CD, Hughson AG, Bongianni M, Fiorini M, Imperiale D, Ladogana A, Pocchiari M, Zanusso G, Caughey B.

Ann Clin Transl Neurol. 2016 Dec 27;4(2):139-144. doi: 10.1002/acn3.378. eCollection 2017 Feb.

13.

Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples.

Bongianni M, Orrù C, Groveman BR, Sacchetto L, Fiorini M, Tonoli G, Triva G, Capaldi S, Testi S, Ferrari S, Cagnin A, Ladogana A, Poleggi A, Colaizzo E, Tiple D, Vaianella L, Castriciano S, Marchioni D, Hughson AG, Imperiale D, Cattaruzza T, Fabrizi GM, Pocchiari M, Monaco S, Caughey B, Zanusso G.

JAMA Neurol. 2017 Feb 1;74(2):155-162. doi: 10.1001/jamaneurol.2016.4614.

PMID:
27942718
14.

Inactivation of Prions and Amyloid Seeds with Hypochlorous Acid.

Hughson AG, Race B, Kraus A, Sangaré LR, Robins L, Groveman BR, Saijo E, Phillips K, Contreras L, Dhaliwal V, Manca M, Zanusso G, Terry D, Williams JF, Caughey B.

PLoS Pathog. 2016 Sep 29;12(9):e1005914. doi: 10.1371/journal.ppat.1005914. eCollection 2016 Sep.

15.

Factors That Improve RT-QuIC Detection of Prion Seeding Activity.

Orrú CD, Hughson AG, Groveman BR, Campbell KJ, Anson KJ, Manca M, Kraus A, Caughey B.

Viruses. 2016 May 23;8(5). pii: E140. doi: 10.3390/v8050140.

16.

Correction for Masujin et al., Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.

Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B.

J Clin Microbiol. 2016 May;54(5):1407. doi: 10.1128/JCM.00472-16. No abstract available.

17.

PrPSc-Specific Antibody Reveals C-Terminal Conformational Differences between Prion Strains.

Saijo E, Hughson AG, Raymond GJ, Suzuki A, Horiuchi M, Caughey B.

J Virol. 2016 Apr 29;90(10):4905-4913. doi: 10.1128/JVI.00088-16. Print 2016 May 15.

18.

Detection of Atypical H-Type Bovine Spongiform Encephalopathy and Discrimination of Bovine Prion Strains by Real-Time Quaking-Induced Conversion.

Masujin K, Orrú CD, Miyazawa K, Groveman BR, Raymond LD, Hughson AG, Caughey B.

J Clin Microbiol. 2016 Mar;54(3):676-86. doi: 10.1128/JCM.02731-15. Epub 2016 Jan 6. Erratum in: J Clin Microbiol. 2016 May;54(5):1407.

19.

Sensitive and specific detection of classical scrapie prions in the brains of goats by real-time quaking-induced conversion.

Dassanayake RP, Orrú CD, Hughson AG, Caughey B, Graça T, Zhuang D, Madsen-Bouterse SA, Knowles DP, Schneider DA.

J Gen Virol. 2016 Mar;97(3):803-12. doi: 10.1099/jgv.0.000367. Epub 2015 Dec 10.

20.

Correction: Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B.

PLoS Pathog. 2015 Aug 18;11(8):e1005117. doi: 10.1371/journal.ppat.1005117. eCollection 2015 Aug. No abstract available.

21.

Bank Vole Prion Protein As an Apparently Universal Substrate for RT-QuIC-Based Detection and Discrimination of Prion Strains.

Orrú CD, Groveman BR, Raymond LD, Hughson AG, Nonno R, Zou W, Ghetti B, Gambetti P, Caughey B.

PLoS Pathog. 2015 Jun 18;11(6):e1004983. doi: 10.1371/journal.ppat.1004983. eCollection 2015 Jun. Erratum in: PLoS Pathog. 2015 Aug;11(8):e1005117.

22.

Detection and discrimination of classical and atypical L-type bovine spongiform encephalopathy by real-time quaking-induced conversion.

Orrú CD, Favole A, Corona C, Mazza M, Manca M, Groveman BR, Hughson AG, Acutis PL, Caramelli M, Zanusso G, Casalone C, Caughey B.

J Clin Microbiol. 2015 Apr;53(4):1115-20. doi: 10.1128/JCM.02906-14. Epub 2015 Jan 21.

23.

Rapid and sensitive RT-QuIC detection of human Creutzfeldt-Jakob disease using cerebrospinal fluid.

Orrú CD, Groveman BR, Hughson AG, Zanusso G, Coulthart MB, Caughey B.

MBio. 2015 Jan 20;6(1). pii: e02451-14. doi: 10.1128/mBio.02451-14.

24.

A test for Creutzfeldt-Jakob disease using nasal brushings.

Orrú CD, Bongianni M, Tonoli G, Ferrari S, Hughson AG, Groveman BR, Fiorini M, Pocchiari M, Monaco S, Caughey B, Zanusso G.

N Engl J Med. 2014 Aug 7;371(6):519-29. doi: 10.1056/NEJMoa1315200. Erratum in: N Engl J Med. 2014 Nov 6;371(19):1852.

25.

Anti-prion activity of a panel of aromatic chemical compounds: in vitro and in silico approaches.

Ferreira NC, Marques IA, Conceição WA, Macedo B, Machado CS, Mascarello A, Chiaradia-Delatorre LD, Yunes RA, Nunes RJ, Hughson AG, Raymond LD, Pascutti PG, Caughey B, Cordeiro Y.

PLoS One. 2014 Jan 6;9(1):e84531. doi: 10.1371/journal.pone.0084531. eCollection 2014.

26.

Prion seeding activities of mouse scrapie strains with divergent PrPSc protease sensitivities and amyloid plaque content using RT-QuIC and eQuIC.

Vascellari S, Orrù CD, Hughson AG, King D, Barron R, Wilham JM, Baron GS, Race B, Pani A, Caughey B.

PLoS One. 2012;7(11):e48969. doi: 10.1371/journal.pone.0048969. Epub 2012 Nov 5.

27.

Isolation of novel synthetic prion strains by amplification in transgenic mice coexpressing wild-type and anchorless prion proteins.

Raymond GJ, Race B, Hollister JR, Offerdahl DK, Moore RA, Kodali R, Raymond LD, Hughson AG, Rosenke R, Long D, Dorward DW, Baron GS.

J Virol. 2012 Nov;86(21):11763-78. doi: 10.1128/JVI.01353-12. Epub 2012 Aug 22.

28.

New generation QuIC assays for prion seeding activity.

Orrù CD, Wilham JM, Vascellari S, Hughson AG, Caughey B.

Prion. 2012 Apr-Jun;6(2):147-52. doi: 10.4161/pri.19430. Epub 2012 Apr 1. Review.

PMID:
22421206
29.

Time course of prion seeding activity in cerebrospinal fluid of scrapie-infected hamsters after intratongue and intracerebral inoculations.

Orrù CD, Hughson AG, Race B, Raymond GJ, Caughey B.

J Clin Microbiol. 2012 Apr;50(4):1464-6. doi: 10.1128/JCM.06099-11. Epub 2012 Jan 11.

30.

Effect of glycans and the glycophosphatidylinositol anchor on strain dependent conformations of scrapie prion protein: improved purifications and infrared spectra.

Baron GS, Hughson AG, Raymond GJ, Offerdahl DK, Barton KA, Raymond LD, Dorward DW, Caughey B.

Biochemistry. 2011 May 31;50(21):4479-90. doi: 10.1021/bi2003907. Epub 2011 May 3.

31.

Human variant Creutzfeldt-Jakob disease and sheep scrapie PrP(res) detection using seeded conversion of recombinant prion protein.

Orrú CD, Wilham JM, Hughson AG, Raymond LD, McNally KL, Bossers A, Ligios C, Caughey B.

Protein Eng Des Sel. 2009 Aug;22(8):515-21. doi: 10.1093/protein/gzp031. Epub 2009 Jul 1.

32.

Simplified ultrasensitive prion detection by recombinant PrP conversion with shaking.

Atarashi R, Wilham JM, Christensen L, Hughson AG, Moore RA, Johnson LM, Onwubiko HA, Priola SA, Caughey B.

Nat Methods. 2008 Mar;5(3):211-2. doi: 10.1038/nmeth0308-211. No abstract available.

PMID:
18309304
33.

Ultrasensitive detection of scrapie prion protein using seeded conversion of recombinant prion protein.

Atarashi R, Moore RA, Sim VL, Hughson AG, Dorward DW, Onwubiko HA, Priola SA, Caughey B.

Nat Methods. 2007 Aug;4(8):645-50. Epub 2007 Jul 22.

PMID:
17643109
34.

Transmission and adaptation of chronic wasting disease to hamsters and transgenic mice: evidence for strains.

Raymond GJ, Raymond LD, Meade-White KD, Hughson AG, Favara C, Gardner D, Williams ES, Miller MW, Race RE, Caughey B.

J Virol. 2007 Apr;81(8):4305-14. Epub 2007 Feb 7.

35.

Fractionation of prion protein aggregates by asymmetrical flow field-flow fractionation.

Silveira JR, Hughson AG, Caughey B.

Methods Enzymol. 2006;412:21-33. Review.

PMID:
17046649
36.

The most infectious prion protein particles.

Silveira JR, Raymond GJ, Hughson AG, Race RE, Sim VL, Hayes SF, Caughey B.

Nature. 2005 Sep 8;437(7056):257-61.

Supplemental Content

Loading ...
Support Center